| Enoxaparin | thrombosis prevention, in urologic surgery | vs placebo | all NS | | Endpoint | TE [95% CI] | p val | I2 | n | k | |
|---|
| Symptomatic pulmonary embolism | 1.02 [0.02 52.70] | p=1.00 | 0 | 89 | 1 | LeGagneux , | | asymptomatic DVT | 1.02 [0.02 52.70] | p=1.00 | 0 | 89 | 1 | LeGagneux , | | Symptomatic venous thromboembolism (DVT, PE) | 1.02 [0.02 52.70] | p=1.00 | 0 | 89 | 1 | LeGagneux , | | wound haematoma / infection | no data | | transfusion | 1.36 [0.43 4.31] | p=1.00 | 0 | 89 | 1 | LeGagneux , | | Bleeding | no data | | Major bleeding | 1.36 [0.43 4.31] | p=1.00 | 0 | 89 | 1 | LeGagneux , | | All cause death | no data |
| Trial | Studied treatment | Control | Patients |
|---|
| LeGagneux , 1987 | Enoxaparin 6000 anti-Xa units | Placebo | prostatectomy surgery |
| |
| Heparin | venous thrombosis, in all type of patients | vs intravenous heparin | all NS | | Endpoint | TE [95% CI] | p val | I2 | n | k | |
|---|
| Recurrent thromboembolic event | 0.72 [0.38 1.36] | p=1.00 | 0 | 783 | 6 | Bentley, Hull, Doyle, Walker, Lopaciuk, Pini, | | Major bleeding | 0.81 [0.40 1.64] | p=1.00 | 0 | 783 | 6 | Bentley, Hull, Doyle, Walker, Lopaciuk, Pini, |
| Trial | Studied treatment | Control | Patients |
|---|
| Krahenbuhl, 1979 | subcutaneous sodic heparin 30 000 U daily (mean) | intravenous sodic heparin 30 000 U daily (mean) | | | Bentley, 1980 | subcutaneous calcic heparin 37 000 U daily (mean) | intravenous sodic heparin 36 800 U daily (mean) | | | Andersson, 1982 | subcutaneous sodic heparin 36 800 U daily (mean) | intravenous sodic heparin 33 250 U daily (mean) | | | Hull, 1986 | subcutaneous sodic heparin 32 300 U daily (mean) | intravenous sodic heparin 29 700 U daily (mean) | | | Doyle, 1987 | subcutaneous calcic heparin 29 200 U daily (mean) | intravenous calcic heparin 29 600 U daily (mean) | | | Walker, 1987 | subcutaneous calcic heparin 29 375 U daily (mean) | intravenous calcic heparin 24 384 U daily (mean) | | | Lopaciuk, 3000 | subcutaneous sodic heparin 34 400 U daily (mean) | intravenous sodic heparin 37 000 U daily (mean) | | | Pini, 1990 | subcutaneous calcic heparin 33 800 U daily (mean) | intravenous sodic heparin 31 700 U daily (mean) | |
| |
| UFH | thrombosis prevention, in general surgery | vs no treatment | Deep vein thrombosis by 59% suggested non-fatal pulmonary embolism by 41% suggested Bleeding by 56% suggested | | Endpoint | TE [95% CI] | p val | I2 | n | k | |
|---|
| Deep vein thrombosis | 0.41 [0.34 0.50] | p=0.04 | 0 | 7246 | 16 | Kakkar (IMT), Gruber, Nicolaides, Multiunit, Abernethy, Clarke-Pearson, Plante, Abraham-Inpijn, Sagar, Koppenhagen, Groote Schuur, Kraytman, Kraytman, Kettunen, Caloghera, Ziemski, | | non-fatal pulmonary embolism | 0.59 [0.39 0.88] | p=0.04 | 0 | 8280 | 20 | Kakkar (IMT), Gruber, Nicolaides, Multiunit, Abernethy, Clarke-Pearson, Plante, Abraham-Inpijn, Spebar, Sagar, Koppenhagen, Bergqvist, Gallus, Groote Schuur, Kraytman, Kraytman, Kettunen, Caloghera, Marchelli, Ziemski, | | fatal pulmonary embolism | 0.69 [0.34 1.40] | p=1.00 | 0 | 7248 | 18 | Kakkar (IMT), Gruber, Nicolaides, Multiunit, Abernethy, Clarke-Pearson, Plante, Abraham-Inpijn, Spebar, Sagar, Bergqvist, Groote Schuur, Kraytman, Kraytman, Kettunen, Caloghera, Marchelli, Ziemski, | | Bleeding | 1.56 [1.25 1.93] | p=0.04 | 0 | 6998 | 17 | Kakkar (IMT), Gruber, Multiunit, Abernethy, Clarke-Pearson, Plante, Abraham-Inpijn, Spebar, Sagar, Bergqvist, Groote Schuur, Kraytman, Kraytman, Kettunen, Caloghera, Marchelli, Ziemski, | | Fatal bleeding | 1.03 [0.43 2.42] | p=1.00 | 0 | 7248 | 18 | Kakkar (IMT), Gruber, Nicolaides, Multiunit, Abernethy, Clarke-Pearson, Plante, Abraham-Inpijn, Spebar, Sagar, Bergqvist, Groote Schuur, Kraytman, Kraytman, Kettunen, Caloghera, Marchelli, Ziemski, |
| Trial | Studied treatment | Control | Patients |
|---|
| Kakkar (IMT), 0 | UFH 3 times daily for 7 days | no treatment | All other general surgery | | Gruber, 0 | UFH 3 times daily for 7 days | no treatment | All other general surgery | | Gordon-Smith, 1972 | UFH twice daily for 5 days | no treatment | all other general surgery | | Nicolaides, 1972 | UFH twice daily for 7 days | no treatment | all other general surgery | | Multiunit, 1974 | UFH twice daily for 7 days | no treatment | all other general surgery | | Abernethy, 1974 | UFH twice daily for 7 days | no treatment | all other general surgery | | Clarke-Pearson, 1983 | UFH twice daily for 7 days | no treatment | all other general surgery | | Plante, 1979 | UFH twice daily for 8 days | no treatment | all other general surgery | | Abraham-Inpijn, 1979 | UFH twice daily for 7 days | no treatment | all other general surgery | | Spebar, 1981 | UFH twice daily for 5-7 days | no treatment | all other general surgery | | Sagar, 1974 | UFH twice daily for 5 days | no treatment | all other general surgery | | Koppenhagen, 1982 | UFH twice daily | no treatment | all other general surgery | | Bergqvist, 1980 | UFH twice daily for 5 days | no treatment | all other general surgery | | Gallus, 1973 | UFH 3 times daily for A | no treatment | all other general surgery | | Gallus, 1976 | UFH 3 times daily for 7 days | no treatment | all other general surgery | | Groote Schuur, 1979 | UFH 3 times daily for 6 days | no treatment | all other general surgery | | Kraytman, 1976 | UFH 3 times daily for 6 days | no treatment | all other general surgery | | Kraytman, 1977 | UFH 3 times daily for 6 days | no treatment | all other general surgery | | Kettunen, 1974 | UFH 3 times daily for 7 days | no treatment | all other general surgery | | Caloghera, 1984 | UFH 3 times daily for 7 days | no treatment | all other general surgery | | Marchelli, 1983 | UFH 3 times daily for ? | no treatment | all other general surgery | | Ziemski, 1979 | UFH 3 times daily for 2 days | no treatment | all other general surgery |
| |
| UFH | | vs placebo | Deep vein thrombosis by 58% suggested | | Endpoint | TE [95% CI] | p val | I2 | n | k | |
|---|
| Deep vein thrombosis | 0.42 [0.32 0.56] | p=0.04 | 0 | 1885 | 17 | Kakkar, Torngren, Torngren, Lahnborg, Covey, Belch, Taberner, Strand, Roberts, Ribaudo, Wu, Lawrence, Muiticentre, Jourdan, Kruse-Blinkenberg, Kraytman, Marchetti, | | non-fatal pulmonary embolism | 0.83 [0.40 1.70] | p=1.00 | 0 | 3184 | 18 | Kakkar, Kiil, Torngren, Torngren, Lahnborg, Lahnborg, Covey, Belch, Taberner, Strand, Roberts, Ribaudo, Wu, Lawrence, Muiticentre, Jourdan, Kraytman, Marchetti, | | fatal pulmonary embolism | 0.86 [0.42 1.78] | p=1.00 | 0 | 3246 | 19 | Kakkar, Kiil, Torngren, Torngren, Lahnborg, Lahnborg, Covey, Belch, Taberner, Strand, Roberts, Ribaudo, Wu, Lawrence, Muiticentre, Jourdan, Kruse-Blinkenberg, Kraytman, Marchetti, | | Bleeding | 1.15 [0.83 1.61] | p=1.00 | 0 | 3010 | 16 | Kiil, Torngren, Torngren, Lahnborg, Covey, Belch, Taberner, Roberts, Ribaudo, Wu, Lawrence, Muiticentre, Jourdan, Kruse-Blinkenberg, Kraytman, Marchetti, | | Fatal bleeding | 0.96 [0.43 2.18] | p=1.00 | 0 | 3246 | 19 | Kakkar, Kiil, Torngren, Torngren, Lahnborg, Lahnborg, Covey, Belch, Taberner, Strand, Roberts, Ribaudo, Wu, Lawrence, Muiticentre, Jourdan, Kruse-Blinkenberg, Kraytman, Marchetti, |
| Trial | Studied treatment | Control | Patients |
|---|
| Kakkar, 1972 | UFH twice daily for 7 days | placebo | All other general surgery | | Kiil, 1978 | UFH twice daily for 7 days | placebo | All other general surgery | | Torngren, 1978 | UFH twice daily for 6-8 days | placebo | all other general surgery | | Torngren, 0 | UFH twice daily for 6-8 days | placebo | all other general surgery | | Lahnborg, 1975 | UFH twice daily for 5 days | placebo | all other general surgery | | Lahnborg, 1976 | UFH twice daily for 5 days | placebo | all other general surgery | | Covey, 1975 | UFH twice daily for 8 days | placebo | all other general surgery | | Belch, 1980 | UFH twice daily for 7 days | placebo | all other general surgery | | Taberner, 1978 | UFH twice daily for 7 days | placebo | all other general surgery | | Strand, 1975 | UFH twice daily for 7 days | placebo | all other general surgery | | Roberts, 1975 | UFH twice daily for 7 days | placebo | all other general surgery | | Ribaudo, 1975 | UFH twice daily for A days | placebo | all other general surgery | | Wu, 1977 | UFH twice daily for 7 days | placebo | all other general surgery | | Lawrence, 1977 | UFH twice daily for 5 days | placebo | all other general surgery | | Muiticentre, 1984 | UFH twice daily for 5-7 days | placebo | all other general surgery | | Jourdan, 1984 | UFH twice daily for 5 days | placebo | all other general surgery | | Torngren, 1978 | UFH 3 times daily for 6-8 days | placebo | all other general surgery | | Kruse-Blinkenberg, 1980 | UFH 3 times daily for 8 days | placebo | all other general surgery | | Kraytman, 1977 | UFH 3 times daily for 6 days | placebo | all other general surgery | | Marchetti, 1982 | UFH 3 times daily | placebo | all other general surgery |
| |
| UFH | | vs aspirin | all NS | | Endpoint | TE [95% CI] | p val | I2 | n | k | |
|---|
| Deep vein thrombosis | 0.66 [0.35 1.23] | p=1.00 | 0 | 933 | 2 | Loew, Vinazzer, | | non-fatal pulmonary embolism | 1.06 [0.07 17.04] | p=1.00 | 0 | 933 | 2 | Loew, Vinazzer, | | fatal pulmonary embolism | 0.54 [0.05 6.49] | p=1.00 | 0 | 933 | 2 | Loew, Vinazzer, | | Bleeding | 3.28 [0.97 11.14] | p=1.00 | 0 | 933 | 2 | Loew, Vinazzer, | | Fatal bleeding | 1.06 [0.07 17.04] | p=1.00 | 0 | 933 | 2 | Loew, Vinazzer, |
| Trial | Studied treatment | Control | Patients |
|---|
| Loew, 1977 | UFH twice daily for 7 days | aspirin | all other general surgery | | Vinazzer, 1980 | UFH twice daily for A days | aspirin | all other general surgery |
| |
| UFH | | vs DHE | all NS | | Endpoint | TE [95% CI] | p val | I2 | n | k | |
|---|
| Deep vein thrombosis | 0.69 [0.43 1.09] | p=1.00 | 0 | 660 | 2 | Muiticentre 53,S4, Muiticentre, | | non-fatal pulmonary embolism | 0.96 [0.08 11.53] | p=1.00 | 0 | 660 | 2 | Muiticentre 53,S4, Muiticentre, | | fatal pulmonary embolism | 0.50 [0.03 8.04] | p=1.00 | 0 | 660 | 2 | Muiticentre 53,S4, Muiticentre, | | Bleeding | 1.46 [0.46 4.63] | p=1.00 | 0 | 660 | 2 | Muiticentre 53,S4, Muiticentre, | | Fatal bleeding | 0.97 [0.08 11.66] | p=1.00 | 0 | 660 | 2 | Muiticentre 53,S4, Muiticentre, |
| Trial | Studied treatment | Control | Patients |
|---|
| Muiticentre 53,S4, 1984 | UFH twice daily for 5-7 days | DHE | all other general surgery | | Muiticentre, 1984 | UFH twice daily for 5-7 days | DHE | all other general surgery |
| |
| UFH | | vs oral anticoagulant | Deep vein thrombosis by 72% suggested | | Endpoint | TE [95% CI] | p val | I2 | n | k | |
|---|
| Deep vein thrombosis | 0.28 [0.10 0.81] | p=0.04 | 0 | 154 | 1 | van Geloven, | | non-fatal pulmonary embolism | 0.24 [0.05 1.15] | p=1.00 | 0 | 154 | 1 | van Geloven, | | fatal pulmonary embolism | no data | | Bleeding | 1.08 [0.07 17.60] | p=1.00 | 0 | 154 | 1 | van Geloven, | | Fatal bleeding | no data |
| Trial | Studied treatment | Control | Patients |
|---|
| van Geloven, 1977 | UFH twice daily for 4 days | Oral anticoagulant | all other general surgery |
| |
| UFH | thrombosis prevention, in all type of surgery | vs no treatment | Deep vein thrombosis by 57% suggested Bleeding by 57% suggested | | Endpoint | TE [95% CI] | p val | I2 | n | k | |
|---|
| Deep vein thrombosis | 0.43 [0.36 0.51] | p=0.04 | 0 | 8108 | 30 | Morris, Welin-Berger, Bergqvist , Gallus , Mannucci , Dechavanne, Dechavanne, Bergqvist, Galasko , Gallus , Morris , Kakkar (IMT), Gruber, Nicolaides, Multiunit, Abernethy, Clarke-Pearson, Plante, Abraham-Inpijn, Sagar, Koppenhagen, Groote Schuur, Kraytman, Kraytman, Kettunen, Caloghera, Ziemski, Coe, Sebeseri, Allen, | | non-fatal pulmonary embolism | 0.72 [0.51 1.01] | p=1.00 | 0 | 9143 | 33 | Morris, Welin-Berger, Bergqvist , VTCSG, Mannucci , Dechavanne, Dechavanne, Bergqvist, Galasko , Morris , Kakkar (IMT), Gruber, Clarke-Pearson, Plante, Abraham-Inpijn, Spebar, Sagar, Koppenhagen, Bergqvist, Marchelli, Ziemski, Coe, Sebeseri, Allen, Nicolaides, Multiunit, Abernethy, Gallus, Groote Schuur, Kraytman, Kraytman, Kettunen, Caloghera, | | fatal pulmonary embolism | 0.64 [0.37 1.12] | p=1.00 | 0 | 8111 | 31 | Morris, Welin-Berger, Bergqvist , VTCSG, Mannucci , Dechavanne, Dechavanne, Bergqvist, Galasko , Morris , Kakkar (IMT), Gruber, Nicolaides, Multiunit, Abernethy, Clarke-Pearson, Plante, Abraham-Inpijn, Spebar, Sagar, Bergqvist, Groote Schuur, Kraytman, Kraytman, Kettunen, Caloghera, Marchelli, Ziemski, Coe, Sebeseri, Allen, | | Bleeding | 1.57 [1.27 1.93] | p=0.04 | 0 | 7861 | 30 | Morris, Welin-Berger, Bergqvist , VTCSG, Mannucci , Dechavanne, Dechavanne, Bergqvist, Galasko , Morris , Kakkar (IMT), Gruber, Multiunit, Abernethy, Clarke-Pearson, Plante, Abraham-Inpijn, Spebar, Sagar, Bergqvist, Groote Schuur, Kraytman, Kraytman, Kettunen, Caloghera, Marchelli, Ziemski, Coe, Sebeseri, Allen, | | Fatal bleeding | 1.01 [0.50 2.04] | p=1.00 | 0 | 7908 | 28 | Morris, Welin-Berger, Bergqvist , VTCSG, Mannucci , Dechavanne, Dechavanne, Kakkar (IMT), Gruber, Nicolaides, Multiunit, Abernethy, Clarke-Pearson, Plante, Abraham-Inpijn, Spebar, Sagar, Bergqvist, Groote Schuur, Kraytman, Kraytman, Kettunen, Caloghera, Marchelli, Ziemski, Coe, Sebeseri, Allen, |
| Trial | Studied treatment | Control | Patients |
|---|
| Morris, 1974 | UFH twice daily for 10 days | no treatment | elective orthopedic surgery | | Welin-Berger, 1982 | UFH twice daily for 7 days | no treatment | elective orthopedic surgery | | Bergqvist , 1979 | UFH twice daily for 5 days | no treatment | elective orthopedic surgery | | Gallus , 1973 | UFH twice daily for A days | no treatment | elective orthopedic surgery | | VTCSG, 1975 | UFH twice daily for 10 days | no treatment | elective orthopedic surgery | | Mannucci , 1976 | UFH 3 times daily for 7 days | no treatment | elective orthopedic surgery | | Dechavanne, 1974 | UFH 3 times daily for 10 days | no treatment | elective orthopedic surgery | | Dechavanne, 1975 | UFH 3 times daily for 10 days | no treatment | elective orthopedic surgery | | Bergqvist, 1979 | UFH twice daily for 5 days | no treatment | traumatic orthopedic surgery | | Galasko , 1976 | UFH twice daily (duration unknown) | no treatment | traumatic orthopedic surgery | | Gallus , 1973 | UFH 3 times daily for A | no treatment | traumatic orthopedic surgery | | Morris , 1977 | UFH 3 times daily for 10 days | no treatment | traumatic orthopedic surgery | | Kakkar (IMT), 0 | UFH 3 times daily for 7 days | no treatment | All other general surgery | | Gruber, 0 | UFH 3 times daily for 7 days | no treatment | All other general surgery | | Gordon-Smith, 1972 | UFH twice daily for 5 days | no treatment | all other general surgery | | Nicolaides, 1972 | UFH twice daily for 7 days | no treatment | all other general surgery | | Multiunit, 1974 | UFH twice daily for 7 days | no treatment | all other general surgery | | Abernethy, 1974 | UFH twice daily for 7 days | no treatment | all other general surgery | | Clarke-Pearson, 1983 | UFH twice daily for 7 days | no treatment | all other general surgery | | Plante, 1979 | UFH twice daily for 8 days | no treatment | all other general surgery | | Abraham-Inpijn, 1979 | UFH twice daily for 7 days | no treatment | all other general surgery | | Spebar, 1981 | UFH twice daily for 5-7 days | no treatment | all other general surgery | | Sagar, 1974 | UFH twice daily for 5 days | no treatment | all other general surgery | | Koppenhagen, 1982 | UFH twice daily | no treatment | all other general surgery | | Bergqvist, 1980 | UFH twice daily for 5 days | no treatment | all other general surgery | | Gallus, 1973 | UFH 3 times daily for A | no treatment | all other general surgery | | Gallus, 1976 | UFH 3 times daily for 7 days | no treatment | all other general surgery | | Groote Schuur, 1979 | UFH 3 times daily for 6 days | no treatment | all other general surgery | | Kraytman, 1976 | UFH 3 times daily for 6 days | no treatment | all other general surgery | | Kraytman, 1977 | UFH 3 times daily for 6 days | no treatment | all other general surgery | | Kettunen, 1974 | UFH 3 times daily for 7 days | no treatment | all other general surgery | | Caloghera, 1984 | UFH 3 times daily for 7 days | no treatment | all other general surgery | | Marchelli, 1983 | UFH 3 times daily for ? | no treatment | all other general surgery | | Ziemski, 1979 | UFH 3 times daily for 2 days | no treatment | all other general surgery | | Coe, 1978 | UFH twice daily for D | no treatment | urologic surgery | | Sebeseri, 1975 | UFH twice daily for D | no treatment | urologic surgery | | Allen, 1978 | UFH twice daily for D | no treatment | urologic surgery |
| |
| UFH | | vs placebo | Deep vein thrombosis by 56% suggested | | Endpoint | TE [95% CI] | p val | I2 | n | k | |
|---|
| Deep vein thrombosis | 0.44 [0.36 0.55] | p=0.04 | 0 | 2694 | 28 | Abraham-Inpijn , Lowe , Hampson, Moskovitz, Lahnborg, Xabregas , Moskovitz, Svend-Hansen, Kakkar, Torngren, Torngren, Lahnborg, Covey, Belch, Taberner, Strand, Roberts, Ribaudo, Wu, Lawrence, Muiticentre, Jourdan, Kruse-Blinkenberg, Kraytman, Marchetti, Hedlund, Kutnowski, Vandendris, | | non-fatal pulmonary embolism | 1.25 [0.76 2.05] | p=1.00 | 0 | 4139 | 30 | Williams , Abraham-Inpijn , Lowe , Moskovitz, Lahnborg, Xabregas , Moskovitz, Svend-Hansen, Kakkar, Kiil, Torngren, Torngren, Lahnborg, Lahnborg, Covey, Belch, Taberner, Strand, Roberts, Ribaudo, Wu, Lawrence, Muiticentre, Jourdan, Kraytman, Marchetti, Bejjani, Hedlund, Kutnowski, Vandendris, | | fatal pulmonary embolism | 0.79 [0.44 1.42] | p=1.00 | 0 | 4301 | 32 | Williams , Abraham-Inpijn , Lowe , Hampson, Moskovitz, Lahnborg, Xabregas , Moskovitz, Svend-Hansen, Kakkar, Kiil, Torngren, Torngren, Lahnborg, Lahnborg, Covey, Belch, Taberner, Strand, Roberts, Ribaudo, Wu, Lawrence, Muiticentre, Jourdan, Kruse-Blinkenberg, Kraytman, Marchetti, Bejjani, Hedlund, Kutnowski, Vandendris, | | Bleeding | 1.16 [0.86 1.59] | p=1.00 | 0 | 3584 | 26 | Abraham-Inpijn , Lowe , Hampson, Moskovitz, Xabregas , Moskovitz, Kiil, Torngren, Torngren, Lahnborg, Covey, Belch, Taberner, Roberts, Ribaudo, Wu, Lawrence, Muiticentre, Jourdan, Kruse-Blinkenberg, Kraytman, Marchetti, Bejjani, Hedlund, Kutnowski, Vandendris, | | Fatal bleeding | 1.05 [0.52 2.11] | p=1.00 | 0 | 3715 | 27 | Abraham-Inpijn , Lowe , Hampson, Moskovitz, Kakkar, Kiil, Torngren, Torngren, Lahnborg, Lahnborg, Covey, Belch, Taberner, Strand, Roberts, Ribaudo, Wu, Lawrence, Muiticentre, Jourdan, Kruse-Blinkenberg, Kraytman, Marchetti, Bejjani, Hedlund, Kutnowski, Vandendris, |
| Trial | Studied treatment | Control | Patients |
|---|
| Williams , 1978 | UFH twice daily for 14 days | placebo | elective orthopedic surgery | | Abraham-Inpijn , 1975 | UFH twice daily for 8 days | placebo | elective orthopedic surgery | | Lowe , 1981 | UFH twice daily for 16 days | placebo | elective orthopedic surgery | | Hampson, 1974 | UFH 3 times daily for 7- 10 days | placebo | elective orthopedic surgery | | Moskovitz, 1978 | UFH 3 times daily for 7 days | placebo | elective orthopedic surgery | | Lahnborg, 1980 | UFH twice daily for 10 days | placebo | traumatic orthopedic surgery | | Xabregas , 1977 | UFH twice daily for 14 days | placebo | traumatic orthopedic surgery | | Moskovitz, 1978 | UFH 3 times daily for 7 days | placebo | traumatic orthopedic surgery | | Svend-Hansen, 1981 | UFH 3 times daily for 14 days | placebo | traumatic orthopedic surgery | | Kakkar, 1972 | UFH twice daily for 7 days | placebo | All other general surgery | | Kiil, 1978 | UFH twice daily for 7 days | placebo | All other general surgery | | Torngren, 1978 | UFH twice daily for 6-8 days | placebo | all other general surgery | | Torngren, 0 | UFH twice daily for 6-8 days | placebo | all other general surgery | | Lahnborg, 1975 | UFH twice daily for 5 days | placebo | all other general surgery | | Lahnborg, 1976 | UFH twice daily for 5 days | placebo | all other general surgery | | Covey, 1975 | UFH twice daily for 8 days | placebo | all other general surgery | | Belch, 1980 | UFH twice daily for 7 days | placebo | all other general surgery | | Taberner, 1978 | UFH twice daily for 7 days | placebo | all other general surgery | | Strand, 1975 | UFH twice daily for 7 days | placebo | all other general surgery | | Roberts, 1975 | UFH twice daily for 7 days | placebo | all other general surgery | | Ribaudo, 1975 | UFH twice daily for A days | placebo | all other general surgery | | Wu, 1977 | UFH twice daily for 7 days | placebo | all other general surgery | | Lawrence, 1977 | UFH twice daily for 5 days | placebo | all other general surgery | | Muiticentre, 1984 | UFH twice daily for 5-7 days | placebo | all other general surgery | | Jourdan, 1984 | UFH twice daily for 5 days | placebo | all other general surgery | | Torngren, 1978 | UFH 3 times daily for 6-8 days | placebo | all other general surgery | | Kruse-Blinkenberg, 1980 | UFH 3 times daily for 8 days | placebo | all other general surgery | | Kraytman, 1977 | UFH 3 times daily for 6 days | placebo | all other general surgery | | Marchetti, 1982 | UFH 3 times daily | placebo | all other general surgery | | Bejjani, 1983 | UFH twice daily for 2 days | placebo | urologic surgery | | Hedlund, 1979 | UFH 3 times daily for 5 days | placebo | urologic surgery | | Kutnowski, 1977 | UFH 3 times daily for 6 days | placebo | urologic surgery | | Vandendris, 1980 | UFH 3 times daily for 6 days | placebo | urologic surgery |
| |
| UFH | | vs aspirin | all NS | | Endpoint | TE [95% CI] | p val | I2 | n | k | |
|---|
| Deep vein thrombosis | 0.66 [0.35 1.23] | p=1.00 | 0 | 933 | 2 | Loew, Vinazzer, | | non-fatal pulmonary embolism | 1.06 [0.07 17.04] | p=1.00 | 0 | 933 | 2 | Loew, Vinazzer, | | fatal pulmonary embolism | 0.54 [0.05 6.49] | p=1.00 | 0 | 933 | 2 | Loew, Vinazzer, | | Bleeding | 3.28 [0.97 11.14] | p=1.00 | 0 | 933 | 2 | Loew, Vinazzer, | | Fatal bleeding | 1.06 [0.07 17.04] | p=1.00 | 0 | 933 | 2 | Loew, Vinazzer, |
| Trial | Studied treatment | Control | Patients |
|---|
| Loew, 1977 | UFH twice daily for 7 days | aspirin | all other general surgery | | Vinazzer, 1980 | UFH twice daily for A days | aspirin | all other general surgery |
| |
| UFH | | vs DHE | all NS | | Endpoint | TE [95% CI] | p val | I2 | n | k | |
|---|
| Deep vein thrombosis | 0.69 [0.43 1.09] | p=1.00 | 0 | 660 | 2 | Muiticentre 53,S4, Muiticentre, | | non-fatal pulmonary embolism | 0.96 [0.08 11.53] | p=1.00 | 0 | 660 | 2 | Muiticentre 53,S4, Muiticentre, | | fatal pulmonary embolism | 0.50 [0.03 8.04] | p=1.00 | 0 | 660 | 2 | Muiticentre 53,S4, Muiticentre, | | Bleeding | 1.46 [0.46 4.63] | p=1.00 | 0 | 660 | 2 | Muiticentre 53,S4, Muiticentre, | | Fatal bleeding | 0.97 [0.08 11.66] | p=1.00 | 0 | 660 | 2 | Muiticentre 53,S4, Muiticentre, |
| Trial | Studied treatment | Control | Patients |
|---|
| Muiticentre 53,S4, 1984 | UFH twice daily for 5-7 days | DHE | all other general surgery | | Muiticentre, 1984 | UFH twice daily for 5-7 days | DHE | all other general surgery |
| |
| UFH | | vs oral anticoagulant | Deep vein thrombosis by 72% suggested | | Endpoint | TE [95% CI] | p val | I2 | n | k | |
|---|
| Deep vein thrombosis | 0.28 [0.10 0.81] | p=0.04 | 0 | 154 | 1 | van Geloven, | | non-fatal pulmonary embolism | 0.24 [0.05 1.15] | p=1.00 | 0 | 154 | 1 | van Geloven, | | fatal pulmonary embolism | no data | | Bleeding | 1.08 [0.07 17.60] | p=1.00 | 0 | 154 | 1 | van Geloven, | | Fatal bleeding | no data |
| Trial | Studied treatment | Control | Patients |
|---|
| van Geloven, 1977 | UFH twice daily for 4 days | Oral anticoagulant | all other general surgery |
| |
| UFH | thrombosis prevention, in urologic surgery | vs no treatment | all NS | | Endpoint | TE [95% CI] | p val | I2 | n | k | |
|---|
| Deep vein thrombosis | 0.48 [0.20 1.12] | p=1.00 | 0 | 177 | 3 | Coe, Sebeseri, Allen, | | non-fatal pulmonary embolism | 0.57 [0.07 4.76] | p=1.00 | 0 | 177 | 3 | Coe, Sebeseri, Allen, | | fatal pulmonary embolism | 0.92 [0.09 9.03] | p=1.00 | 0 | 177 | 3 | Coe, Sebeseri, Allen, | | Bleeding | 2.77 [0.99 7.80] | p=1.00 | 0 | 177 | 3 | Coe, Sebeseri, Allen, | | Fatal bleeding | 0.92 [0.09 9.03] | p=1.00 | 0 | 177 | 3 | Coe, Sebeseri, Allen, |
| Trial | Studied treatment | Control | Patients |
|---|
| Coe, 1978 | UFH twice daily for D | no treatment | urologic surgery | | Sebeseri, 1975 | UFH twice daily for D | no treatment | urologic surgery | | Allen, 1978 | UFH twice daily for D | no treatment | urologic surgery |
| |
| UFH | | vs placebo | Deep vein thrombosis by 76% suggested | | Endpoint | TE [95% CI] | p val | I2 | n | k | |
|---|
| Deep vein thrombosis | 0.24 [0.09 0.64] | p=0.04 | 0 | 143 | 3 | Hedlund, Kutnowski, Vandendris, | | non-fatal pulmonary embolism | 0.82 [0.13 5.40] | p=1.00 | 0 | 177 | 4 | Bejjani, Hedlund, Kutnowski, Vandendris, | | fatal pulmonary embolism | 0.81 [0.12 5.32] | p=1.00 | 0 | 177 | 4 | Bejjani, Hedlund, Kutnowski, Vandendris, | | Bleeding | 1.67 [0.40 6.90] | p=1.00 | 0 | 177 | 4 | Bejjani, Hedlund, Kutnowski, Vandendris, | | Fatal bleeding | 1.71 [0.26 11.21] | p=1.00 | 0 | 177 | 4 | Bejjani, Hedlund, Kutnowski, Vandendris, |
| Trial | Studied treatment | Control | Patients |
|---|
| Bejjani, 1983 | UFH twice daily for 2 days | placebo | urologic surgery | | Hedlund, 1979 | UFH 3 times daily for 5 days | placebo | urologic surgery | | Kutnowski, 1977 | UFH 3 times daily for 6 days | placebo | urologic surgery | | Vandendris, 1980 | UFH 3 times daily for 6 days | placebo | urologic surgery |
| |
