Mechanism

treatment

comparator

All cause death

early death

late death

Nitroglycerin

acute coronary syndrome, in all type of patients

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

Trial	Studied treatment	Control	Patients
Doucet, 2000	intravenous nitroglycerin	placebo	patients hospitalized for unstable angina within 6 months after angioplasty (excluding those with intracoronary stents)
Karlberg, 1998	48-hour titrated intravenous infusionof NTG	placebo	patients with ahistory and electrocardiographic changes suggestingunstable angina pectoris

Nitroglycerin

acute myocardial infarction, in all type of patients

Endpoint	TE [95% CI]	p val	n	k	trials
All cause death	0.49 [0.30 0.78]	p=0.04	493	4	Chiche, Bussman, Nelson, Jugdutt,
early death	0.89 [0.78 1.02]	p=1.00	19738	5	Bussman, Nelson, Jugdutt, GISSI-3, Jugdutt,
late death	0.63 [0.41 0.98]	p=0.04	465	3	Chiche, Bussman, Jugdutt,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

Trial	Studied treatment	Control	Patients
Chiche, 1979	Nitroglycerin IV for 7 days	placebo	patients with suspected myocardial infarction, within 12 h of the onset
Bussman, 1981	i.v. nitroglycerin for 48 hours	no i.v. nitroglycerin	patients with acute myocardial infarction within 24 hours
Nelson, 1983	intravenous isosorbide dinitrate (50-200 micrograms/kg/h)	frusemide (1 mg/kg)	men with radiographic and haemodynamic evidence of left ventricular failure following acute myocardial infarction
Jugdutt, 1983	Intravenous nitroglycerin	control	patients with acute myocardial infarction
GISSI-3, 1994	nitrates intravenous for the first 24 h followed by transdermal transdermal glyceryl trinitrate nitrates 10 mg daily	control	patients with acute myocardial infarction
Jugdutt, 1988	intravenous nitroglycerin	control	acute myocardial infarction

Nitroglycerin

acute myocardial infarction, in all type of patients

Endpoint	TE [95% CI]	p val	n	k	trials
All cause death	0.85 [0.44 1.67]	p=1.00	358	3	Flaherty, Jaffe, Lis,
early death	0.63 [0.32 1.21]	p=1.00	478	4	Flaherty, Jaffe, Lis, Charvat,
late death	0.74 [0.36 1.52]	p=1.00	244	2	Flaherty, Lis,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

Trial	Studied treatment	Control	Patients
Flaherty, 1983	Nitroglycerin for 48h	placebo	patients with acute myocardial infarction
Jaffe, 1983	glyceryl trinitrate titrated	placebo	patients with inferior infarction under conventional clinical conditions within 10 hours of the onset of symptoms
Lis, 1984	48-h intravenous infusion of nitroglycer	placebo	patients with acute myocardial infarction
Charvat, 1990	intravenous nitroglycerin for 48h	placebo	patients with acute myocardial infarction and ST segment elevation on admission but no Q wave in the infarcted area within 6 hours of onset

Isosorbide dinitrate

acute myocardial infarction, in all type of patients

Endpoint	TE [95% CI]	p val	I2	n	k	trials
All cause death	no data
early death	0.91 [0.85 0.98]	p=0.04	0	58561	4	ISIS-4, Hildebrandt, Hargreaves, Fitzgerald,
late death	1.31 [0.70 2.46]	p=1.00	0	360	1	Fitzgerald,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

Trial	Studied treatment	Control	Patients
ISIS-4, 1995	oral controlled-release mononitrate 30 mg initial dose titrated up to 60 mg once daily for 1 month	placebo	patients with suspected acute myocardial infarction up to 24h
Hildebrandt, 1992	titrated isosorbide dinitrate (ISDN) for 48h	placebo	patients with strong clinical and electrocardiographic suspicion of myocardial infarction within 8 hours after the onset of symptoms
Hargreaves, 1992	20 mg of isosorbide mononitrate three times daily for 28 days	placebo	patients with acute myocardial infarction (systolic blood pressure > 90 mm Hg) within 24 hours of the start of pain
Fitzgerald, 1990	oral isosorbide 5-mononitrate (ISMN) for 5 days	placebo	patients with suspected acute myocardial infarction

Molsidomine

acute myocardial infarction, in all type of patients

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

Trial	Studied treatment	Control	Patients
ESPRIM, 1994	linsidomine 1 mg/h intravenously for 48 h, followed by 16 mg molsidomine by mouth daily for 12 days	placebo	patients with acute myocardial infarction within 24 h of symptom onset
Beaufils, 1988	molsidomine for 10 days	placebo	patients with a first myocardial infarction within 6 hours from onset of symptoms

nitrates