| Nitroglycerin | acute coronary syndrome, in all type of patients | vs placebo | all NS | | Endpoint | TE [95% CI] | p val | I2 | n | k | |
|---|
| Trial | Studied treatment | Control | Patients |
|---|
| Doucet, 2000 | intravenous nitroglycerin | placebo | patients hospitalized for unstable angina within 6 months after angioplasty (excluding those with intracoronary stents) | | Karlberg, 1998 | 48-hour titrated intravenous infusionof NTG | placebo | patients with ahistory and electrocardiographic changes suggestingunstable angina pectoris |
| |
| Nitroglycerin | | vs control | All cause death by 51% suggested | | Endpoint | TE [95% CI] | p val | I2 | n | k | |
|---|
| early death | 0.89 [0.78 1.02] | p=1.00 | 0 | 19738 | 5 | Bussman, Nelson, Jugdutt, GISSI-3, Jugdutt, | | All cause death | 0.49 [0.30 0.78] | p=0.04 | 0 | 493 | 4 | Chiche, Bussman, Nelson, Jugdutt, |
| Trial | Studied treatment | Control | Patients |
|---|
| Chiche, 1979 | Nitroglycerin IV for 7 days | placebo | patients with suspected myocardial infarction, within 12 h of the onset | | Bussman, 1981 | i.v. nitroglycerin for 48 hours | no i.v. nitroglycerin | patients with acute myocardial infarction within 24 hours | | Nelson, 1983 | intravenous isosorbide dinitrate (50-200 micrograms/kg/h) | frusemide (1 mg/kg) | men with radiographic and haemodynamic evidence of left ventricular failure following acute myocardial infarction | | Jugdutt, 1983 | Intravenous nitroglycerin | control | patients with acute myocardial infarction | | GISSI-3, 1994 | nitrates intravenous for the first 24 h followed by transdermal transdermal glyceryl trinitrate nitrates 10 mg daily | control | patients with acute myocardial infarction | | Jugdutt, 1988 | intravenous nitroglycerin | control | acute myocardial infarction |
| |
| Nitroglycerin | | vs placebo | all NS | | Endpoint | TE [95% CI] | p val | I2 | n | k | |
|---|
| early death | 0.63 [0.32 1.21] | p=1.00 | 0 | 478 | 4 | Flaherty, Jaffe, Lis, Charvat, | | All cause death | 0.85 [0.44 1.67] | p=1.00 | 0 | 358 | 3 | Flaherty, Jaffe, Lis, |
| Trial | Studied treatment | Control | Patients |
|---|
| Flaherty, 1983 | Nitroglycerin for 48h | placebo | patients with acute myocardial infarction | | Jaffe, 1983 | glyceryl trinitrate titrated | placebo | patients with inferior infarction under conventional clinical conditions within 10 hours of the onset of symptoms | | Lis, 1984 | 48-h intravenous infusion of nitroglycer | placebo | patients with acute myocardial infarction | | Charvat, 1990 | intravenous nitroglycerin for 48h | placebo | patients with acute myocardial infarction and ST segment elevation on admission but no Q wave in the infarcted area within 6 hours of onset |
| |
| Isosorbide dinitrate | acute myocardial infarction, in all type of patients | vs placebo | early death by 9% suggested | | Endpoint | TE [95% CI] | p val | I2 | n | k | |
|---|
| early death | 0.91 [0.85 0.98] | p=0.04 | 0 | 58561 | 4 | ISIS-4, Hildebrandt, Hargreaves, Fitzgerald, | | All cause death | no data |
| Trial | Studied treatment | Control | Patients |
|---|
| ISIS-4, 1995 | oral controlled-release mononitrate 30 mg initial dose titrated up to 60 mg once daily for 1 month | placebo | patients with suspected acute myocardial infarction up to 24h | | Hildebrandt, 1992 | titrated isosorbide dinitrate (ISDN) for 48h | placebo | patients with strong clinical and electrocardiographic suspicion of myocardial infarction within 8 hours after the onset of symptoms | | Hargreaves, 1992 | 20 mg of isosorbide mononitrate three times daily for 28 days | placebo | patients with acute myocardial infarction (systolic blood pressure > 90 mm Hg) within 24 hours of the start of pain | | Fitzgerald, 1990 | oral isosorbide 5-mononitrate (ISMN) for 5 days | placebo | patients with suspected acute myocardial infarction |
| |
| Molsidomine | acute myocardial infarction, in all type of patients | vs placebo | all NS | | Endpoint | TE [95% CI] | p val | I2 | n | k | |
|---|
| early death | 1.00 [0.78 1.28] | p=1.00 | 0 | 4287 | 2 | ESPRIM, Beaufils, | | All cause death | no data |
| Trial | Studied treatment | Control | Patients |
|---|
| ESPRIM, 1994 | linsidomine 1 mg/h intravenously for 48 h, followed by 16 mg molsidomine by mouth daily for 12 days | placebo | patients with acute myocardial infarction within 24 h of symptom onset | | Beaufils, 1988 | molsidomine for 10 days | placebo | patients with a first myocardial infarction within 6 hours from onset of symptoms |
| |
