treatment |
|
comparator |
All cause death | Cardiovascular death | Death from cancer | Vascular death | Non fatal MI | Vascular events | Cancer | stroke (fatal and non fatal) | myocardial infarction (fatal and non fatal) | hospitalisation for heart failure | cardiac death | cardiovascular events | Diabetes | atrial fibrillation | cardiovascular death, MI, stroke | atrial fibrillation recurrence | more than one AF recurrence | normoglycemia | mild-to-moderate postthrombotic syndrome | mild to-severe postthrombotic syndrome | severe postthrombotic syndrome |
|
|
Voglibose | diabetes type 2, in all type of patients | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | by 54% | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | 0.46 [0.33 0.66] | p=0.04 | 0 | 1778 | 1 | Voglibose Ph-3, | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Voglibose Ph-3, 2009 | voglibose 0.2 mg three times daily | placebo | patients with impaired fasting glucose |
|
Voglibose | diabetes type 2, in people with impaired glucose tolerance | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | by 54% | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | 0.46 [0.33 0.66] | p=0.04 | 0 | 1778 | 1 | Voglibose Ph-3, | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Voglibose Ph-3, 2009 | voglibose 0.2 mg three times daily | placebo | patients with impaired fasting glucose |
|
Voglibose | impaired fasting glucose , in all type of patients | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | by 54% | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | 0.46 [0.33 0.66] | p=0.04 | 0 | 1778 | 1 | Voglibose Ph-3, | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Voglibose Ph-3, 2009 | voglibose 0.2 mg three times daily | placebo | patients with impaired fasting glucose |
|
Candesartan | atrial fibrillation, in patient with history of atrial fibrillation | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | no data | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
CAPRAF (Tveit), 2007 | candesartan 8 mg once daily for 3-6 weeks before and candesartan 16 mg once daily for 6 months after electrical cardioversion | placebo | patients undergoing electrical cardioversion for persistent AF |
|
Candesartan | atrial fibrillation, in patients without history of AF (primary prevention) | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | - | NS | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | no data | atrial fibrillation | 0.82 [0.67 1.01] | p=1.00 | 0 | 6446 | 1 | CHARM (AF ancillary study), | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
CHARM (AF ancillary study), 2005 | candesartan | placebo | Heart failure |
|
Irbesartan | atrial fibrillation, in patient with history of atrial fibrillation | vs placebo | - | - | - | NS | - | NS | - | NS | NS | by 13% | - | - | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | 1.03 [0.91 1.15] | p=1.00 | 0 | 9016 | 1 | ACTIVE I, | Non fatal MI | no data | Vascular events | 1.00 [0.90 1.10] | p=1.00 | 0 | 9016 | 1 | ACTIVE I, | Cancer | no data | stroke (fatal and non fatal) | 0.92 [0.80 1.07] | p=1.00 | 0 | 9016 | 1 | ACTIVE I, | myocardial infarction (fatal and non fatal) | 1.05 [0.83 1.34] | p=1.00 | 0 | 9016 | 1 | ACTIVE I, | hospitalisation for heart failure | 0.87 [0.76 0.99] | p=0.04 | 0 | 9016 | 1 | ACTIVE I, | cardiac death | no data | cardiovascular events | no data | Diabetes | no data | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
ACTIVE I, 2009 | irbesartan 300mg once daily | placebo | patients with atrial fibrillation and with a systolic blood pressure of at least 110 mmHg associated with at least one major risk of vascular events |
|
Irbesartan | atrial fibrillation, in patient with history of atrial fibrillation | vs control | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | by 61% | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | no data | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | 0.39 [0.17 0.91] | p=0.04 | 0 | 154 | 1 | Madrid, | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Madrid, 2002 | irbesartan | control | atrial fibrillation |
|
Valsartan | atrial fibrillation, in patient with history of atrial fibrillation | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | NS | NS | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | no data | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | 0.99 [0.80 1.21] | p=1.00 | 0 | 1442 | 1 | GISSI-AF (Disertori), | more than one AF recurrence | 0.96 [0.76 1.21] | p=1.00 | 0 | 1442 | 1 | GISSI-AF (Disertori), | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
GISSI-AF (Disertori), 2009 | valsartan | placebo | patients in sinus rhythm but with either two or more documented episodes of atrial fibrillation in the previous 6 months or successful cardioversion for atrial fibrillation in the previous 2 weeks
and with underlying cardiovascular disease, diabetes, or left atrial enlargement |
|
Valsartan | atrial fibrillation, in patients without history of AF (primary prevention) | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | - | by 33% | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | no data | atrial fibrillation | 0.67 [0.53 0.84] | p=0.04 | 0 | 5000 | 1 | Val-HeFT (AF ancillary study), | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Val-HeFT (AF ancillary study), 2003 | valsartan | placebo | Heart failure |
|
Valsartan | diabetes type 2, in all type of patients | vs placebo | NS | NS | - | - | - | - | - | NS | NS | NS | - | NS | by 10% | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 0.91 [0.77 1.07] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR valsartan, | Cardiovascular death | 1.11 [0.86 1.44] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR valsartan, | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | 0.80 [0.62 1.04] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR valsartan, | myocardial infarction (fatal and non fatal) | 1.00 [0.78 1.26] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR valsartan, | hospitalisation for heart failure | 0.98 [0.73 1.31] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR valsartan, | cardiac death | no data | cardiovascular events | 0.98 [0.87 1.10] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR valsartan, | Diabetes | 0.90 [0.82 0.98] | p=0.04 | 0 | 9306 | 1 | NAVIGATOR valsartan, | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
NAVIGATOR valsartan, 2010 | valsartan up to 160 mg daily | placebo | subjects with impaired glucose tolerance and either CV disease or CV risk factors |
|
Valsartan | diabetes type 2, in people with impaired glucose tolerance | vs placebo | NS | NS | - | - | - | - | - | NS | NS | NS | - | NS | by 10% | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 0.91 [0.77 1.07] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR valsartan, | Cardiovascular death | 1.11 [0.86 1.44] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR valsartan, | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | 0.80 [0.62 1.04] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR valsartan, | myocardial infarction (fatal and non fatal) | 1.00 [0.78 1.26] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR valsartan, | hospitalisation for heart failure | 0.98 [0.73 1.31] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR valsartan, | cardiac death | no data | cardiovascular events | 0.98 [0.87 1.10] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR valsartan, | Diabetes | 0.90 [0.82 0.98] | p=0.04 | 0 | 9306 | 1 | NAVIGATOR valsartan, | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
NAVIGATOR valsartan, 2010 | valsartan up to 160 mg daily | placebo | subjects with impaired glucose tolerance and either CV disease or CV risk factors |
|
Valsartan | impaired fasting glucose , in all type of patients | vs placebo | NS | NS | - | - | - | - | - | NS | NS | NS | - | NS | by 10% | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 0.91 [0.77 1.07] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR valsartan, | Cardiovascular death | 1.11 [0.86 1.44] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR valsartan, | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | 0.80 [0.62 1.04] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR valsartan, | myocardial infarction (fatal and non fatal) | 1.00 [0.78 1.26] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR valsartan, | hospitalisation for heart failure | 0.98 [0.73 1.31] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR valsartan, | cardiac death | no data | cardiovascular events | 0.98 [0.87 1.10] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR valsartan, | Diabetes | 0.90 [0.82 0.98] | p=0.04 | 0 | 9306 | 1 | NAVIGATOR valsartan, | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
NAVIGATOR valsartan, 2010 | valsartan up to 160 mg daily | placebo | subjects with impaired glucose tolerance and either CV disease or CV risk factors |
|
Orlistat | diabetes type 2, in all type of patients | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | by 57% | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | 0.43 [0.20 0.96] | p=0.04 | 0 | -36 | 2 | Heymsfield, XENDOS (Chiasson), | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Heymsfield, 2000 | orlistat 120 mg three times/day | placebo | obese (body mass index, 30-43 kg/m2) adults (WHO 1985 criteria) | XENDOS (Chiasson), 2002 | orlistat 120 mg three times/day | placebo | patients with impaired glucose tolerance (WHO 1994) |
|
Orlistat | diabetes type 2, in people with impaired glucose tolerance | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | by 57% | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | 0.43 [0.20 0.96] | p=0.04 | 0 | -36 | 2 | Heymsfield, XENDOS (Chiasson), | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Heymsfield, 2000 | orlistat 120 mg three times/day | placebo | obese (body mass index, 30-43 kg/m2) adults (WHO 1985 criteria) | XENDOS (Chiasson), 2002 | orlistat 120 mg three times/day | placebo | patients with impaired glucose tolerance (WHO 1994) |
|
Glipizide | diabetes type 2, in all type of patients | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | NS | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | 0.18 [0.02 1.37] | p=1.00 | 0 | -18 | 1 | Eriksson, | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Eriksson, 2006 | glipizide 2.5 mg daily | placebo | first-degree relatives of patients with type 2 diabetes fulfilling WHO criteria for IGT (WHO criteria in 2006) |
|
Glipizide | diabetes type 2, in people with impaired glucose tolerance | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | NS | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | 0.18 [0.02 1.37] | p=1.00 | 0 | -18 | 1 | Eriksson, | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Eriksson, 2006 | glipizide 2.5 mg daily | placebo | first-degree relatives of patients with type 2 diabetes fulfilling WHO criteria for IGT (WHO criteria in 2006) |
|
Metformin | diabetes type 2, in all type of patients | vs control | - | - | - | - | - | - | - | - | - | - | - | - | NS | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | 0.71 [0.35 1.45] | p=1.00 | 0 | 109 | 2 | IDDP (Ramachandran), Jarret, | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
IDDP (Ramachandran), 2006 | advice on lifestyle modification, metformin, or both | given standard health care advice (control) | native Asian Indians with impaired glucose tolerance | Jarret, 1979 | carbohydrate restriction with phenformin 50 mg daily | carbohydrate restriction alone | men with impaired glucose toleranc | James, 2005 | metformin 1 g BID | no treatment | Abdominal obesity with insulin resistance[ |
|
Metformin | diabetes type 2, in all type of patients | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | by 33% | - | - | - | - | NS | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | 0.67 [0.56 0.80] | p=0.04 | 0 | 2628 | 7 | US-DPP (metformin) (Knowler), Li, Charles, Lehtovirta, Orchard, Rodriguez-Moctezuma, CANOE, | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | NaN [NaN NaN] | p=1.00 | 0 | 122 | 1 | CANOE, | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
US-DPP (metformin) (Knowler), 2002 | metformin 850mg twice daily | placebo | nondiabetic patients with elevated glucose and high risk for diabetes | EDIT (Holman), 2003 | metformin 500 mg three times/day, | placebo | (WHO 1985 criteria) | Li, 1999 | metformin 250 mg three times/day | placebo | patients with impaired glucose tolerance (WHO 1985 criteria) | Baillargeon, 2004 | metformin 850 mg BID | placebo | Non obese women with PCOS | Bridger, 2006 | metformin 750 mg BID | placebo | Adolescents with PCOS and insulin resistance | Charles, 1998 | metformin 850 mg BID | placebo | Abdominal obesity | Charles, 2000 | metformin 850 mg BID | placebo | Abdominal obesity, hypertension, and elevated triglycerides | Choux, 2003 | metformin 500 mg TID | placebo | PCO | Crave, 1995 | metformin 850 mg BID | placebo | Overweight with PCO | Fleming, 2002 | metformin 850 mg BID | placebo | PCO | Freemark, 2001 | metformin 500 mg BID | placebo | Insulin resistance and family history of diabetes | Gambineri, 2004 | metformin 850 mg BID | placebo | Obesity and PCOS | Giugliano, 1993 | metformin 850 mg BID | placebo | Hypertension with normal glucose tolerance | Hoeger, 2004 | metformin 850 mg BID + lifestyle modification | placebo + lifestyle modification | Overweight with PCOSo[ | Kay, 2001 | metformin 850 mg BID | placebo | Adolescents with morbid obesity | Kelly, 2002 | metformin 500 mg TID | placebo | PCO | Kocak, 2002 | metformin 850 mg BID | placebo | PCO | Lehtovirta, 2001 | metformin 500 mg BID | placebo | Overweight with impaired glucose tolerance and family history of diabetes | Moghetti, 2000 | metformin 500 mg TID | placebo | PCOS with normal glucose tolerance | Morel, 1999 | metformin 850 mg BID | placebo | Impaired glucose tolerancee | Ng, 2001 | metformin 500 mg TID | placebo | PCO | Orchard, 2005 | metformin 850 mg BID | placebo | Impaired glucose tolerance | Pasquali, 2000 | metformin 850 mg BID | placebo | Abdominal obesity with and without PCO | Rodriguez, 2004 | metformin 1.7 g/d | placebo | Obesity with insulin resistance | Rodriguez-Moctezuma, 2004 | metformin 850 mg BID | placebo | Family history of diabetes | Sirtori, 1984 | metformin 850 mg BID | placebo | Peripheral vascular disease | Srinivasan, 2006 | metformin 1 g BID | placebo | Children and adolescents with obesity and insulin resistance | Stakos, 2005 | metformin 500 mg/d | placebo | African-Americans with insulin resistance and family history of diabetes | Sturrock, 2002 | metformin 1500 mg/d | placebo | PCO | Tang, 2006 | metformin 850 mg BID | placebo | Obesity with PCO | Vitale, 2005 | metformin 500 mg BID | placebo | Metabolic syndrome | CANOE, 2010 | rosiglitazone (2 mg) and metformin (500 mg) twice-daily | placebo | patients with impaired glucose tolerance |
|
Metformin | diabetes type 2, in people with impaired glucose tolerance | vs control | - | - | - | - | - | - | - | - | - | - | - | - | NS | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | 0.71 [0.35 1.45] | p=1.00 | 0 | 109 | 2 | IDDP (Ramachandran), Jarret, | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
IDDP (Ramachandran), 2006 | advice on lifestyle modification, metformin, or both | given standard health care advice (control) | native Asian Indians with impaired glucose tolerance | Jarret, 1979 | carbohydrate restriction with phenformin 50 mg daily | carbohydrate restriction alone | men with impaired glucose toleranc |
|
Metformin | diabetes type 2, in people with impaired glucose tolerance | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | by 50% | - | - | - | - | NS | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | 0.50 [0.31 0.81] | p=0.04 | 0 | 86 | 3 | US-DPP (metformin) (Knowler), Li, CANOE, | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | NaN [NaN NaN] | p=1.00 | 0 | 122 | 1 | CANOE, | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
US-DPP (metformin) (Knowler), 2002 | metformin 850mg twice daily | placebo | nondiabetic patients with elevated glucose and high risk for diabetes | EDIT (Holman), 2003 | metformin 500 mg three times/day, | placebo | (WHO 1985 criteria) | Li, 1999 | metformin 250 mg three times/day | placebo | patients with impaired glucose tolerance (WHO 1985 criteria) | CANOE, 2010 | rosiglitazone (2 mg) and metformin (500 mg) twice-daily | placebo | patients with impaired glucose tolerance |
|
Metformin | impaired fasting glucose , in all type of patients | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | by 50% | - | - | - | - | NS | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | 0.50 [0.30 0.83] | p=0.04 | 0 | 104 | 2 | US-DPP (metformin) (Knowler), CANOE, | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | NaN [NaN NaN] | p=1.00 | 0 | 122 | 1 | CANOE, | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
US-DPP (metformin) (Knowler), 2002 | metformin 850mg twice daily | placebo | nondiabetic patients with elevated glucose and high risk for diabetes | CANOE, 2010 | rosiglitazone (2 mg) and metformin (500 mg) twice-daily | placebo | patients with impaired glucose tolerance |
|
Nateglinide | diabetes type 2, in all type of patients | vs placebo | NS | NS | - | - | - | - | - | NS | NS | NS | - | NS | NS | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 1.00 [0.85 1.17] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR nateglinide, | Cardiovascular death | 1.07 [0.83 1.38] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR nateglinide, | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | 0.88 [0.68 1.14] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR nateglinide, | myocardial infarction (fatal and non fatal) | 0.95 [0.75 1.20] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR nateglinide, | hospitalisation for heart failure | 0.85 [0.64 1.14] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR nateglinide, | cardiac death | no data | cardiovascular events | 0.95 [0.82 1.10] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR nateglinide, | Diabetes | 1.06 [0.98 1.16] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR nateglinide, | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
NAVIGATOR nateglinide, 2010 | nateglinide 60mg 3 times daily | placebo | subjects with impaired glucose tolerance and either CV disease or CV risk factors |
|
Nateglinide | diabetes type 2, in people with impaired glucose tolerance | vs placebo | NS | NS | - | - | - | - | - | NS | NS | NS | - | NS | NS | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 1.00 [0.85 1.17] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR nateglinide, | Cardiovascular death | 1.07 [0.83 1.38] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR nateglinide, | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | 0.88 [0.68 1.14] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR nateglinide, | myocardial infarction (fatal and non fatal) | 0.95 [0.75 1.20] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR nateglinide, | hospitalisation for heart failure | 0.85 [0.64 1.14] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR nateglinide, | cardiac death | no data | cardiovascular events | 0.95 [0.82 1.10] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR nateglinide, | Diabetes | 1.06 [0.98 1.16] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR nateglinide, | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
NAVIGATOR nateglinide, 2010 | nateglinide 60mg 3 times daily | placebo | subjects with impaired glucose tolerance and either CV disease or CV risk factors |
|
Nateglinide | impaired fasting glucose , in all type of patients | vs placebo | NS | NS | - | - | - | - | - | NS | NS | NS | - | NS | NS | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 1.00 [0.85 1.17] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR nateglinide, | Cardiovascular death | 1.07 [0.83 1.38] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR nateglinide, | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | 0.88 [0.68 1.14] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR nateglinide, | myocardial infarction (fatal and non fatal) | 0.95 [0.75 1.20] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR nateglinide, | hospitalisation for heart failure | 0.85 [0.64 1.14] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR nateglinide, | cardiac death | no data | cardiovascular events | 0.95 [0.82 1.10] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR nateglinide, | Diabetes | 1.06 [0.98 1.16] | p=1.00 | 0 | 9306 | 1 | NAVIGATOR nateglinide, | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
NAVIGATOR nateglinide, 2010 | nateglinide 60mg 3 times daily | placebo | subjects with impaired glucose tolerance and either CV disease or CV risk factors |
|
Rosiglitazone | diabetes type 2, in all type of patients | vs placebo | NS | NS | - | - | - | - | - | - | - | - | - | by 52% | by 53% | - | NS | - | - | by 110% | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 1.01 [0.62 1.67] | p=1.00 | 0 | 4999 | 1 | DREAM rosiglitazone, | Cardiovascular death | 1.34 [0.58 3.10] | p=1.00 | 0 | 4999 | 1 | DREAM rosiglitazone, | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | 1.52 [1.07 2.16] | p=0.04 | 0 | 4999 | 1 | DREAM rosiglitazone, | Diabetes | 0.47 [0.41 0.55] | p=0.04 | 0 | 4999 | 1 | DREAM rosiglitazone, | atrial fibrillation | no data | cardiovascular death, MI, stroke | 1.55 [0.90 2.66] | p=1.00 | 0 | 4999 | 1 | DREAM rosiglitazone, | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | 2.10 [1.85 2.37] | p=0.04 | 0 | 4999 | 1 | DREAM rosiglitazone, | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
DREAM rosiglitazone, 2006 | rosiglitazone 8 mg daily | placebo | patients with impaired fasting glucose or impaired glucose tolerance, or both |
|
Rosiglitazone | diabetes type 2, in people with impaired glucose tolerance | vs placebo | NS | NS | - | - | - | - | - | - | - | - | - | by 52% | by 53% | - | NS | - | - | by 110% | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 1.01 [0.62 1.67] | p=1.00 | 0 | 4999 | 1 | DREAM rosiglitazone, | Cardiovascular death | 1.34 [0.58 3.10] | p=1.00 | 0 | 4999 | 1 | DREAM rosiglitazone, | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | 1.52 [1.07 2.16] | p=0.04 | 0 | 4999 | 1 | DREAM rosiglitazone, | Diabetes | 0.47 [0.41 0.55] | p=0.04 | 0 | 4999 | 1 | DREAM rosiglitazone, | atrial fibrillation | no data | cardiovascular death, MI, stroke | 1.55 [0.90 2.66] | p=1.00 | 0 | 4999 | 1 | DREAM rosiglitazone, | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | 2.10 [1.85 2.37] | p=0.04 | 0 | 4999 | 1 | DREAM rosiglitazone, | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
DREAM rosiglitazone, 2006 | rosiglitazone 8 mg daily | placebo | patients with impaired fasting glucose or impaired glucose tolerance, or both |
|
Rosiglitazone | impaired fasting glucose , in all type of patients | vs placebo | NS | NS | - | - | - | - | - | - | - | - | - | by 52% | by 53% | - | NS | - | - | by 110% | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 1.01 [0.62 1.67] | p=1.00 | 0 | 4999 | 1 | DREAM rosiglitazone, | Cardiovascular death | 1.34 [0.58 3.10] | p=1.00 | 0 | 4999 | 1 | DREAM rosiglitazone, | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | 1.52 [1.07 2.16] | p=0.04 | 0 | 4999 | 1 | DREAM rosiglitazone, | Diabetes | 0.47 [0.41 0.55] | p=0.04 | 0 | 4999 | 1 | DREAM rosiglitazone, | atrial fibrillation | no data | cardiovascular death, MI, stroke | 1.55 [0.90 2.66] | p=1.00 | 0 | 4999 | 1 | DREAM rosiglitazone, | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | 2.10 [1.85 2.37] | p=0.04 | 0 | 4999 | 1 | DREAM rosiglitazone, | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
DREAM rosiglitazone, 2006 | rosiglitazone 8 mg daily | placebo | patients with impaired fasting glucose or impaired glucose tolerance, or both |
|
Troglitazone | diabetes type 2, in all type of patients | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | no data | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
TRIPOD (Buchanan), 2002 | troglitazone 400 mg once daily | placebo | Hispanic women with previous gestational diabetes | US DDP troglitazone (Knowler), 2005 | troglitazone | double placebo | nondiabetic patients with elevated glucose and high risk for diabetes |
|
Troglitazone | diabetes type 2, in people with impaired glucose tolerance | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | no data | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
TRIPOD (Buchanan), 2002 | troglitazone 400 mg once daily | placebo | Hispanic women with previous gestational diabetes | US DDP troglitazone (Knowler), 2005 | troglitazone | double placebo | nondiabetic patients with elevated glucose and high risk for diabetes |
|
Enalapril | atrial fibrillation, in patients without history of AF (primary prevention) | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | - | by 78% | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | no data | atrial fibrillation | 0.22 [0.11 0.46] | p=0.04 | 0 | 374 | 1 | SOLVD (AF ancillary study), | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
SOLVD (AF ancillary study), 2003 | enalapril | placebo | Heart failure |
|
Enalapril | atrial fibrillation, in patient with history of atrial fibrillation | vs control | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | NS | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | no data | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | 0.60 [0.30 1.22] | p=1.00 | 0 | 145 | 1 | Ueng, | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Ueng, 2003 | enalapril | control | atrial fibrillation |
|
Lisinopril | atrial fibrillation, in patients without history of AF (primary prevention) | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | - | NS | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | no data | atrial fibrillation | 0.92 [0.82 1.02] | p=1.00 | 0 | 17748 | 1 | GISSI-3 (AF ancillary study), | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
GISSI-3 (AF ancillary study), 2003 | lisinopril | placebo | Post–myocardial infarction |
|
Lisinopril | atrial fibrillation, in patient with history of atrial fibrillation | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | NS | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | no data | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | 0.45 [0.06 3.48] | p=1.00 | 0 | 18 | 1 | Van den Burg, | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Van den Burg, 1995 | lisinopril | placebo | atrial fibrillation, congestive heart failure |
|
Ramipril | diabetes type 2, in all type of patients | vs placebo | NS | NS | - | - | - | - | - | - | - | - | - | NS | NS | - | - | - | - | NS | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 0.98 [0.59 1.61] | p=1.00 | 0 | 5269 | 1 | DREAM ramipril, | Cardiovascular death | 1.21 [0.52 2.81] | p=1.00 | 0 | 5269 | 1 | DREAM ramipril, | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | 1.07 [0.76 1.52] | p=1.00 | 0 | 5269 | 1 | DREAM ramipril, | Diabetes | 0.93 [0.80 1.07] | p=1.00 | 0 | 5269 | 1 | DREAM ramipril, | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | 1.11 [1.00 1.24] | p=1.00 | 0 | 5269 | 1 | DREAM ramipril, | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
DREAM ramipril, 2006 | ramipril up to 15 mg daily | placebo | patients with impaired fasting glucose or impaired glucose tolerance, or both, and no previous cardiovascular disease |
|
Ramipril | diabetes type 2, in people with impaired glucose tolerance | vs placebo | NS | NS | - | - | - | - | - | - | - | - | - | NS | NS | - | - | - | - | NS | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 0.98 [0.59 1.61] | p=1.00 | 0 | 5269 | 1 | DREAM ramipril, | Cardiovascular death | 1.21 [0.52 2.81] | p=1.00 | 0 | 5269 | 1 | DREAM ramipril, | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | 1.07 [0.76 1.52] | p=1.00 | 0 | 5269 | 1 | DREAM ramipril, | Diabetes | 0.93 [0.80 1.07] | p=1.00 | 0 | 5269 | 1 | DREAM ramipril, | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | 1.11 [1.00 1.24] | p=1.00 | 0 | 5269 | 1 | DREAM ramipril, | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
DREAM ramipril, 2006 | ramipril up to 15 mg daily | placebo | patients with impaired fasting glucose or impaired glucose tolerance, or both, and no previous cardiovascular disease |
|
Ramipril | impaired fasting glucose , in all type of patients | vs placebo | NS | NS | - | - | - | - | - | - | - | - | - | NS | NS | - | - | - | - | NS | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 0.98 [0.59 1.61] | p=1.00 | 0 | 5269 | 1 | DREAM ramipril, | Cardiovascular death | 1.21 [0.52 2.81] | p=1.00 | 0 | 5269 | 1 | DREAM ramipril, | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | 1.07 [0.76 1.52] | p=1.00 | 0 | 5269 | 1 | DREAM ramipril, | Diabetes | 0.93 [0.80 1.07] | p=1.00 | 0 | 5269 | 1 | DREAM ramipril, | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | 1.11 [1.00 1.24] | p=1.00 | 0 | 5269 | 1 | DREAM ramipril, | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
DREAM ramipril, 2006 | ramipril up to 15 mg daily | placebo | patients with impaired fasting glucose or impaired glucose tolerance, or both, and no previous cardiovascular disease |
|
Gemfibrozil | atrial fibrillation, in patients without history of AF (primary prevention) | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | - | NS | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | no data | atrial fibrillation | 1.07 [0.75 1.55] | p=1.00 | 0 | 2130 | 1 | VA HIT (AF ancillary study), | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
VA HIT (AF ancillary study), 1999 | gemfibrozil | placebo | men with coronary heart disease, an HDL cholesterol level of 40 mg per deciliter (1.0 mmol per liter) or less, and an LDL cholesterol level of 140 mg per deciliter (3.6 mmol per liter) or less |
|
Losartan | atrial fibrillation, in patients without history of AF (primary prevention) | vs atenolol | - | - | - | - | - | - | - | - | - | - | - | - | - | by 34% | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | no data | atrial fibrillation | 0.66 [0.53 0.82] | p=0.04 | 0 | 8480 | 1 | LIFE (AF ancillary study), | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
LIFE (AF ancillary study), 2005 | losartan | atenolol | hypertension |
|
Glargine | diabetes type 2, in all type of patients | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | no data | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
GRACE - ORIGIN (glargine), 2012 | insulin glargine (with a target fasting blood glucose level of <=95 mg per deciliter [5.3 mmol per liter]) | standard glycemic care alone | subject with known CV disease and/or CV risk factors plus impaired fasting glucose, impaired glucose tolerance, or type 2 diabetes |
|
Glargine | diabetes type 2, in people with impaired glucose tolerance | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | no data | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
GRACE - ORIGIN (glargine), 2012 | insulin glargine (with a target fasting blood glucose level of <=95 mg per deciliter [5.3 mmol per liter]) | standard glycemic care alone | subject with known CV disease and/or CV risk factors plus impaired fasting glucose, impaired glucose tolerance, or type 2 diabetes |
|
Glargine | impaired fasting glucose , in all type of patients | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | no data | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
GRACE - ORIGIN (glargine), 2012 | insulin glargine (with a target fasting blood glucose level of <=95 mg per deciliter [5.3 mmol per liter]) | standard glycemic care alone | subject with known CV disease and/or CV risk factors plus impaired fasting glucose, impaired glucose tolerance, or type 2 diabetes |
|
Diet | diabetes type 2, in all type of patients | vs AHA 1 diet | - | - | - | - | - | - | - | - | - | - | - | - | NS | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | 0.52 [0.06 4.50] | p=1.00 | 0 | -18 | 1 | Liao, | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Liao, 2002 | American Heart Association (AHA) step 2 diet (<30% of total calories as fat, <7% saturated fat, 55% carbohydrate, and < 200 mg cholesterol daily) plus endurance exercise for 1 h three times a week | AHA step 1 diet (30% of total calories as fat, 10% saturated fat, 50% carbohydrate, and <300 mg cholesterol) plus stretching exercise three times a week | Japanese American subjects with impaired glucose tolerance (WHO criteria 1998) |
|
Diet | diabetes type 2, in people with impaired glucose tolerance | vs AHA 1 diet | - | - | - | - | - | - | - | - | - | - | - | - | NS | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | 0.52 [0.06 4.50] | p=1.00 | 0 | -18 | 1 | Liao, | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Liao, 2002 | American Heart Association (AHA) step 2 diet (<30% of total calories as fat, <7% saturated fat, 55% carbohydrate, and < 200 mg cholesterol daily) plus endurance exercise for 1 h three times a week | AHA step 1 diet (30% of total calories as fat, 10% saturated fat, 50% carbohydrate, and <300 mg cholesterol) plus stretching exercise three times a week | Japanese American subjects with impaired glucose tolerance (WHO criteria 1998) |
|
Folic acid | post stroke, in patients with prior stroke or TIA | vs placebo | - | - | - | - | - | - | - | - | - | - | - | NS | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | 0.91 [0.80 1.02] | p=1.00 | 0 | 8164 | 1 | VITATOPS, | Diabetes | no data | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
VITATOPS, 2010 | folic acid and vitamins B12 and B6 in a single tablet | placebo | patients with recent stroke or TIA (within the past seven months) |
|
Folic acid | post stroke, in patients with prior stroke or TIA | vs low dose - folic acid, vit B12 and vit B6 | NS | - | - | - | NS | - | - | NS | - | - | - | NS | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 0.86 [0.65 1.13] | p=1.00 | 0 | 3680 | 1 | VISP (Toole), | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | 0.90 [0.65 1.25] | p=1.00 | 0 | 3680 | 1 | VISP (Toole), | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | 1.04 [0.82 1.32] | p=1.00 | 0 | 3680 | 1 | VISP (Toole), | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | 0.97 [0.82 1.16] | p=1.00 | 0 | 3680 | 1 | VISP (Toole), | Diabetes | no data | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
VISP (Toole), 2004 | high-dose of folic acid, pyridoxine (vitamin B6),
and cobalamin (vitamin B12) | low-dose of folic acid, pyridoxine (vitamin B6),
and cobalamin (vitamin B12) | adults with nondisabling cerebral infarction |
|
Atorvastatin | atrial fibrillation, in patient with history of atrial fibrillation | vs control | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | NS | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | no data | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | 0.27 [0.06 1.16] | p=1.00 | 0 | 48 | 1 | Ozaydin, | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Ozaydin, 2006 | atorvastatin 10 mg | standard therapy | Persistent AF and scheduled EC |
|
Atorvastatin | atrial fibrillation, in patient with history of atrial fibrillation | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | by 36% | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | no data | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | 0.64 [0.44 0.94] | p=0.04 | 0 | 500 | 3 | Almroth, MIRACL (sub-group) (Schwartz), Dernellis, | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Almroth, 2009 | atorvastatin 80 mg daily | placebo | patients with persistent atrial fibrillation undergoing electrical cardioversion | MIRACL (sub-group) (Schwartz), 2004 | atorvastatin 80 mg | placebo | Acute coronary syndrome | Dernellis, 2006 | atorvastatin 20–40 mg | placebo | Paroxysmal AF with CRP between 0.8 and 13 mg/L |
|
Atorvastatin | atrial fibrillation, in patients without history of AF (primary prevention) | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | - | NS | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | no data | atrial fibrillation | 0.79 [0.53 1.18] | p=1.00 | 0 | 3101 | 3 | ARMYDA-3 (AF ancillary study), Chello, MIRACL (AF ancillary study), | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
ARMYDA-3 (AF ancillary study), 2006 | atorvastatin 40mg daily | placebo | patients with scheduled cardiac surgery without history of AF | Chello, 2006 | atorvastatin 20mg daily | placebo | patients with scheduled coronary bypass surgery | MIRACL (AF ancillary study), 2001 | atorvastatin 80mg daily | placebo | Acute coronary syndrome; subgroup without history of AF |
|
Pravastatin | atrial fibrillation, in patient with history of atrial fibrillation | vs control | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | NS | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | no data | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | 1.06 [0.47 2.40] | p=1.00 | 0 | 102 | 1 | Tveit, | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Tveit, 2004 | pravastatin 40 mg | standard therapy | AF >48 h and scheduled EC |
|
Rosuvastatin | atrial fibrillation, in patients without history of AF (primary prevention) | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Cardiovascular death | no data | Death from cancer | no data | Vascular death | no data | Non fatal MI | no data | Vascular events | no data | Cancer | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | hospitalisation for heart failure | no data | cardiac death | no data | cardiovascular events | no data | Diabetes | no data | atrial fibrillation | no data | cardiovascular death, MI, stroke | no data | atrial fibrillation recurrence | no data | more than one AF recurrence | no data | normoglycemia | no data | mild-to-moderate postthrombotic syndrome | no data | mild to-severe postthrombotic syndrome | no data | severe postthrombotic syndrome | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
GISSI HF (subgroup and ancillary study), 2009 | rosuvastatin 10mg daily | placebo | patients with chronic heart failure who were not in AF at study entry |
|