treatment |
|
comparator |
All cause death | Coronary death | Coronary event | Adverse events | Cardiovascular death | Death from cancer | MACE | Fatal MI | Revascularization | Haemmorhagic stroke | Fatal stroke | Non fatal stroke | Non fatal MI | Cancer | Rhabdomyolysis | Non vascular death | stroke (fatal and non fatal) | myocardial infarction (fatal and non fatal) | cardiac death | cardiovascular events | Coronary death and non fatal MI | Myopathy | LDL | non cardiovascular death | Venous thromboembolism | new-onset diabetes | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | total cholesterol (at 1 y) | HDL (at 1 y) |
|
|
Fluvastatin | cardiovascular prevention, in secondary prevention | vs placebo | NS | NS | by 33% | - | - | - | NS | - | - | - | - | - | NS | - | NS | - | - | - | NS | - | NS | - | - | NS | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 0.69 [0.47 1.03] | p=1.00 | 0 | 3197 | 4 | LIPS, LCAS, Riegger et al., FLARE, | Coronary death | 0.53 [0.27 1.06] | p=1.00 | 0 | 1677 | 1 | LIPS, | Coronary event | 0.67 [0.48 0.94] | p=0.04 | 0 | 1998 | 2 | LIPS, LCAS, | Adverse events | no data | Cardiovascular death | no data | Death from cancer | no data | MACE | 0.85 [0.71 1.03] | p=1.00 | 0 | 2511 | 2 | LIPS, FLARE, | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | 0.31 [0.09 1.14] | p=1.00 | 0 | 834 | 1 | FLARE, | Cancer | no data | Rhabdomyolysis | 0.98 [0.14 6.99] | p=1.00 | 0 | 3197 | 4 | LIPS, Riegger et al., LCAS, FLARE, | Non vascular death | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | cardiac death | 0.56 [0.30 1.04] | p=1.00 | 0 | 2363 | 3 | LIPS, LCAS, Riegger et al., | cardiovascular events | no data | Coronary death and non fatal MI | 0.69 [0.46 1.04] | p=1.00 | 0 | 1677 | 1 | LIPS, | Myopathy | no data | LDL | no data | non cardiovascular death | 0.84 [0.48 1.47] | p=1.00 | 0 | 2363 | 3 | LIPS, LCAS, Riegger et al., | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
LIPS, 2002 | fluvastatin, 80 mg/d | placebo | patients (aged 18-80 years) with stable or unstable angina or silent ischemia following successful completion of their first PCI who had baseline total cholesterol levels between 3.5-7.0 mmol/L and with fasting triglyceride levels of less than 4.5 mmol/L | LCAS, 1997 | fluvastatin 20 mg twice daily | placebo | men and women aged 35 to 75 years with angiographic CHD and mean low-density lipoprotein (LDL) cholesterol of 115 to 190 mg/dl despite diet | Riegger et al., 1999 | fluvastatin 40 mg (o.a.d. or b.i.d.) | placebo | hyperlipidaemic patients with symptomatic, clinically-diagnosed (exercise-ECG) coronary heart disease | FLARE, 1999 | fluvastatin 40 mg twice daily | placebo | successful coronary balloon angioplasty |
|
Fluvastatin | cardiovascular prevention, in primary prevention | vs placebo | NS | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | NS | - | - | - | - | NS | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 1.01 [0.32 3.15] | p=1.00 | 0 | 793 | 1 | BCAPS, | Coronary death | no data | Coronary event | no data | Adverse events | no data | Cardiovascular death | no data | Death from cancer | no data | MACE | no data | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | no data | Cancer | no data | Rhabdomyolysis | no data | Non vascular death | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | cardiac death | 0.50 [0.05 5.58] | p=1.00 | 0 | 793 | 1 | BCAPS, | cardiovascular events | no data | Coronary death and non fatal MI | no data | Myopathy | no data | LDL | no data | non cardiovascular death | 1.26 [0.34 4.73] | p=1.00 | 0 | 793 | 1 | BCAPS, | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
BCAPS, 2001 | fluvastatin 40 mg once daily | placebo | subjects who had carotid plaque but no symptoms of carotid artery disease |
|
Fluvastatin | cardiovascular prevention, in hypertensive patients | vs placebo | NS | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | NS | - | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 0.81 [0.21 3.03] | p=1.00 | 0 | 568 | 1 | HYRIM, | Coronary death | no data | Coronary event | no data | Adverse events | no data | Cardiovascular death | no data | Death from cancer | no data | MACE | no data | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | no data | Cancer | no data | Rhabdomyolysis | no data | Non vascular death | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | cardiac death | no data | cardiovascular events | 0.74 [0.33 1.64] | p=1.00 | 0 | 568 | 1 | HYRIM, | Coronary death and non fatal MI | no data | Myopathy | no data | LDL | no data | non cardiovascular death | no data | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
HYRIM, 2005 | fluvastatin 40 mg daily | placebo | drug-treated hypertensive men aged 40-74 years with total cholesterol 4.5-8.0 mmol/L, triglycerides <4.5 mmol/L, body mass index 25-35 kg/m2, and a sedentary lifestyle |
|
Fluvastatin | percutaneous coronary intervention, in all type of patients | vs placebo | NS | - | - | - | NS | - | - | - | NS | - | - | - | NS | - | - | - | NS | - | - | - | - | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 0.69 [0.45 1.05] | p=1.00 | 0 | 2511 | 2 | FLARE, LIPS, | Coronary death | no data | Coronary event | no data | Adverse events | no data | Cardiovascular death | 0.53 [0.27 1.06] | p=1.00 | 0 | 1677 | 1 | LIPS, | Death from cancer | no data | MACE | no data | Fatal MI | no data | Revascularization | 0.92 [0.76 1.12] | p=1.00 | 0 | 2511 | 2 | FLARE, LIPS, | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | 0.70 [0.44 1.10] | p=1.00 | 0 | 2511 | 2 | FLARE, LIPS, | Cancer | no data | Rhabdomyolysis | no data | Non vascular death | no data | stroke (fatal and non fatal) | 1.97 [0.18 21.81] | p=1.00 | 0 | 1677 | 1 | LIPS, | myocardial infarction (fatal and non fatal) | no data | cardiac death | no data | cardiovascular events | no data | Coronary death and non fatal MI | no data | Myopathy | no data | LDL | no data | non cardiovascular death | no data | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
FLARE, 1999 | Fluvastatin 40 mg twice daily 15–30 d before PCI | placebo | patients undergoing PTCA | LIPS, 2002 | Fluvastatin 40 mg twice daily 0–22 d after PCI | placebo | patients with stable or unstable angina or silent ischemia and successful completion of their first PCI |
|
Atorvastatin | cardiovascular prevention, in secondary prevention | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Coronary death | no data | Coronary event | no data | Adverse events | no data | Cardiovascular death | no data | Death from cancer | no data | MACE | no data | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | no data | Cancer | no data | Rhabdomyolysis | no data | Non vascular death | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | cardiac death | no data | cardiovascular events | no data | Coronary death and non fatal MI | no data | Myopathy | no data | LDL | no data | non cardiovascular death | no data | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Mohler, 2003 | atorvastatin (10 mg per day) | placebo | patients with intermittent claudication |
|
Atorvastatin | cardiovascular prevention, in secondary prevention | vs usual care | by 43% | - | by 51% | - | - | - | - | - | - | NS | NS | - | - | - | NS | - | - | - | by 43% | - | - | - | - | NS | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 0.58 [0.34 0.97] | p=0.04 | 0 | 1600 | 1 | GREACE, | Coronary death | no data | Coronary event | 0.49 [0.37 0.64] | p=0.04 | 0 | 1600 | 1 | GREACE, | Adverse events | no data | Cardiovascular death | no data | Death from cancer | no data | MACE | no data | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | 1.00 [0.06 16.02] | p=1.00 | 0 | 1600 | 1 | GREACE, | Fatal stroke | 0.33 [0.01 8.20] | p=1.00 | 0 | 1600 | 1 | GREACE, | Non fatal stroke | no data | Non fatal MI | no data | Cancer | no data | Rhabdomyolysis | 1.00 [0.02 50.46] | p=1.00 | 0 | 1600 | 1 | GREACE, | Non vascular death | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | cardiac death | 0.58 [0.34 0.97] | p=0.04 | 0 | 1600 | 1 | GREACE, | cardiovascular events | no data | Coronary death and non fatal MI | no data | Myopathy | no data | LDL | no data | non cardiovascular death | 1.50 [0.25 9.00] | p=1.00 | 0 | 1600 | 1 | GREACE, | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
GREACE, 2002 | atorvastatin 10-80 mg/d | usual care | patients with established coronary heart disease |
|
Atorvastatin | cardiovascular prevention, in secondary prevention | vs angioplasty | - | NS | - | - | - | - | NS | - | - | - | - | - | NS | - | - | - | NS | - | NS | NS | - | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Coronary death | 1.08 [0.07 17.40] | p=1.00 | 0 | 341 | 1 | AVERT, | Coronary event | no data | Adverse events | no data | Cardiovascular death | no data | Death from cancer | no data | MACE | 0.64 [0.36 1.14] | p=1.00 | 0 | 341 | 1 | AVERT, | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | 0.86 [0.23 3.27] | p=1.00 | 0 | 341 | 1 | AVERT, | Cancer | no data | Rhabdomyolysis | no data | Non vascular death | no data | stroke (fatal and non fatal) | 1.08 [0.02 54.71] | p=1.00 | 0 | 341 | 1 | AVERT, | myocardial infarction (fatal and non fatal) | no data | cardiac death | 1.08 [0.07 17.40] | p=1.00 | 0 | 341 | 1 | AVERT, | cardiovascular events | 0.64 [0.36 1.14] | p=1.00 | 0 | 341 | 1 | AVERT, | Coronary death and non fatal MI | no data | Myopathy | no data | LDL | no data | non cardiovascular death | no data | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
AVERT, 1999 | atorvastatin 80 mg/d | recommended percutaneous revascularization procedure(angioplasty) followed by usual care, whichcould include lipid-lowering treatment | patients referred for percutaneous revascularization, with stable coronary artery disease, relatively normal left ventricular function, asymptomatic or mild-to-moderate angina, and a serum level of low-density lipoprotein (LDL) cholesterol of at least 115 mg per deciliter (3.0 mmol per liter) |
|
Atorvastatin | cardiovascular prevention, in secondary prevention | vs atorvastatin | NS | NS | by 20% | by 36% | - | - | - | - | - | NS | - | - | by 21% | - | NS | - | by 24% | - | - | by 21% [demonstrated] | by 20% | by 568% | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 1.01 [0.85 1.20] | p=1.00 | 0 | 10001 | 1 | TNT, | Coronary death | 0.80 [0.61 1.04] | p=1.00 | 0 | 10001 | 1 | TNT, | Coronary event | 0.80 [0.69 0.93] | p=0.04 | 0 | 10001 | 1 | TNT, | Adverse events | 1.36 [1.16 1.60] | p=0.04 | 0 | 10001 | 1 | TNT, | Cardiovascular death | no data | Death from cancer | no data | MACE | no data | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | 0.84 [0.43 1.64] | p=1.00 | 0 | 10001 | 1 | TNT, | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | 0.79 [0.67 0.94] | p=0.04 | 0 | 10001 | 1 | TNT, | Cancer | no data | Rhabdomyolysis | 0.67 [0.11 4.00] | p=1.00 | 0 | 10001 | 1 | TNT, | Non vascular death | no data | stroke (fatal and non fatal) | 0.76 [0.59 0.96] | p=0.04 | 0 | 10001 | 1 | TNT, | myocardial infarction (fatal and non fatal) | no data | cardiac death | no data | cardiovascular events | 0.79 [0.70 0.91] | p=0.04 | 0 | 10001 | 1 | TNT, | Coronary death and non fatal MI | 0.80 [0.69 0.93] | p=0.04 | 0 | 10001 | 1 | TNT, | Myopathy | 6.68 [3.31 13.48] | p=0.04 | 0 | 10001 | 1 | TNT, | LDL | no data | non cardiovascular death | no data | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
TNT, 2005 | 80 mg of atorvastatin
daily | 10 mg of atorvastatin daily | Chronic coronary artery disease LDL cholesterol < 3.4 mmol/L |
|
Atorvastatin | cardiovascular prevention, in secondary prevention | vs lovastatin | NS | - | - | - | - | - | NS | - | - | - | - | - | - | - | - | - | NS | - | - | - | NS | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 1.57 [0.06 38.85] | p=1.00 | 0 | 300 | 1 | Vascular basis, | Coronary death | no data | Coronary event | no data | Adverse events | no data | Cardiovascular death | no data | Death from cancer | no data | MACE | 1.57 [0.55 4.44] | p=1.00 | 0 | 300 | 1 | Vascular basis, | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | no data | Cancer | no data | Rhabdomyolysis | no data | Non vascular death | no data | stroke (fatal and non fatal) | 0.52 [0.03 8.45] | p=1.00 | 0 | 300 | 1 | Vascular basis, | myocardial infarction (fatal and non fatal) | no data | cardiac death | no data | cardiovascular events | no data | Coronary death and non fatal MI | 2.09 [0.23 18.96] | p=1.00 | 0 | 300 | 1 | Vascular basis, | Myopathy | no data | LDL | no data | non cardiovascular death | no data | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Vascular basis, 2005 | atorvastatin (80 mg) with or without vitamin C and E | low dose lovastatin (5 mg) | Chronic coronary artery disease |
|
Atorvastatin | cardiovascular prevention, in secondary prevention | vs pravastatin | by 67% | NS | - | NS | NS | NS | NS | - | - | - | - | - | NS | - | NS | - | NS | - | - | - | NS | NS | - | NS | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 0.33 [0.13 0.85] | p=0.04 | 0 | 891 | 1 | SAGE, | Coronary death | 0.33 [0.07 1.66] | p=1.00 | 0 | 891 | 1 | SAGE, | Coronary event | no data | Adverse events | 1.01 [0.71 1.44] | p=1.00 | 0 | 1545 | 2 | REVERSAL, SAGE, | Cardiovascular death | 0.40 [0.12 1.28] | p=1.00 | 0 | 891 | 1 | SAGE, | Death from cancer | 0.20 [0.01 4.17] | p=1.00 | 0 | 891 | 1 | SAGE, | MACE | 0.72 [0.46 1.13] | p=1.00 | 0 | 891 | 1 | SAGE, | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | 0.94 [0.47 1.88] | p=1.00 | 0 | 891 | 1 | SAGE, | Cancer | no data | Rhabdomyolysis | 1.00 [0.06 16.00] | p=1.00 | 0 | 1545 | 2 | REVERSAL, SAGE, | Non vascular death | no data | stroke (fatal and non fatal) | 0.52 [0.09 2.99] | p=1.00 | 0 | 1545 | 2 | REVERSAL, SAGE, | myocardial infarction (fatal and non fatal) | no data | cardiac death | no data | cardiovascular events | no data | Coronary death and non fatal MI | 0.76 [0.45 1.29] | p=1.00 | 0 | 1545 | 2 | REVERSAL, SAGE, | Myopathy | 1.00 [0.06 16.00] | p=1.00 | 0 | 1545 | 2 | REVERSAL, SAGE, | LDL | no data | non cardiovascular death | 0.33 [0.07 1.66] | p=1.00 | 0 | 891 | 1 | SAGE, | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
REVERSAL, 2004 | atorvastatin 80 mg daily | Pravastatin(40 mg) | Chronic coronary artery disease | SAGE, 2007 | atorvastatin 80 mg daily | pravastatin(40 mg) | Chronic coronary artery disease |
|
Atorvastatin | cardiovascular prevention, in secondary prevention | vs simvastatin | NS | NS | NS | by 130% | - | NS | - | - | - | - | - | - | by 17% | - | NS | - | NS | - | - | - | NS | by 802% | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 0.98 [0.84 1.14] | p=1.00 | 0 | 8888 | 1 | IDEAL, | Coronary death | 0.99 [0.80 1.22] | p=1.00 | 0 | 8888 | 1 | IDEAL, | Coronary event | 0.89 [0.77 1.02] | p=1.00 | 0 | 8888 | 1 | IDEAL, | Adverse events | 2.30 [1.92 2.74] | p=0.04 | 0 | 8888 | 1 | IDEAL, | Cardiovascular death | no data | Death from cancer | 0.89 [0.67 1.16] | p=1.00 | 0 | 8888 | 1 | IDEAL, | MACE | no data | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | 0.83 [0.70 0.99] | p=0.04 | 0 | 8888 | 1 | IDEAL, | Cancer | no data | Rhabdomyolysis | 0.67 [0.11 4.00] | p=1.00 | 0 | 8888 | 1 | IDEAL, | Non vascular death | no data | stroke (fatal and non fatal) | 0.87 [0.70 1.09] | p=1.00 | 0 | 8888 | 1 | IDEAL, | myocardial infarction (fatal and non fatal) | no data | cardiac death | no data | cardiovascular events | no data | Coronary death and non fatal MI | 0.89 [0.77 1.02] | p=1.00 | 0 | 8888 | 1 | IDEAL, | Myopathy | 9.02 [2.09 38.90] | p=0.04 | 0 | 8888 | 1 | IDEAL, | LDL | no data | non cardiovascular death | no data | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
IDEAL, 2005 | atorvastatin 80mg daily | simvastatine 20mg/j | Men and women aged 80 years or younger with a history of a definite myocardial infarction and who qualified for statin therapy according to national guidelines |
|
Atorvastatin | cardiovascular prevention, in diabetic patients | vs placebo | NS | NS | by 31% | NS | NS | NS | by 20% [demonstrated] | - | - | NS | NS | - | by 40% | - | NS | - | NS | - | - | by 19% | - | NS | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 0.74 [0.52 1.03] | p=1.00 | 0 | 2841 | 1 | CARDS, | Coronary death | 0.74 [0.40 1.37] | p=1.00 | 0 | 2841 | 1 | CARDS, | Coronary event | 0.69 [0.53 0.90] | p=0.04 | 0 | 5251 | 2 | CARDS, ASPEN, | Adverse events | 0.94 [0.50 1.77] | p=1.00 | 0 | 2841 | 1 | CARDS, | Cardiovascular death | 0.86 [0.60 1.23] | p=1.00 | 0 | 5251 | 2 | CARDS, ASPEN, | Death from cancer | 0.66 [0.37 1.17] | p=1.00 | 0 | 2841 | 1 | CARDS, | MACE | 0.80 [0.67 0.95] | p=0.04 | 0 | 5251 | 2 | CARDS, ASPEN, | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | 0.99 [0.02 49.84] | p=1.00 | 0 | 2841 | 1 | CARDS, | Fatal stroke | 0.14 [0.02 1.15] | p=1.00 | 0 | 2841 | 1 | CARDS, | Non fatal stroke | no data | Non fatal MI | 0.60 [0.36 1.00] | p=0.04 | 0 | 2841 | 1 | CARDS, | Cancer | no data | Rhabdomyolysis | 0.99 [0.02 49.84] | p=1.00 | 0 | 2841 | 1 | CARDS, | Non vascular death | no data | stroke (fatal and non fatal) | 0.71 [0.50 1.01] | p=1.00 | 0 | 5251 | 2 | CARDS, ASPEN, | myocardial infarction (fatal and non fatal) | no data | cardiac death | no data | cardiovascular events | 0.81 [0.67 0.97] | p=0.04 | 0 | 5251 | 2 | CARDS, ASPEN, | Coronary death and non fatal MI | no data | Myopathy | 0.99 [0.06 15.81] | p=1.00 | 0 | 2841 | 1 | CARDS, | LDL | no data | non cardiovascular death | no data | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
CARDS, 2004 | atorvastatin 10mg/d | placebo | patients with type 2 diabetes without high concentrations of LDL-cholesterol and at least one of the following: retinopathy, albuminuria, current smoking, or hypertension. | ASPEN, 2006 | atorvastatin 10mg | placebo | subjects with type 2 diabetes and LDL cholesterol levels below contemporaryguideline targets |
|
Atorvastatin | cardiovascular prevention, in hypertensive patients | vs placebo | NS | - | by 28% [demonstrated] | - | NS | - | by 20% | - | - | - | - | - | - | - | NS | - | by 27% | - | - | - | by 35% | - | - | NS | - | NS | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 0.87 [0.71 1.06] | p=1.00 | 0 | 10305 | 1 | ASCOT, | Coronary death | no data | Coronary event | 0.72 [0.59 0.87] | p=0.04 | 0 | 10305 | 1 | ASCOT, | Adverse events | no data | Cardiovascular death | 0.90 [0.65 1.23] | p=1.00 | 0 | 10305 | 1 | ASCOT, | Death from cancer | no data | MACE | 0.80 [0.69 0.91] | p=0.04 | 0 | 10305 | 1 | ASCOT, | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | no data | Cancer | no data | Rhabdomyolysis | 2.98 [0.12 73.22] | p=1.00 | 0 | 10305 | 1 | ASCOT, | Non vascular death | no data | stroke (fatal and non fatal) | 0.73 [0.55 0.96] | p=0.04 | 0 | 10305 | 1 | ASCOT, | myocardial infarction (fatal and non fatal) | no data | cardiac death | no data | cardiovascular events | no data | Coronary death and non fatal MI | 0.65 [0.50 0.83] | p=0.04 | 0 | 10305 | 1 | ASCOT, | Myopathy | no data | LDL | no data | non cardiovascular death | 0.85 [0.66 1.10] | p=1.00 | 0 | 10305 | 1 | ASCOT, | Venous thromboembolism | no data | new-onset diabetes | 1.14 [0.89 1.46] | p=1.00 | 0 | 7773 | 1 | ASCOT, | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
ASCOT, 2003 | atorvastatin 10mg/d | placebo | hypertensive patients aged 40-79 years with at least three other cardiovascular risk factors |
|
Atorvastatin | heart failure, in all type of patients | vs control | NS | - | - | - | NS | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 0.25 [0.02 2.76] | p=1.00 | 0 | 112 | 2 | Wojnicz, Yamada, | Coronary death | no data | Coronary event | no data | Adverse events | no data | Cardiovascular death | 0.25 [0.02 2.76] | p=1.00 | 0 | 112 | 2 | Wojnicz, Yamada, | Death from cancer | no data | MACE | no data | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | no data | Cancer | no data | Rhabdomyolysis | no data | Non vascular death | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | cardiac death | no data | cardiovascular events | no data | Coronary death and non fatal MI | no data | Myopathy | no data | LDL | no data | non cardiovascular death | no data | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Wojnicz, 2006 | atorvastatin 40 mg/day | conventional treatment for heart
failure | patients with inflammatory dilated cardiomyopathy (DC) (positive immunohistochemistry results on endomyocardial biopsy) | Yamada, 2007 | atorvastatin 10 mg/d | standard treatment | outpatients with mild to moderate CHF and radionuclide left ventricular ejection fraction
(LVEF) <40% |
|
Atorvastatin | heart failure, in all type of patients | vs placebo | NS | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 1.00 [0.24 4.22] | p=1.00 | 0 | 108 | 1 | Sola, | Coronary death | no data | Coronary event | no data | Adverse events | no data | Cardiovascular death | no data | Death from cancer | no data | MACE | no data | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | no data | Cancer | no data | Rhabdomyolysis | no data | Non vascular death | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | cardiac death | no data | cardiovascular events | no data | Coronary death and non fatal MI | no data | Myopathy | no data | LDL | no data | non cardiovascular death | no data | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Strey, 2005 | atorvastatin 40mg | placebo | patients with stable, symptomatic heart failure (New York Heart Association Class II or III) and a left ventricular ejection fraction <40% | Sola, 2006 | atorvastatin 20 mg/day | placebo | patients with nonischemic HF and a left ventricular ejection fraction (LVEF) <=35% |
|
Atorvastatin | percutaneous coronary intervention, in all type of patients | vs control | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | by 44% | by 44% | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Coronary death | no data | Coronary event | no data | Adverse events | no data | Cardiovascular death | no data | Death from cancer | no data | MACE | no data | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | no data | Cancer | no data | Rhabdomyolysis | no data | Non vascular death | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | cardiac death | no data | cardiovascular events | no data | Coronary death and non fatal MI | no data | Myopathy | no data | LDL | no data | non cardiovascular death | no data | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | 0.56 [0.40 0.79] | p=0.04 | 0 | 668 | 1 | NAPLES II (Briguori), | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | 0.56 [0.35 0.91] | p=0.04 | 0 | 668 | 1 | NAPLES II (Briguori), | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
NAPLES II (Briguori), 2009 | atorvastatin 80 mg loading dose administered within 24 hours prior to elective PCI | no statin therapy | Patients with coronary artery disease scheduled for elective PCI and not on statin therapy |
|
Atorvastatin | percutaneous coronary intervention, in all type of patients | vs placebo | NS | - | - | - | - | - | by 61% | - | NS | - | - | - | by 64% | - | - | - | by 71% | - | - | - | - | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 0.33 [0.01 8.19] | p=1.00 | 0 | 383 | 1 | ARMYDA-RECAPTURE, | Coronary death | no data | Coronary event | no data | Adverse events | no data | Cardiovascular death | no data | Death from cancer | no data | MACE | 0.39 [0.16 0.95] | p=0.04 | 0 | 457 | 1 | ARMYDA-RECAPTURE, | Fatal MI | no data | Revascularization | 0.33 [0.01 8.19] | p=1.00 | 0 | 383 | 1 | ARMYDA-RECAPTURE, | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | 0.36 [0.18 0.73] | p=0.04 | 0 | 536 | 2 | ARMYDA, ARMYDA-RECAPTURE, | Cancer | no data | Rhabdomyolysis | no data | Non vascular death | no data | stroke (fatal and non fatal) | 0.29 [0.09 0.92] | p=0.04 | 0 | 153 | 1 | ARMYDA, | myocardial infarction (fatal and non fatal) | no data | cardiac death | no data | cardiovascular events | no data | Coronary death and non fatal MI | no data | Myopathy | no data | LDL | no data | non cardiovascular death | no data | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
ARMYDA, 2004 | atorvastatin 40 mg/day seven days prior to the procedure | placebo | Patients scheduled for elective PCI | ARMYDA-RECAPTURE, 2009 | atorvastatin reload (80 mg 12 h before intervention, with a further 40-mg pre-procedural dose) | placebo | patient with long-term atorvastatin treatment thereafter (40 mg/day) undergoing PCI (for stable angina or NSTEMI ACS) |
|
Atorvastatin | percutaneous coronary intervention, in all type of patients | vs usual care | NS | - | - | - | NS | - | - | - | NS | - | - | - | NS | - | - | - | NS | - | - | - | - | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 1.02 [0.02 51.95] | p=1.00 | 0 | 131 | 1 | GAIN, | Coronary death | no data | Coronary event | no data | Adverse events | no data | Cardiovascular death | 1.02 [0.02 51.95] | p=1.00 | 0 | 131 | 1 | GAIN, | Death from cancer | no data | MACE | no data | Fatal MI | no data | Revascularization | 0.44 [0.17 1.17] | p=1.00 | 0 | 131 | 1 | GAIN, | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | 0.20 [0.01 4.31] | p=1.00 | 0 | 131 | 1 | GAIN, | Cancer | no data | Rhabdomyolysis | no data | Non vascular death | no data | stroke (fatal and non fatal) | 5.08 [0.24 107.86] | p=1.00 | 0 | 131 | 1 | GAIN, | myocardial infarction (fatal and non fatal) | no data | cardiac death | no data | cardiovascular events | no data | Coronary death and non fatal MI | no data | Myopathy | no data | LDL | no data | non cardiovascular death | no data | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
GAIN, 2001 | Atorvastatin 20–40 mg/d 1 d after PCI | usual care | |
|
Cerivastatin | heart failure, in all type of patients | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Coronary death | no data | Coronary event | no data | Adverse events | no data | Cardiovascular death | no data | Death from cancer | no data | MACE | no data | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | no data | Cancer | no data | Rhabdomyolysis | no data | Non vascular death | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | cardiac death | no data | cardiovascular events | no data | Coronary death and non fatal MI | no data | Myopathy | no data | LDL | no data | non cardiovascular death | no data | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Laufs, 2004 | cerivastatin 0.4 mg | placebo | patients with heart failure NYHA
II-III caused by non-ischemic dilated
cardiomyopathy |
|
Lovastatin | cardiovascular prevention, in secondary prevention | vs placebo | NS | NS | by 24% [demonstrated] | - | NS | - | - | - | - | - | - | - | NS | - | NS | - | NS | - | NS | - | by 24% | - | - | NS | - | NS | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 1.02 [0.75 1.38] | p=1.00 | 0 | 8506 | 5 | CCAIT, MARS, AFCAPS/TexCAPS, Weintraub, ACAPS, | Coronary death | 0.78 [0.40 1.53] | p=1.00 | 0 | 8509 | 5 | CCAIT, MARS, AFCAPS/TexCAPS, Weintraub, ACAPS, | Coronary event | 0.76 [0.61 0.93] | p=0.04 | 0 | 6605 | 1 | AFCAPS/TexCAPS, | Adverse events | no data | Cardiovascular death | 0.62 [0.34 1.13] | p=1.00 | 0 | 7524 | 2 | AFCAPS/TexCAPS, ACAPS, | Death from cancer | no data | MACE | no data | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | 0.91 [0.38 2.17] | p=1.00 | 0 | 1250 | 2 | CCAIT, ACAPS, | Cancer | no data | Rhabdomyolysis | 0.60 [0.08 4.68] | p=1.00 | 0 | 7524 | 2 | AFCAPS/TexCAPS, ACAPS, | Non vascular death | no data | stroke (fatal and non fatal) | 0.73 [0.36 1.45] | p=1.00 | 0 | 7524 | 2 | AFCAPS/TexCAPS, ACAPS, | myocardial infarction (fatal and non fatal) | no data | cardiac death | 0.11 [0.01 2.07] | p=1.00 | 0 | 919 | 1 | ACAPS, | cardiovascular events | no data | Coronary death and non fatal MI | 0.76 [0.61 0.93] | p=0.04 | 0 | 6605 | 1 | AFCAPS/TexCAPS, | Myopathy | no data | LDL | no data | non cardiovascular death | 1.18 [0.82 1.69] | p=1.00 | 0 | 8509 | 5 | CCAIT, MARS, AFCAPS/TexCAPS, Weintraub, ACAPS, | Venous thromboembolism | no data | new-onset diabetes | 0.98 [0.70 1.38] | p=1.00 | 0 | 6211 | 1 | AFCAPS/TexCAPS, | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
CCAIT, 1994 | lovastatin begun at 20 mg/d and titrated to 40 and 80 mg during the first 16 weeks to attain a fasting low-density lipoprotein (LDL) cholesterol < or = 130 mg/dL | placebo | patients with diffuse but not necessarily severe coronary atherosclerosis documented on a recent arteriogram and with fasting serum cholesterol between 220 and 300 mg/dL | MARS, 1993 | lovastatin 80 mg/day | placebo | patients, 37 to 67 years old, with total cholesterol ranging from 4.92 to 7.64 mmol/L (190 to 295 mg/dL) and angiographically defined coronary artery disease | AFCAPS/TexCAPS, 1998 | lovastatin 20-40 mg/d | placebo | men and women without clinically evident atherosclerotic cardiovascular disease with average total cholesterol (TC) and LDL-C levels and below-average high-density lipoprotein cholesterol (HDL-C) levels | Weintraub, 1994 | lovastatin 40 mg orally twice daily | placebo | patients undergoing PTCA | ACAPS, 1994 | lovastatin 20mg daily | placebo | men and women, 40 to 79 years old, with early carotid atherosclerosis and moderately elevated LDL cholesterol. |
|
Lovastatin | cardiovascular prevention, in secondary prevention | vs usual care | NS | NS | - | - | - | - | - | - | - | - | - | - | NS | - | - | - | - | - | NS | - | - | - | - | NS | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 0.63 [0.18 2.18] | p=1.00 | 0 | 383 | 2 | Sahni, CLAPT, | Coronary death | 0.49 [0.09 2.78] | p=1.00 | 0 | 157 | 1 | Sahni, | Coronary event | no data | Adverse events | no data | Cardiovascular death | no data | Death from cancer | no data | MACE | no data | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | 0.20 [0.01 4.29] | p=1.00 | 0 | 226 | 1 | CLAPT, | Cancer | no data | Rhabdomyolysis | no data | Non vascular death | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | cardiac death | 0.20 [0.01 4.29] | p=1.00 | 0 | 226 | 1 | CLAPT, | cardiovascular events | no data | Coronary death and non fatal MI | no data | Myopathy | no data | LDL | no data | non cardiovascular death | 1.65 [0.21 12.93] | p=1.00 | 0 | 383 | 2 | Sahni, CLAPT, | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Sahni, 1991 | lovastatin 20-40mg/d | conventional therapy alone | patients undergoing successful PTCA | CLAPT, 1999 | lovastatin begun at 20 mg daily and tritrated up to 80 mg daily | usual care | patients underwenting PTCA |
|
Lovastatin | cardiovascular prevention, in diabetic patients | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Coronary death | no data | Coronary event | no data | Adverse events | no data | Cardiovascular death | no data | Death from cancer | no data | MACE | no data | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | no data | Cancer | no data | Rhabdomyolysis | no data | Non vascular death | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | cardiac death | no data | cardiovascular events | no data | Coronary death and non fatal MI | no data | Myopathy | no data | LDL | no data | non cardiovascular death | no data | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
CRISP 20mg, 1994 | lovastatin 20mg daily | placebo | elderly (mean 71y) with low-density lipoprotein cholesterol levels greater than 4.1 and less than 5.7 mmol/L | CRISP 40mg, 1994 | lovastatin 40 mg daily | placebo | elderly (mean 71y) with low-density lipoprotein cholesterol levels greater than 4.1 and less than 5.7 mmol/L
|
|
Pravastatin | cardiovascular prevention, in secondary prevention | vs placebo | by 15% | by 21% [demonstrated] | by 22% [demonstrated] | - | by 21% | NS | by 18% | - | - | NS | NS | - | by 14% | - | NS | - | by 13% | - | NS | by 17% [demonstrated] | by 22% | NS | - | NS | - | NS | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 0.85 [0.78 0.93] | p=0.04 | 0 | 23819 | 7 | PROSPER, PLAC I, PLAC II, PACT, LIPID, CARE, REGRESS, | Coronary death | 0.79 [0.70 0.89] | p=0.04 | 0 | 23411 | 6 | PROSPER, PLAC II, PACT, LIPID, CARE, REGRESS, | Coronary event | 0.78 [0.72 0.85] | p=0.04 | 0 | 20421 | 6 | PROSPER, PLAC I, PLAC II, LIPID, CARE, REGRESS, | Adverse events | no data | Cardiovascular death | 0.79 [0.70 0.90] | p=0.04 | 0 | 14818 | 2 | PROSPER, LIPID, | Death from cancer | 1.05 [0.89 1.25] | p=1.00 | 0 | 18977 | 3 | PROSPER, LIPID, CARE, | MACE | 0.82 [0.72 0.92] | p=0.04 | 0 | 7248 | 4 | PROSPER, PLAC I, PLAC II, REGRESS, | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | 1.29 [0.59 2.84] | p=1.00 | 0 | 13173 | 2 | LIPID, CARE, | Fatal stroke | 1.14 [0.74 1.74] | p=1.00 | 0 | 18977 | 3 | PROSPER, LIPID, CARE, | Non fatal stroke | no data | Non fatal MI | 0.86 [0.75 0.99] | p=0.04 | 0 | 13362 | 3 | PROSPER, PACT, CARE, | Cancer | no data | Rhabdomyolysis | 0.69 [0.11 4.37] | p=1.00 | 0 | 19862 | 4 | LIPID, CARE, REGRESS, PROSPER, | Non vascular death | no data | stroke (fatal and non fatal) | 0.87 [0.75 1.00] | p=0.04 | 0 | 19385 | 4 | PROSPER, PLAC I, LIPID, CARE, | myocardial infarction (fatal and non fatal) | no data | cardiac death | 0.78 [0.59 1.02] | p=1.00 | 0 | 5804 | 1 | PROSPER, | cardiovascular events | 0.83 [0.73 0.94] | p=0.04 | 0 | 7248 | 4 | PROSPER, PLAC I, PLAC II, REGRESS, | Coronary death and non fatal MI | 0.78 [0.71 0.86] | p=0.04 | 0 | 16262 | 5 | LIPID, REGRESS, PROSPER, PLAC I, PLAC II, | Myopathy | 0.92 [0.69 1.21] | p=1.00 | 0 | 18977 | 3 | LIPID, CARE, PROSPER, | LDL | no data | non cardiovascular death | 1.04 [0.77 1.41] | p=1.00 | 0 | 5602 | 4 | PLAC I, PLAC II, CARE, REGRESS, | Venous thromboembolism | no data | new-onset diabetes | 1.21 [0.97 1.50] | p=1.00 | 0 | 12020 | 2 | PROSPER, LIPID, | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
PROSPER, 2002 | pravastatin 40mg daily | placebo | men and women aged 70-82 years with a history of, or risk factors for, vascular disease | PLAC I, 1995 | pravastatin 40mg daily | placebo | men and women with coronary artery disease and mild to moderate elevations in cholesterol levels | PLAC II, 1995 | pravastatin 20-40mg daily | placebo | coronary patients (men and women ) | PACT, 2004 | pravastatin initiated within 24 hours of onset of synmptoms and for 4 weeks | placebo | patients with unstable angina, non-ST-segment elevation myocardial infarction, or ST-segment elevation myocardial infarction <24 hours | LIPID, 1998 | pravastatin 40 mg/d | placebo | patients with previous myocardial infarction or unstable angina and a baseline plasma cholesterol concentration of 4.0-7.0 mmol/L | CARE, 1996 | pravastatin 40 mg/d | placebo | men and women with myocardial infarction who had plasma totalcholesterol levels below 240 mg per deciliter (mean,209) and low-density lipoprotein (LDL) cholesterollevels of 115 to 174 mg per deciliter | REGRESS, 1995 | pravastatin 40 mg daily | placebo | symptomatic men with normal to moderately elevated serum cholesterol levels |
|
Pravastatin | cardiovascular prevention, in secondary prevention | vs usual care | NS | - | - | - | - | - | - | - | - | - | NS | - | - | - | - | - | NS | - | - | NS | - | - | - | NS | - | NS | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 0.82 [0.59 1.12] | p=1.00 | 0 | 4271 | 1 | GISSI Prevenzione, | Coronary death | no data | Coronary event | no data | Adverse events | no data | Cardiovascular death | no data | Death from cancer | no data | MACE | no data | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | 1.00 [0.25 3.99] | p=1.00 | 0 | 4271 | 1 | GISSI Prevenzione, | Non fatal stroke | no data | Non fatal MI | no data | Cancer | no data | Rhabdomyolysis | no data | Non vascular death | no data | stroke (fatal and non fatal) | 1.05 [0.56 1.97] | p=1.00 | 0 | 4271 | 1 | GISSI Prevenzione, | myocardial infarction (fatal and non fatal) | no data | cardiac death | no data | cardiovascular events | 0.88 [0.68 1.13] | p=1.00 | 0 | 4271 | 1 | GISSI Prevenzione, | Coronary death and non fatal MI | no data | Myopathy | no data | LDL | no data | non cardiovascular death | 0.94 [0.46 1.90] | p=1.00 | 0 | 4271 | 1 | GISSI Prevenzione, | Venous thromboembolism | no data | new-onset diabetes | 0.89 [0.67 1.19] | p=1.00 | 0 | 3460 | 1 | GISSI Prevenzione, | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
GISSI Prevenzione, 2000 | low-dose pravastatin regimen 20 mg daily | control | recent acute myocardial infarction patients (<= 6 months) with total blood cholesterol >= 200 mg/dl and < 250 mg/dl and after a period of 3–6 months showed plasma cholesterol levels >=200 mg/ dL despite adequate dietary recommendations |
|
Pravastatin | cardiovascular prevention, in hypertensive patients | vs usual care | NS | NS | NS | - | NS | NS | - | - | - | - | NS | - | - | NS | - | - | NS | - | NS | NS | NS | - | - | NS | - | NS | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 0.99 [0.88 1.11] | p=1.00 | 0 | 10355 | 1 | ALLHAT, | Coronary death | 0.99 [0.79 1.24] | p=1.00 | 0 | 10355 | 1 | ALLHAT, | Coronary event | 0.91 [0.78 1.05] | p=1.00 | 0 | 10355 | 1 | ALLHAT, | Adverse events | no data | Cardiovascular death | 0.99 [0.84 1.16] | p=1.00 | 0 | 10355 | 1 | ALLHAT, | Death from cancer | 1.10 [0.88 1.38] | p=1.00 | 0 | 10355 | 1 | ALLHAT, | MACE | no data | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | 0.95 [0.65 1.38] | p=1.00 | 0 | 10355 | 1 | ALLHAT, | Non fatal stroke | no data | Non fatal MI | no data | Cancer | 1.03 [0.89 1.19] | p=1.00 | 0 | 10355 | 1 | ALLHAT, | Rhabdomyolysis | no data | Non vascular death | no data | stroke (fatal and non fatal) | 0.91 [0.75 1.10] | p=1.00 | 0 | 10355 | 1 | ALLHAT, | myocardial infarction (fatal and non fatal) | no data | cardiac death | 0.99 [0.79 1.24] | p=1.00 | 0 | 10355 | 1 | ALLHAT, | cardiovascular events | 0.91 [0.78 1.05] | p=1.00 | 0 | 10355 | 1 | ALLHAT, | Coronary death and non fatal MI | 0.91 [0.78 1.05] | p=1.00 | 0 | 10355 | 1 | ALLHAT, | Myopathy | no data | LDL | no data | non cardiovascular death | 1.00 [0.85 1.18] | p=1.00 | 0 | 10355 | 1 | ALLHAT, | Venous thromboembolism | no data | new-onset diabetes | 1.15 [0.94 1.40] | p=1.00 | 0 | 6087 | 1 | ALLHAT, | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
ALLHAT, 2002 | pravastatin 40mg/d | usual care | aged 55 years or older, moderately hypercholesterolemic, hypertensive participants with at least 1 additional CHD risk factor |
|
Pravastatin | cardiovascular prevention, in primary prevention | vs control | NS | by 47% | by 33% | - | NS | - | by 30% | - | - | NS | - | - | NS | - | - | - | NS | - | - | by 25% | - | - | - | NS | - | NS | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 0.71 [0.50 1.01] | p=1.00 | 0 | 7832 | 1 | MEGA, | Coronary death | 0.53 [0.29 0.95] | p=0.04 | 0 | 7832 | 1 | MEGA, | Coronary event | 0.67 [0.49 0.92] | p=0.04 | 0 | 7832 | 1 | MEGA, | Adverse events | no data | Cardiovascular death | 0.63 [0.30 1.33] | p=1.00 | 0 | 7832 | 1 | MEGA, | Death from cancer | no data | MACE | 0.70 [0.54 0.91] | p=0.04 | 0 | 7832 | 1 | MEGA, | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | 0.90 [0.44 1.84] | p=1.00 | 0 | 7832 | 1 | MEGA, | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | 0.55 [0.30 1.01] | p=1.00 | 0 | 7832 | 1 | MEGA, | Cancer | no data | Rhabdomyolysis | no data | Non vascular death | no data | stroke (fatal and non fatal) | 0.83 [0.57 1.20] | p=1.00 | 0 | 7832 | 1 | MEGA, | myocardial infarction (fatal and non fatal) | no data | cardiac death | no data | cardiovascular events | 0.75 [0.59 0.94] | p=0.04 | 0 | 7832 | 1 | MEGA, | Coronary death and non fatal MI | no data | Myopathy | no data | LDL | no data | non cardiovascular death | 0.74 [0.50 1.09] | p=1.00 | 0 | 7832 | 1 | MEGA, | Venous thromboembolism | no data | new-onset diabetes | 1.07 [0.85 1.34] | p=1.00 | 0 | 6086 | 1 | MEGA, | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
MEGA, 2006 | pravastatin 10 mg daily (20 mg per day if the total cholesterolconcentration did not decrease to 5·69 mmol/L or less) | control | patients with hypercholesterolaemia (total cholesterol 5·69–6·98 mmol/L) and no history of coronary heart disease or stroke | FAST Fukuoka pravastatin, 2002 | pravastatin 10 mg/day | control group (diet alone) | asymptomatic hypercholesterolemic patients
|
|
Pravastatin | cardiovascular prevention, in primary prevention | vs placebo | NS | NS | by 23% [demonstrated] | - | by 32% | NS | - | - | - | - | NS | - | by 30% | - | NS | - | NS | - | NS | by 41% | by 30% | - | - | NS | - | NS | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 0.88 [0.75 1.05] | p=1.00 | 0 | 10895 | 3 | WOSCOPS, PMSG, PROSPER (primary prevention subgroup), | Coronary death | 0.74 [0.49 1.11] | p=1.00 | 0 | 7962 | 3 | WOSCOPS, PMSG, CAIUS, | Coronary event | 0.77 [0.66 0.91] | p=0.04 | 0 | 9834 | 2 | WOSCOPS, PROSPER (primary prevention subgroup), | Adverse events | no data | Cardiovascular death | 0.68 [0.48 0.98] | p=0.04 | 0 | 6595 | 1 | WOSCOPS, | Death from cancer | 0.90 [0.59 1.35] | p=1.00 | 0 | 6595 | 1 | WOSCOPS, | MACE | no data | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | 1.50 [0.42 5.31] | p=1.00 | 0 | 6595 | 1 | WOSCOPS, | Non fatal stroke | no data | Non fatal MI | 0.70 [0.56 0.87] | p=0.04 | 0 | 6900 | 2 | WOSCOPS, CAIUS, | Cancer | no data | Rhabdomyolysis | 1.00 [0.06 16.01] | p=1.00 | 0 | 7657 | 2 | WOSCOPS, PMSG, | Non vascular death | no data | stroke (fatal and non fatal) | 0.97 [0.74 1.27] | p=1.00 | 0 | 9834 | 2 | WOSCOPS, PROSPER (primary prevention subgroup), | myocardial infarction (fatal and non fatal) | no data | cardiac death | 0.73 [0.48 1.11] | p=1.00 | 0 | 6595 | 1 | WOSCOPS, | cardiovascular events | 0.59 [0.48 0.73] | p=0.04 | 0 | 6900 | 2 | WOSCOPS, CAIUS, | Coronary death and non fatal MI | 0.70 [0.57 0.85] | p=0.04 | 0 | 6595 | 1 | WOSCOPS, | Myopathy | no data | LDL | no data | non cardiovascular death | 0.82 [0.59 1.13] | p=1.00 | 0 | 7657 | 2 | WOSCOPS, PMSG, | Venous thromboembolism | no data | new-onset diabetes | 0.79 [0.57 1.09] | p=1.00 | 0 | 5974 | 1 | WOSCOPS, | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
WOSCOPS, 1995 | pravastatine 40 mg daily | placebo | men aged 45-64 yr with no history of myocardial infarction and with raised plasma cholesterol levels (LDL cholesterol of at least 155 mg/dL, total cholesterol
of at least 252 mg/dL) | PMSG, 1993 | pravastatin 20 mg once daily | placebo | patients with hypercholesterolemia(serum total cholesterol concentrations of 5.2 to 7.8 mmol/liter) and > or = 2 additional risk factors for atherosclerotic coronary artery disease | CAIUS, 1996 | pravastatin 40mg/d | placebo | asymptomatic patients with hypercholesterolemia and at least one 1.3 < IMT < 3.5 mm in the carotid arteries | PROSPER (primary prevention subgroup), 2002 | pravastatin 40mg/d | placebo | men and women aged 70-82 years with a history of, or risk factors for, vascular disease; primary prevention subgroup
|
|
Pravastatin | cardiovascular prevention, in primary prevention | vs usual care | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Coronary death | no data | Coronary event | no data | Adverse events | no data | Cardiovascular death | no data | Death from cancer | no data | MACE | no data | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | no data | Cancer | no data | Rhabdomyolysis | no data | Non vascular death | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | cardiac death | no data | cardiovascular events | no data | Coronary death and non fatal MI | no data | Myopathy | no data | LDL | no data | non cardiovascular death | no data | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
KLIS, 2000 | pravastatin 10-20 mg/day | conventional treatment | Japanese men aged 45-74 years with serum total cholesterol of > or = 220 mg/dl (5.69 mmol/l), primary prevenion |
|
Pravastatin | cardiovascular prevention, in diabetic patients | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Coronary death | no data | Coronary event | no data | Adverse events | no data | Cardiovascular death | no data | Death from cancer | no data | MACE | no data | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | no data | Cancer | no data | Rhabdomyolysis | no data | Non vascular death | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | cardiac death | no data | cardiovascular events | no data | Coronary death and non fatal MI | no data | Myopathy | no data | LDL | no data | non cardiovascular death | no data | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
PHYLLIS, 2004 | pravastatin (40 mg per day) | placebo | hypertensive, hypercholesterolemic patients with asymptomatic carotid atherosclerosis |
|
Pravastatin | percutaneous coronary intervention, in all type of patients | vs placebo | NS | - | - | - | NS | - | - | - | NS | - | - | - | NS | - | - | - | NS | - | - | - | - | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 4.01 [0.45 36.07] | p=1.00 | 0 | 695 | 1 | PREDICT, | Coronary death | no data | Coronary event | no data | Adverse events | no data | Cardiovascular death | 3.01 [0.12 74.12] | p=1.00 | 0 | 695 | 1 | PREDICT, | Death from cancer | no data | MACE | no data | Fatal MI | no data | Revascularization | 0.88 [0.61 1.28] | p=1.00 | 0 | 695 | 1 | PREDICT, | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | 1.00 [0.25 4.04] | p=1.00 | 0 | 695 | 1 | PREDICT, | Cancer | no data | Rhabdomyolysis | no data | Non vascular death | no data | stroke (fatal and non fatal) | 3.01 [0.12 74.12] | p=1.00 | 0 | 695 | 1 | PREDICT, | myocardial infarction (fatal and non fatal) | no data | cardiac death | no data | cardiovascular events | no data | Coronary death and non fatal MI | no data | Myopathy | no data | LDL | no data | non cardiovascular death | no data | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
PREDICT, 1997 | Pravastatin 40 mg/d 1 d after PCI | placebo | patient undergoing PCI |
|
Rosuvastatin | cardiovascular prevention, in diabetic patients | vs placebo | NS | NS | - | - | NS | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 1.21 [0.05 29.67] | p=1.00 | 0 | 984 | 1 | METEOR, | Coronary death | 0.40 [0.01 20.30] | p=1.00 | 0 | 984 | 1 | METEOR, | Coronary event | no data | Adverse events | no data | Cardiovascular death | 0.40 [0.01 20.30] | p=1.00 | 0 | 984 | 1 | METEOR, | Death from cancer | no data | MACE | no data | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | no data | Cancer | no data | Rhabdomyolysis | no data | Non vascular death | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | cardiac death | no data | cardiovascular events | no data | Coronary death and non fatal MI | no data | Myopathy | no data | LDL | no data | non cardiovascular death | no data | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
METEOR, 2007 | rosuvastatin 40mg daily | placebo | individuals, with either age (mean, 57 years) as the only coronary heart disease risk factor or a 10-year Framingham risk score of less than 10%, modest CIMT thickening (1.2-<3.5 mm), and elevated LDL cholesterol |
|
Rosuvastatin | cardiovascular prevention, in primary prevention | vs placebo | by 12% | - | by 35% | - | NS | - | by 32% [demonstrated] | - | - | NS | NS | - | by 65% | - | - | - | by 37% | - | by 26% | by 32% [demonstrated] | by 35% | - | - | - | by 43% | NS | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 0.88 [0.78 0.99] | p=0.04 | 0 | 30507 | 2 | JUPITER, HOPE 3, | Coronary death | no data | Coronary event | 0.65 [0.53 0.81] | p=0.04 | 0 | 30507 | 2 | JUPITER, HOPE 3, | Adverse events | no data | Cardiovascular death | 0.89 [0.72 1.11] | p=1.00 | 0 | 12705 | 1 | HOPE 3, | Death from cancer | no data | MACE | 0.68 [0.60 0.77] | p=0.04 | 0 | 30507 | 2 | JUPITER, HOPE 3, | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | 0.67 [0.24 1.87] | p=1.00 | 0 | 17802 | 1 | JUPITER, | Fatal stroke | 0.50 [0.13 2.00] | p=1.00 | 0 | 17802 | 1 | JUPITER, | Non fatal stroke | no data | Non fatal MI | 0.35 [0.22 0.58] | p=0.04 | 0 | 17802 | 1 | JUPITER, | Cancer | no data | Rhabdomyolysis | no data | Non vascular death | no data | stroke (fatal and non fatal) | 0.63 [0.49 0.81] | p=0.04 | 0 | 30507 | 2 | JUPITER, HOPE 3, | myocardial infarction (fatal and non fatal) | no data | cardiac death | 0.74 [0.58 0.95] | p=0.04 | 0 | 12705 | 1 | HOPE 3, | cardiovascular events | 0.68 [0.59 0.79] | p=0.04 | 0 | 30507 | 2 | JUPITER, HOPE 3, | Coronary death and non fatal MI | 0.65 [0.44 0.95] | p=0.04 | 0 | 12705 | 1 | HOPE 3, | Myopathy | no data | LDL | no data | non cardiovascular death | no data | Venous thromboembolism | 0.57 [0.37 0.86] | p=0.04 | 0 | 17802 | 1 | JUPITER, | new-onset diabetes | 1.13 [0.99 1.29] | p=1.00 | 0 | 30507 | 2 | JUPITER, HOPE 3, | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
JUPITER, 2008 | rosuvastatin 20 mg daily | placebo | apparently healthy individuals with low LDL-cholesterol levels of less than 130 mg per deciliter but elevated C-reactive-protein (high-sensitivity C-reactive protein levels of 2.0 mg per liter or higher) | HOPE 3, 2016 | rosuvastatin 10 mg per day | placebo | subjects who did
not have cardiovascular disease and were at intermediate
risk |
|
Rosuvastatin | heart failure, in all type of patients | vs placebo | NS | - | NS | - | NS | - | - | NS | - | - | NS | NS | NS | - | - | NS | NS | NS | - | NS | - | - | - | - | - | NS | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 0.98 [0.90 1.07] | p=1.00 | 0 | 9728 | 3 | CORONA, Krum, GISSI-HF rosuvastatine, | Coronary death | no data | Coronary event | 0.93 [0.82 1.05] | p=1.00 | 0 | 9642 | 2 | CORONA, GISSI-HF rosuvastatine, | Adverse events | no data | Cardiovascular death | 0.99 [0.89 1.09] | p=1.00 | 0 | 9642 | 2 | CORONA, GISSI-HF rosuvastatine, | Death from cancer | no data | MACE | no data | Fatal MI | 1.04 [0.58 1.84] | p=1.00 | 0 | 9642 | 2 | CORONA, GISSI-HF rosuvastatine, | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | 1.19 [0.85 1.68] | p=1.00 | 0 | 9642 | 2 | CORONA, GISSI-HF rosuvastatine, | Non fatal stroke | 0.85 [0.64 1.13] | p=1.00 | 0 | 5011 | 1 | CORONA, | Non fatal MI | 0.81 [0.63 1.04] | p=1.00 | 0 | 5011 | 1 | CORONA, | Cancer | no data | Rhabdomyolysis | no data | Non vascular death | 1.01 [0.86 1.20] | p=1.00 | 0 | 9642 | 2 | CORONA, GISSI-HF rosuvastatine, | stroke (fatal and non fatal) | 1.24 [0.89 1.73] | p=1.00 | 0 | 4631 | 1 | GISSI-HF rosuvastatine, | myocardial infarction (fatal and non fatal) | 0.87 [0.62 1.24] | p=1.00 | 0 | 4631 | 1 | GISSI-HF rosuvastatine, | cardiac death | no data | cardiovascular events | 0.96 [0.88 1.04] | p=1.00 | 0 | 9642 | 2 | CORONA, GISSI-HF rosuvastatine, | Coronary death and non fatal MI | no data | Myopathy | no data | LDL | no data | non cardiovascular death | no data | Venous thromboembolism | no data | new-onset diabetes | 1.10 [0.93 1.30] | p=1.00 | 0 | 6912 | 2 | CORONA, GISSI-HF rosuvastatine, | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
CORONA, 2007 | rosuvastatin 10mg/d | placebo | patients at least 60 years of age with NYHA class II, III, or IV ischemic, systolic heart failure | Krum, 2007 | rosuvastatine 40mg/d | placebo | patients with systolic (LVEF<40%) CHF of ischemic or
nonischemic etiology | GISSI-HF rosuvastatine, 2008 | low-dose rosuvastatin 10 mg daily | placebo | Patients with NYHA classes II to IV heart failure, whatever the cause and the LVEF
and already receiving optimized recommended therapy with no clear indication or contraindication to cholesterollowering therapy |
|
Simvastatin | cardiovascular prevention, in secondary prevention | vs placebo | by 15% [demonstrated] | by 22% | by 27% | - | by 20% | NS | - | - | - | NS | NS | - | by 36% | - | NS | - | by 25% | - | by 41% | by 26% | by 26% | NS | - | NS | - | NS | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | 0.85 [0.79 0.92] | p=0.04 | 0 | 25615 | 4 | MAAS, HPS, 4S, CIS, | Coronary death | 0.78 [0.70 0.86] | p=0.04 | 0 | 25615 | 4 | MAAS, HPS, 4S, CIS, | Coronary event | 0.73 [0.67 0.78] | p=0.04 | 0 | 25234 | 3 | HPS, 4S, CIS, | Adverse events | no data | Cardiovascular death | 0.80 [0.73 0.88] | p=0.04 | 0 | 24980 | 2 | HPS, 4S, | Death from cancer | 1.03 [0.89 1.19] | p=1.00 | 0 | 24980 | 2 | HPS, 4S, | MACE | no data | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | 0.94 [0.64 1.38] | p=1.00 | 0 | 24980 | 2 | HPS, 4S, | Fatal stroke | 0.84 [0.65 1.08] | p=1.00 | 0 | 24980 | 2 | HPS, 4S, | Non fatal stroke | no data | Non fatal MI | 0.64 [0.58 0.71] | p=0.04 | 0 | 25234 | 3 | HPS, 4S, CIS, | Cancer | no data | Rhabdomyolysis | 1.56 [0.41 6.00] | p=1.00 | 0 | 20917 | 2 | HPS, MAAS, | Non vascular death | no data | stroke (fatal and non fatal) | 0.75 [0.67 0.85] | p=0.04 | 0 | 24980 | 2 | HPS, 4S, | myocardial infarction (fatal and non fatal) | no data | cardiac death | 0.59 [0.46 0.75] | p=0.04 | 0 | 4444 | 1 | 4S, | cardiovascular events | 0.74 [0.67 0.81] | p=0.04 | 0 | 4444 | 1 | 4S, | Coronary death and non fatal MI | 0.74 [0.68 0.81] | p=0.04 | 0 | 20536 | 1 | HPS, | Myopathy | 2.50 [0.78 7.97] | p=1.00 | 0 | 20536 | 1 | HPS, | LDL | no data | non cardiovascular death | 0.87 [0.58 1.30] | p=1.00 | 0 | 5079 | 3 | MAAS, 4S, CIS, | Venous thromboembolism | no data | new-onset diabetes | 1.10 [0.97 1.25] | p=1.00 | 0 | 18815 | 2 | HPS, 4S, | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
MAAS, 1994 | simvastatin 20 mg daily | placebo | patients with coronary heart disease | HPS, 2002 | simvastatin 40 mg/d | placebo | adults (aged 40-80 years) with coronary disease, other occlusive arterial disease, or diabete | 4S, 1994 | simvastatin 20 or 40 mg/d, target CT between 3 et 5.2 mmol/l | placebo | patients with angina pectoris or previous myocardial infarction and serum cholesterol 5.5-8.0 mmol/L on a lipid-lowering diet | CIS, 1997 | simvastatin 40 mg | placebo | men with documented coronary artery disease and hypercholesterolaemia |
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Simvastatin | cardiovascular prevention, in secondary prevention | vs simvastatin | NS | NS | NS | - | NS | NS | NS | - | - | - | NS | - | by 14% | - | by 1667% | - | NS | - | NS | NS | - | - | - | NS | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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All cause death | 1.00 [0.90 1.10] | p=1.00 | 0 | 12064 | 1 | SEARCH, | Coronary death | 1.02 [0.89 1.17] | p=1.00 | 0 | 12064 | 1 | SEARCH, | Coronary event | 0.97 [0.89 1.06] | p=1.00 | 0 | 12064 | 1 | SEARCH, | Adverse events | no data | Cardiovascular death | 0.99 [0.88 1.12] | p=1.00 | 0 | 12064 | 1 | SEARCH, | Death from cancer | 0.92 [0.77 1.10] | p=1.00 | 0 | 12064 | 1 | SEARCH, | MACE | 0.95 [0.88 1.03] | p=1.00 | 0 | 12064 | 1 | SEARCH, | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | 0.85 [0.60 1.21] | p=1.00 | 0 | 12064 | 1 | SEARCH, | Non fatal stroke | no data | Non fatal MI | 0.86 [0.75 0.99] | p=0.04 | 0 | 12064 | 1 | SEARCH, | Cancer | no data | Rhabdomyolysis | 17.67 [5.52 56.59] | p=0.04 | 0 | 12064 | 1 | SEARCH, | Non vascular death | no data | stroke (fatal and non fatal) | 0.91 [0.77 1.09] | p=1.00 | 0 | 12064 | 1 | SEARCH, | myocardial infarction (fatal and non fatal) | no data | cardiac death | 1.02 [0.89 1.17] | p=1.00 | 0 | 12064 | 1 | SEARCH, | cardiovascular events | 0.95 [0.88 1.03] | p=1.00 | 0 | 12064 | 1 | SEARCH, | Coronary death and non fatal MI | no data | Myopathy | no data | LDL | no data | non cardiovascular death | 1.00 [0.87 1.15] | p=1.00 | 0 | 12064 | 1 | SEARCH, | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
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SEARCH, 2010 | simvastatin 80 mg daily | simvastatin 20mg daily | MI survivors |
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Simvastatin | cardiovascular prevention, in diabetic patients | vs placebo | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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All cause death | no data | Coronary death | no data | Coronary event | no data | Adverse events | no data | Cardiovascular death | no data | Death from cancer | no data | MACE | no data | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | no data | Cancer | no data | Rhabdomyolysis | no data | Non vascular death | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | cardiac death | no data | cardiovascular events | no data | Coronary death and non fatal MI | no data | Myopathy | no data | LDL | no data | non cardiovascular death | no data | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
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HPS (diabetic primary prevention sub group), 2003 | simvastatin 40 mg/d | placebo | adults (aged 40-80 years) with diabetes (primary prevention subgroup) |
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Simvastatin | heart failure, in all type of patients | vs control | - | - | - | - | NS | - | - | - | - | - | - | - | NS | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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All cause death | no data | Coronary death | no data | Coronary event | no data | Adverse events | no data | Cardiovascular death | 0.26 [0.05 1.26] | p=1.00 | 0 | 197 | 1 | Hong, | Death from cancer | no data | MACE | no data | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | 0.45 [0.08 2.50] | p=1.00 | 0 | 197 | 1 | Hong, | Cancer | no data | Rhabdomyolysis | no data | Non vascular death | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | cardiac death | no data | cardiovascular events | no data | Coronary death and non fatal MI | no data | Myopathy | no data | LDL | no data | non cardiovascular death | no data | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
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Hong, 2005 | simvastatin | no treatment | patients with ischemic heart failure who underwent percutaneous coronary intervention (PCI) for acute myocardial infarction (left ventricular [LV] ejection fraction <40%) |
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Simvastatin | heart failure, in all type of patients | vs placebo | NS | - | - | - | NS | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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All cause death | 1.13 [0.02 58.96] | p=1.00 | 0 | 51 | 1 | Node, | Coronary death | no data | Coronary event | no data | Adverse events | no data | Cardiovascular death | 1.13 [0.02 58.96] | p=1.00 | 0 | 51 | 1 | Node, | Death from cancer | no data | MACE | no data | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | no data | Cancer | no data | Rhabdomyolysis | no data | Non vascular death | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | cardiac death | no data | cardiovascular events | no data | Coronary death and non fatal MI | no data | Myopathy | no data | LDL | no data | non cardiovascular death | no data | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
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Node, 2003 | simvastatin 10mg/d | placebo | patients with symptomatic, nonischemic, dilated cardiomyopathy |
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Simvastatin | heart failure, in all type of patients | vs ezetimibe | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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All cause death | no data | Coronary death | no data | Coronary event | no data | Adverse events | no data | Cardiovascular death | no data | Death from cancer | no data | MACE | no data | Fatal MI | no data | Revascularization | no data | Haemmorhagic stroke | no data | Fatal stroke | no data | Non fatal stroke | no data | Non fatal MI | no data | Cancer | no data | Rhabdomyolysis | no data | Non vascular death | no data | stroke (fatal and non fatal) | no data | myocardial infarction (fatal and non fatal) | no data | cardiac death | no data | cardiovascular events | no data | Coronary death and non fatal MI | no data | Myopathy | no data | LDL | no data | non cardiovascular death | no data | Venous thromboembolism | no data | new-onset diabetes | no data | MI (CK-MB >3x ULN at 6 and 12 hours after PCI) | no data | MI (troponin I >3x ULN at 6 and 12 hours after PCI) | no data | total cholesterol (at 1 y) | no data | HDL (at 1 y) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
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Landmesser, 2005 | simvastatin 10mg/d | ezetimibe 10mg/d | patients with chronic heart failure |
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