Candesartan | heart failure, in all type of patients | vs placebo | by 130% adverse event Hyperkalaemia by 535% adverse event Hypotension by 130% adverse event Cardiovascular death or hospital admission for CHF by 18% suggested hospitalisation for heart failure by 28% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | 0.86 [0.72 1.02] | p=1.00 | 0 | 2298 | 2 | CHARM-Alternative, SPICE, | Cardiovascular death or hospital admission for CHF | 0.82 [0.69 0.99] | p=0.04 | 0 | 2028 | 1 | CHARM-Alternative, | death or cardiovascular hospitalization | no data | Cardiovascular death | 0.87 [0.71 1.06] | p=1.00 | 0 | 2246 | 2 | CHARM-Alternative, Mitrovic et al., | hospitalisation for heart failure | 0.72 [0.59 0.88] | p=0.04 | 0 | 2298 | 2 | CHARM-Alternative, SPICE, | Hospitalization for any reason | 0.93 [0.78 1.11] | p=1.00 | 0 | 2298 | 2 | CHARM-Alternative, SPICE, | | 2.30 [1.45 3.65] | p=0.04 | 0 | 2028 | 1 | CHARM-Alternative, | Hyperkalaemia | 6.35 [1.87 21.51] | p=0.04 | 0 | 2028 | 1 | CHARM-Alternative, | Cough | 0.98 [0.59 1.64] | p=1.00 | 0 | 2298 | 2 | CHARM-Alternative, SPICE, | Hypotension | 2.30 [1.20 4.42] | p=0.04 | 0 | 2246 | 2 | CHARM-Alternative, Mitrovic et al., | angiodema | 3.01 [0.12 73.88] | p=1.00 | 0 | 2028 | 1 | CHARM-Alternative, | Adverse events | 0.96 [0.79 1.18] | p=1.00 | 0 | 2464 | 3 | CHARM-Alternative, Mitrovic et al., Mitrovic et al., | All cause death | 0.90 [0.75 1.09] | p=1.00 | 0 | 3652 | 5 | ARCH-J, CHARM-Alternative, Mitrovic et al., SPICE, STRETCH, |
Trial | Studied treatment | Control | Patients |
---|
ARCH-J, 2003 | Candesartan, 8 mg daily | Placebo | patients with chronic heart failure who were not receiving ACE inhibitor therapy | CHARM-Alternative, 2003 | candesartan (target dose32 mg once daily) | Placebo | patients with symptomatic heart failure and left-ventricular ejection fraction 40% or less who were notreceiving ACE inhibitors because of previous intolerance | Mitrovic et al., 2003 | Candesartan, 2 mg, 4mg, 8mg, 16mg daily | Placebo | patients with CHF (New York Heart Association
class II or III) with impaired left ventricular function (ejection fraction <=40%) and pulmonary capillary wedge pressure
>=13 mm Hg | SPICE, 2000 | Candesartan, 16 mg daily | Placebo | patients with chronic heart failure and left ventricular ejection fraction less than 35%, and history of discontinuing an ACE inhibitor because of intolerance | STRETCH, 1999 | Candesartan, 4 mg, 8mg, 16mg daily | Placebo | Male and female patients 21 to 80 years of age with mild to moderate symptomatic CHF
(NYHA class II or III) |
| |
Candesartan | | vs ACE inhibitor only | by 91% adverse event Hyperkalaemia by 387% adverse event Adverse events by 32% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | 0.95 [0.81 1.10] | p=1.00 | 0 | 2989 | 2 | CHARM-Added, RESOLVD association, | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | no data | Cardiovascular death | no data | hospitalisation for heart failure | 0.88 [0.74 1.05] | p=1.00 | 0 | 2989 | 2 | CHARM-Added, RESOLVD association, | Hospitalization for any reason | 1.00 [0.85 1.17] | p=1.00 | 0 | 2989 | 2 | CHARM-Added, RESOLVD association, | | 1.91 [1.36 2.69] | p=0.04 | 0 | 2989 | 2 | CHARM-Added, RESOLVD association, | Hyperkalaemia | 4.87 [2.37 10.03] | p=0.04 | 0 | 2548 | 1 | CHARM-Added, | Cough | no data | Hypotension | 1.45 [0.96 2.18] | p=1.00 | 0 | 2548 | 1 | CHARM-Added, | angiodema | 0.66 [0.11 3.98] | p=1.00 | 0 | 2548 | 1 | CHARM-Added, | Adverse events | 1.32 [1.15 1.51] | p=0.04 | 0 | 5096 | 2 | CHARM-Added, CHARM-Added, | All cause death | 0.93 [0.79 1.10] | p=1.00 | 0 | 2989 | 2 | CHARM-Added, RESOLVD association, |
Trial | Studied treatment | Control | Patients |
---|
CHARM-Added, 2003 | Candesartantarget dose 32 mg once daily | Placebo | patients with New York Heart Association functional class II–IV CHF and left-ventricular ejection fraction40% or lower, and who were being treated with ACE inhibitors. | RESOLVD association, 1999 | Candesartan, 4 mg, 8mg daily, plus enalapril, 10 mg twice daily | Enalapril, 10 mg twice daily | Patients with New York Heart Association functional class NYHA
II, III, or IV CHF, 6-minute walk distance (6MWD) >500 m, and ejection fraction (EF) <0.40 |
| |
Candesartan | | vs enalapril | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | 1.83 [0.90 3.74] | p=1.00 | 0 | 436 | 1 | RESOLVD (candesartan alone), | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | no data | Cardiovascular death | no data | hospitalisation for heart failure | 2.05 [0.89 4.70] | p=1.00 | 0 | 436 | 1 | RESOLVD (candesartan alone), | Hospitalization for any reason | 1.21 [0.72 2.02] | p=1.00 | 0 | 436 | 1 | RESOLVD (candesartan alone), | | no data | Hyperkalaemia | no data | Cough | no data | Hypotension | 1.00 [0.10 9.71] | p=1.00 | 0 | 436 | 1 | RESOLVD (candesartan alone), | angiodema | no data | Adverse events | no data | All cause death | 1.67 [0.56 4.99] | p=1.00 | 0 | 436 | 1 | RESOLVD (candesartan alone), |
Trial | Studied treatment | Control | Patients |
---|
RESOLVD (candesartan alone), 1999 | Candesartan, 4 mg, 8mg, 16mg daily | Enalapril, 10 mg twice daily | Patients with New York Heart Association functional class NYHA
II, III, or IV CHF, 6-minute walk distance (6MWD) >500 m, and ejection fraction (EF) <0.40 |
| |
Candesartan | heart failure, in patients previously untreated with ACE inhibitors | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | no data | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | no data | Cardiovascular death | no data | hospitalisation for heart failure | no data | Hospitalization for any reason | no data | | no data | Hyperkalaemia | no data | Cough | no data | Hypotension | no data | angiodema | no data | Adverse events | no data | All cause death | 0.65 [0.11 3.94] | p=1.00 | 0 | 292 | 1 | ARCH-J, |
Trial | Studied treatment | Control | Patients |
---|
ARCH-J, 2003 | Candesartan, 8 mg daily | Placebo | patients with chronic heart failure who were not receiving ACE inhibitor therapy |
| |
Candesartan | heart failure, in patients already receiving ACE inhibitor | vs ACE inhibitor only | by 92% adverse event Hyperkalaemia by 387% adverse event Adverse events by 32% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | 0.92 [0.78 1.07] | p=1.00 | 0 | 2548 | 1 | CHARM-Added, | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | no data | Cardiovascular death | no data | hospitalisation for heart failure | 0.87 [0.72 1.03] | p=1.00 | 0 | 2548 | 1 | CHARM-Added, | Hospitalization for any reason | 0.99 [0.84 1.17] | p=1.00 | 0 | 2548 | 1 | CHARM-Added, | | 1.92 [1.36 2.71] | p=0.04 | 0 | 2548 | 1 | CHARM-Added, | Hyperkalaemia | 4.87 [2.37 10.03] | p=0.04 | 0 | 2548 | 1 | CHARM-Added, | Cough | no data | Hypotension | 1.45 [0.96 2.18] | p=1.00 | 0 | 2548 | 1 | CHARM-Added, | angiodema | 0.66 [0.11 3.98] | p=1.00 | 0 | 2548 | 1 | CHARM-Added, | Adverse events | 1.32 [1.15 1.51] | p=0.04 | 0 | 5096 | 2 | CHARM-Added, CHARM-Added, | All cause death | 0.91 [0.77 1.08] | p=1.00 | 0 | 2548 | 1 | CHARM-Added, |
Trial | Studied treatment | Control | Patients |
---|
CHARM-Added, 2003 | Candesartantarget dose 32 mg once daily | Placebo | patients with New York Heart Association functional class II–IV CHF and left-ventricular ejection fraction40% or lower, and who were being treated with ACE inhibitors. |
| |
Candesartan | heart failure, in patients intolerant to ACE inhibitors | vs placebo | by 130% adverse event Hyperkalaemia by 535% adverse event Hypotension by 312% adverse event Cardiovascular death or hospital admission for CHF by 18% suggested hospitalisation for heart failure by 28% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | 0.86 [0.72 1.02] | p=1.00 | 0 | 2298 | 2 | CHARM-Alternative, SPICE, | Cardiovascular death or hospital admission for CHF | 0.82 [0.69 0.99] | p=0.04 | 0 | 2028 | 1 | CHARM-Alternative, | death or cardiovascular hospitalization | no data | Cardiovascular death | 0.87 [0.71 1.07] | p=1.00 | 0 | 2028 | 1 | CHARM-Alternative, | hospitalisation for heart failure | 0.72 [0.59 0.88] | p=0.04 | 0 | 2298 | 2 | CHARM-Alternative, SPICE, | Hospitalization for any reason | 0.93 [0.78 1.11] | p=1.00 | 0 | 2298 | 2 | CHARM-Alternative, SPICE, | | 2.30 [1.45 3.65] | p=0.04 | 0 | 2028 | 1 | CHARM-Alternative, | Hyperkalaemia | 6.35 [1.87 21.51] | p=0.04 | 0 | 2028 | 1 | CHARM-Alternative, | Cough | 0.98 [0.59 1.64] | p=1.00 | 0 | 2298 | 2 | CHARM-Alternative, SPICE, | Hypotension | 4.12 [1.98 8.58] | p=0.04 | 0 | 2028 | 1 | CHARM-Alternative, | angiodema | 3.01 [0.12 73.88] | p=1.00 | 0 | 2028 | 1 | CHARM-Alternative, | Adverse events | 1.11 [0.90 1.38] | p=1.00 | 0 | 2028 | 1 | CHARM-Alternative, | All cause death | 0.90 [0.74 1.09] | p=1.00 | 0 | 2298 | 2 | CHARM-Alternative, SPICE, |
Trial | Studied treatment | Control | Patients |
---|
CHARM-Alternative, 2003 | candesartan (target dose32 mg once daily) | Placebo | patients with symptomatic heart failure and left-ventricular ejection fraction 40% or less who were notreceiving ACE inhibitors because of previous intolerance | SPICE, 2000 | Candesartan, 16 mg daily | Placebo | patients with chronic heart failure and left ventricular ejection fraction less than 35%, and history of discontinuing an ACE inhibitor because of intolerance |
| |
Candesartan | heart failure, in patients with preserved-LVEF heart failure | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | no data | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | no data | Cardiovascular death | no data | hospitalisation for heart failure | no data | Hospitalization for any reason | no data | | no data | Hyperkalaemia | no data | Cough | no data | Hypotension | no data | angiodema | no data | Adverse events | no data | All cause death | no data |
Trial | Studied treatment | Control | Patients |
---|
CHARM preserved, 2003 | candesartan target dose 32 mg once daily | placebo | patients with NYHA II-IV heart failure and LVEF higher than 40% |
| |
Candesartan | hypertension, in all diseases requiring ACEi (HF, CHD, HT,...) | vs control | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | Coronary event | no data | cardiac death | no data | cancer related death | no data | Heart failure | 0.39 [0.12 1.26] | p=1.00 | 0 | 80 | 1 | Takahashi, | All cause death | 0.06 [0.00 1.04] | p=1.00 | 0 | 80 | 1 | Takahashi, | lung cancer | no data | breast cancer | no data | prostate cancer | no data | Cancer | no data | Diabetes onset | no data |
Trial | Studied treatment | Control | Patients |
---|
Takahashi, 2006 | candesartan | control | patients on chronic haemodialysis in stable condition and with no clinical evidence of cardiac disorders |
| |
Candesartan | | vs conventional treatment | stroke (fatal and non fatal) by 27% suggested Diabetes onset by 61% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | 1.14 [0.69 1.88] | p=1.00 | 0 | 4238 | 3 | E-COST, E-COST-R, HIJ-CREATE, | myocardial infarction (fatal and non fatal) | 0.84 [0.55 1.28] | p=1.00 | 0 | 4238 | 3 | E-COST, E-COST-R, HIJ-CREATE, | stroke (fatal and non fatal) | 0.73 [0.56 0.95] | p=0.04 | 0 | 4238 | 3 | E-COST, E-COST-R, HIJ-CREATE, | Coronary event | no data | cardiac death | no data | cancer related death | no data | Heart failure | 0.83 [0.62 1.12] | p=1.00 | 0 | 4238 | 3 | E-COST, E-COST-R, HIJ-CREATE, | All cause death | 1.15 [0.82 1.61] | p=1.00 | 0 | 4238 | 3 | E-COST, E-COST-R, HIJ-CREATE, | lung cancer | no data | breast cancer | no data | prostate cancer | no data | Cancer | no data | Diabetes onset | 0.39 [0.16 0.94] | p=0.04 | 0 | 2049 | 1 | HIJ-CREATE, |
Trial | Studied treatment | Control | Patients |
---|
E-COST, 2005 | candesartan, 2 to 12 mg daily | conventional antihypertensive drugs other than angiotensin converting enzyme inhibitors or ARBs | Japanese essential hypertensive subjects (sitting blood pressure 140-180/90-110 mmHg) aged 35-79 years | E-COST-R, 2005 | candesartan | conventional treatment | hypertensive subjects 60 to 75 years old with non-diabetic chronic renal insufficiency | HIJ-CREATE, 2009 | angiotensin II receptor blocker-based therapy | non-angiotensin II receptor blocker-based therapy | patients with angiographically documented coronary artery disease and hypertension |
| |
Candesartan | | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | 0.90 [0.75 1.08] | p=1.00 | 0 | 4937 | 1 | SCOPE, | Cardiovascular death | 0.95 [0.75 1.20] | p=1.00 | 0 | 4937 | 1 | SCOPE, | myocardial infarction (fatal and non fatal) | 1.10 [0.78 1.56] | p=1.00 | 0 | 4937 | 1 | SCOPE, | stroke (fatal and non fatal) | 0.77 [0.58 1.02] | p=1.00 | 0 | 4937 | 1 | SCOPE, | Coronary event | 1.10 [0.78 1.56] | p=1.00 | 0 | 4937 | 1 | SCOPE, | cardiac death | 0.99 [0.52 1.91] | p=1.00 | 0 | 4937 | 1 | SCOPE, | cancer related death | no data | Heart failure | no data | All cause death | 0.97 [0.81 1.16] | p=1.00 | 0 | 4937 | 1 | SCOPE, | lung cancer | no data | breast cancer | no data | prostate cancer | no data | Cancer | 1.08 [0.87 1.33] | p=1.00 | 0 | 4937 | 1 | SCOPE, | Diabetes onset | 0.80 [0.62 1.04] | p=1.00 | 0 | 4937 | 1 | SCOPE, |
Trial | Studied treatment | Control | Patients |
---|
SCOPE, 2003 | candesartan, 8–16 mg once daily (target 160/90) | placebo | patients aged 70–89 years, with systolic blood pressure 160– 179 mmHg, and/or diastolic blood pressure 90–99 mmHg, and a Mini Mental State Examination (MMSE) test score > 24 |
| |
Candesartan | | vs usual care | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data |
Trial | Studied treatment | Control | Patients |
---|
HIJ-CREATE, 2009 | cardesartan adjusted dose for target arterial pressure of <130/85 mmHg | usual care (non-ARB-based pharmacotherapy including angiotensin-converting enzyme-inhibitors) | hypertension with angiographically documented coronary artery disease (acute or stable) |
| |
Candesartan | | vs amlodipine | Diabetes onset by 36% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | 0.94 [0.48 1.83] | p=1.00 | 0 | 4703 | 1 | CASE-J, | stroke (fatal and non fatal) | 1.27 [0.87 1.87] | p=1.00 | 0 | 4703 | 1 | CASE-J, | Coronary event | no data | cardiac death | no data | cancer related death | no data | Heart failure | 1.25 [0.64 2.41] | p=1.00 | 0 | 4703 | 1 | CASE-J, | All cause death | 0.85 [0.62 1.16] | p=1.00 | 0 | 4703 | 1 | CASE-J, | lung cancer | no data | breast cancer | no data | prostate cancer | no data | Cancer | no data | Diabetes onset | 0.64 [0.42 0.97] | p=0.04 | 0 | 4703 | 1 | CASE-J, |
Trial | Studied treatment | Control | Patients |
---|
CASE-J, 2008 | candesartan-based regimen | amlodipine-based regimen | high-risk Japanese hypertensive patients |
| |
Candesartan | | vs hydrochlorothiazide | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | 0.99 [0.06 16.02] | p=1.00 | 0 | 393 | 1 | ALPINE, | Cardiovascular death | 0.99 [0.02 50.40] | p=1.00 | 0 | 393 | 1 | ALPINE, | myocardial infarction (fatal and non fatal) | 0.99 [0.06 16.02] | p=1.00 | 0 | 393 | 1 | ALPINE, | stroke (fatal and non fatal) | 0.99 [0.02 50.40] | p=1.00 | 0 | 393 | 1 | ALPINE, | Coronary event | 0.99 [0.06 16.02] | p=1.00 | 0 | 393 | 1 | ALPINE, | cardiac death | no data | cancer related death | no data | Heart failure | no data | All cause death | 0.99 [0.02 50.40] | p=1.00 | 0 | 393 | 1 | ALPINE, | lung cancer | no data | breast cancer | no data | prostate cancer | no data | Cancer | no data | Diabetes onset | 0.12 [0.02 1.00] | p=1.00 | 0 | 393 | 1 | ALPINE, |
Trial | Studied treatment | Control | Patients |
---|
ALPINE, 2003 | candesartan | hydrochlorothiazide | newly detected hypertensives |
| |
Candesartan | miscellaneous, in all type of patients | vs control | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | Coronary event | no data | cardiac death | no data | cancer related death | no data | Heart failure | 0.39 [0.12 1.26] | p=1.00 | 0 | 80 | 1 | Takahashi, | All cause death | 0.06 [0.00 1.04] | p=1.00 | 0 | 80 | 1 | Takahashi, | lung cancer | no data | breast cancer | no data | prostate cancer | no data | Cancer | no data | Diabetes onset | no data |
Trial | Studied treatment | Control | Patients |
---|
Takahashi, 2006 | candesartan | control | patients on chronic haemodialysis in stable condition and with no clinical evidence of cardiac disorders |
| |
Candesartan | | vs conventional treatment | stroke (fatal and non fatal) by 27% suggested Diabetes onset by 61% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | 1.14 [0.69 1.88] | p=1.00 | 0 | 4238 | 3 | E-COST, E-COST-R, HIJ-CREATE, | myocardial infarction (fatal and non fatal) | 0.84 [0.55 1.28] | p=1.00 | 0 | 4238 | 3 | E-COST, E-COST-R, HIJ-CREATE, | stroke (fatal and non fatal) | 0.73 [0.56 0.95] | p=0.04 | 0 | 4238 | 3 | E-COST, E-COST-R, HIJ-CREATE, | Coronary event | no data | cardiac death | no data | cancer related death | no data | Heart failure | 0.83 [0.62 1.12] | p=1.00 | 0 | 4238 | 3 | E-COST, E-COST-R, HIJ-CREATE, | All cause death | 1.15 [0.82 1.61] | p=1.00 | 0 | 4238 | 3 | E-COST, E-COST-R, HIJ-CREATE, | lung cancer | no data | breast cancer | no data | prostate cancer | no data | Cancer | no data | Diabetes onset | 0.39 [0.16 0.94] | p=0.04 | 0 | 2049 | 1 | HIJ-CREATE, |
Trial | Studied treatment | Control | Patients |
---|
E-COST, 2005 | candesartan, 2 to 12 mg daily | conventional antihypertensive drugs other than angiotensin converting enzyme inhibitors or ARBs | Japanese essential hypertensive subjects (sitting blood pressure 140-180/90-110 mmHg) aged 35-79 years | E-COST-R, 2005 | candesartan | conventional treatment | hypertensive subjects 60 to 75 years old with non-diabetic chronic renal insufficiency | HIJ-CREATE, 2009 | angiotensin II receptor blocker-based therapy | non-angiotensin II receptor blocker-based therapy | patients with angiographically documented coronary artery disease and hypertension |
| |
Candesartan | | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | 0.89 [0.74 1.06] | p=1.00 | 0 | 5724 | 2 | SCOPE, TROPHY, | Cardiovascular death | 0.95 [0.75 1.20] | p=1.00 | 0 | 4937 | 1 | SCOPE, | myocardial infarction (fatal and non fatal) | 1.10 [0.78 1.56] | p=1.00 | 0 | 4937 | 1 | SCOPE, | stroke (fatal and non fatal) | 0.77 [0.58 1.02] | p=1.00 | 0 | 4937 | 1 | SCOPE, | Coronary event | 1.10 [0.78 1.56] | p=1.00 | 0 | 4937 | 1 | SCOPE, | cardiac death | 0.99 [0.52 1.91] | p=1.00 | 0 | 4937 | 1 | SCOPE, | cancer related death | no data | Heart failure | no data | hypertension | 0.84 [0.63 1.13] | p=1.00 | 0 | 772 | 1 | TROPHY, | All cause death | 0.97 [0.81 1.16] | p=1.00 | 0 | 4937 | 1 | SCOPE, | lung cancer | no data | breast cancer | no data | prostate cancer | no data | Cancer | 1.08 [0.87 1.33] | p=1.00 | 0 | 4937 | 1 | SCOPE, | Serious adverse event | 0.60 [0.30 1.19] | p=1.00 | 0 | 787 | 1 | TROPHY, | cardiovascular events | 0.89 [0.74 1.06] | p=1.00 | 0 | 5724 | 2 | SCOPE, TROPHY, | Diabetes onset | 0.80 [0.62 1.04] | p=1.00 | 0 | 4937 | 1 | SCOPE, |
Trial | Studied treatment | Control | Patients |
---|
SCOPE, 2003 | candesartan, 8–16 mg once daily (target 160/90) | placebo | patients aged 70–89 years, with systolic blood pressure 160– 179 mmHg, and/or diastolic blood pressure 90–99 mmHg, and a Mini Mental State Examination (MMSE) test score > 24 | TROPHY, 2006 | candesartan during 2y followed by 2y
of placebo | placebo | subjects with repeated measurements of systolic pressure of 130 to 139 mm Hg
and diastolic pressure of 89 mm Hg or lower, or systolic pressure of 139 mm Hg or
lower and diastolic pressure of 85 to 89 mm Hg |
| |
Candesartan | | vs amlodipine | Diabetes onset by 36% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | 0.94 [0.48 1.83] | p=1.00 | 0 | 4703 | 1 | CASE-J, | stroke (fatal and non fatal) | 1.27 [0.87 1.87] | p=1.00 | 0 | 4703 | 1 | CASE-J, | Coronary event | no data | cardiac death | no data | cancer related death | no data | Heart failure | 1.25 [0.64 2.41] | p=1.00 | 0 | 4703 | 1 | CASE-J, | All cause death | 0.85 [0.62 1.16] | p=1.00 | 0 | 4703 | 1 | CASE-J, | lung cancer | no data | breast cancer | no data | prostate cancer | no data | Cancer | no data | Diabetes onset | 0.64 [0.42 0.97] | p=0.04 | 0 | 4703 | 1 | CASE-J, |
Trial | Studied treatment | Control | Patients |
---|
CASE-J, 2008 | candesartan-based regimen | amlodipine-based regimen | high-risk Japanese hypertensive patients |
| |
Candesartan | | vs hydrochlorothiazide | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | 0.99 [0.06 16.02] | p=1.00 | 0 | 393 | 1 | ALPINE, | Cardiovascular death | 0.99 [0.02 50.40] | p=1.00 | 0 | 393 | 1 | ALPINE, | myocardial infarction (fatal and non fatal) | 0.99 [0.06 16.02] | p=1.00 | 0 | 393 | 1 | ALPINE, | stroke (fatal and non fatal) | 0.99 [0.02 50.40] | p=1.00 | 0 | 393 | 1 | ALPINE, | Coronary event | 0.99 [0.06 16.02] | p=1.00 | 0 | 393 | 1 | ALPINE, | cardiac death | no data | cancer related death | no data | Heart failure | no data | All cause death | 0.99 [0.02 50.40] | p=1.00 | 0 | 393 | 1 | ALPINE, | lung cancer | no data | breast cancer | no data | prostate cancer | no data | Cancer | no data | Diabetes onset | 0.12 [0.02 1.00] | p=1.00 | 0 | 393 | 1 | ALPINE, |
Trial | Studied treatment | Control | Patients |
---|
ALPINE, 2003 | candesartan | hydrochlorothiazide | newly detected hypertensives |
| |
Candesartan | | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | 0.90 [0.75 1.08] | p=1.00 | 0 | 4937 | 1 | SCOPE, | Cardiovascular death | 0.95 [0.75 1.20] | p=1.00 | 0 | 4937 | 1 | SCOPE, | myocardial infarction (fatal and non fatal) | 1.10 [0.78 1.56] | p=1.00 | 0 | 4937 | 1 | SCOPE, | stroke (fatal and non fatal) | 0.77 [0.58 1.02] | p=1.00 | 0 | 4937 | 1 | SCOPE, | Coronary event | 1.10 [0.78 1.56] | p=1.00 | 0 | 4937 | 1 | SCOPE, | cardiac death | 0.99 [0.52 1.91] | p=1.00 | 0 | 4937 | 1 | SCOPE, | cancer related death | no data | Heart failure | no data | All cause death | 0.97 [0.81 1.16] | p=1.00 | 0 | 4937 | 1 | SCOPE, | lung cancer | no data | breast cancer | no data | prostate cancer | no data | Cancer | 1.08 [0.87 1.33] | p=1.00 | 0 | 4937 | 1 | SCOPE, | Diabetes onset | 0.80 [0.62 1.04] | p=1.00 | 0 | 4937 | 1 | SCOPE, |
Trial | Studied treatment | Control | Patients |
---|
SCOPE, 2003 | candesartan, 8–16 mg once daily (target 160/90) | placebo | patients aged 70–89 years, with systolic blood pressure 160– 179 mmHg, and/or diastolic blood pressure 90–99 mmHg, and a Mini Mental State Examination (MMSE) test score > 24 |
| |
Olmesartan | diabetes type 2, in all type of patients | vs placebo | Cardiovascular death by 312% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
macrovascular events | 0.88 [0.62 1.24] | p=1.00 | 0 | 4447 | 1 | ROADMAP, | Cardiovascular death | 4.12 [1.68 10.11] | p=0.04 | 0 | 5013 | 2 | ROADMAP, ORIENT, | Non fatal MI | 0.61 [0.35 1.06] | p=1.00 | 0 | 5013 | 2 | ROADMAP, ORIENT, | All cause death | 1.29 [0.82 2.03] | p=1.00 | 0 | 5013 | 2 | ROADMAP, ORIENT, | Non fatal stroke | 1.16 [0.61 2.18] | p=1.00 | 0 | 5013 | 2 | ROADMAP, ORIENT, |
Trial | Studied treatment | Control | Patients |
---|
ROADMAP, 2010 | olmesartan at 40 mg/day | placebo | patients with diabetes and at least one additional cardiovascular risk factor, but no evidence of renal dysfunction | ORIENT, | olmesartan | placebo | patients with diabetic Nephropathy and overt proteinuria secondary to type 2 diabetes mellitus |
| |
Olmesartan | | vs placebo | Cardiovascular death by 312% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
macrovascular events | 0.88 [0.62 1.24] | p=1.00 | 0 | 4447 | 1 | ROADMAP, | Cardiovascular death | 4.12 [1.68 10.11] | p=0.04 | 0 | 5013 | 2 | ROADMAP, ORIENT, | Non fatal MI | 0.61 [0.35 1.06] | p=1.00 | 0 | 5013 | 2 | ROADMAP, ORIENT, | All cause death | 1.29 [0.82 2.03] | p=1.00 | 0 | 5013 | 2 | ROADMAP, ORIENT, | Non fatal stroke | 1.16 [0.61 2.18] | p=1.00 | 0 | 5013 | 2 | ROADMAP, ORIENT, |
Trial | Studied treatment | Control | Patients |
---|
ROADMAP, 2010 | olmesartan at 40 mg/day | placebo | patients with diabetes and at least one additional cardiovascular risk factor, but no evidence of renal dysfunction | ORIENT, | olmesartan | placebo | patients with diabetic Nephropathy and overt proteinuria secondary to type 2 diabetes mellitus |
| |
Telmisartan | heart failure, in all type of patients | vs enalapril | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | no data | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | no data | Cardiovascular death | no data | hospitalisation for heart failure | no data | Hospitalization for any reason | no data | | no data | Hyperkalaemia | no data | Cough | 0.58 [0.17 1.92] | p=1.00 | 0 | 378 | 1 | REPLACE, | Hypotension | no data | angiodema | no data | Adverse events | 1.79 [0.09 35.04] | p=1.00 | 0 | 378 | 1 | REPLACE, | All cause death | 0.51 [0.09 2.85] | p=1.00 | 0 | 378 | 1 | REPLACE, |
Trial | Studied treatment | Control | Patients |
---|
REPLACE, 2001 | Telmisartan, 10 mg, 20mg, 40mg, 80mg daily | Enalapril, 10 mg twice daily | ambulatory patients at least 21 years of age, in sinus rhythm, with chronic moderatesymptomatic heart failure (New York Heart Associatality.tion class II–III) and a left ventricular ejection fraction of 40% or lower |
| |
Telmisartan | heart failure, in patients already receiving ACE inhibitor | vs enalapril | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | no data | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | no data | Cardiovascular death | no data | hospitalisation for heart failure | no data | Hospitalization for any reason | no data | | no data | Hyperkalaemia | no data | Cough | 0.58 [0.17 1.92] | p=1.00 | 0 | 378 | 1 | REPLACE, | Hypotension | no data | angiodema | no data | Adverse events | 1.79 [0.09 35.04] | p=1.00 | 0 | 378 | 1 | REPLACE, | All cause death | 0.51 [0.09 2.85] | p=1.00 | 0 | 378 | 1 | REPLACE, |
Trial | Studied treatment | Control | Patients |
---|
REPLACE, 2001 | Telmisartan, 10 mg, 20mg, 40mg, 80mg daily | Enalapril, 10 mg twice daily | ambulatory patients at least 21 years of age, in sinus rhythm, with chronic moderatesymptomatic heart failure (New York Heart Associatality.tion class II–III) and a left ventricular ejection fraction of 40% or lower |
| |
Telmisartan | hypertension, in all diseases requiring ACEi (HF, CHD, HT,...) | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | 0.94 [0.87 1.02] | p=1.00 | 0 | 20332 | 1 | PROPHESS, | Cardiovascular death | 0.85 [0.71 1.02] | p=1.00 | 0 | 20332 | 1 | PROPHESS, | myocardial infarction (fatal and non fatal) | 1.00 [0.80 1.24] | p=1.00 | 0 | 20332 | 1 | PROPHESS, | stroke (fatal and non fatal) | 0.95 [0.86 1.04] | p=1.00 | 0 | 20332 | 1 | PROPHESS, | Coronary event | no data | cardiac death | no data | cancer related death | no data | Heart failure | no data | All cause death | 1.02 [0.92 1.14] | p=1.00 | 0 | 20332 | 1 | PROPHESS, | lung cancer | 1.24 [0.76 2.00] | p=1.00 | 0 | 20064 | 1 | PROPHESS, | breast cancer | no data | prostate cancer | no data | Cancer | 0.96 [0.82 1.12] | p=1.00 | 0 | 20064 | 1 | PROPHESS, | Diabetes onset | 0.83 [0.65 1.06] | p=1.00 | 0 | 20332 | 1 | PROPHESS, |
Trial | Studied treatment | Control | Patients |
---|
PROPHESS, 2008 | telmisartan 80 mg daily | placebo | patients who recently had an ischemic stroke |
| |
Telmisartan | | vs Enalapril | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | 1.63 [0.27 9.90] | p=1.00 | 0 | 250 | 1 | DETAIL, | myocardial infarction (fatal and non fatal) | 1.63 [0.56 4.71] | p=1.00 | 0 | 250 | 1 | DETAIL, | stroke (fatal and non fatal) | 1.08 [0.34 3.46] | p=1.00 | 0 | 250 | 1 | DETAIL, | All cause death | 1.08 [0.34 3.46] | p=1.00 | 0 | 250 | 1 | DETAIL, |
Trial | Studied treatment | Control | Patients |
---|
DETAIL, 2004 | Telmisartan 80 mg daily | Enalapril 20 mg daily | pateintspatients with type 2 diabetes and early nephropathy |
| |
Telmisartan | | vs Ramipril | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | 1.00 [0.89 1.12] | p=1.00 | 0 | 17118 | 1 | ONTARGET/Tel, | myocardial infarction (fatal and non fatal) | 1.07 [0.93 1.23] | p=1.00 | 0 | 17118 | 1 | ONTARGET/Tel, | stroke (fatal and non fatal) | 0.91 [0.79 1.06] | p=1.00 | 0 | 17118 | 1 | ONTARGET/Tel, | All cause death | 0.98 [0.89 1.07] | p=1.00 | 0 | 17118 | 1 | ONTARGET/Tel, |
Trial | Studied treatment | Control | Patients |
---|
ONTARGET/Tel, 2008 | Telmisartan 80 mg daily | Ramipril 10 mg daily | patients with vascular disease or high-risk diabetes |
| |
Telmisartan | miscellaneous, in all type of patients | vs placebo | cardiovascular events by 8% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | 0.92 [0.86 0.99] | p=0.04 | 0 | 26258 | 2 | TRANSCEND, PROPHESS, | Cardiovascular death | 0.93 [0.81 1.06] | p=1.00 | 0 | 26258 | 2 | TRANSCEND, PROPHESS, | myocardial infarction (fatal and non fatal) | 1.00 [0.80 1.24] | p=1.00 | 0 | 20332 | 1 | PROPHESS, | stroke (fatal and non fatal) | 0.93 [0.85 1.02] | p=1.00 | 0 | 26258 | 2 | TRANSCEND, PROPHESS, | Coronary event | 0.79 [0.62 1.02] | p=1.00 | 0 | 5926 | 1 | TRANSCEND, | Coronary death | no data | cardiac death | no data | cardiovascular death, MI, stroke | 0.88 [0.76 1.02] | p=1.00 | 0 | 5926 | 1 | TRANSCEND, | cancer related death | no data | Non fatal MI | no data | Heart failure | no data | Revascularization | 0.90 [0.77 1.05] | p=1.00 | 0 | 5926 | 1 | TRANSCEND, | All cause death | 1.03 [0.95 1.13] | p=1.00 | 0 | 26258 | 2 | TRANSCEND, PROPHESS, | lung cancer | 1.24 [0.76 2.00] | p=1.00 | 0 | 20064 | 1 | PROPHESS, | breast cancer | no data | prostate cancer | no data | Cancer | 0.96 [0.82 1.12] | p=1.00 | 0 | 20064 | 1 | PROPHESS, | Cough | 0.84 [0.42 1.67] | p=1.00 | 0 | 5926 | 1 | TRANSCEND, | Hypotension | 1.82 [0.99 3.36] | p=1.00 | 0 | 5926 | 1 | TRANSCEND, | angiodema | 0.67 [0.11 4.02] | p=1.00 | 0 | 5926 | 1 | TRANSCEND, | Adverse events leading to treatment discontinuation | 0.91 [0.81 1.03] | p=1.00 | 0 | 5926 | 1 | TRANSCEND, | Diabetes onset | 0.83 [0.65 1.06] | p=1.00 | 0 | 20332 | 1 | PROPHESS, |
Trial | Studied treatment | Control | Patients |
---|
TRANSCEND, 2008 | telmisartan 80 mg/day | placebo | high-risk patients intolerant to
angiotensin-converting enzyme inhibitors | PROPHESS, 2008 | telmisartan 80 mg daily | placebo | patients who recently had an ischemic stroke |
| |
Telmisartan | | vs ramipril | Hypotension by 54% adverse event Cough by 74% suggested angiodema by 60% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | 0.99 [0.91 1.08] | p=1.00 | 0 | 17118 | 1 | ONTARGET (telmisartan alone), | Cardiovascular death | 1.00 [0.89 1.12] | p=1.00 | 0 | 17118 | 1 | ONTARGET (telmisartan alone), | stroke (fatal and non fatal) | 0.91 [0.79 1.06] | p=1.00 | 0 | 17118 | 1 | ONTARGET (telmisartan alone), | Coronary event | 1.07 [0.93 1.23] | p=1.00 | 0 | 17118 | 1 | ONTARGET (telmisartan alone), | Coronary death | no data | cardiovascular death, MI, stroke | no data | Non fatal MI | no data | Revascularization | 1.02 [0.94 1.11] | p=1.00 | 0 | 17118 | 1 | ONTARGET (telmisartan alone), | All cause death | 0.98 [0.89 1.07] | p=1.00 | 0 | 17118 | 1 | ONTARGET (telmisartan alone), | Cough | 0.26 [0.21 0.33] | p=0.04 | 0 | 17118 | 1 | ONTARGET (telmisartan alone), | Hypotension | 1.54 [1.25 1.90] | p=0.04 | 0 | 17118 | 1 | ONTARGET (telmisartan alone), | angiodema | 0.40 [0.19 0.84] | p=0.04 | 0 | 17118 | 1 | ONTARGET (telmisartan alone), | Adverse events leading to treatment discontinuation | 0.94 [0.87 1.01] | p=1.00 | 0 | 17118 | 1 | ONTARGET (telmisartan alone), |
Trial | Studied treatment | Control | Patients |
---|
ONTARGET (telmisartan alone), 2008 | telmisartan 80mg daily | ramipril 10 mg daily | patients patients with coronary, peripheral, or cerebrovascular disease or diabetes with end-organ damage |
| |
Telmisartan | | vs placebo | cardiovascular events by 8% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | 0.92 [0.86 0.99] | p=0.04 | 0 | 26258 | 2 | TRANSCEND, PROPHESS, | Cardiovascular death | 0.93 [0.81 1.06] | p=1.00 | 0 | 26258 | 2 | TRANSCEND, PROPHESS, | myocardial infarction (fatal and non fatal) | 1.00 [0.80 1.24] | p=1.00 | 0 | 20332 | 1 | PROPHESS, | stroke (fatal and non fatal) | 0.93 [0.85 1.02] | p=1.00 | 0 | 26258 | 2 | TRANSCEND, PROPHESS, | Coronary event | 0.79 [0.62 1.02] | p=1.00 | 0 | 5926 | 1 | TRANSCEND, | Coronary death | no data | cardiac death | no data | cardiovascular death, MI, stroke | 0.88 [0.76 1.02] | p=1.00 | 0 | 5926 | 1 | TRANSCEND, | cancer related death | no data | Non fatal MI | no data | Heart failure | no data | Revascularization | 0.90 [0.77 1.05] | p=1.00 | 0 | 5926 | 1 | TRANSCEND, | All cause death | 1.03 [0.95 1.13] | p=1.00 | 0 | 26258 | 2 | TRANSCEND, PROPHESS, | lung cancer | 1.24 [0.76 2.00] | p=1.00 | 0 | 20064 | 1 | PROPHESS, | breast cancer | no data | prostate cancer | no data | Cancer | 0.96 [0.82 1.12] | p=1.00 | 0 | 20064 | 1 | PROPHESS, | Cough | 0.84 [0.42 1.67] | p=1.00 | 0 | 5926 | 1 | TRANSCEND, | Hypotension | 1.82 [0.99 3.36] | p=1.00 | 0 | 5926 | 1 | TRANSCEND, | angiodema | 0.67 [0.11 4.02] | p=1.00 | 0 | 5926 | 1 | TRANSCEND, | Adverse events leading to treatment discontinuation | 0.91 [0.81 1.03] | p=1.00 | 0 | 5926 | 1 | TRANSCEND, | Diabetes onset | 0.83 [0.65 1.06] | p=1.00 | 0 | 20332 | 1 | PROPHESS, |
Trial | Studied treatment | Control | Patients |
---|
TRANSCEND, 2008 | telmisartan 80 mg/day | placebo | high-risk patients intolerant to
angiotensin-converting enzyme inhibitors | PROPHESS, 2008 | telmisartan 80 mg daily | placebo | patients who recently had an ischemic stroke |
| |
Telmisartan | | vs ramipril | Hypotension by 54% adverse event Cough by 74% suggested angiodema by 60% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | 0.99 [0.91 1.08] | p=1.00 | 0 | 17118 | 1 | ONTARGET (telmisartan alone), | Cardiovascular death | 1.00 [0.89 1.12] | p=1.00 | 0 | 17118 | 1 | ONTARGET (telmisartan alone), | stroke (fatal and non fatal) | 0.91 [0.79 1.06] | p=1.00 | 0 | 17118 | 1 | ONTARGET (telmisartan alone), | Coronary event | 1.07 [0.93 1.23] | p=1.00 | 0 | 17118 | 1 | ONTARGET (telmisartan alone), | Coronary death | no data | cardiovascular death, MI, stroke | no data | Non fatal MI | no data | Revascularization | 1.02 [0.94 1.11] | p=1.00 | 0 | 17118 | 1 | ONTARGET (telmisartan alone), | All cause death | 0.98 [0.89 1.07] | p=1.00 | 0 | 17118 | 1 | ONTARGET (telmisartan alone), | Cough | 0.26 [0.21 0.33] | p=0.04 | 0 | 17118 | 1 | ONTARGET (telmisartan alone), | Hypotension | 1.54 [1.25 1.90] | p=0.04 | 0 | 17118 | 1 | ONTARGET (telmisartan alone), | angiodema | 0.40 [0.19 0.84] | p=0.04 | 0 | 17118 | 1 | ONTARGET (telmisartan alone), | Adverse events leading to treatment discontinuation | 0.94 [0.87 1.01] | p=1.00 | 0 | 17118 | 1 | ONTARGET (telmisartan alone), |
Trial | Studied treatment | Control | Patients |
---|
ONTARGET (telmisartan alone), 2008 | telmisartan 80mg daily | ramipril 10 mg daily | patients patients with coronary, peripheral, or cerebrovascular disease or diabetes with end-organ damage |
| |
Telmisartan | patients at high risk for cardiovascular events, in patients intolerant to ACE inhibitors | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | 0.88 [0.76 1.02] | p=1.00 | 0 | 5926 | 1 | TRANSCEND, | Cardiovascular death | 1.02 [0.85 1.24] | p=1.00 | 0 | 5926 | 1 | TRANSCEND, | stroke (fatal and non fatal) | 0.83 [0.64 1.07] | p=1.00 | 0 | 5926 | 1 | TRANSCEND, | Coronary event | 0.79 [0.62 1.02] | p=1.00 | 0 | 5926 | 1 | TRANSCEND, | Coronary death | no data | cardiovascular death, MI, stroke | 0.88 [0.76 1.02] | p=1.00 | 0 | 5926 | 1 | TRANSCEND, | Non fatal MI | no data | Revascularization | 0.90 [0.77 1.05] | p=1.00 | 0 | 5926 | 1 | TRANSCEND, | All cause death | 1.05 [0.90 1.23] | p=1.00 | 0 | 5926 | 1 | TRANSCEND, | Cough | 0.84 [0.42 1.67] | p=1.00 | 0 | 5926 | 1 | TRANSCEND, | Hypotension | 1.82 [0.99 3.36] | p=1.00 | 0 | 5926 | 1 | TRANSCEND, | angiodema | 0.67 [0.11 4.02] | p=1.00 | 0 | 5926 | 1 | TRANSCEND, | Adverse events leading to treatment discontinuation | 0.91 [0.81 1.03] | p=1.00 | 0 | 5926 | 1 | TRANSCEND, |
Trial | Studied treatment | Control | Patients |
---|
TRANSCEND, 2008 | telmisartan 80 mg/day | placebo | high-risk patients intolerant to
angiotensin-converting enzyme inhibitors |
| |
Valsartan | acute myocardial infarction, in all type of patients | vs ACE inhibitor only | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | no data | death from cardiovascular causes or hospitalization for cardiovascular causes | no data | Cardiovascular death | 1.00 [0.90 1.11] | p=1.00 | 0 | 9794 | 1 | VALIANT (valsartan+capropril), | hospitalisation for heart failure | no data | Hyperkalaemia | no data | Cough | no data | Hypotension | no data | angiodema | no data | Adverse events | no data | All cause death | 0.99 [0.89 1.09] | p=1.00 | 0 | 9794 | 1 | VALIANT (valsartan+capropril), |
Trial | Studied treatment | Control | Patients |
---|
VALIANT (valsartan+capropril), 2003 | Valsartan, 40 mg twice daily, plus captopril, 25 mg three times daily | Captopril, 25 mg 3 times daily | patients within 10 days of a MI complicated by HF |
| |
Valsartan | | vs Captopril | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | no data | death from cardiovascular causes or hospitalization for cardiovascular causes | no data | Cardiovascular death | 1.00 [0.90 1.11] | p=1.00 | 0 | 9818 | 1 | VALIANT (valsartan alone), | hospitalisation for heart failure | no data | Hyperkalaemia | no data | Cough | no data | Hypotension | no data | angiodema | no data | Adverse events | no data | All cause death | 1.02 [0.93 1.13] | p=1.00 | 0 | 9818 | 1 | VALIANT (valsartan alone), |
Trial | Studied treatment | Control | Patients |
---|
VALIANT (valsartan alone), 2003 | Valsartan, 160 mg twice daily | Captopril, 50 mg 3 times daily | patients within 10 days of a MI complicated by HF |
| |
Valsartan | | vs no valsartan | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | no data | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | no data | Cardiovascular death | no data | hospitalisation for heart failure | no data | Hospitalization for any reason | no data | | no data | Hyperkalaemia | no data | Cough | no data | Hypotension | no data | angiodema | no data | Adverse events | no data | All cause death | no data |
Trial | Studied treatment | Control | Patients |
---|
VALIDD, 2007 | valsartan titrated up to 320 mg once daily | placebo | Patients with hypertension and evidence of diastolic dysfunction |
| |
Valsartan | | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | no data | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | no data | Cardiovascular death | no data | hospitalisation for heart failure | no data | Hospitalization for any reason | no data | | no data | Hyperkalaemia | no data | Cough | no data | Hypotension | no data | angiodema | no data | Adverse events | 1.52 [0.59 3.92] | p=1.00 | 0 | 101 | 1 | Mazayev et al. (vs placebo), | All cause death | 0.35 [0.02 5.75] | p=1.00 | 0 | 101 | 1 | Mazayev et al. (vs placebo), |
Trial | Studied treatment | Control | Patients |
---|
Mazayev et al. (vs placebo), 1998 | valsartan 40, 80 or 160 mg twice daily | Placebo | patients with chronic heart failure previously untreated with ACE inhibitors |
| |
Valsartan | | vs ACE inhibitor only | by 401% adverse event Adverse events by 46% adverse event hospitalisation for heart failure by 24% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | no data | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | no data | Cardiovascular death | no data | hospitalisation for heart failure | 0.76 [0.65 0.88] | p=0.04 | 0 | 5010 | 1 | Val-HeFT, | Hospitalization for any reason | no data | | 5.01 [1.91 13.16] | p=0.04 | 0 | 4727 | 2 | V-HeFT, Val-HeFT, | Hyperkalaemia | 4.58 [0.24 88.29] | p=1.00 | 0 | 83 | 1 | V-HeFT, | Cough | no data | Hypotension | 1.70 [0.97 2.98] | p=1.00 | 0 | 4727 | 2 | V-HeFT, Val-HeFT, | angiodema | no data | Adverse events | 1.46 [1.18 1.80] | p=0.04 | 0 | 4644 | 1 | Val-HeFT, | All cause death | 1.02 [0.89 1.17] | p=1.00 | 0 | 5093 | 2 | V-HeFT, Val-HeFT, |
Trial | Studied treatment | Control | Patients |
---|
V-HeFT, 1999 | Valsartan 80 mg and 160mg twice daily (plus ACE inhibitor) | Placebo (plus usual ACE inhibitor) | Patients with stable symptomatic congestive heart failure (CHF) receiving long-term ACE inhibitor therapy (NYHA functional class II,III, or IV) and PCWP >or=to 15 mm Hg | Val-HeFT, 2001 | Valsartan, 160 mg twice daily (plus ACE inhibitor) | Placebo (plus ACE inhibitor) | patients with heart failure of New York Heart Association (NYHA) class II, III, or IV |
| |
Valsartan | | vs enalapril | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | no data | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | no data | Cardiovascular death | no data | hospitalisation for heart failure | no data | Hospitalization for any reason | no data | | no data | Hyperkalaemia | no data | Cough | no data | Hypotension | no data | angiodema | no data | Adverse events | 0.55 [0.19 1.59] | p=1.00 | 0 | 141 | 1 | HEAVEN, | All cause death | 0.20 [0.02 1.78] | p=1.00 | 0 | 141 | 1 | HEAVEN, |
Trial | Studied treatment | Control | Patients |
---|
HEAVEN, 2002 | Valsartan, 160 mg daily | Enalapril, 10 mg twice daily | Men and women with mild/moderate heart failure stabilised on an angiotensin-converting enzyme inhibitor and left ventricular ejection fraction 0.45 or less |
| |
Valsartan | | vs Lisinopril | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | no data | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | no data | Cardiovascular death | no data | hospitalisation for heart failure | no data | Hospitalization for any reason | no data | | no data | Hyperkalaemia | no data | Cough | no data | Hypotension | no data | angiodema | no data | Adverse events | 0.78 [0.25 2.40] | p=1.00 | 0 | 90 | 1 | Mazayev et al. (vs lisinopril, | All cause death | 0.20 [0.00 10.49] | p=1.00 | 0 | 90 | 1 | Mazayev et al. (vs lisinopril, |
Trial | Studied treatment | Control | Patients |
---|
Mazayev et al. (vs lisinopril, 1998 | Valsartan, 40 mg, 80mg, 160mg twice daily | lisinopril 10mg once daily | patients with chronic heart failure |
| |
Valsartan | heart failure, in patients already receiving ACE inhibitor | vs ACE inhibitor only | by 401% adverse event Adverse events by 46% adverse event hospitalisation for heart failure by 24% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | no data | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | no data | Cardiovascular death | no data | hospitalisation for heart failure | 0.76 [0.65 0.88] | p=0.04 | 0 | 5010 | 1 | Val-HeFT, | Hospitalization for any reason | no data | | 5.01 [1.91 13.16] | p=0.04 | 0 | 4727 | 2 | V-HeFT, Val-HeFT, | Hyperkalaemia | 4.58 [0.24 88.29] | p=1.00 | 0 | 83 | 1 | V-HeFT, | Cough | no data | Hypotension | 1.70 [0.97 2.98] | p=1.00 | 0 | 4727 | 2 | V-HeFT, Val-HeFT, | angiodema | no data | Adverse events | 1.46 [1.18 1.80] | p=0.04 | 0 | 4644 | 1 | Val-HeFT, | All cause death | 1.02 [0.89 1.17] | p=1.00 | 0 | 5093 | 2 | V-HeFT, Val-HeFT, |
Trial | Studied treatment | Control | Patients |
---|
V-HeFT, 1999 | Valsartan 80 mg and 160mg twice daily (plus ACE inhibitor) | Placebo (plus usual ACE inhibitor) | Patients with stable symptomatic congestive heart failure (CHF) receiving long-term ACE inhibitor therapy (NYHA functional class II,III, or IV) and PCWP >or=to 15 mm Hg | Val-HeFT, 2001 | Valsartan, 160 mg twice daily (plus ACE inhibitor) | Placebo (plus ACE inhibitor) | patients with heart failure of New York Heart Association (NYHA) class II, III, or IV |
| |
Valsartan | | vs enalapril | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | no data | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | no data | Cardiovascular death | no data | hospitalisation for heart failure | no data | Hospitalization for any reason | no data | | no data | Hyperkalaemia | no data | Cough | no data | Hypotension | no data | angiodema | no data | Adverse events | 0.55 [0.19 1.59] | p=1.00 | 0 | 141 | 1 | HEAVEN, | All cause death | 0.20 [0.02 1.78] | p=1.00 | 0 | 141 | 1 | HEAVEN, |
Trial | Studied treatment | Control | Patients |
---|
HEAVEN, 2002 | Valsartan, 160 mg daily | Enalapril, 10 mg twice daily | Men and women with mild/moderate heart failure stabilised on an angiotensin-converting enzyme inhibitor and left ventricular ejection fraction 0.45 or less |
| |
Valsartan | heart failure, in patients previously untreated with ACE inhibitors | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | no data | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | no data | Cardiovascular death | no data | hospitalisation for heart failure | no data | Hospitalization for any reason | no data | | no data | Hyperkalaemia | no data | Cough | no data | Hypotension | no data | angiodema | no data | Adverse events | 1.52 [0.59 3.92] | p=1.00 | 0 | 101 | 1 | Mazayev et al. (vs placebo), | All cause death | 0.35 [0.02 5.75] | p=1.00 | 0 | 101 | 1 | Mazayev et al. (vs placebo), |
Trial | Studied treatment | Control | Patients |
---|
Mazayev et al. (vs placebo), 1998 | valsartan 40, 80 or 160 mg twice daily | Placebo | patients with chronic heart failure previously untreated with ACE inhibitors |
| |
Valsartan | | vs Lisinopril | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | no data | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | no data | Cardiovascular death | no data | hospitalisation for heart failure | no data | Hospitalization for any reason | no data | | no data | Hyperkalaemia | no data | Cough | no data | Hypotension | no data | angiodema | no data | Adverse events | 0.78 [0.25 2.40] | p=1.00 | 0 | 90 | 1 | Mazayev et al. (vs lisinopril, | All cause death | 0.20 [0.00 10.49] | p=1.00 | 0 | 90 | 1 | Mazayev et al. (vs lisinopril, |
Trial | Studied treatment | Control | Patients |
---|
Mazayev et al. (vs lisinopril, 1998 | Valsartan, 40 mg, 80mg, 160mg twice daily | lisinopril 10mg once daily | patients with chronic heart failure |
| |
Valsartan | heart failure, in patients with preserved-LVEF heart failure | vs no valsartan | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | no data | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | no data | Cardiovascular death | no data | hospitalisation for heart failure | no data | Hospitalization for any reason | no data | | no data | Hyperkalaemia | no data | Cough | no data | Hypotension | no data | angiodema | no data | Adverse events | no data | All cause death | no data |
Trial | Studied treatment | Control | Patients |
---|
VALIDD, 2007 | valsartan titrated up to 320 mg once daily | placebo | Patients with hypertension and evidence of diastolic dysfunction |
| |
Valsartan | hypertension, in all diseases requiring ACEi (HF, CHD, HT,...) | vs Captopril | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | 1.00 [0.90 1.11] | p=1.00 | 0 | 9818 | 1 | VALIANT/Val, | myocardial infarction (fatal and non fatal) | 1.00 [0.90 1.11] | p=1.00 | 0 | 9818 | 1 | VALIANT/Val, | stroke (fatal and non fatal) | 0.85 [0.70 1.05] | p=1.00 | 0 | 9818 | 1 | VALIANT/Val, | All cause death | 1.02 [0.93 1.13] | p=1.00 | 0 | 9818 | 1 | VALIANT/Val, |
Trial | Studied treatment | Control | Patients |
---|
VALIANT/Val, 2003 | Valsartan | Captopril | patients with myocardial infarction complicated by left ventricular systolic dysfunction, heart failure, or both |
| |
Irbesartan | diabetes type 2, in all type of patients | vs placebo | microvascular events by 70% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | microvascular events | 0.30 [0.14 0.64] | p=0.04 | 0 | 590 | 1 | IPDM (150mg), | Non fatal MI | no data | All cause death | no data | Non fatal stroke | no data |
Trial | Studied treatment | Control | Patients |
---|
IPDM (150mg), 2001 | irbesartan 150 mg daily | placebo | hypertensive patients with type 2 diabetes and microalbuminuria |
| |
Irbesartan | | vs amlodipine | microvascular events by 23% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | 1.03 [0.81 1.31] | p=1.00 | 0 | 1146 | 1 | IDNT (irbesartan vs amlodipine), | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | microvascular events | 0.77 [0.63 0.94] | p=0.04 | 0 | 1146 | 1 | IDNT (irbesartan vs amlodipine), | Non fatal MI | no data | All cause death | 1.04 [0.77 1.40] | p=1.00 | 0 | 1146 | 1 | IDNT (irbesartan vs amlodipine), | Non fatal stroke | no data |
Trial | Studied treatment | Control | Patients |
---|
IDNT (irbesartan vs amlodipine), 2001 | Irbesartan 300 mg daily | amlodipine 10 mg daily | hypertensive patients with nephropathy due to type 2 diabetes
|
| |
Irbesartan | | vs ACE inhibitor only | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | no data | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | no data | Cardiovascular death | no data | hospitalisation for heart failure | no data | Hospitalization for any reason | no data | | no data | Hyperkalaemia | no data | Cough | no data | Hypotension | no data | angiodema | no data | Adverse events | no data | All cause death | 0.91 [0.02 46.82] | p=1.00 | 0 | 109 | 1 | Tonkon et al., |
Trial | Studied treatment | Control | Patients |
---|
Tonkon et al., 2000 | Irbesartan, 150 mg daily (plus ACE inhibitor) | Placebo (plus ACE inhibitor) | patients with heart failure (New York Heart Association functional class II and III) and left ventricular ejection fraction (LVEF) < or = 40% received stable doses of ACE inhibitors and diuretics |
| |
Irbesartan | heart failure, in patients already receiving ACE inhibitor | vs ACE inhibitor only | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | no data | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | no data | Cardiovascular death | no data | hospitalisation for heart failure | no data | Hospitalization for any reason | no data | | no data | Hyperkalaemia | no data | Cough | no data | Hypotension | no data | angiodema | no data | Adverse events | no data | All cause death | 0.91 [0.02 46.82] | p=1.00 | 0 | 109 | 1 | Tonkon et al., |
Trial | Studied treatment | Control | Patients |
---|
Tonkon et al., 2000 | Irbesartan, 150 mg daily (plus ACE inhibitor) | Placebo (plus ACE inhibitor) | patients with heart failure (New York Heart Association functional class II and III) and left ventricular ejection fraction (LVEF) < or = 40% received stable doses of ACE inhibitors and diuretics |
| |
Irbesartan | heart failure, in patients with preserved-LVEF heart failure | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | no data | Cardiovascular death or hospital admission for CHF | 0.97 [0.84 1.13] | p=1.00 | 0 | 4128 | 1 | I-PRESERVE (McMurray), | death or cardiovascular hospitalization | 0.97 [0.85 1.10] | p=1.00 | 0 | 4128 | 1 | I-PRESERVE (McMurray), | Cardiovascular death | 1.03 [0.86 1.22] | p=1.00 | 0 | 4128 | 1 | I-PRESERVE (McMurray), | hospitalisation for heart failure | 0.96 [0.82 1.14] | p=1.00 | 0 | 4128 | 1 | I-PRESERVE (McMurray), | Hospitalization for any reason | 1.02 [0.90 1.15] | p=1.00 | 0 | 4128 | 1 | I-PRESERVE (McMurray), | | no data | Hyperkalaemia | no data | Cough | no data | Hypotension | no data | angiodema | no data | Adverse events | no data | All cause death | 1.02 [0.88 1.18] | p=1.00 | 0 | 4128 | 1 | I-PRESERVE (McMurray), |
Trial | Studied treatment | Control | Patients |
---|
I-PRESERVE (McMurray), 2008 | ibersatan 300mg daily | placebo | patients with NYHA
II, III, or IV heart failure and an ejection fraction of at least 45% |
| |
Irbesartan | hypertension, in all diseases requiring ACEi (HF, CHD, HT,...) | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | 1.11 [0.73 1.68] | p=1.00 | 0 | 1148 | 1 | IDNT (irbesartan vs pbo), | myocardial infarction (fatal and non fatal) | 0.88 [0.59 1.32] | p=1.00 | 0 | 1759 | 2 | IDNT (irbesartan vs pbo), IRMA 2, | stroke (fatal and non fatal) | 1.06 [0.61 1.83] | p=1.00 | 0 | 1148 | 1 | IDNT (irbesartan vs pbo), | Coronary event | 0.91 [0.72 1.15] | p=1.00 | 0 | 1148 | 1 | IDNT (irbesartan vs pbo), | cardiac death | no data | cancer related death | no data | Heart failure | 0.82 [0.57 1.18] | p=1.00 | 0 | 1148 | 1 | IDNT (irbesartan vs pbo), | All cause death | 0.93 [0.69 1.27] | p=1.00 | 0 | 1759 | 2 | IDNT (irbesartan vs pbo), IRMA 2, | lung cancer | no data | breast cancer | no data | prostate cancer | no data | Cancer | no data | Diabetes onset | no data |
Trial | Studied treatment | Control | Patients |
---|
IDNT (irbesartan vs pbo), 2001 | Irbesartan 300mg/d (target 135/85) | placebo | hypertensive patients with nephropathy due to type 2 diabetes | IRMA 2, 2001 | irbesartan 150 mg daily or 300 mg daily | placebo | hypertensive patients with type 2 diabetes and microalbuminuria |
| |
Irbesartan | miscellaneous, in all type of patients | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | 1.11 [0.73 1.68] | p=1.00 | 0 | 1148 | 1 | IDNT (irbesartan vs pbo), | myocardial infarction (fatal and non fatal) | 0.88 [0.59 1.32] | p=1.00 | 0 | 1759 | 2 | IDNT (irbesartan vs pbo), IRMA 2, | stroke (fatal and non fatal) | 1.06 [0.61 1.83] | p=1.00 | 0 | 1148 | 1 | IDNT (irbesartan vs pbo), | Coronary event | 0.91 [0.72 1.15] | p=1.00 | 0 | 1148 | 1 | IDNT (irbesartan vs pbo), | cardiac death | no data | cancer related death | no data | Heart failure | 0.82 [0.57 1.18] | p=1.00 | 0 | 1148 | 1 | IDNT (irbesartan vs pbo), | All cause death | 0.93 [0.69 1.27] | p=1.00 | 0 | 1759 | 2 | IDNT (irbesartan vs pbo), IRMA 2, | lung cancer | no data | breast cancer | no data | prostate cancer | no data | Cancer | no data | Diabetes onset | no data |
Trial | Studied treatment | Control | Patients |
---|
IDNT (irbesartan vs pbo), 2001 | Irbesartan 300mg/d (target 135/85) | placebo | hypertensive patients with nephropathy due to type 2 diabetes | IRMA 2, 2001 | irbesartan 150 mg daily or 300 mg daily | placebo | hypertensive patients with type 2 diabetes and microalbuminuria |
| |
Losartan | acute myocardial infarction, in all type of patients | vs Captopril | Cough by 75% suggested angiodema by 72% suggested Adverse events by 48% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | 1.17 [0.96 1.43] | p=1.00 | 0 | 5477 | 1 | OPTIMAAL, | Death from any cause or hospitalization for any reason | no data | death from cardiovascular causes or hospitalization for cardiovascular causes | no data | Cardiovascular death | 1.15 [0.99 1.34] | p=1.00 | 0 | 5477 | 1 | OPTIMAAL, | hospitalisation for heart failure | 1.15 [0.97 1.37] | p=1.00 | 0 | 5477 | 1 | OPTIMAAL, | Hyperkalaemia | no data | Cough | 0.25 [0.16 0.37] | p=0.04 | 0 | 5477 | 1 | OPTIMAAL, | Hypotension | 0.77 [0.52 1.13] | p=1.00 | 0 | 5477 | 1 | OPTIMAAL, | angiodema | 0.28 [0.09 0.87] | p=0.04 | 0 | 5477 | 1 | OPTIMAAL, | Adverse events | 0.52 [0.43 0.62] | p=0.04 | 0 | 5477 | 1 | OPTIMAAL, | All cause death | 1.11 [0.97 1.28] | p=1.00 | 0 | 5477 | 1 | OPTIMAAL, |
Trial | Studied treatment | Control | Patients |
---|
OPTIMAAL, 2002 | Losartan, target dose of 50 mg daily | Captopril, traget dose of 50 mg 3 times daily | patients within 10 days of a confirmed acute myocardial
infarction and heart failure during the acute phase or a new
Q-wave anterior infarction or reinfarction |
| |
Losartan | | vs placebo | microvascular events by 21% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | microvascular events | 0.79 [0.66 0.95] | p=0.04 | 0 | 2275 | 1 | RENAAL, | Non fatal MI | no data | All cause death | 1.02 [0.80 1.30] | p=1.00 | 0 | 2275 | 1 | RENAAL, | Non fatal stroke | no data |
Trial | Studied treatment | Control | Patients |
---|
RENAAL, 2001 | losartan 50 to 100 mg once daily | placebo | patients with type 2 diabetes and nephropathy |
| |
Losartan | | vs losartan 50mg | Death from any cause or hospitalization for any reason by 10% suggested hospitalisation for heart failure by 13% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | 0.90 [0.82 0.99] | p=0.04 | 0 | 3834 | 1 | HEAAL, | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | 0.92 [0.84 1.00] | p=1.00 | 0 | 3834 | 1 | HEAAL, | Cardiovascular death | no data | hospitalisation for heart failure | 0.87 [0.77 0.99] | p=0.04 | 0 | 3834 | 1 | HEAAL, | Hospitalization for any reason | no data | | 1.33 [0.86 2.06] | p=1.00 | 0 | 3834 | 1 | HEAAL, | Hyperkalaemia | 2.24 [0.69 7.29] | p=1.00 | 0 | 3834 | 1 | HEAAL, | Cough | no data | Hypotension | 1.18 [0.61 2.31] | p=1.00 | 0 | 3834 | 1 | HEAAL, | angiodema | 8.96 [0.48 166.59] | p=1.00 | 0 | 3834 | 1 | HEAAL, | Adverse events | 1.11 [0.87 1.41] | p=1.00 | 0 | 3834 | 1 | HEAAL, | All cause death | 0.94 [0.84 1.05] | p=1.00 | 0 | 3834 | 1 | HEAAL, |
Trial | Studied treatment | Control | Patients |
---|
HEAAL, 2009 | losartan 150mg daily | losartan 50 mg daily | patients with systolic heart failure who couldnt tolerate ACE inhibitors |
| |
Losartan | | vs placebo | All cause death by 72% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | no data | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | no data | Cardiovascular death | no data | hospitalisation for heart failure | no data | Hospitalization for any reason | no data | | no data | Hyperkalaemia | no data | Cough | no data | Hypotension | no data | angiodema | no data | Adverse events | no data | All cause death | 0.28 [0.11 0.73] | p=0.04 | 0 | 736 | 2 | Losartan Phase III International, Losartan Phase III U.S., |
Trial | Studied treatment | Control | Patients |
---|
Losartan Phase III International, 1996 | Losartan, 50 mg daily | Placebo | patients with heart failure who had never received ACE inibitors or who had discontinued ACE inhibitors | Losartan Phase III U.S., 1995 | Losartan, 50 mg daily | Placebo | patients with heart failure who had never received ACE inibitors or who had discontinued ACE inhibitors |
| |
Losartan | | vs ACE inhibitor only | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | no data | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | no data | Cardiovascular death | no data | hospitalisation for heart failure | no data | Hospitalization for any reason | no data | | no data | Hyperkalaemia | no data | Cough | no data | Hypotension | no data | angiodema | no data | Adverse events | no data | All cause death | 0.35 [0.01 9.39] | p=1.00 | 0 | 33 | 1 | Hamroff et al., |
Trial | Studied treatment | Control | Patients |
---|
Hamroff et al., 1999 | Losartan, 50 mg daily (plus ACE inhibitor) | Placebo (plus ACE inhibitor) | patients with severe congestive heart failure (NYHA III-IV) despite treatment with maximally recommended or tolerated doses of ACE inhibitors |
| |
Losartan | | vs captopril | Cough by 96% suggested Adverse events by 41% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | 1.23 [0.95 1.59] | p=1.00 | 0 | 3152 | 1 | ELITE II, | Death from any cause or hospitalization for any reason | 1.03 [0.90 1.17] | p=1.00 | 0 | 3874 | 2 | ELITE, ELITE II, | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | no data | Cardiovascular death | 0.53 [0.26 1.07] | p=1.00 | 0 | 722 | 1 | ELITE, | hospitalisation for heart failure | 0.93 [0.78 1.10] | p=1.00 | 0 | 3874 | 2 | ELITE, ELITE II, | Hospitalization for any reason | 0.98 [0.86 1.12] | p=1.00 | 0 | 3874 | 2 | ELITE, ELITE II, | | 1.00 [0.62 1.60] | p=1.00 | 0 | 722 | 1 | ELITE, | Hyperkalaemia | 0.35 [0.07 1.75] | p=1.00 | 0 | 722 | 1 | ELITE, | Cough | 0.04 [0.00 0.61] | p=0.04 | 0 | 722 | 1 | ELITE, | Hypotension | 1.68 [0.54 5.19] | p=1.00 | 0 | 722 | 1 | ELITE, | angiodema | 0.15 [0.01 2.92] | p=1.00 | 0 | 722 | 1 | ELITE, | Adverse events | 0.59 [0.44 0.78] | p=0.04 | 0 | 1444 | 2 | ELITE, ELITE, | All cause death | 1.05 [0.88 1.26] | p=1.00 | 0 | 3874 | 2 | ELITE, ELITE II, |
Trial | Studied treatment | Control | Patients |
---|
ELITE, 1997 | Losartan titrated to 50 mg once daily | Captopril,titratedto 50 mg three times daily | ACE inhibitor naive patients (aged 65 years or more) with New York HeartAssociation (NYHA) class II–IV heart failure and ejection fractions of 40% or less | ELITE II, 2000 | Losartan, target dose 50 mg daily | Captopril, target dose 50 mg 3 times daily | patients aged 60 years or older with New York Heart Association class II–IV heart failure and ejection fraction of 40% or less. |
| |
Losartan | | vs enalapril | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | no data | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | no data | Cardiovascular death | no data | hospitalisation for heart failure | no data | Hospitalization for any reason | no data | | no data | Hyperkalaemia | no data | Cough | no data | Hypotension | no data | angiodema | no data | Adverse events | 1.12 [0.51 2.44] | p=1.00 | 0 | 232 | 2 | Lang et al., Lang et al., | All cause death | 1.18 [0.37 3.76] | p=1.00 | 0 | 564 | 4 | Dickstein et al., Lang et al., Losartan phase II S, losartan phase II US, |
Trial | Studied treatment | Control | Patients |
---|
Dickstein et al., 1995 | Losartan, 25 mg, 50mg daily | Enalapril, 10 mg twice daily | patients with moderate or severe chronic heart failure in New York Heart Association functional class III or IV and an ejection fraction < or = 35% | Lang et al., 1997 | Losartan titrated to 25 mg ou 50 mg daily | Enalapril, titrated to 10 mg twice daily | patients with congestive heart failure (New York Heart Association functionalclasses II to IV) and left ventricular ejection fraction <= 45%previously treated with stable doses of ACE inhibitors and diureticagents, with or without concurrent digitalis and othervasodilators | Losartan phase II S, 1996 | losartan 50 or 25 mg/d | enalapril 10mg twice daily | patient with heart failure | losartan phase II US, 1996 | losartan 25 and 50 mg/d | enalapril 10mg twice daily | patients with heart failure |
| |
Losartan | heart failure, in patients already receiving ACE inhibitor | vs ACE inhibitor only | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | no data | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | no data | Cardiovascular death | no data | hospitalisation for heart failure | no data | Hospitalization for any reason | no data | | no data | Hyperkalaemia | no data | Cough | no data | Hypotension | no data | angiodema | no data | Adverse events | no data | All cause death | 0.35 [0.01 9.39] | p=1.00 | 0 | 33 | 1 | Hamroff et al., |
Trial | Studied treatment | Control | Patients |
---|
Hamroff et al., 1999 | Losartan, 50 mg daily (plus ACE inhibitor) | Placebo (plus ACE inhibitor) | patients with severe congestive heart failure (NYHA III-IV) despite treatment with maximally recommended or tolerated doses of ACE inhibitors |
| |
Losartan | | vs enalapril | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | no data | Death from any cause or hospitalization for any reason | no data | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | no data | Cardiovascular death | no data | hospitalisation for heart failure | no data | Hospitalization for any reason | no data | | no data | Hyperkalaemia | no data | Cough | no data | Hypotension | no data | angiodema | no data | Adverse events | 1.12 [0.51 2.44] | p=1.00 | 0 | 232 | 2 | Lang et al., Lang et al., | All cause death | 1.18 [0.23 6.08] | p=1.00 | 0 | 282 | 2 | Dickstein et al., Lang et al., |
Trial | Studied treatment | Control | Patients |
---|
Dickstein et al., 1995 | Losartan, 25 mg, 50mg daily | Enalapril, 10 mg twice daily | patients with moderate or severe chronic heart failure in New York Heart Association functional class III or IV and an ejection fraction < or = 35% | Lang et al., 1997 | Losartan titrated to 25 mg ou 50 mg daily | Enalapril, titrated to 10 mg twice daily | patients with congestive heart failure (New York Heart Association functionalclasses II to IV) and left ventricular ejection fraction <= 45%previously treated with stable doses of ACE inhibitors and diureticagents, with or without concurrent digitalis and othervasodilators |
| |
Losartan | heart failure, in patients previously untreated with ACE inhibitors | vs captopril | Cough by 96% suggested Adverse events by 41% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Sudden death | 1.23 [0.95 1.59] | p=1.00 | 0 | 3152 | 1 | ELITE II, | Death from any cause or hospitalization for any reason | 1.03 [0.90 1.17] | p=1.00 | 0 | 3874 | 2 | ELITE, ELITE II, | Cardiovascular death or hospital admission for CHF | no data | death or cardiovascular hospitalization | no data | Cardiovascular death | 0.53 [0.26 1.07] | p=1.00 | 0 | 722 | 1 | ELITE, | hospitalisation for heart failure | 0.93 [0.78 1.10] | p=1.00 | 0 | 3874 | 2 | ELITE, ELITE II, | Hospitalization for any reason | 0.98 [0.86 1.12] | p=1.00 | 0 | 3874 | 2 | ELITE, ELITE II, | | 1.00 [0.62 1.60] | p=1.00 | 0 | 722 | 1 | ELITE, | Hyperkalaemia | 0.35 [0.07 1.75] | p=1.00 | 0 | 722 | 1 | ELITE, | Cough | 0.04 [0.00 0.61] | p=0.04 | 0 | 722 | 1 | ELITE, | Hypotension | 1.68 [0.54 5.19] | p=1.00 | 0 | 722 | 1 | ELITE, | angiodema | 0.15 [0.01 2.92] | p=1.00 | 0 | 722 | 1 | ELITE, | Adverse events | 0.59 [0.44 0.78] | p=0.04 | 0 | 1444 | 2 | ELITE, ELITE, | All cause death | 1.05 [0.88 1.26] | p=1.00 | 0 | 3874 | 2 | ELITE, ELITE II, |
Trial | Studied treatment | Control | Patients |
---|
ELITE, 1997 | Losartan titrated to 50 mg once daily | Captopril,titratedto 50 mg three times daily | ACE inhibitor naive patients (aged 65 years or more) with New York HeartAssociation (NYHA) class II–IV heart failure and ejection fractions of 40% or less | ELITE II, 2000 | Losartan, target dose 50 mg daily | Captopril, target dose 50 mg 3 times daily | patients aged 60 years or older with New York Heart Association class II–IV heart failure and ejection fraction of 40% or less. |
| |
Losartan | hypertension, in all diseases requiring ACEi (HF, CHD, HT,...) | vs placebo | Heart failure by 29% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | 1.16 [0.84 1.59] | p=1.00 | 0 | 1513 | 1 | RENAAL, | myocardial infarction (fatal and non fatal) | 0.75 [0.51 1.09] | p=1.00 | 0 | 1513 | 1 | RENAAL, | stroke (fatal and non fatal) | 0.97 [0.65 1.47] | p=1.00 | 0 | 1513 | 1 | RENAAL, | Coronary event | no data | cardiac death | no data | cancer related death | no data | Heart failure | 0.71 [0.53 0.95] | p=0.04 | 0 | 1513 | 1 | RENAAL, | All cause death | 1.03 [0.81 1.33] | p=1.00 | 0 | 1513 | 1 | RENAAL, | lung cancer | no data | breast cancer | no data | prostate cancer | no data | Cancer | no data | Diabetes onset | no data |
Trial | Studied treatment | Control | Patients |
---|
RENAAL, 2001 | lLosartan 50 to 100 mg once daily | placebo | patients with type 2 diabetes and nephropathy |
| |
Losartan | | vs Captopril | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | 1.13 [1.00 1.27] | p=1.00 | 0 | 9351 | 3 | ELITE, ELITE-II, OPTIMAAL, | myocardial infarction (fatal and non fatal) | 1.01 [0.88 1.17] | p=1.00 | 0 | 9351 | 3 | ELITE, ELITE-II, OPTIMAAL, | stroke (fatal and non fatal) | 1.11 [0.88 1.39] | p=1.00 | 0 | 9351 | 3 | ELITE, ELITE-II, OPTIMAAL, | All cause death | 1.09 [0.97 1.22] | p=1.00 | 0 | 9351 | 3 | ELITE, ELITE-II, OPTIMAAL, |
Trial | Studied treatment | Control | Patients |
---|
ELITE, 1997 | Losartan titrated to 50 mg once daily for 48 weeks | Captopril titrated to 50 mg three times daily for 48 weeks | naive patients (aged 65 years or more) with NYHA class II-IV heart failure and ejection fractions of 40% or less | ELITE-II, 2000 | Losartan titrated to 50 mg once daily | Captopril titrated to 50 mg three times daily | patients aged 60 years or older with New York Heart Association class II-IV heart failure and ejection fraction of 40% or less. Patients | OPTIMAAL, 2001 | losartan (titrated to 50 mg once daily) | Captopril (titrated to 50 mg three times daily) | patients 50 years of age or older, with confirmed acute myocardial infarction and heart failure during the acute phase or a new Q-wave anterior infarction or reinfarction |
| |
Losartan | | vs atenolol | lung cancer by 141% adverse event cardiovascular events by 14% suggested stroke (fatal and non fatal) by 25% suggested Diabetes onset by 25% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | 0.86 [0.76 0.98] | p=0.04 | 0 | 9193 | 1 | LIFE, | Cardiovascular death | 0.87 [0.72 1.05] | p=1.00 | 0 | 9193 | 1 | LIFE, | myocardial infarction (fatal and non fatal) | 1.05 [0.86 1.29] | p=1.00 | 0 | 9193 | 1 | LIFE, | stroke (fatal and non fatal) | 0.75 [0.63 0.89] | p=0.04 | 0 | 9193 | 1 | LIFE, | Coronary event | 1.05 [0.86 1.29] | p=1.00 | 0 | 9193 | 1 | LIFE, | cardiac death | no data | cancer related death | 1.03 [0.79 1.34] | p=1.00 | 0 | 9193 | 1 | LIFE, | Heart failure | 0.95 [0.76 1.19] | p=1.00 | 0 | 9193 | 1 | LIFE, | All cause death | 0.89 [0.77 1.02] | p=1.00 | 0 | 9193 | 1 | LIFE, | lung cancer | 2.41 [1.23 4.72] | p=0.04 | 0 | 9193 | 1 | LIFE, | breast cancer | no data | prostate cancer | no data | Cancer | 1.11 [0.95 1.30] | p=1.00 | 0 | 9193 | 1 | LIFE, | Diabetes onset | 0.75 [0.63 0.89] | p=0.04 | 0 | 9193 | 1 | LIFE, |
Trial | Studied treatment | Control | Patients |
---|
LIFE, 2002 | losartan | atenolol | patients aged 55–80 years, with previously treated or untreated hypertension (sitting blood pressure 160–200/95–115 mm Hg) and ECG signs of LVH. |
| |
Losartan | miscellaneous, in all type of patients | vs placebo | Heart failure by 29% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | 1.16 [0.84 1.59] | p=1.00 | 0 | 1513 | 1 | RENAAL, | myocardial infarction (fatal and non fatal) | 0.75 [0.51 1.09] | p=1.00 | 0 | 1513 | 1 | RENAAL, | stroke (fatal and non fatal) | 0.97 [0.65 1.47] | p=1.00 | 0 | 1513 | 1 | RENAAL, | Coronary event | no data | cardiac death | no data | cancer related death | no data | Heart failure | 0.71 [0.53 0.95] | p=0.04 | 0 | 1513 | 1 | RENAAL, | All cause death | 1.03 [0.81 1.33] | p=1.00 | 0 | 1513 | 1 | RENAAL, | lung cancer | no data | breast cancer | no data | prostate cancer | no data | Cancer | no data | Diabetes onset | no data |
Trial | Studied treatment | Control | Patients |
---|
RENAAL, 2001 | lLosartan 50 to 100 mg once daily | placebo | patients with type 2 diabetes and nephropathy |
| |
Losartan | | vs atenolol | lung cancer by 141% adverse event cardiovascular events by 14% suggested stroke (fatal and non fatal) by 25% suggested Diabetes onset by 25% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | 0.86 [0.76 0.98] | p=0.04 | 0 | 9193 | 1 | LIFE, | Cardiovascular death | 0.87 [0.72 1.05] | p=1.00 | 0 | 9193 | 1 | LIFE, | myocardial infarction (fatal and non fatal) | 1.05 [0.86 1.29] | p=1.00 | 0 | 9193 | 1 | LIFE, | stroke (fatal and non fatal) | 0.75 [0.63 0.89] | p=0.04 | 0 | 9193 | 1 | LIFE, | Coronary event | 1.05 [0.86 1.29] | p=1.00 | 0 | 9193 | 1 | LIFE, | cardiac death | no data | cancer related death | 1.03 [0.79 1.34] | p=1.00 | 0 | 9193 | 1 | LIFE, | Heart failure | 0.95 [0.76 1.19] | p=1.00 | 0 | 9193 | 1 | LIFE, | All cause death | 0.89 [0.77 1.02] | p=1.00 | 0 | 9193 | 1 | LIFE, | lung cancer | 2.41 [1.23 4.72] | p=0.04 | 0 | 9193 | 1 | LIFE, | breast cancer | no data | prostate cancer | no data | Cancer | 1.11 [0.95 1.30] | p=1.00 | 0 | 9193 | 1 | LIFE, | Diabetes onset | 0.75 [0.63 0.89] | p=0.04 | 0 | 9193 | 1 | LIFE, |
Trial | Studied treatment | Control | Patients |
---|
LIFE, 2002 | losartan | atenolol | patients aged 55–80 years, with previously treated or untreated hypertension (sitting blood pressure 160–200/95–115 mm Hg) and ECG signs of LVH. |
| |
Losartan | | vs placebo | Heart failure by 29% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | 1.16 [0.84 1.59] | p=1.00 | 0 | 1513 | 1 | RENAAL, | myocardial infarction (fatal and non fatal) | 0.75 [0.51 1.09] | p=1.00 | 0 | 1513 | 1 | RENAAL, | stroke (fatal and non fatal) | 0.97 [0.65 1.47] | p=1.00 | 0 | 1513 | 1 | RENAAL, | Coronary event | no data | cardiac death | no data | cancer related death | no data | Heart failure | 0.71 [0.53 0.95] | p=0.04 | 0 | 1513 | 1 | RENAAL, | All cause death | 1.03 [0.81 1.33] | p=1.00 | 0 | 1513 | 1 | RENAAL, | lung cancer | no data | breast cancer | no data | prostate cancer | no data | Cancer | no data | Diabetes onset | no data |
Trial | Studied treatment | Control | Patients |
---|
RENAAL, 2001 | lLosartan 50 to 100 mg once daily | placebo | patients with type 2 diabetes and nephropathy |
| |
Losartan | | vs atenolol | lung cancer by 141% adverse event cardiovascular events by 14% suggested stroke (fatal and non fatal) by 25% suggested Diabetes onset by 25% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | 0.86 [0.76 0.98] | p=0.04 | 0 | 9193 | 1 | LIFE, | Cardiovascular death | 0.87 [0.72 1.05] | p=1.00 | 0 | 9193 | 1 | LIFE, | myocardial infarction (fatal and non fatal) | 1.05 [0.86 1.29] | p=1.00 | 0 | 9193 | 1 | LIFE, | stroke (fatal and non fatal) | 0.75 [0.63 0.89] | p=0.04 | 0 | 9193 | 1 | LIFE, | Coronary event | 1.05 [0.86 1.29] | p=1.00 | 0 | 9193 | 1 | LIFE, | cardiac death | no data | cancer related death | 1.03 [0.79 1.34] | p=1.00 | 0 | 9193 | 1 | LIFE, | Heart failure | 0.95 [0.76 1.19] | p=1.00 | 0 | 9193 | 1 | LIFE, | All cause death | 0.89 [0.77 1.02] | p=1.00 | 0 | 9193 | 1 | LIFE, | lung cancer | 2.41 [1.23 4.72] | p=0.04 | 0 | 9193 | 1 | LIFE, | breast cancer | no data | prostate cancer | no data | Cancer | 1.11 [0.95 1.30] | p=1.00 | 0 | 9193 | 1 | LIFE, | Diabetes onset | 0.75 [0.63 0.89] | p=0.04 | 0 | 9193 | 1 | LIFE, |
Trial | Studied treatment | Control | Patients |
---|
LIFE, 2002 | losartan | atenolol | patients aged 55–80 years, with previously treated or untreated hypertension (sitting blood pressure 160–200/95–115 mm Hg) and ECG signs of LVH. |
| |
Captopril | hypertension, in all diseases requiring ACEi (HF, CHD, HT,...) | vs Captopril | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | 1.00 [0.90 1.11] | p=1.00 | 0 | 9794 | 1 | VALIANT/Val+Cap, | myocardial infarction (fatal and non fatal) | 0.95 [0.85 1.06] | p=1.00 | 0 | 9794 | 1 | VALIANT/Val+Cap, | stroke (fatal and non fatal) | 0.87 [0.71 1.07] | p=1.00 | 0 | 9794 | 1 | VALIANT/Val+Cap, | All cause death | 0.99 [0.89 1.09] | p=1.00 | 0 | 9794 | 1 | VALIANT/Val+Cap, |
Trial | Studied treatment | Control | Patients |
---|
VALIANT/Val+Cap, 2003 | Valsartan + captopril | Captopril | patients with myocardial infarction complicated by left ventricular systolic dysfunction, heart failure, or both |
| |
Ramipril | hypertension, in all diseases requiring ACEi (HF, CHD, HT,...) | vs Ramipril | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | 1.04 [0.92 1.17] | p=1.00 | 0 | 17078 | 1 | ONTARGET/Tel+Ram, | myocardial infarction (fatal and non fatal) | 1.07 [0.93 1.23] | p=1.00 | 0 | 17078 | 1 | ONTARGET/Tel+Ram, | stroke (fatal and non fatal) | 0.93 [0.80 1.07] | p=1.00 | 0 | 17078 | 1 | ONTARGET/Tel+Ram, | All cause death | 1.06 [0.97 1.16] | p=1.00 | 0 | 17078 | 1 | ONTARGET/Tel+Ram, |
Trial | Studied treatment | Control | Patients |
---|
ONTARGET/Tel+Ram, 2008 | Telmisartan + ramipril | Ramipril | patients with vascular disease or high-risk diabetes |
| |
Ramipril | miscellaneous, in all type of patients | vs ramipril | Hypotension by 175% adverse event Adverse events leading to treatment discontinuation by 20% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | 1.00 [0.92 1.09] | p=1.00 | 0 | 17077 | 1 | ONTARGET (association vs ramipril), | Cardiovascular death | 1.04 [0.92 1.17] | p=1.00 | 0 | 17077 | 1 | ONTARGET (association vs ramipril), | stroke (fatal and non fatal) | 0.93 [0.80 1.07] | p=1.00 | 0 | 17077 | 1 | ONTARGET (association vs ramipril), | Coronary event | 1.07 [0.93 1.23] | p=1.00 | 0 | 17077 | 1 | ONTARGET (association vs ramipril), | Coronary death | no data | cardiovascular death, MI, stroke | no data | Non fatal MI | no data | Revascularization | 1.04 [0.95 1.13] | p=1.00 | 0 | 17077 | 1 | ONTARGET (association vs ramipril), | All cause death | 1.06 [0.97 1.16] | p=1.00 | 0 | 17077 | 1 | ONTARGET (association vs ramipril), | Cough | 1.10 [0.95 1.27] | p=1.00 | 0 | 17077 | 1 | ONTARGET (association vs ramipril), | Hypotension | 2.75 [2.27 3.32] | p=0.04 | 0 | 17077 | 1 | ONTARGET (association vs ramipril), | angiodema | 0.73 [0.40 1.33] | p=1.00 | 0 | 17077 | 1 | ONTARGET (association vs ramipril), | Adverse events leading to treatment discontinuation | 1.20 [1.12 1.28] | p=0.04 | 0 | 17077 | 1 | ONTARGET (association vs ramipril), |
Trial | Studied treatment | Control | Patients |
---|
ONTARGET (association vs ramipril), 2008 | telmisartan 80mg + ramipril 10mg daily | ramipril 10 mg daily
| patients patients with coronary, peripheral, or cerebrovascular disease or diabetes with end-organ damage
|
| |
Ramipril | | vs telmisartan | Cough by 323% adverse event Hypotension by 78% adverse event Adverse events leading to treatment discontinuation by 28% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | 1.01 [0.93 1.10] | p=1.00 | 0 | 17044 | 1 | ONTARGET (association vs telmisartan), | Cardiovascular death | 1.04 [0.93 1.17] | p=1.00 | 0 | 17044 | 1 | ONTARGET (association vs telmisartan), | stroke (fatal and non fatal) | 1.02 [0.88 1.18] | p=1.00 | 0 | 17044 | 1 | ONTARGET (association vs telmisartan), | Coronary event | 1.00 [0.87 1.15] | p=1.00 | 0 | 17044 | 1 | ONTARGET (association vs telmisartan), | Coronary death | no data | cardiovascular death, MI, stroke | no data | Non fatal MI | no data | Revascularization | 1.01 [0.93 1.10] | p=1.00 | 0 | 17044 | 1 | ONTARGET (association vs telmisartan), | All cause death | 1.08 [0.99 1.19] | p=1.00 | 0 | 17044 | 1 | ONTARGET (association vs telmisartan), | Cough | 4.23 [3.37 5.32] | p=0.04 | 0 | 17044 | 1 | ONTARGET (association vs telmisartan), | Hypotension | 1.78 [1.51 2.10] | p=0.04 | 0 | 17044 | 1 | ONTARGET (association vs telmisartan), | angiodema | 1.81 [0.83 3.92] | p=1.00 | 0 | 17044 | 1 | ONTARGET (association vs telmisartan), | Adverse events leading to treatment discontinuation | 1.28 [1.19 1.37] | p=0.04 | 0 | 17044 | 1 | ONTARGET (association vs telmisartan), |
Trial | Studied treatment | Control | Patients |
---|
ONTARGET (association vs telmisartan), 2008 | telmisartan 80mg + ramipril 10mg daily
| telmisartan 80 mg daily | patients patients with coronary, peripheral, or cerebrovascular disease or diabetes with end-organ damage
|
| |
Ramipril | | vs ramipril | Hypotension by 175% adverse event Adverse events leading to treatment discontinuation by 20% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | 1.00 [0.92 1.09] | p=1.00 | 0 | 17077 | 1 | ONTARGET (association vs ramipril), | Cardiovascular death | 1.04 [0.92 1.17] | p=1.00 | 0 | 17077 | 1 | ONTARGET (association vs ramipril), | stroke (fatal and non fatal) | 0.93 [0.80 1.07] | p=1.00 | 0 | 17077 | 1 | ONTARGET (association vs ramipril), | Coronary event | 1.07 [0.93 1.23] | p=1.00 | 0 | 17077 | 1 | ONTARGET (association vs ramipril), | Coronary death | no data | cardiovascular death, MI, stroke | no data | Non fatal MI | no data | Revascularization | 1.04 [0.95 1.13] | p=1.00 | 0 | 17077 | 1 | ONTARGET (association vs ramipril), | All cause death | 1.06 [0.97 1.16] | p=1.00 | 0 | 17077 | 1 | ONTARGET (association vs ramipril), | Cough | 1.10 [0.95 1.27] | p=1.00 | 0 | 17077 | 1 | ONTARGET (association vs ramipril), | Hypotension | 2.75 [2.27 3.32] | p=0.04 | 0 | 17077 | 1 | ONTARGET (association vs ramipril), | angiodema | 0.73 [0.40 1.33] | p=1.00 | 0 | 17077 | 1 | ONTARGET (association vs ramipril), | Adverse events leading to treatment discontinuation | 1.20 [1.12 1.28] | p=0.04 | 0 | 17077 | 1 | ONTARGET (association vs ramipril), |
Trial | Studied treatment | Control | Patients |
---|
ONTARGET (association vs ramipril), 2008 | telmisartan 80mg + ramipril 10mg daily | ramipril 10 mg daily
| patients patients with coronary, peripheral, or cerebrovascular disease or diabetes with end-organ damage
|
| |
Ramipril | | vs telmisartan | Cough by 323% adverse event Hypotension by 78% adverse event Adverse events leading to treatment discontinuation by 28% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | 1.01 [0.93 1.10] | p=1.00 | 0 | 17044 | 1 | ONTARGET (association vs telmisartan), | Cardiovascular death | 1.04 [0.93 1.17] | p=1.00 | 0 | 17044 | 1 | ONTARGET (association vs telmisartan), | stroke (fatal and non fatal) | 1.02 [0.88 1.18] | p=1.00 | 0 | 17044 | 1 | ONTARGET (association vs telmisartan), | Coronary event | 1.00 [0.87 1.15] | p=1.00 | 0 | 17044 | 1 | ONTARGET (association vs telmisartan), | Coronary death | no data | cardiovascular death, MI, stroke | no data | Non fatal MI | no data | Revascularization | 1.01 [0.93 1.10] | p=1.00 | 0 | 17044 | 1 | ONTARGET (association vs telmisartan), | All cause death | 1.08 [0.99 1.19] | p=1.00 | 0 | 17044 | 1 | ONTARGET (association vs telmisartan), | Cough | 4.23 [3.37 5.32] | p=0.04 | 0 | 17044 | 1 | ONTARGET (association vs telmisartan), | Hypotension | 1.78 [1.51 2.10] | p=0.04 | 0 | 17044 | 1 | ONTARGET (association vs telmisartan), | angiodema | 1.81 [0.83 3.92] | p=1.00 | 0 | 17044 | 1 | ONTARGET (association vs telmisartan), | Adverse events leading to treatment discontinuation | 1.28 [1.19 1.37] | p=0.04 | 0 | 17044 | 1 | ONTARGET (association vs telmisartan), |
Trial | Studied treatment | Control | Patients |
---|
ONTARGET (association vs telmisartan), 2008 | telmisartan 80mg + ramipril 10mg daily
| telmisartan 80 mg daily | patients patients with coronary, peripheral, or cerebrovascular disease or diabetes with end-organ damage
|
| |