new version V2017

Ivabradine HR-slowing agents
Description Results

S-16257 - S 16257 - S 16260-2 - S-16260-2 - S-16257-2 - S 16257-2 - Procorolan - Corlanor - ivabradine      

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TrialStudied treatmentControl treatmentpatientsROBResultNCT

heart failure

BEAUTIFUL, 2008ivabradine 15mgplacebo Low risk of bias NegativeNCT00143507
SHIFT, 2010ivabradineplacebo Low risk of bias SuggestingISRCTN70429960

stable angina

BEAUTIFUL (angina subgroup)ivabradine 15mgplacebo (on top standard treatment) Exploratory Suggesting
CL3-023 (15mg)ivabradineamlodipine Low risk of bias -
CL3-023 (20mg)ivabradineamlodipine Low risk of bias -
Borer (CL2-009) 5mg, 2003ivabradine 5mgplacebo -
Borer (CL2-009) 10mg, 2003ivabradine 10mgplacebo -
Borer (CL2-009) 20mg, 2003ivabradine 20mgplacebo -
INITIATIVE (CL3-017, Tardif) 20mg, 2005ivabradine 20mgatenolol Low risk of bias -
INITIATIVE (CL3-017, Tardif) 15mg, 2005ivabradine 15mgatenolol -
Ruzyllo (CL3-023) 15mg, 2007ivabradine 15mgamlodipine Low risk of bias -
Ruzyllo (CL3-023) 20mg, 2007ivabradine 20mgamlodipine Low risk of bias -
BEAUTIFUL, 2008ivabradine 15mgplacebo Low risk of bias NegativeNCT00143507
ASSOCIATE (Tardif), 2009ivabradine 15mgplacebo on top of atenolol Low risk of bias - NCT00202566
SIGNIFY, 2014ivabradine 20mgplaceboNegativeISRCTN61576291
CL3-018 15mgivabradine 15mgplacebo on top of amlodipine -
CL3-018 10mgivabradine 10mgplacebo on top of amlodipine -



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