Clinical trials of metformin - TrialResults-center.org

Trial	Studied treatment	Control treatment	ROB	Result	NCT
diabetes type 2
UKPDS (vs SU or INS)	metformin	SU/Insulin		Suggesting
Jarret, 1979	lifestyle modification + metformin	control	Exploratory	Negative
Sirtori, 1984	metformin	placebo		-
Teupe, 1991	metformin	placebo		Negative
Giugliano, 1993	metformin	placebo		-
Campbell, 1994	metformin	Glipizide		Negative
Crave, 1995	metformin	placebo		-
Charles, 1998	metformin	placebo		Negative
Morel, 1999	metformin	placebo		-
Li, 1999	metformin	placebo	Exploratory	Negative
Moghetti, 2000	metformin	placebo		-
Charles, 2000	metformin	placebo		-
Pasquali, 2000	metformin	placebo		-
Lehtovirta, 2001	metformin	placebo		Negative
Freemark, 2001	metformin	placebo		-
Kay, 2001	metformin	placebo		-
Ng, 2001	metformin	placebo		-
Kocak, 2002	metformin	placebo		-
US-DPP (metformin) (Knowler), 2002	metformin	placebo	Low risk of bias	Negative
Fleming, 2002	metformin	placebo		-
Kelly, 2002	metformin	placebo		-
Sturrock, 2002	metformin	placebo		-
EDIT (Holman), 2003	metformin	placebo		-
Choux, 2003	metformin	placebo		-
Baillargeon, 2004	metformin	placebo		-
Gambineri, 2004	metformin	placebo		-
Rodriguez, 2004	metformin	placebo		-
Rodriguez-Moctezuma, 2004	metformin	placebo		Negative
Hoeger, 2004	metformin	placebo		-
James, 2005	metformin	control		-
Orchard, 2005	metformin	placebo		Suggesting
Stakos, 2005	metformin	placebo		-
Vitale, 2005	metformin	placebo		-
IDDP (Ramachandran), 2006	lifestyle modification + metformin	control	Risk of bias	Negative
Bridger, 2006	metformin	placebo		-
Srinivasan, 2006	metformin	placebo		-
Tang, 2006	metformin	placebo		-
Kooy (HOME), 2009	metformin	placebo	Low risk of bias	Suggesting
CANOE, 2010	rosiglitazone and metformin	placebo	Low risk of bias	Suggesting	NCT00116932
impaired fasting glucose
US-DPP (metformin) (Knowler), 2002	metformin	placebo	Low risk of bias	Negative
CANOE, 2010	rosiglitazone and metformin	placebo	Low risk of bias	Suggesting	NCT00116932

Metformin antidiabetic drugs Description Results

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diabetes type 2

impaired fasting glucose

Metformin antidiabetic drugs
Description Results