new version V2017

new drug under development
Description Results

     

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TrialStudied treatmentControl treatmentpatientsROBResultNCT

acute heart failure

levosimendan
CASINOlevosimendandobutamine Low risk of bias -
LIDO, 2002levosimendandobutamine Exploratory -
RUSSLAN, 2002levosimendanplacebo Exploratory -
REVIVE-I, 2003levosimendanplacebo Exploratory -
SURVIVE, 2007levosimendandobutamine Low risk of bias NegativeNCT00348504
REVIVE II, 2013levosimendanplacebo Exploratory - NCT00048425
nesiritide
NSGET (comparative trial), 2000nesiritidecontrol Low risk of bias -
NSGET (efficacy trial), 2000nesiritideplacebo Low risk of bias Negative
PRECEDENT, 2002nesiritidedobutamine Exploratory - NCT00270400
VMAC (24h), 2002nesiritidenitroglycerin Risk of bias NegativeNCT00083772
VMAC (intravenous neseritide), 2002nesiritideplacebo Low risk of bias - NCT00083772
PROACTION, 2003nesiritideplacebo Low risk of bias Negative
FUSION 1, 2004nesiritidestandard care Low risk of bias - NCT00270361
BNP-CARDS, 2007nesiritideplacebo Exploratory - NCT00186329
FUSION 2, 2008nesiritideplacebo Low risk of bias - NCT00091520
ASCEND-HF, 2011nesiritideplacebo Low risk of bias Negative NCT00475852
rolofylline
PROTECT, 2010rolofyllineplacebo Low risk of bias NegativeNCT00328692
REACH UP ongoing rolofyllineplacebo - NCT00443690
PROTECT-2 ongoing rolofyllineplacebo - NCT00354458
PROTECT-1 ongoing rolofyllineplacebo - NCT00328692
7418-503 ongoing rolofyllineplacebo - NCT00729222
2007_806 ongoing rolofyllineplacebo - NCT00652782
serelaxin
Pre-RELAX-AHF, 2009serelaxinplacebo Exploratory - NCT00520806
RELAX-AHF, 2013serelaxinplacebo - NCT00520806
RELAX-AHF-2 ongoing serelaxinplacebo - NCT01870778
tonapofylline
TRIDENT-1 ongoing tonapofyllineplacebo - NCT00709865
POSEIDON ongoing tonapofyllineplacebo - NCT00745316



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