new version V2017

anti hypertensive agents
Description Results

     

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TrialStudied treatmentControl treatmentpatientsROBResultNCT

diabetes type 2

amlodipine
FACET, 1997amlodipinefosinopril Risk of bias Suggesting
IDNT (amlodipine vs PBO), 2001amlodipineplacebo Low risk of bias Negative
ALLHAT (amlodipine vs chlor, diabetic subgroup), 2002amlodipinechlorthalidone Exploratory Negative
candesartan
SCOPE (diabetic subgroup), 2003candesartancontrol Exploratory Negative
captopril
UKPDS 39, 1998captoprilatenolol Exploratory Negative
UKPDS 38, 1998captopril or atenololcontrol Exploratory Suggesting
CAPP (diabetic subgroup), 1999captoprildiuretic and/or beta-blockers Exploratory Suggesting
chlorthalidone
SHEP (diabetic subgroup), 1996chlorthalidoneplacebo Exploratory Suggesting
intensive blood pressure lowering strategies
ABCD target (H) , 2000more intensive blood pressure lowering strategieless intensive blood pressure lowering strategieSuggesting
ABCD target (N) , 2002more intensive blood pressure lowering strategieless intensive blood pressure lowering strategieSuggesting
irbesartan
IDNT (irbesartan vs amlodipine), 2001irbesartanamlodipine Low risk of bias Suggesting
IPDM (150mg), 2001irbesartanplacebo Exploratory Suggesting
IDNT (irbesartan vs pbo), 2001irbesartanplacebo Low risk of bias Suggesting
lisinopril
ALLHAT (lisi vs chlor, diabetic subgroup), 2002lisinoprilchlorthalidone Exploratory Negative
losartan
RENAAL, 2001losartanplacebo Low risk of bias Suggesting
LIFE (diabetic subgroup), 2002losartanatenolol Exploratory Suggesting
metoprolol
MERIT-HF, 2005metoprololplaceboNegative
nidrendipine
Syst-Eur (diabetic subgroup), 1999nitrendipineplacebo Exploratory Suggesting
nifedipine
INSIGHT (diabetic subgroup), 2000nifedipinecoamilozide Exploratory Negative
nisoldipine
ABCD (hypertension), 1998nisoldipineenalapril Exploratory Suggesting
olmesartan
ORIENTolmesartanplaceboNegativeNCT00141453
ROADMAP, 2010olmesartanplacebo Low risk of bias Suggesting NCT00185159
ramipril
DIABHYCAR, 2004ramiprilplacebo Low risk of bias Negative
DREAM, 2008ramiprilplaceboNegative

hypertension

aliskiren
AVOID, 2008aliskirenplacebo Exploratory NegativeNCT00097955
Andersen, 2008aliskirenramipril Exploratory -
Schmieder (vs HCTZ), 2009aliskirenhydrochlorothiazide Exploratory Negative
ALLAY, 2009aliskirenlosartan Exploratory NegativeNCT00219141
ACCELERATE, 2011aliskiren amlodipine - NCT00797862
amlodipine
FACET, 1997amlodipinefosinopril Risk of bias Suggesting
IDNT (amlodipine vs PBO), 2001amlodipineplacebo Low risk of bias Negative
IDNT (amlodipine vs pbo), 2001amlodipineplaceboNegative
ALLHAT (amlodipine vs chlor, diabetic subgroup), 2002amlodipinechlorthalidone Exploratory Negative
ALLHAT (CCB vs diu), 2002amlodipinechlorthalidoneNegative
ALLHAT (CCB vs ACEI), 2002amlodipinelisinoprilSuggesting
AASK (amlodipine vs metoprolol), 2002amlodipinemetoprololNegative
ASCOT-BPLA, 2005amlodipineatenolol Risk of bias Suggesting
ACCOMPLISH, 2008amlodipine plus benazeprilhydrochlorothiazide plus benazepril Low risk of bias SuggestingNCT00170950
Tepel et al, 2008amlodipineplaceboNegativeNCT00124969
atenolol
MRC I (vs diuretics), 1985atenololbendroflumethiazide Risk of bias Negative
MRC I (vs placebo), 1985atenololplaceboSuggesting
Coope, 1986atenololcontrol Suggesting
Coope (subgroup ), 1986atenololcontrolNegative
MRC old (vs diuretics), 1992atenololhydrochlorothiazide+amilorideNegative
MRC old (vs placebo), 1992atenololplaceboNegative
Dutch TIA, 1993atenololplaceboSuggesting
TEST, 1995atenololplaceboNegative
candesartan
HSCS, 1974deserpidine +methylclothiazideplaceboNegative
ALPINE, 2003candesartanhydrochlorothiazide Low risk of bias Suggesting
SCOPE, 2003candesartanplacebo Low risk of bias Negative
E-COST, 2005candesartanconventional treatment Risk of bias Suggesting
E-COST-R, 2005candesartanconventional treatment Risk of bias Negative
Takahashi, 2006candesartancontrol Exploratory Negative
TROPHY, 2006candesartanplacebo Exploratory SuggestingNCT00227318
Takahashi et al, 2006candesartanusual careSuggesting
CASE-J, 2008candesartanamlodipine Risk of bias Suggesting
Suzuki et al, 2008candesartanusual careSuggesting
HIJ-CREATE, 2009candesartanconventional treatment Risk of bias Suggesting
captopril
UKPDS 39, 1998captoprilatenolol Exploratory Negative
UKPDS 38, 1998captopril or atenololcontrol Exploratory Suggesting
UKPDS-HDS, 1998captoprildiuretic or beta-blockerNegative
CAPP (diabetic subgroup), 1999captoprildiuretic and/or beta-blockers Exploratory Suggesting
CAPPP, 1999captoprildiuretic or beta-blocker Risk of bias Negative
carvedilol
Cice et al, 2003carvedilolplaceboSuggesting
Nakao et al, 2007carvedilolplacebo -
chlorthalidone
VA-NHLBI, 1977chlorthalidoneplaceboNegative
SHEP-pilot, 1989chlorthalidoneplaceboNegative
SHEP-P (subgroup ), 1989chlorthalidoneplaceboSuggesting
SHEP, 1991chlorthalidoneplaceboSuggesting NCT00000514
SHEP (subgroup ), 1991chlorthalidoneplaceboSuggesting
SHEP (diabetic subgroup), 1996chlorthalidoneplacebo Exploratory Suggesting
diltiazem
NORDIL, 2000diltiazemdiuretic or beta-blockerSuggesting
enalapril
ABCD (H), 1998enalaprilnisoldipineSuggesting
ANBP2, 2003enalaprildiuretics Risk of bias Negative
fosinopril
Zannad et al, 2006fosinoprilplaceboNegative
hydrochlorothiazide
Kuramoto, 1981hydrochlorothiazide + triamtereneplaceboNegative
EWPHE, 1985hydrochlorothiazide + triamtereneplaceboSuggesting
EWPHE (subgroup ), 1985hydrochlorothiazideplaceboNegative
indapamide
HAPPY, 1987Negative
PATS, 1995indapamideplaceboNegative
HYVET pilot, 2003 -
HYVET, 2008indapamideplaceboSuggesting NCT00122811
intensive blood pressure lowering strategies
ABCD target (H) , 2000more intensive blood pressure lowering strategieless intensive blood pressure lowering strategieSuggesting
ABCD target (N) , 2002more intensive blood pressure lowering strategieless intensive blood pressure lowering strategieSuggesting
irbesartan
IDNT (irbesartan vs amlodipine), 2001irbesartanamlodipine Low risk of bias Suggesting
IPDM (150mg), 2001irbesartanplacebo Exploratory Suggesting
IDNT (irbesartan vs pbo), 2001irbesartanplacebo Low risk of bias Suggesting
IRMA 2, 2001irbesartanplacebo Low risk of bias Negative
IDNT (irbesartan vs pbo), 2001irbesartanplacebo Low risk of bias Negative
isradipine
MIDAS, 1996isradipinehydrochlorothiazideNegative
lacidipine
ELSA, 2002lacidipineatenolol -
SHELL, 2003lacidipinechlorthalidone -
lisinopril
ALLHAT (ACEI vs amlodipine), 2002lisinoprilamlodipineSuggesting
ALLHAT (lisi vs chlor, diabetic subgroup), 2002lisinoprilchlorthalidone Exploratory Negative
ALLHAT (ACEI vs chlorthalidone), 2002lisinoprildiuretics Low risk of bias Negative
losartan
RENAAL, 2001losartanplacebo Low risk of bias Suggesting
RENAAL, 2001losartanplacebo Low risk of bias -
LIFE (diabetic subgroup), 2002losartanatenolol Exploratory Suggesting
LIFE, 2002losartanatenolol Low risk of bias Suggesting
nicardipine
NICS-EH, 1999nicardipinetrichlormethiazideNegative
nidrendipine
SYST-EUR, 1997nitrendipineplaceboSuggesting
Syst-Eur (subgroup ), 1997nidrendipineplaceboNegative
Syst-Eur (diabetic subgroup), 1999nitrendipineplacebo Exploratory Suggesting
nifedipine
Castel, 1994nifedipineatenolol+chlorthalidoneNegative
INSIGHT (diabetic subgroup), 2000nifedipinecoamilozide Exploratory Negative
INSIGHT, 2000nifedipinehydrochlorothiazide+amilorideSuggesting
nisoldipine
ABCD (hypertension), 1998nisoldipineenalapril Exploratory Suggesting
oxprenolol
IPPPSH, 1985oxprenololplaceboNegative
propranolol
Berglund, 1986propranololbendroflumethiazideNegative
ramipril
AASK (ramipril vs amlodipine), 2002ramiprilamlodipineNegative
AASK (ramipril vs metoprolol), 2002ramiprilmetoprololNegative
Li et al, 2003ramiprilusual careNegative
telmisartan
Cice et al, 2006telmisartanplaceboSuggesting
PROPHESS, 2008telmisartanplacebo Low risk of bias NegativeNCT00153062
thiazid diuretic
Carter, 1970thiazide diureticscontrolSuggesting
ANBPS (Australian ), 1980thiazide diureticscontrolNegative
Oslo (Hegeland), 1980thiazide diureticscontrolNegative
MCR 35-64 (diuretics vs pbo), 1985thiazide diureticsplaceboSuggesting
various ACEI
STOP-2 (ACEI vs felodipine or isradipine), 1999various ACEIcalcium-channel blockerSuggesting
STOP 2 (ACEI vs diurectic or beta-blocker), 1999various ACEIdiuretic or beta-blockerSuggesting
JMIC-B, 2002various ACEInifedipine -
various beta blockers
HAPPHY, 1988various beta-blockersdiureticsNegative
STOP, 1991various beta-blockersplaceboSuggesting
Yurenev, 1992various beta-blockersdiureticsNegative
various diuretics
VA-I, 1967High-dose diureticsplaceboSuggesting
VA II, 1970High-dose diureticsplaceboSuggesting
Barraclough, 1973High-dose diureticsplaceboNegative
HDFP, 1979High-dose diureticscontrolSuggestingNCT00000485
MRC (diu vs BB), 1985High-dose diureticsbeta-blockers -
verapamil
VHAS, 1998verapamilchlorthalidoneNegative
INVEST (Pepine), 2003verapamilatenololNegativeNCT00133692
CONVINCE, 2003verapamildiuretic or beta-blockerNegative

post stroke

telmisartan
PROFESS, 2008telmisartanplacebo -



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