Sorafenib angiogenesis inhibitors

Nexavar - BAY 43-9006 - sorafenib tosylate - BAY-545-9085 - BAY 545-9085 - 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate - sorafenib N-oxide - sorafenib



Trial Studied treatment Control Patients Size Study type Results NCT

Advanced breast cancer (metastatic) - multi target TKI in all type of patients - angiogenesis inhibitors in all type of patients

RESILIENCE, 2013 ongoing sorafenib + capecitabinecapecitabine aloneNA
Baselga, 2012sorafenib + capecitabinecapecitabine aloneNA Exploratory
Schwartzberg, 2013sorafenib + gemcitabine or capecitabinegemcitabine or capecitabine aloneNA Exploratory NCT00493636
Gradishar, 2013sorafenib + paclitaxelpaclitaxel aloneNA Exploratory

Lung cancer (metastatic) - angiogenesis inhibitors in all type of patients

Wakelee, 2012sorafenib NA
Paz-Ares, 2012sorafenib -9002
Scagliotti, 2010sorafenibplacebo 926 (464/462)
Spigel, 2011sorafenib and erlotinib erlotinib NA

Renal-cell carcinoma (advanced) - multi target TKI in all type of patients

Escudier, 2009sorafenibinterferon alpha189 (97/92) Exploratory
TARGET, 2007sorafenibplacebo903 (451/452) Confirmatory NCT00073307
Ratain, 2006sorafenibplaceboNA Exploratory