Atorvastatin cholesterol lowering intervention

Lipitor



Trial Studied treatment Control Patients Size Study type Results NCT

Acute coronary syndrome - cholesterol lowering intervention in early initiation

MIRACL, 2001atorvastatinplaceboacute coronary syndrome3086 (1538/1548) Confirmatory
PROVE IT - TIMI 22, 2004atorvastatinpravastatinacute coronary syndrome4162 (2099/2063)
Colivicchi, 2002atorvastatinusual careacute coronary syndrome81 (40/41) Exploratory
ESTABLISH, 2004atorvastatinusual careacute coronary syndrome70 (35/35) Exploratory

Acute myocardial infarction - cholesterol lowering intervention in all type of patients

PROVE-IT, 2004atorvastatin high dosepravastatindiabetic4162 (2099/2063) Confirmatory

Aortic stenosis - cholesterol lowering intervention in all type of patients

SALTIRE, 2005atorvastatinplaceboaortic stenosis155 (77/78) Exploratory

Atrial fibrillation - prevention in patient with history of atrial fibrillation - prevention in patients without history of AF (primary prevention)

Ozaydin, 2006atorvastatincontrol48 (24/24) Exploratory
STOP-AF ongoing atorvastatinplaceboNA NCT00252967
MIRACL (AF ancillary study), 2001atorvastatinplacebo2861 (1421/1440) Exploratory
Chello, 2006atorvastatinplacebo40 (20/20) Exploratory
ARMYDA-3 (AF ancillary study), 2006atorvastatinplacebo200 (101/99)
Almroth, 2009atorvastatin placebo234 (118/116) Confirmatory -
MIRACL (sub-group) (Schwartz), 2004atorvastatinplacebo226 (118/108) Exploratory
Dernellis, 2006atorvastatinplacebo80 (40/40) Exploratory

CABG surgery - cholesterol lowering intervention in preoperative statins

Chello et al., 2006preoperative atorvastatinplacebo40 (20/20)
Patti et al., 2006preoperative atorvastatinplacebo200 (101/99)

Cardiovascular prevention - cholesterol lowering intervention in diabetic patients - cholesterol lowering intervention in all chronical situations - cholesterol lowering intervention in patients with prior MI or with CHD - statins in secondary prevention - cholesterol lowering intervention in primary prevention - statins in diabetic patients - cholesterol lowering intervention in high risk patients with or without LDL cholesterol elevation - statins in hypertensive patients - cholesterol lowering intervention in patients with renal insufficiency (on hemodialysis or transplant) - cholesterol lowering intervention in post stroke (or TIA) - cholesterol lowering intervention in patient with related disease - cholesterol lowering intervention in women

SALTIRE, 2005atorvastatinplaceboaortic stenosis155 (77/78) Exploratory
ASCOT (diabetics sub group), 2003atorvastatinplacebodiabetic patients2532 (1258/1274) Exploratory
Deutsche Diabetes Dialyse Studie (4D), 2005atorvastatinplacebo1255 (619/636) Confirmatory
SPARCL, 2006atorvastatinplacebopost stroke4731 (2365/2366) Confirmatory NCT00147602
Strey, 2005atorvastatinplaceboheart failure48 (24/24)
ASPEN, 2006atorvastatinplacebodiabetic patients2410 (1211/1199) Confirmatory
ASCOT, 2003atorvastatinplaceboat risk hypertensive10305 (5168/5137) Confirmatory
MIRACL, 2001atorvastatinplaceboacute coronary syndrome3086 (1538/1548) Confirmatory
ASPEN, 2006atorvastatinplacebodiabetic2410 (1211/1199) Confirmatory
ASPEN (primary prevention sub group), 2006atorvastatinplacebodiabetic1906 (959/947) Exploratory
macin, 2005atorvastatinplaceboacute coronary syndromeNA Exploratory
Mohler III, 2003atorvastatinplaceboPeripheral Arterial Disease354 (240/114) Exploratory
CARDS, 2004atorvastatinplacebodiabetic2841 (1429/1412) Confirmatory NCT00327418
Mohler, 2003atorvastatinplacebosecondary preventionNA Confirmatory
ASCOT (women subgroup) , 2003Atorvastatinplacebowomen1942 (979/963) Exploratory
PROVE IT - TIMI 22, 2004atorvastatinpravastatinacute coronary syndrome4162 (2099/2063)
Colivicchi, 2002atorvastatinusual careacute coronary syndrome81 (40/41) Exploratory
ESTABLISH, 2004atorvastatinusual careacute coronary syndrome70 (35/35) Exploratory
GREACE, 2002atorvastatinusual caresecondary prevention1600 (800/800) Confirmatory -
AVERT, 1999atorvastatin high doseangioplastysecondary prevention341 (164/177) Confirmatory -
TNT (diabetic sub group), 2006atorvastatin high doseatorvastatindiabetic patients1501 (748/753) Exploratory
TNT, 2005atorvastatin high doseatorvastatinsecondary prevention10001 (4995/5006) Confirmatory NCT00327691
Vascular basis, 2005atorvastatin high doselovastatinsecondary prevention300 (197/103) Exploratory
PROVE-IT, 2004atorvastatin high dosepravastatindiabetic4162 (2099/2063) Confirmatory
REVERSAL, 2004atorvastatin high dosepravastatinsecondary prevention654 (327/327) Exploratory
SAGE, 2007atorvastatin high dosepravastatinsecondary prevention891 (446/445) Exploratory
IDEAL, 2005atorvastatin high dosesimvastatinsecondary prevention8888 (4439/4449) Confirmatory - NCT00159835

Diabetes type 2 - cholesterol lowering intervention in diabetic patients with or withour hypercholesterolemia - cholesterol lowering intervention in primary prevention - cholesterol lowering intervention in secondary prevention

ASCOT (diabetics sub group), 2003atorvastatinplacebodiabetic patients2532 (1258/1274) Exploratory
ASPEN, 2006atorvastatinplacebodiabetic patients2410 (1211/1199) Confirmatory
ASPEN (primary prevention sub group), 2006atorvastatinplacebodiabetic1906 (959/947) Exploratory
CARDS, 2004atorvastatinplacebodiabetic2841 (1429/1412) Confirmatory NCT00327418
TNT (diabetic sub group), 2006atorvastatin high doseatorvastatindiabetic patients1501 (748/753) Exploratory

Heart failure - cholesterol lowering intervention in all type of patients - statins in all type of patients

Wojnicz, 2006atorvastatincontrolheart failure74 (36/38)
Yamada, 2007atorvastatincontrolheart failure38 (19/19)
Strey, 2005atorvastatinplaceboheart failure48 (24/24)
Sola, 2006atorvastatinplaceboheart failure108 (54/54)

Hypertension - cholesterol lowering intervention in all type of patients

ASCOT, 2003atorvastatinplaceboat risk hypertensive10305 (5168/5137) Confirmatory

Percutaneous coronary intervention - statins in all type of patients

NAPLES II (Briguori), 2009atorvastatincontrol668 (338/330)
ESTATE ongoing AtorvastatincontrolNA NCT00979940
ARMYDA, 2004atorvastatinplacebo153 (76/77)
GAIN, 2001atorvastatinusual care131 (65/66)
ARMYDA-RECAPTURE, 2009atorvastatin reloadplacebo457 (229/228) Confirmatory

Peripheral vascular diseases - cholesterol lowering intervention in all type of patients

Mohler III, 2003atorvastatinplaceboPeripheral Arterial Disease354 (240/114) Exploratory

Post myocardial infarction - cholesterol lowering intervention in all type of patients

TNT, 2005atorvastatin high doseatorvastatinsecondary prevention10001 (4995/5006) Confirmatory NCT00327691
Vascular basis, 2005atorvastatin high doselovastatinsecondary prevention300 (197/103) Exploratory
REVERSAL, 2004atorvastatin high dosepravastatinsecondary prevention654 (327/327) Exploratory
SAGE, 2007atorvastatin high dosepravastatinsecondary prevention891 (446/445) Exploratory
IDEAL, 2005atorvastatin high dosesimvastatinsecondary prevention8888 (4439/4449) Confirmatory - NCT00159835

Post stroke - cholesterol lowering intervention in all type of patients

SPARCL, 2006atorvastatinplacebopost stroke4731 (2365/2366) Confirmatory NCT00147602



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