trandolapril trial summary

Patients with left ventricular dysfunction after MI : 1 trials - TRACE

No demonstrated result

suggested All cause death by 18% (not demonstrated)

Endpoint	TE [95% CI]	p val	I2	n	k	trials
reinfarction	no data
NYHA class improvement	no data
death or severe congestive heart failure	no data
stroke (fatal and non fatal)	no data
Long term death	no data
All cause death	0.82 [0.68 1.00]	p=0.04	0	1749	1	TRACE,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

Patients with or without HF: 1 trials - TRACE

No demonstrated result

suggested All cause death by 18% (not demonstrated)

Endpoint	TE [95% CI]	p val	I2	n	k	trials
reinfarction	no data
NYHA class improvement	no data
death or severe congestive heart failure	no data
stroke (fatal and non fatal)	no data
Long term death	no data
All cause death	0.82 [0.68 1.00]	p=0.04	0	1749	1	TRACE,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

All type of heart failure: 1 trials - Hampton

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
Death from any cause or hospitalization for any reason	no data
NYHA class improvement	no data
death or severe congestive heart failure	no data
Long term death	no data
hospitalisation for heart failure	no data
All cause death	no data

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

MI patients with LV dysfunction without clinical evidence of HF: 1 trials - TRACE

No demonstrated result

suggested All cause death by 18% (not demonstrated)

Endpoint	TE [95% CI]	p val	I2	n	k	trials
reinfarction	no data
NYHA class improvement	no data
death or severe congestive heart failure	no data
stroke (fatal and non fatal)	no data
Long term death	no data
All cause death	0.82 [0.68 1.00]	p=0.04	0	1749	1	TRACE,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

All type of patients: 1 trials - PEACE

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
cardiovascular events	0.97 [0.83 1.13]	p=1.00	0	8290	1	PEACE,
Cardiovascular death	0.95 [0.76 1.20]	p=1.00	0	8290	1	PEACE,
stroke (fatal and non fatal)	0.77 [0.56 1.05]	p=1.00	0	8290	1	PEACE,
Coronary event	0.97 [0.88 1.08]	p=1.00	0	8290	1	PEACE,
Coronary death	no data
cardiovascular death, MI, stroke	0.94 [0.81 1.08]	p=1.00	0	8290	1	PEACE,
Non fatal MI	1.00 [0.83 1.21]	p=1.00	0	8290	1	PEACE,
Revascularization	0.92 [0.77 1.09]	p=1.00	0	8290	1	PEACE,
All cause death	0.89 [0.76 1.05]	p=1.00	0	8290	1	PEACE,
Cough	no data
Hypotension	no data
angiodema	no data
Adverse events leading to treatment discontinuation	no data

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

Trandolapril angiotensin-Converting Enzyme Inhibitors