diuretics
Trials Results

A EFFACER - Amiloride - Furosemide - Hydrochlorothiazide - Indapamide - Rolofylline - Thiazid diuretic - Tonapofylline - Various diuretics

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TrialStudied treatmentControl treatmentpatientsROBResultNCT

acute heart failure

rolofylline
PROTECT, 2010rolofyllineplacebo Low risk of bias NegativeNCT00328692
2007_806 ongoing rolofyllineplacebo - NCT00652782
7418-503 ongoing rolofyllineplacebo - NCT00729222
PROTECT-1 ongoing rolofyllineplacebo - NCT00328692
PROTECT-2 ongoing rolofyllineplacebo - NCT00354458
REACH UP ongoing rolofyllineplacebo - NCT00443690
tonapofylline
POSEIDON ongoing tonapofyllineplacebo - NCT00745316
TRIDENT-1 ongoing tonapofyllineplacebo - NCT00709865

heart failure

amiloride
Cheitlin, 1991amilorideplacebo Exploratory -
eplerenone
EPHESUS, 2003eplerenoneplacebo Low risk of bias Suggesting
EMPHASIS-HF, 2010eplerenoneplacebo Low risk of bias Suggesting NCT00232180
Weir ongoing eplerenoneplacebo Exploratory - NCT00132093
REMODEL ongoing eplerenoneplacebo - NCT00082589
furosemide
Cowley, 1986furosemidecaptopril Exploratory -
Boccanelli, 1986furosemidecaptopril Exploratory Negative
hydrochlorothiazide
Sievert, 1989hydrochlorothiazide+triamterenedigoxin Exploratory -
Nordrehaug, 1992hydrochlorothiazidebenazepril Exploratory Suggesting
rolofylline
PROTECT-1rolofyllineplacebo - NCT00328692
spironolactone
Mauersberger, 1985spironolactone+furosemidespironolactone+butizide Exploratory -
Dalhstrom, 1986furosemide + spironolactoneprenalterol Exploratory Negative
Han, 1994spironolactone+captoprilcaptopril Exploratory -
Barr, 1995spironolactoneplacebo Exploratory -
MacFadyen, 1997spironolactoneplacebo Exploratory -
RALES, 1998spironolactoneplacebo Risk of bias Suggesting
Farquharson, 2000spironolactoneplacebo Exploratory -
Ramires, 2000spironolactonecontrol Exploratory -
Bednarz, 2000aldactonefurosemide Exploratory -
Tsutamoto, 2001spironolactoneplacebo Exploratory -
Yee, 2001spironolactoneplacebo -
Cicoira, 2002spironolactonecontrol Exploratory -
Mottram, 2004spironolactoneplacebo Exploratory -
Macdonald, 2004spironolactoneplacebo Exploratory -
Cicoira, 2004spironolactonecontrol -
Agostoni, 2005spironolactoneplacebo Exploratory -
PIE II ongoing spironolactoneplacebo - NCT00123955



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