prevention trial summary

Trial	Studied treatment	Control treatment	ROB	Result	NCT
atrial fibrillation
atorvastatin
MIRACL (AF ancillary study), 2001	atorvastatin	placebo	Exploratory	Negative
MIRACL (sub-group) (Schwartz), 2004	atorvastatin	placebo	Exploratory	Suggesting
Dernellis, 2006	atorvastatin	placebo	Exploratory	Suggesting
ARMYDA-3 (AF ancillary study), 2006	atorvastatin	placebo		Suggesting
Chello, 2006	atorvastatin	placebo	Exploratory	Negative
Ozaydin, 2006	atorvastatin	control	Exploratory	Suggesting
Almroth, 2009	atorvastatin	placebo	Risk of bias	Suggesting
STOP-AF ongoing	atorvastatin	placebo		-	NCT00252967
candesartan
CHARM (AF ancillary study), 2005	candesartan	placebo		Suggesting
CAPRAF (Tveit), 2007	candesartan	placebo	Risk of bias	-	NCT00130975
enalapril
Ueng, 2003	enalapril	control		Suggesting
SOLVD (AF ancillary study), 2003	enalapril	placebo		Suggesting
gemfibrozil
VA HIT (AF ancillary study), 1999	gemfibrozil	placebo	Exploratory	Negative
irbesartan
Madrid, 2002	irbesartan	control		Suggesting
ACTIVE I, 2009	irbesartan	placebo	Low risk of bias	Suggesting	NCT00249795
lisinopril
Van den Burg, 1995	lisinopril	placebo		Negative
GISSI-3 (AF ancillary study), 2003	lisinopril	placebo		Negative
losartan
LIFE (AF ancillary study), 2005	losartan	atenolol		Suggesting
olmesartan
ANTIPAF ongoing	olmesartan	placebo	Low risk of bias	-	NCT00098137
pravastatin
Tveit, 2004	pravastatin	control	Exploratory	Negative
ramipril
Brown ongoing	ramipril	placebo		-	NCT00141778
rosuvastatin
GISSI HF (subgroup and ancillary study), 2009	rosuvastatin	placebo	Exploratory	Negative	NCT00336336
valsartan
Val-HeFT (AF ancillary study), 2003	valsartan	placebo		Suggesting
GISSI-AF (Disertori), 2009	valsartan	placebo	Low risk of bias	Negative	NCT00376272
diabetes type 2
diet
Liao, 2002	AHA 2 diet	AHA 1 diet	Exploratory	Negative
glargine
GRACE - ORIGIN (glargine), 2012	insulin glargine	placebo		-
glipizide
Eriksson, 2006	glipizide	placebo	Exploratory	Negative
metformin
Jarret, 1979	lifestyle modification + metformin	control	Exploratory	Negative
Sirtori, 1984	metformin	placebo		-
Giugliano, 1993	metformin	placebo		-
Crave, 1995	metformin	placebo		-
Charles, 1998	metformin	placebo		Negative
Morel, 1999	metformin	placebo		-
Li, 1999	metformin	placebo	Exploratory	Negative
Pasquali, 2000	metformin	placebo		-
Charles, 2000	metformin	placebo		-
Moghetti, 2000	metformin	placebo		-
Freemark, 2001	metformin	placebo		-
Lehtovirta, 2001	metformin	placebo		Negative
Ng, 2001	metformin	placebo		-
Kay, 2001	metformin	placebo		-
Kelly, 2002	metformin	placebo		-
Kocak, 2002	metformin	placebo		-
US-DPP (metformin) (Knowler), 2002	metformin	placebo	Low risk of bias	Negative
Fleming, 2002	metformin	placebo		-
Sturrock, 2002	metformin	placebo		-
EDIT (Holman), 2003	metformin	placebo		-
Choux, 2003	metformin	placebo		-
Baillargeon, 2004	metformin	placebo		-
Rodriguez-Moctezuma, 2004	metformin	placebo		Negative
Rodriguez, 2004	metformin	placebo		-
Gambineri, 2004	metformin	placebo		-
Hoeger, 2004	metformin	placebo		-
Vitale, 2005	metformin	placebo		-
James, 2005	metformin	control		-
Orchard, 2005	metformin	placebo		Suggesting
Stakos, 2005	metformin	placebo		-
Bridger, 2006	metformin	placebo		-
Srinivasan, 2006	metformin	placebo		-
Tang, 2006	metformin	placebo		-
IDDP (Ramachandran), 2006	lifestyle modification + metformin	control	Risk of bias	Negative
CANOE, 2010	rosiglitazone and metformin	placebo	Low risk of bias	Suggesting	NCT00116932
nateglinide
NAVIGATOR nateglinide, 2010	nateglinide	placebo	Low risk of bias	Negative	NCT00097786
orlistat
Heymsfield, 2000	orlistat	placebo	Low risk of bias	Negative
XENDOS (Chiasson), 2002	orlistat	placebo	Risk of bias	Negative
ramipril
DREAM ramipril, 2006	ramipril	placebo	Low risk of bias	Negative	NCT00095654
rosiglitazone
DREAM rosiglitazone, 2006	rosiglitazone	placebo	Low risk of bias	Suggesting	NCT00095654
troglitazone
TRIPOD (Buchanan), 2002	troglitazone	placebo	Exploratory	-
US DDP troglitazone (Knowler), 2005	troglitazone	placebo	Low risk of bias	-
valsartan
NAVIGATOR valsartan, 2010	valsartan	placebo	Low risk of bias	Suggesting	NCT00097786
voglibose
Voglibose Ph-3, 2009	voglibose	placebo	Low risk of bias	Suggesting	UMIN 000001109-
impaired fasting glucose
glargine
GRACE - ORIGIN (glargine), 2012	insulin glargine	placebo		-
metformin
US-DPP (metformin) (Knowler), 2002	metformin	placebo	Low risk of bias	Negative
CANOE, 2010	rosiglitazone and metformin	placebo	Low risk of bias	Suggesting	NCT00116932
nateglinide
NAVIGATOR nateglinide, 2010	nateglinide	placebo	Low risk of bias	Negative	NCT00097786
ramipril
DREAM ramipril, 2006	ramipril	placebo	Low risk of bias	Negative	NCT00095654
rosiglitazone
DREAM rosiglitazone, 2006	rosiglitazone	placebo	Low risk of bias	Suggesting	NCT00095654
valsartan
NAVIGATOR valsartan, 2010	valsartan	placebo	Low risk of bias	Suggesting	NCT00097786
voglibose
Voglibose Ph-3, 2009	voglibose	placebo	Low risk of bias	Suggesting	UMIN 000001109-
post stroke
folic acid
VISP (Toole), 2004	high dose - folic acid, vit B12 and vit B6	low dose - folic acid, vit B12 and vit B6	Low risk of bias	Negative
VITATOPS, 2010	folic acid, vit B12 and vit B6	placebo	Low risk of bias	Suggesting	NCT00097669ÐX&

prevention Trials Results

Group by...

atrial fibrillation

atorvastatin

candesartan

enalapril

gemfibrozil

irbesartan

lisinopril

losartan

olmesartan

pravastatin

ramipril

rosuvastatin

valsartan

diabetes type 2

diet

glargine

glipizide

metformin

nateglinide

orlistat

ramipril

rosiglitazone

troglitazone

valsartan

voglibose

impaired fasting glucose

glargine

metformin

nateglinide

ramipril

rosiglitazone

valsartan

voglibose

post stroke

folic acid

prevention
Trials Results