statins
Trials Results

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TrialStudied treatmentControl treatmentpatientsROBResultNCT

cardiovascular prevention

atorvastatin
AVERT, 1999atorvastatin high doseangioplastysecondary prevention Risk of bias Negative
GREACE, 2002atorvastatinusual caresecondary prevention Risk of bias Suggesting
Mohler, 2003atorvastatinplacebosecondary prevention Low risk of bias -
ASCOT, 2003atorvastatinplaceboat risk hypertensive Low risk of bias Conclusive
CARDS, 2004atorvastatinplacebodiabetic Low risk of bias ConclusiveNCT00327418
REVERSAL, 2004atorvastatin high dosepravastatinsecondary prevention Exploratory Negative
Vascular basis, 2005atorvastatin high doselovastatinsecondary prevention Exploratory Negative
IDEAL, 2005atorvastatin high dosesimvastatinsecondary prevention Risk of bias Suggesting NCT00159835
TNT, 2005atorvastatin high doseatorvastatinsecondary prevention Low risk of bias Conclusive NCT00327691
ASPEN, 2006atorvastatinplacebodiabetic Low risk of bias Negative
SAGE, 2007atorvastatin high dosepravastatinsecondary prevention Exploratory Suggesting
fluvastatin
LCAS, 1997fluvastatinplacebosecondary prevention Exploratory Negative
FLARE, 1999fluvastatinplacebosecondary prevention Exploratory Negative
Riegger et al., 1999fluvastatinplacebosecondary prevention Low risk of bias Negative
BCAPS, 2001fluvastatinplaceboprimary prevention Exploratory Negative
LIPS, 2002fluvastatinplacebosecondary prevention Low risk of bias Suggesting
HYRIM, 2005fluvastatinplacebohypertensive Exploratory Negative
lovastatin
Sahni, 1991lovastatinusual caresecondary prevention Risk of bias Negative
MARS, 1993lovastatinplacebosecondary prevention Exploratory NegativeNCT00116870
CCAIT, 1994lovastatinplacebosecondary prevention Exploratory Negative
Weintraub, 1994lovastatinplacebosecondary prevention Low risk of bias Negative
CRISP 20mg, 1994lovastatinplacebodiabetic Exploratory - NCT00000477
CRISP 40mg, 1994lovastatinplacebodiabetic Exploratory - NCT00000477
ACAPS, 1994lovastatinplacebosecondary prevention Exploratory SuggestingNCT00000469
AFCAPS/TexCAPS, 1998lovastatinplaceboprimary prevention Low risk of bias Conclusive
CLAPT, 1999lovastatinusual caresecondary prevention Exploratory Negative
pravastatin
PMSG, 1993pravastatinplaceboprimary prevention Exploratory Negative
REGRESS, 1995pravastatinplacebosecondary prevention Exploratory Suggesting
PLAC I, 1995pravastatinplacebosecondary prevention Exploratory Suggesting
PLAC II, 1995pravastatinplacebosecondary prevention Exploratory Negative
WOSCOPS, 1995pravastatinplaceboprimary prevention Low risk of bias Conclusive
CAIUS, 1996pravastatinplaceboprimary prevention Exploratory Negative
CARE, 1996pravastatinplacebosecondary prevention Low risk of bias Conclusive
LIPID, 1998pravastatinplacebosecondary prevention Low risk of bias Conclusive
KLIS, 2000pravastatinusual careprimary prevention Risk of bias -
GISSI Prevenzione, 2000pravastatinusual caresecondary prevention Risk of bias Negative
FAST Fukuoka pravastatin, 2002pravastatincontrolprimary prevention Exploratory -
PROSPER, 2002pravastatinplacebosecondary prevention Low risk of bias Conclusive
ALLHAT, 2002pravastatinusual careat risk hypertensive Risk of bias NegativeNCT00000542
PROSPER (primary prevention subgroup), 2002pravastatinplaceboprimary prevention Exploratory Negative
PHYLLIS, 2004pravastatinplacebodiabetic Exploratory -
PACT, 2004pravastatinplacebosecondary prevention Low risk of bias Negative
MEGA, 2006pravastatincontrolprimary prevention Risk of bias SuggestingNCT00211705
rosuvastatin
METEOR, 2007rosuvastatinplacebodiabetic Exploratory NegativeNCT00225589
JUPITER, 2008rosuvastatinplaceboprimary prevention Low risk of bias Conclusive NCT00239681
HOPE 3, 2016rosuvastatinplaceboprimary prevention Low risk of bias ConclusiveNCT00468923
simvastatin
MAAS, 1994simvastatinplacebosecondary prevention Exploratory Negative
4S, 1994simvastatinplacebosecondary prevention Low risk of bias Conclusive
CIS, 1997simvastatinplacebosecondary prevention Exploratory Negative
HPS, 2002simvastatinplacebosecondary prevention Low risk of bias Conclusive
HPS (diabetic primary prevention sub group), 2003simvastatinplacebodiabetic Exploratory -
SEARCH, 2010simvastatin high dosesimvastatinsecondary prevention Low risk of bias Suggesting NCT00124072

heart failure

atorvastatin
Strey, 2005atorvastatinplaceboheart failure -
Wojnicz, 2006atorvastatincontrolheart failureNegative
Sola, 2006atorvastatinplaceboheart failureNegative
Yamada, 2007atorvastatincontrolheart failureNegative
cerivastatin
Laufs, 2004cerivastatinplaceboheart failure -
rosuvastatin
CORONA, 2007rosuvastatinplaceboheart failure Low risk of bias NegativeNCT00206310
Krum, 2007rosuvastatinplaceboheart failure Exploratory Negative
GISSI-HF rosuvastatine, 2008rosuvastatinplaceboheart failure Low risk of bias Negative NCT00336336
simvastatin
Node, 2003simvastatinplaceboheart failureNegative
Hong, 2005simvastatincontrolheart failure Risk of bias Negative
Landmesser, 2005simvastatinezetimibeheart failure -

percutaneous coronary intervention

atorvastatin
GAIN, 2001atorvastatinusual careNegative
ARMYDA, 2004atorvastatinplaceboSuggesting
ARMYDA-RECAPTURE, 2009atorvastatin reloadplacebo Low risk of bias Suggesting
NAPLES II (Briguori), 2009atorvastatincontrolSuggesting
ESTATE ongoing Atorvastatincontrol - NCT00979940
fluvastatin
FLARE, 1999fluvastatinplaceboNegative
LIPS, 2002fluvastatinplaceboNegative
pravastatin
PREDICT, 1997pravastatinplaceboNegative



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