diabetes type 2 | versus placebo semaglutide superior to placebo in terms of CV events in SUSTAIN 6, 2016 semaglutide inferior to placebo in terms of Retinopathy in SUSTAIN 6, 2016 | 1 trial | meta-analysis | | Trial | control | p<0.05 | harm | NS |
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SUSTAIN 6, 2016 | semaglutide vs placebo | CV events 0.74 [0.58; 0.95] Demonstrated Nephropathy 0.64 [0.46; 0.89] | Retinopathy 1.76 [1.11; 2.79] | all causes death 1.05 [0.74; 1.49] CVdeath 0.98 [0.65; 1.48] |
Trial | Treatments | Patients | Method |
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SUSTAIN 6, 2016 | once-weekly semaglutide (0.5 mg or 1.0 mg) (n=1648) vs. placebo (n=1649) | patients with type 2 diabetes who were on a standardcare
regimen | double-blind Parallel groups Sample size: 1648/1649 Primary endpoint: CV death, MI or stroke FU duration: 2.1 y (median) |
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