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pathology

Demonstrated benefit and harm

k

lung cancer (metastatic)

versus

No demonstrated result for efficacy

Trial	control	p<0.05	harm	NS
	T1 vs T0

Trial

Treatments

Patients

Method

Ramlau, 2012

(n=456)

vs.

(n=457)

platinum-pretreated patients with advanced or metastatic nonsquamous non-small-cell lung cancer

double-blind

Sample size: 456/457

Primary endpoint: overall survival (OS).

FU duration:

phase III

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