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pathology

Demonstrated benefit and harm

k

venous thrombosis

versus oral anticoagulant

No demonstrated result for efficacy

Trial	control	p<0.05	harm	NS
Kakkar, 2003	Bemiparin vs warfarin			VTE during active anticoagulant treatment 0.78 [0.19; 3.19]

Trial

Treatments

Patients

Method

Kakkar, 2003

LMWH, 115 IU/kg qd followed by Bemiparin 3,500 IU qd (n=221)

vs.

A: UFH, 30/40,000IU qd; B: LMWH, 115 IU/kg qd followed by Warfarin target INR 2-3 (n=103)

patients with objective diagnosis of DVT by Venography/compression ultrasonography

open

Sample size: 221/103

Primary endpoint: none defined

FU duration: 3 mo

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