pathology | Demonstrated benefit and harm | k | | | |
---|
atrial fibrillation | versus placebo or control No demonstrated result for efficacy | 2 trials | meta-analysis | | Trial | control | p<0.05 | harm | NS |
---|
Karlson, 1998 | disopyramide vs placebo | | | all cause mortality ∞ [NaN; ∞] Withdrawals due to adverse effects 3.50 [0.77; 15.96] Pro-arrhythmia NaN [NaN; NaN] Atrial fibrillation recurrence 0.75 [0.54; 1.05] | Lloyd (Disopyramide vs placebo), 1984 | disopyramide vs placebo | | | all cause mortality NaN [NaN; NaN] Pro-arrhythmia NaN [NaN; NaN] Atrial fibrillation recurrence 0.81 [0.53; 1.24] |
Trial | Treatments | Patients | Method |
---|
Karlson, 1998 | Disopyramide 500 mg/d (n=46) vs. palcebo (n=46) | Persistent AF between 6 weeks and 1 year | open Parallel groups Sample size: 46/46 Primary endpoint: FU duration: 12 months | Lloyd (Disopyramide vs placebo), 1984 | Disopyramide 450 mg/d , (n=29) vs. placebo
(n=25)
| Persistent AF lasting 1 month to 3 years
| double blind Parallel groups Sample size: 29/25 Primary endpoint: FU duration: 6 months
|
|
atrial fibrillation | versus Class Ia No demonstrated result for efficacy | 1 trial | meta-analysis | | Trial | control | p<0.05 | harm | NS |
---|
Lloyd (Disopyramide vs quinidine), 1984 | disopyramide vs quinidine | | | |
Trial | Treatments | Patients | Method |
---|
Lloyd (Disopyramide vs quinidine), 1984 | Disopyramide 450 mg/d ,
,
(n=29) vs. placebo
(n=28)
| Persistent AF lasting 1 month to 3 years
| double blind Parallel groups Sample size: 29/28 Primary endpoint: FU duration: 6 months
|
|
atrial fibrillation | versus Class Ic No demonstrated result for efficacy | 1 trial | meta-analysis | | Trial | control | p<0.05 | harm | NS |
---|
PRODIS, 1996 | disopyramide vs propafenone | | | all cause mortality ∞ [NaN; ∞] Withdrawals due to adverse effects 0.40 [0.14; 1.19] Pro-arrhythmia 0.81 [0.05; 12.26] Atrial fibrillation recurrence 0.73 [0.37; 1.44] |
Trial | Treatments | Patients | Method |
---|
PRODIS, 1996 | Disopyramide 750 mg/d (n=31) vs. propafenone 900 mg/d (n=25) | Persistent AF | double blind Parallel groups Sample size: 31/25 Primary endpoint: FU duration: 6 months |
|