acute myocardial infarction | versus No demonstrated result for efficacy alteplase inferior to primary intervention in terms of Initial TIMI 3 flow in LIMI (Vermeer), 1999 alteplase inferior to primary intervention in terms of Initial TIMI 3 flow in PACT (Ross,), 1999 | 2 trials | meta-analysis | | Trial | control | p<0.05 | harm | NS |
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LIMI (Vermeer), 1999 | alteplase vs primary intervention | | Initial TIMI 3 flow 5.20 [2.63; 10.29] | Short-term death 1.22 [0.39; 3.81] Short-term major bleeding in patients treated NaN [NaN; NaN] Short-term non-fatal reinfarction 4.05 [0.46; 35.42] Short-term urgent target vessel revascularisation 6.08 [0.75; 49.29] Final TIMI 3 flow 0.89 [0.78; 1.02] | PACT (Ross,), 1999 | alteplase vs primary intervention | | Initial TIMI 3 flow 2.19 [1.60; 2.99] | Short-term death 1.11 [0.48; 2.57] Short-term major bleeding in patients treated 1.05 [0.62; 1.77] Short-term non-fatal reinfarction 1.13 [0.44; 2.90] Final TIMI 3 flow 0.98 [0.92; 1.04] |
Trial | Treatments | Patients | Method |
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LIMI (Vermeer), 1999 | facilated PCI with Alteplase 50 mg(intravenous bolus)mag (n=74) vs. primary intervention (n=75) | symptom duration <6h | Sample size: 74/75 Primary endpoint: FU duration: 42-day | PACT (Ross,), 1999 | facilated PCI with alteplase 50 mg (intravenous bolus) (n=302) vs. primary intervention (n=304) | symptom duration <6h | Sample size: 302/304 Primary endpoint: FU duration: 30-day |
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