heart failure | versus placebo or control No demonstrated result for efficacy Milrinone inferior to placebo in terms of Total mortality in PROMISE, 1991 Milrinone inferior to placebo in terms of Sudden death in PROMISE, 1991 Milrinone inferior to placebo in terms of Cardiac death in PROMISE, 1991 Milrinone inferior to placebo in terms of Vertigo in PROMISE, 1991 | 2 trials | meta-analysis | | Trial | control | p<0.05 | harm | NS |
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PROMISE, 1991 | Milrinone vs placebo | | Total mortality 1.24 [1.02; 1.51] Sudden death 1.57 [1.14; 2.17] Cardiac death 1.30 [1.06; 1.60] Vertigo 1.90 [1.40; 2.57] | Myocardial infarction (fatal & non fatal) 5.64 [0.68; 46.66] Worsening heart failure (requiring intervention) 1.88 [0.65; 5.46] Transplantation 0.63 [0.11; 3.73] Arrhythmia 1.22 [0.95; 1.56] | MMTG, 1989 | Milrinone vs placebo | | | Total mortality 2.33 [0.94; 5.80] Myocardial infarction (fatal & non fatal) ∞ [NaN; ∞] Cardiac death 1.87 [0.72; 4.80] Worsening heart failure (requiring intervention) 0.87 [0.57; 1.34] Arrhythmia 1.87 [0.91; 3.81] Vertigo 2.05 [0.74; 5.72] |
Trial | Treatments | Patients | Method |
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PROMISE, 1991 | Milrinone 40mg/d (n=561) vs. placebo (n=527) | NYHA III,IV | double blind Parallel groups Sample size: 561/527 Primary endpoint: Total mortality FU duration: 20 months | MMTG, 1989 | Milrinone <40mg/d (n=119) vs. placebo (n=111) | NYHA II-IV | double blind Parallel groups Sample size: 119/111 Primary endpoint: none FU duration: 3 months |
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