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pathology

Demonstrated benefit and harm

k

acute coronary syndrome

versus heparin

No demonstrated result for efficacy

Trial	control	p<0.05	harm	NS
TRIM, 1997	Inogatran vs heparin

Trial

Treatments

Patients

Method

TRIM, 1997

Inogatran 0.1–5.5 mg bolus; 2.0–10.0 mg/h infusion for 72h (n=1209)

vs.

UFH 5000 IU bolus; 1200 IU/h infusion (n=0)

patients with suspected unstable angina, or non-Q wave myocardial infarction

double blind

Parallel groups

Sample size: 1209/0

Primary endpoint: death, MI, refractory angina, recurrent angina

FU duration: 30 days

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