acute myocardial infarction | versus No demonstrated result for efficacy Tirofiban inferior to primary intervention in terms of Initial TIMI 3 flow in TIGER-PA (Lee), 2003 | 3 trials | meta-analysis | | Trial | control | p<0.05 | harm | NS |
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On-Time (van’t Hof), 2004 | Tirofiban vs primary intervention | | | Short-term death 4.54 [0.99; 20.78] Short-term major bleeding 1.39 [0.57; 3.39] Short-term non-fatal reinfarction 1.51 [0.25; 8.97] Short-term urgent target vessel revascularisation ∞ [NaN; ∞] Final TIMI 3 flow 0.99 [0.93; 1.05] Initial TIMI 3 flow 1.28 [0.86; 1.91] | TIGER-PA (Lee), 2003 | Tirofiban vs primary intervention | | Initial TIMI 3 flow 3.20 [1.27; 8.07] | Short-term death 1.00 [0.06; 15.55] Short-term major bleeding 1.00 [0.06; 15.55] Short-term non-fatal reinfarction 0.00 [0.00; NaN] Short-term urgent target vessel revascularisation 0.00 [0.00; NaN] Final TIMI 3 flow 1.00 [0.89; 1.12] | Cutlip, 2003 | Tirofiban vs primary intervention | | | Short-term death 0.00 [0.00; NaN] Short-term major bleeding 1.07 [0.16; 7.10] Short-term non-fatal reinfarction 0.00 [0.00; NaN] Short-term urgent target vessel revascularisation 0.00 [0.00; NaN] Final TIMI 3 flow 1.08 [0.97; 1.20] Initial TIMI 3 flow 1.61 [0.66; 3.94] |
Trial | Treatments | Patients | Method |
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On-Time (van’t Hof), 2004 | facilated PCI with Tirofiban; 10 µg/kg intravenous bolus, 0·15 µg/kg per min infusion (n=245) vs. primary intervention (n=247) | symptom duration <6h | Sample size: 245/247 Primary endpoint: FU duration: 30-day | TIGER-PA (Lee), 2003 | facilated PCI with Tirofiban; 10 µg/kg intravenous bolus, 0·15 µg/kg per min infusion (n=50) vs. primary intervention (n=50) | symptom duration <12h | Sample size: 50/50 Primary endpoint: FU duration: 30-day | Cutlip, 2003 | facilated PCI with Tirofiban; 10 µg/kg intravenous bolus, 0·15 µg/kg per min infusion (n=28) vs. primary intervention (n=30) | symptom duration <12h | Sample size: 28/30 Primary endpoint: FU duration: 30-day |
|
percutaneous coronary intervention | versus placebo or control No demonstrated result for efficacy | 2 trials | meta-analysis | | Trial | control | p<0.05 | harm | NS |
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| T1 vs T0 | | | | | T1 vs T0 | | | |
Trial | Treatments | Patients | Method |
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RESTORE, 1997 | loading dose 10µg/kg infusion 0.15µg/kg/min for 36h (n=-9) vs. (n=-9) | PCI <72 h after USA or MI | Sample size: -9/-9 Primary endpoint: FU duration: | Kereiakis, 1996 | loading dose µg/kg infusion µg/min for h (n=-9) vs. (n=-9) | | Sample size: -9/-9 Primary endpoint: FU duration: |
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