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pathology

Demonstrated benefit and harm

k

abdominal aortic aneurysm

versus placebo or control

No demonstrated result for efficacy

Trial	control	p<0.05	harm	NS
	vs placebo
	vs placebo
	vs control

Trial

Treatments

Patients

Method

Lindholt, 1999

Propanolol 40 mg/bid (n=30)

vs.

Placebo (n=24)

double blind

Parallel groups

Sample size: 30/24

Primary endpoint:

FU duration: 24 mo

PATI, 2002

Propanolol 20–240 mg/d (n=276)

vs.

Placebo (n=272)

double blind

Parallel groups

Sample size: 276/272

Primary endpoint:

FU duration: 30 mo

Wilmink, 2000

Propanolol 40 mg/d (n=256)

vs.

control (n=221)

open

Parallel groups

Sample size: 256/221

Primary endpoint:

FU duration: 33 mo

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