mechanism | treatment | Demonstrated benefit and harm | k | | | |
---|
antiarrythmic drugs | Azimilide | versus placebo or control No demonstrated result for efficacy | 1 trial | meta-analysis | | Trial | control | p<0.05 | harm | NS |
---|
ALIVE, 2004 | azimilide vs placebo | | | |
Trial | Treatments | Patients | Method |
---|
ALIVE, 2004 | azimilide 100 mg (n=-9) vs. placebo (n=-9) | post-MI patients with depressed LVF | double blind Parallel groups Sample size: -9/-9 Primary endpoint: FU duration: 1y |
|
antiarrythmic drugs | dofetilide | versus placebo or control No demonstrated result for efficacy | 1 trial | meta-analysis | | Trial | control | p<0.05 | harm | NS |
---|
DIAMOND MI, 1997 | dofetilide vs placebo | | | |
Trial | Treatments | Patients | Method |
---|
DIAMOND MI, 1997 | dofetilide (n=-9) vs. placebo (n=-9) | patients with acute myocardial infarction within 7 days and left ventricular systolic dysfunction (EF <= 35%) | double blind Parallel groups Sample size: -9/-9 Primary endpoint: FU duration: >12 months |
|
antiarrythmic drugs | moricizine | versus placebo or control No demonstrated result for efficacy | 2 trials | meta-analysis | | Trial | control | p<0.05 | harm | NS |
---|
CAST II (early treatment), 1992 | moricizine vs placebo | | | | CAST II (late treatment), 1992 | moricizine vs placebo | | | |
Trial | Treatments | Patients | Method |
---|
CAST II (early treatment), 1992 | moricizine for 14 days (n=665) vs. placebo (n=660) | acute myocardial infarction | double blind Parallel groups Sample size: 665/660 Primary endpoint: mortality FU duration: 14 days | CAST II (late treatment), 1992 | long term moricizine (n=1155) vs. placebo (n=0)
| patient survivor to a myocardial infarctionwhose ventricular premature depolarizations were adequately suppressed by moricizine
| double blind Parallel groups Sample size: 1155/0 Primary endpoint: mortality FU duration:
|
|