Induction chemotherapy

Description Results NMA

Overall response (CR + PR) to induction CT 1.18 [1.05; 1.34]

Overall response (CR + PR) to study treatment 1.71 [1.36; 2.14]

Complete response to induction CT 2.47 [1.64; 3.73]

complete response to study treatment 1.75 [1.36; 2.25]

All grade 3 to 4 events during induction CT 0.90 [0.68; 1.20]

frebrile neutropenia (grade 3-4) during induction CT 1.63 [0.54; 4.90]

neutropenia (grade 3-4) during induction CT 1.05 [0.69; 1.59]

Toxic death during induction CT 0.51 [0.09; 2.75]

death (overall survival) 0.85 [0.69; 1.06]

progression or death (progression free survival) 1.00 [1.00; 1.00]

induction chemotherapy with paclitaxel, cisplatin, and fluorouracil (n=189)

vs.

induction chemotherapy with cisplatin and FU (n=193)

Open

Parallel groups

Sample size: 189/193

Primary endpoint: CR

FU duration: 1.93y (0.025-5y)