dual antiplatelet therapy

Description Results NMA

all cause death 1.52 [0.76; 3.05]

major bleeding 2.97 [0.31; 28.51]

stroke 2.23 [0.69; 7.21]

MI 1.41 [0.54; 3.70]

definite stent thrombosis 1.24 [0.33; 4.60]

clopidogrel plus aspirin (n=1357)

vs.

aspirin alone (n=1344)

open

Parallel groups

Sample size: 1357/1344

Primary endpoint: CV death, MI

FU duration: 19.2 months

all cause death 0.70 [0.27; 1.83]

Cardiovascular death 0.37 [0.10; 1.40]

MI 1.11 [0.59; 2.08]

any bleeding 1.17 [0.93; 1.49]

GUSTO severe/moderate bleeding 0.60 [0.32; 1.13]

Cardiovascular death/MI/stent thrombosis 1.01 [0.58; 1.76]

definite stent thrombosis 0.62 [0.20; 1.90]

High-dose clopidogrel (600-mg initial dose, 150 mg daily thereafter) (n=1109)

vs.

regular clopidogrel dose (n=1105)

open

Parallel groups

Sample size: 1109/1105

Primary endpoint: Cardiovascular death/MI/stent thrombosis

FU duration: 6 months