| Trial | control | p<0.05 | harm | NS |
|---|
| Veterans Ad. (Dayton), 1969 | diet vs usual diet | MI non fatal 0.41 [0.20; 0.86] | décès par cancer 1.81 [1.02; 3.23] | all cause deaths 0.98 [0.83; 1.15] coronary deaths 0.82 [0.55; 1.21] coronary events 0.80 [0.57; 1.12] stroke (fatal et non fatal) 0.59 [0.30; 1.15] |
| MRC Soya, 1968 | diet vs usual diet | | | all cause deaths 0.88 [0.55; 1.41] coronary deaths 0.97 [0.58; 1.64] coronary events 0.86 [0.61; 1.22] décès par cancer 0.16 [0.02; 1.34] MI non fatal 0.75 [0.43; 1.30] cardiac death 0.97 [0.58; 1.64] non cardiovascular death 0.16 [0.02; 1.34] |
| Woodhill, 1966 | diet vs usual diet | | | all cause deaths 1.49 [0.95; 2.34] coronary deaths 1.44 [0.90; 2.32] cardiac death 1.44 [0.90; 2.32] non cardiovascular death 2.14 [0.40; 11.59] |
| Oslo Diet Heart Study (Leren), 1966 | diet vs usual diet | coronary events 0.75 [0.57; 0.99] | | all cause deaths 0.75 [0.52; 1.06] coronary deaths 0.74 [0.51; 1.08] MI non fatal 0.77 [0.47; 1.27] non cardiovascular death 0.80 [0.22; 2.94] |
| Rose, 1965 | diet vs usual diet | | | all cause deaths 3.85 [0.51; 29.20] coronary deaths 2.41 [0.30; 19.57] coronary events 0.96 [0.41; 2.28] MI non fatal 0.67 [0.24; 1.92] cardiac death 3.85 [0.51; 29.20] non cardiovascular death NaN [NaN; NaN] |
| MRC low fat, 1965 | diet vs usual diet | | | all cause deaths 0.87 [0.51; 1.50] coronary events 1.01 [0.73; 1.38] |
| WHI low fat, 2005 | diet vs usual diet | | | coronary deaths 1.01 [0.83; 1.24] coronary events 0.97 [0.87; 1.08] CV events (including revascularization) 0.97 [0.90; 1.05] MI non fatal 0.97 [0.86; 1.09] stroke (fatal et non fatal) 1.01 [0.90; 1.14] cardiovascular events 0.97 [0.91; 1.04] |
| Tuttle, 2008 | low fat diet vs mediterranean-style diet | | | |
| Singh, 1992 | diet vs usual diet | | | |
| STARS (St Thomas, diet), 1992 | diet vs usual diet | | | all cause deaths 0.33 [0.04; 3.03] cardiac death 0.33 [0.04; 3.03] non cardiovascular death NaN [NaN; NaN] |
| Los Angeles VA (Dayton), 1969 | diet vs usual diet | | | |
| Ornish, 1990 | diet vs usual diet | | | all cause deaths ∞ [NaN; ∞] cardiac death ∞ [NaN; ∞] non cardiovascular death NaN [NaN; NaN] |
| Kallio, 1979 | diet vs usual diet | | | |
| MRFIT, 1982 | diet vs usual diet | | | |
| Hjermann, 1981 | diet vs usual diet | | | |
| Göteborg (Wilhelmsen), 1986 | diet vs usual diet | | | all cause deaths 0.98 [0.92; 1.04] cardiac death 1.00 [0.90; 1.12] non cardiovascular death 0.98 [0.91; 1.07] |
| Black, 1994 | diet vs usual diet | | | all cause deaths 0.49 [0.05; 5.26] cardiac death 0.00 [0.00; NaN] non cardiovascular death ∞ [NaN; ∞] |
| Goteborg, 1986 | diet vs usual diet | | | |
| Minnesota coronary survey (Frantz), 1975 | diet vs usual diet | | | all cause deaths 1.03 [0.83; 1.28] coronary deaths 1.15 [0.73; 1.81] coronary events 1.08 [0.85; 1.38] décès par cancer 1.33 [0.63; 2.81] |
| Trial | Treatments | Patients | Method |
|---|
| Veterans Ad. (Dayton), 1969 | cholesterol lowering diet (n=424) vs. usual diet (n=422) | men in domicilary care, age>55, with or without CHD | double blind Parallel groups Sample size: 424/422 Primary endpoint: MI, sudden death FU duration: 3.6 and 8 y |
| MRC Soya, 1968 | Régime pauvre en graisses saturées + 85 g/j d'huile de soja (n=199) vs. usual diet (n=194) | ambulatory men with recent MI | open, blind assessment Parallel groups Sample size: 199/194 Primary endpoint: MI FU duration: 3.5 y |
| Woodhill, 1966 | diet (n=221) vs. usual diet (n=237) | men, 30-59 years | open Parallel groups Sample size: 221/237 Primary endpoint: death FU duration: < 7 years |
| Oslo Diet Heart Study (Leren), 1966 | diet (n=206) vs. usual care (n=206) | middle-aged ambulatory men with prior MI | open, blind assessment Parallel groups Sample size: 206/206 Primary endpoint: IDM fatal ou non fatal FU duration: 5 y (11y) |
| Rose, 1965 | Régime restreint en graisses + 80 g/j huile de maïs (n=28) vs. usual diet (n=26)
| men, <70 years
| open Parallel groups Sample size: 28/26 Primary endpoint: Mort subite FU duration: 1.2 years
|
| MRC low fat, 1965 | (n=123) vs. (n=129)
|
| open Parallel groups Sample size: 123/129 Primary endpoint: death, MI FU duration: 3 y
|
| WHI low fat, 2005 | dietary modification intervention to promote dietary change with the goals of reducing intake of total fat to 20% of energy and increasing consumption of vegetables and fruit to at least 5 servings daily and grains to at least 6 servings daily (n=19541) vs. usual diet (n=29294) | postmenopausal women, aged 50 to 79 years, without prior breast cancer | open Parallel groups Sample size: 19541/29294 Primary endpoint: Invasive breast cancer FU duration: 8.1y mean |
| Tuttle, 2008 | low-fat (n=-9) vs. Mediterranean-style diets (n=-9) | First MI survivors | open Parallel groups Sample size: -9/-9 Primary endpoint: cardiovascular events FU duration: 24 months |
| Singh, 1992 | strict diet (n=204) vs. usual diet (n=202) | patients with suspected acute myocardial infarction | open Parallel groups Sample size: 204/202 Primary endpoint: not unique FU duration: 2.0 years |
| STARS (St Thomas, diet), 1992 | dietary advice (n=30) vs. usual diet (n=30)
| patients with angina or past myocardial infarction
| open, blind assessment Sample size: 30/30 Primary endpoint: not defined FU duration: 3.0 years
|
| Los Angeles VA (Dayton), 1969 | diet (n=424) vs. usual diet (n=422) | men in domicilary care, age>55, with or without CHD | double blind Parallel groups Sample size: 424/422 Primary endpoint: FU duration: 8.0 y |
| Ornish, 1990 | low-fat vegetarian diet, stopping smoking, stress management training, and moderate exercise (n=28) vs. usual-care (n=20) | Patients with angiographically documented coronary artery disease | open Parallel groups Sample size: 28/20 Primary endpoint: quantitative coronary angiography FU duration: 1.0 y |
| Kallio, 1979 | diet (multifactorial intervention programme) (n=188) vs. usual diet (n=187) | patients below 65 years who had an acute myocardial infarction | open Parallel groups Sample size: 188/187 Primary endpoint: not defined FU duration: 3.0 years |
| MRFIT, 1982 | multifactor intervention program (n=6428) vs. usual diet (n=6438) | high-risk men aged 35 to 57 years | open Parallel groups Sample size: 6428/6438 Primary endpoint: CHD death FU duration: 6.5 y |
| Hjermann, 1981 | diet (n=604) vs. usual diet (n=628) | healthy, normotensive men at high risk of coronary heart disease | open Parallel groups Sample size: 604/628 Primary endpoint: not defined FU duration: 6.5 years |
| Göteborg (Wilhelmsen), 1986 | multifactorial intervention programme (n=10004) vs. usual care (n=20028) | men, 47-55 years old at entry | open Parallel groups Sample size: 10004/20028 Primary endpoint: FU duration: 10.0 years |
| Black, 1994 | diet with 20 percent of total caloric intake as fat (n=56) vs. usual diet (n=55) | patients with nonmelanoma skin cancer | open Parallel groups Sample size: 56/55 Primary endpoint: not defined FU duration: 2.0 years |
| Goteborg, 1986 | multifactorial intervention programme (n=10004) vs. no intervention (n=20028) | men, 47-55 years old at entry | open Parallel groups Sample size: 10004/20028 Primary endpoint: not defined FU duration: 10 years |
| Minnesota coronary survey (Frantz), 1975 | cholesterol lowering diet (n=2197) vs. control diet (n=2196)
| Adult residents ofmental hospitals; no illness restrictions, no cholesterol concentration requirements
| double-blind Parallel groups Sample size: 2197/2196 Primary endpoint: not defined FU duration: 1.1 y (max 4.5y)
|
