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Dronedarone
antiarrythmic drugs
systematic review
meta-analysis
network meta-analysis
Multaq
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atrial fibrillation
heart failure
amiodarone/dronedarone
dronedarone
vs placebo or control
vs amiodarone
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Description
Synopsis
Comparison
Treatments
Patients
Characteristics
Method
Risk of bias
References
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Indexation
Results
Global trial result
Main results
All results
All result tag
NCT results
All cause death (12)
Adverse events leading to treatment discontinuation (11)
Pro-arrhythmia (11)
Atrial fibrillation recurrence (11)
Cardiovascular death (11)
non cardiovascular death (11)
Cardiac nonarrhythmic death (11)
Cardiac arrhythmic death (11)
Vascular noncardiac death (11)
hospitalization for AF (11)
cardiovascular events (11)
death or hospitalization for cardiac causes (11)
stroke (fatal and non fatal) (11)
myocardial infarction (fatal and non fatal) (11)
hospitalisation for heart failure (11)
Sudden death (1)
Death from any cause or hospitalization for any reason (1)
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medians
Trial
Studied trt
Control trt
patients
tags
ROB
Trial result
All cause death
Adverse events leading to treatment discontinuation
atrial fibrillation
EURIDIS, 2007
NCT
dronedarone
placebo
Low risk of bias
suggesting
ADONIS, 2007
NCT
dronedarone
placebo
Low risk of bias
suggesting
DAFNE, 2003
dronedarone
placebo
Low risk of bias
suggesting
∞%
∞%
EURIDIS ADONIS (pooled analysis), 2009
dronedarone
placebo
Low risk of bias
negative
32%
36%
ATHENA, 2009
NCT
dronedarone
placebo
Low risk of bias
suggesting
-16%
57%
ERATO, 2008
dronedarone
placebo
Low risk of bias
negative
∞%
51%
PALLAS, 2011
NCT
dronedarone
placebo
Low risk of bias
negative
128%
DIONISOS, 2007
NCT
dronedarone
amiodarone
Low risk of bias
suggesting
-59%
-52%
heart failure
ANDROMEDA, 2008
NCT
dronedarone
placebo
Low risk of bias
negative
113%
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