Coumadin antithrombotics  

     

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Trial Studied trt Control trt patientstagsROB Trial resultMajor bleedingExtracranial hemorrhage

acute coronary syndrome  

ASPECT-2 (coumadin+asp vs asp), 2002     coumadincontrol (on top of aspirin)suggesting135%102%
ASPECT-2 (coumadin vs aspirin), 2002   coumadinaspirinsuggesting3%

acute myocardial infarction  

ASPECT-2 (coumadin+ASA vs ASA), 2002     coumadincontrol (on top of aspirin)negative 126%
ASPECT, 1994   coumadinplaceboLow risk of bias suggesting 285%
ASPECT-2 (coumadin alone), 2002     coumadinaspirinsuggesting3%

atrial fibrillation  

PATAF (coumadin low dose vs coumadin standard dose), 1999     coumadin low dosecoumadin standard doseRisk of bias negative

post myocardial infarction  

ASPECT-2 (coumadin+ASA vs ASA), 2002     coumadincontrol (on top of aspirin)negative 126%
ASPECT, 1994   coumadinplaceboLow risk of bias suggesting 285%
ASPECT-2 (coumadin alone), 2002     coumadinaspirinsuggesting3%

superficial thrombophlebitis  

Belcaro (coumadin vs low dose hep), 1999   coumadinlow dose heparin -