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diabetes type 2
impaired fasting glucose
a
basal + bolus
basal insulin
insulin
vs basal insulin
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Description
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Comparison
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Characteristics
Method
Risk of bias
References
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All result tag
NCT results
change in HbA1c (%) (5)
weight change from baseline (%) (5)
HbA1c <7% (5)
HbA1c < 6.5% (5)
all hypoglycemia (5)
severe hypoglycemia (5)
noctural hypoglycemia (5)
hypoglycemia rate, overall (5)
hypoglycemia rate, nocturnal (5)
cardiovascular events (2)
All cause death (2)
Cardiovascular death (2)
myocardial infarction (fatal and non fatal) (2)
stroke (fatal and non fatal) (2)
hospitalisation for heart failure (2)
Diabetes (1)
normoglycemia (1)
cardiovascular death, MI, stroke (1)
retinopathy (1)
nephropathy (1)
microvascular events (1)
Amputations (1)
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medians
Trial
Studied trt
Control trt
patients
tags
ROB
Trial result
change in HbA1c (%)
weight change from baseline (%)
diabetes type 2
Rosenstock
glargine
suggesting
Eliaschewitz
glargine
suggesting
Massi
glargine
suggesting
Yki-Yarvinen
glargine
negative
Fonseca
glargine
negative
Pan
glargine
-
Philis-Tsimikas
glargine
suggesting
Wang
glargine
suggesting
Yki-Yarvinen
glargine
suggesting
Yokoyama
glargine
negative
Fritche
morning insulin glargine
bedtime insulin glargine
suggesting
Herman, 2005
lispro +glargine
continuous infusion
-
ORIGINE, 2012
NCT
insulin glargine
control
negative
Owens, 2011
insulin glulisine + glargine
glargine once daily
Risk of bias
negative
OPAL, 2008
glulisine + glargine
glulisine + glargine
-
Riddle POC 4002 Glargine, 2003
glargine
NPH
Risk of bias
-
HOE 901/3002, 2000
glargine
NPH
-
Riddle
glargine
NPH + SU
negative
GRACE - ORIGIN (glargine), 2012
insulin glargine
placebo
Risk of bias
-
Levin, 2011
insulin glargine plus insulin glulisine
premixed insulin analogues
-
impaired fasting glucose
GRACE - ORIGIN (glargine), 2012
insulin glargine
placebo
Risk of bias
-
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