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Saxagliptin
antidiabetic drugs
systematic review
meta-analysis
network meta-analysis
BMS-477118 - BMS477118 - BMS 477118 - Onglyza - saxagliptin
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diabetes type 2
DPP-4 inhibitors
DPP-4 inhibitors add on current treatment
DPP-4 inhibitors add on insulin
DPP-4 inhibitors add on MET
DPP-4 inhibitors add on TZD
DPP-4 inhibitors in combination
DPP-4 inhibitors monotherapy
vs biguanides
vs placebo
vs placebo or control
vs SU
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Description
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Comparison
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Characteristics
Method
Risk of bias
References
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Global trial result
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All result tag
NCT results
cardiovascular events (26)
Cardiovascular death (26)
myocardial infarction (fatal and non fatal) (26)
stroke (fatal and non fatal) (26)
All cause death (26)
change in HbA1c (%) (25)
Adverse events leading to treatment discontinuation (25)
change in body weight (kg) (25)
retinopathy (1)
nephropathy (1)
microvascular events (1)
hospitalisation for heart failure (1)
Amputations (1)
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medians
Trial
Studied trt
Control trt
patients
tags
ROB
Trial result
cardiovascular events
Cardiovascular death
diabetes type 2
Kawamori, 2012
NCT
saxagliptin
-
Forst, 2011
Saxagliptin
-
Fonseca, 2012
NCT
saxagliptin
-
Nowicki, 2011
NCT
saxagliptin
-
Yang, 2011
NCT
saxagliptin
-
Nowicki, 2011
NCT
saxagliptin
-
Göke, 2010
saxagliptin
-
Scheen , 2010
saxagliptin
-
Stenlöf , 2010
Saxagliptin
-
CV181-040
NCT
saxagliptin + glyburide
glyburide uptitration
-
CV181-085
NCT
saxagliptin plus metformin XR 1500mg
metformin up to 2000mg
-
SAVOR-TIMI 53, 2013
NCT
saxagliptin
placebo
negative
0%
3%
SAVOR TIMI, 2013
NCT
saxagliptin
placebo
Low risk of bias
negative
0%
3%
saxgliptin, renal study
saxagliptin
placebo (add on current treatment)
-
CV181-057
NCT
saxagliptin
placebo (add on insulin)
-
DeFronzo, 2009
NCT
saxagliptin
placebo (add on MET)
negative
Jadzinsky, 2009
NCT
saxagliptin
placebo (add on MET)
-
CV181-066
NCT
saxagliptin
placebo (add on MET)
-
CV181-080
NCT
saxagliptin
placebo (add on MET)
-
Hollander
NCT
saxagliptin
placebo (add on TZD)
-
Rosenstock, 2008
NCT
saxagliptin
placebo (monotherapy)
-
CV181-011
NCT
saxagliptin
placebo (monotherapy)
-
CV181-038
NCT
saxagliptin
placebo (monotherapy)
-
CV181-041
NCT
saxagliptin
placebo (monotherapy)
-
saxagliptin vs sitagliptin
saxagliptin
sitagliptin (add on MET)
-
saxagliptin
saxagliptin
glipizide
Low risk of bias
-
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