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UFH
antithrombotics
systematic review
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acute coronary syndrome
acute myocardial infarction
peripheral vascular diseases
superficial thrombophlebitis
thrombosis prevention
extended prophylaxis
GCS (adjunctive therapy)
heparin
IPC
IPC adjunctive therapy
Prophylactic UFH
short term UFH
UFH
unfractionated heparin
vs control
vs control or placebo
vs placebo or control
vs aspirin
vs DHE
vs heparin
vs oral anticoagulant
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Description
Synopsis
Comparison
Treatments
Patients
Characteristics
Method
Risk of bias
References
None
Tools
Indexation
Results
Global trial result
Main results
All results
All result tag
NCT results
Deep vein thrombosis (96)
fatal pulmonary embolism (81)
Bleeding (79)
non-fatal pulmonary embolism (78)
Fatal bleeding (78)
All cause death (34)
Major bleeding (30)
Minor bleeding (18)
pulmonary embolism (symptomatic and asymptomatic) (17)
death, myocardial infarction, or recurrent at 14 days (11)
death, myocardial infarction, or recurrent at 30 days (11)
death at 30 days (11)
myocardial infarction at 30 days (11)
stroke (fatal and non fatal) (11)
myocardial infarction or death (11)
Drop in platelet count of 50% (11)
Revascularization (11)
myocardial infarction (fatal and non fatal) (11)
recurrent angina (11)
proximal DVT (8)
Venous thromboembolism (7)
asymptomatic DVT (5)
Symptomatic pulmonary embolism (5)
Symptomatic deep-vein thrombosis (4)
Deaths or MI (4)
reinfarction (4)
In-hospital death (4)
reinfarction at 30 days (4)
death at 30 days (4)
proximal deep-vein thrombosis (3)
Venous thromboembolism or death (3)
net benefit (3)
Amputation (2)
cardiovascular events (2)
Symptomatic venous thromboembolism (DVT, PE) (2)
Amputations (2)
distal DVT (1)
transfusion (1)
Venous thromboembolism end of treatment (1)
Extension and/or recurrence of SVT (1)
Heparin-induced thrombocytopenia (1)
wound haematoma / infection (1)
Pain disappearance (1)
Options
Numeric
bar chart
forest plot
medians
Trial
Studied trt
Control trt
patients
tags
ROB
Trial result
Deep vein thrombosis
fatal pulmonary embolism
acute coronary syndrome
Holdright, 1994
UFH
control (on top of aspirin)
negative
RISC (heparin+aspirin vs ASP), 1990
UFH
control (on top of aspirin)
negative
Theroux (heparin+ASP vs ASP), 1988
UFH
control (on top of aspirin)
Low risk of bias
suggesting
ATACS (Cohen), 1994
UFH, warfarin
control (on top of aspirin)
negative
Cohen (ATACS pilot) (heparin+aspirin vs asp), 1990
UFH, warfarin
control (on top of aspirin)
negative
Theroux (heparin vs PBO), 1988
UFH
placebo
Low risk of bias
suggesting
RISC (heparin vs PBO), 1990
UFH
placebo
negative
Theroux (heparin+aspirin vs PBO), 1988
UFH + aspirin
placebo
Low risk of bias
suggesting
RISC (ASP+ heparin vs PBO), 1990
UFH + aspirin
placebo
suggesting
Gurfinkel (UFH+aspririn vs aspirin), 1995
UFH
placebo (on top of aspirin)
Low risk of bias
negative
Cohen (ATACS pilot) (heparin vs asp), 1990
UFH, warfarin
aspirin
negative
acute myocardial infarction
ISIS-2 Pilot, 1987
UFH
no heparin
negative
DUCCS, 1994
UFH
no heparin
negative
ECSG, 1992
UFH
placebo
Low risk of bias
negative
OSIRIS, 1992
UFH
placebo
Low risk of bias
negative
peripheral vascular diseases
Antonicelli, 1999
HNF
placebo
-
Tesi, 1989
HNF
placebo
-
superficial thrombophlebitis
Belcaro (prophylactic UFH vs no), 1999
Prophylactic UFH
no treatment
-
thrombosis prevention
Killewich, 1997
IPC + UFH
control
negative
-60%
Blech, 1981
UFH
control
medical patients
suggesting
-85%
Cade
UFH
control
medical patients
-
Gardlund, 1996
UFH
control
medical patients
suggesting
34%
-74%
Handley (low dose), 1972
UFH
control
Risk of bias
negative
-100%
Handley, 1972
UFH
control
Risk of bias
negative
Gallus, 1973
UFH
control
Risk of bias
negative
Emerson, 1973
UFH
control
Risk of bias
suggesting
-84%
Zawilska, 1989
UFH
control
Risk of bias
suggesting
-79%
Warlow, 1973
UFH
control
Low risk of bias
suggesting
-84%
Morris, 1974
UFH
no treatment
suggesting
-81%
-100%
Welin-Berger, 1982
UFH
no treatment
negative
33%
Bergqvist , 1979
UFH
no treatment
suggesting
-29%
-100%
Gallus , 1973
UFH
no treatment
negative
-63%
VTCSG, 1975
UFH
no treatment
negative
Mannucci , 1976
UFH
no treatment
suggesting
-69%
Dechavanne, 1974
UFH
no treatment
suggesting
-85%
-100%
Dechavanne, 1975
UFH
no treatment
suggesting
-87%
-100%
Bergqvist, 1979
UFH
no treatment
suggesting
-35%
∞%
Galasko , 1976
UFH
no treatment
suggesting
-64%
-60%
Gallus , 1973
UFH
no treatment
suggesting
-73%
Morris , 1977
UFH
no treatment
negative
-25%
Kakkar (IMT)
UFH
no treatment
-
Gruber
UFH
no treatment
-
Gordon-Smith, 1972
UFH
no treatment
-
Nicolaides, 1972
UFH
no treatment
-
Multiunit, 1974
UFH
no treatment
-
Abernethy, 1974
UFH
no treatment
-
Clarke-Pearson, 1983
UFH
no treatment
-
Plante, 1979
UFH
no treatment
-
Abraham-Inpijn, 1979
UFH
no treatment
-
Spebar, 1981
UFH
no treatment
-
Sagar, 1974
UFH
no treatment
-
Koppenhagen, 1982
UFH
no treatment
-
Bergqvist, 1980
UFH
no treatment
-
Gallus, 1973
UFH
no treatment
-
Gallus, 1976
UFH
no treatment
-
Groote Schuur, 1979
UFH
no treatment
-
Kraytman, 1976
UFH
no treatment
-
Kraytman, 1977
UFH
no treatment
-
Kettunen, 1974
UFH
no treatment
-
Caloghera, 1984
UFH
no treatment
-
Marchelli, 1983
UFH
no treatment
-
Ziemski, 1979
UFH
no treatment
-
Coe, 1978
UFH
no treatment
-
Sebeseri, 1975
UFH
no treatment
-
Allen, 1978
UFH
no treatment
-
Cerrato, 1978
UFH
no treatment
suggesting
Williams , 1978
UFH
placebo
negative
-100%
Abraham-Inpijn , 1975
UFH
placebo
negative
-78%
Lowe , 1981
UFH
placebo
suggesting
-58%
Hampson, 1974
UFH
placebo
negative
-35%
Moskovitz, 1978
UFH
placebo
suggesting
-62%
Lahnborg, 1980
UFH
placebo
suggesting
-47%
Xabregas , 1977
UFH
placebo
negative
-100%
Moskovitz, 1978
UFH
placebo
negative
-1%
-100%
Svend-Hansen, 1981
UFH
placebo
suggesting
-46%
0%
Kakkar, 1972
UFH
placebo
-
Kiil, 1978
UFH
placebo
-
Torngren, 1978
UFH
placebo
-
Torngren
UFH
placebo
-
Lahnborg, 1975
UFH
placebo
-
Lahnborg, 1976
UFH
placebo
-
Covey, 1975
UFH
placebo
-
Belch, 1980
UFH
placebo
-
Taberner, 1978
UFH
placebo
-
Strand, 1975
UFH
placebo
-
Roberts, 1975
UFH
placebo
-
Ribaudo, 1975
UFH
placebo
-
Wu, 1977
UFH
placebo
-
Lawrence, 1977
UFH
placebo
-
Muiticentre, 1984
UFH
placebo
-
Jourdan, 1984
UFH
placebo
-
Torngren, 1978
UFH
placebo
-
Kruse-Blinkenberg, 1980
UFH
placebo
-
Kraytman, 1977
UFH
placebo
-
Marchetti, 1982
UFH
placebo
-
Bejjani, 1983
UFH
placebo
-
Hedlund, 1979
UFH
placebo
-
Kutnowski, 1977
UFH
placebo
-
Vandendris, 1980
UFH
placebo
-
Pitt, 1980
UFH
placebo
Risk of bias
negative
-53%
Siragusa (H), 1994
IPC + UFH
UFH
negative
-40%
Ramos, 1996
IPC + UFH
UFH
suggesting
Loew, 1977
UFH
aspirin
-
Vinazzer, 1980
UFH
aspirin
-
Muiticentre 53,S4, 1984
UFH
DHE
-
Muiticentre, 1984
UFH
DHE
-
van Geloven, 1977
UFH
oral anticoagulant
-
Manganelli, 1998
out of hospital UFH
standard prophylaxis
negative
Wille-Jorgensen, 1991
GCS + UFH
UFH
suggesting
-83%
Wille-Jorgensen, 1985
GCS + UFH
UFH
suggesting
-81%
*Rasmussen (adj), 1988
GCS + UFH
UFH
negative
-12%
Torngren, 1980
GCS + UFH
UFH
suggesting
-67%
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