UFH antithrombotics  

     

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Trial Studied trt Control trt patientstagsROB Trial resultDeep vein thrombosis fatal pulmonary embolism

acute coronary syndrome  

Holdright, 1994   UFHcontrol (on top of aspirin)negative
RISC (heparin+aspirin vs ASP), 1990   UFHcontrol (on top of aspirin)negative
Theroux (heparin+ASP vs ASP), 1988   UFHcontrol (on top of aspirin)Low risk of bias suggesting
ATACS (Cohen), 1994   UFH, warfarincontrol (on top of aspirin)negative
Cohen (ATACS pilot) (heparin+aspirin vs asp), 1990     UFH, warfarincontrol (on top of aspirin)negative
Theroux (heparin vs PBO), 1988   UFHplaceboLow risk of bias suggesting
RISC (heparin vs PBO), 1990   UFHplacebonegative
Theroux (heparin+aspirin vs PBO), 1988   UFH + aspirinplaceboLow risk of bias suggesting
RISC (ASP+ heparin vs PBO), 1990   UFH + aspirinplacebosuggesting
Gurfinkel (UFH+aspririn vs aspirin), 1995     UFHplacebo (on top of aspirin)Low risk of bias negative
Cohen (ATACS pilot) (heparin vs asp), 1990     UFH, warfarinaspirinnegative

acute myocardial infarction  

ISIS-2 Pilot, 1987     UFHno heparinnegative
DUCCS, 1994   UFHno heparinnegative
ECSG, 1992     UFHplaceboLow risk of bias negative
OSIRIS, 1992   UFHplaceboLow risk of bias negative

peripheral vascular diseases  

Antonicelli, 1999   HNFplacebo -
Tesi, 1989   HNFplacebo -

superficial thrombophlebitis  

Belcaro (prophylactic UFH vs no), 1999   Prophylactic UFHno treatment -

thrombosis prevention  

Killewich, 1997     IPC + UFHcontrolnegative-60%
Blech, 1981   UFHcontrolmedical patientssuggesting-85%
Cade   UFHcontrolmedical patients -
Gardlund, 1996   UFHcontrolmedical patientssuggesting34%-74%
Handley (low dose), 1972   UFHcontrolRisk of bias negative-100%
Handley, 1972   UFHcontrolRisk of bias negative
Gallus, 1973   UFHcontrolRisk of bias negative
Emerson, 1973   UFHcontrolRisk of bias suggesting-84%
Zawilska, 1989   UFHcontrolRisk of bias suggesting-79%
Warlow, 1973     UFHcontrolLow risk of bias suggesting-84%
Morris, 1974     UFHno treatmentsuggesting-81%-100%
Welin-Berger, 1982   UFHno treatmentnegative33%
Bergqvist , 1979   UFHno treatmentsuggesting-29%-100%
Gallus , 1973   UFHno treatmentnegative-63%
VTCSG, 1975   UFHno treatmentnegative
Mannucci , 1976   UFHno treatmentsuggesting-69%
Dechavanne, 1974   UFHno treatmentsuggesting-85%-100%
Dechavanne, 1975   UFHno treatmentsuggesting-87%-100%
Bergqvist, 1979   UFHno treatmentsuggesting-35%∞%
Galasko , 1976   UFHno treatmentsuggesting-64%-60%
Gallus , 1973   UFHno treatmentsuggesting-73%
Morris , 1977   UFHno treatmentnegative-25%
Kakkar (IMT)     UFHno treatment -
Gruber     UFHno treatment -
Gordon-Smith, 1972   UFHno treatment -
Nicolaides, 1972     UFHno treatment -
Multiunit, 1974   UFHno treatment -
Abernethy, 1974   UFHno treatment -
Clarke-Pearson, 1983   UFHno treatment -
Plante, 1979     UFHno treatment -
Abraham-Inpijn, 1979   UFHno treatment -
Spebar, 1981   UFHno treatment -
Sagar, 1974     UFHno treatment -
Koppenhagen, 1982   UFHno treatment -
Bergqvist, 1980   UFHno treatment -
Gallus, 1973   UFHno treatment -
Gallus, 1976   UFHno treatment -
Groote Schuur, 1979   UFHno treatment -
Kraytman, 1976   UFHno treatment -
Kraytman, 1977   UFHno treatment -
Kettunen, 1974   UFHno treatment -
Caloghera, 1984   UFHno treatment -
Marchelli, 1983   UFHno treatment -
Ziemski, 1979   UFHno treatment -
Coe, 1978   UFHno treatment -
Sebeseri, 1975   UFHno treatment -
Allen, 1978   UFHno treatment -
Cerrato, 1978   UFHno treatmentsuggesting
Williams , 1978   UFHplacebonegative -100%
Abraham-Inpijn , 1975   UFHplacebonegative-78%
Lowe , 1981     UFHplacebosuggesting-58%
Hampson, 1974     UFHplacebonegative-35%
Moskovitz, 1978   UFHplacebosuggesting-62%
Lahnborg, 1980   UFHplacebosuggesting-47%
Xabregas , 1977   UFHplacebonegative-100%
Moskovitz, 1978   UFHplacebonegative-1%-100%
Svend-Hansen, 1981   UFHplacebosuggesting-46%0%
Kakkar, 1972     UFHplacebo -
Kiil, 1978     UFHplacebo -
Torngren, 1978   UFHplacebo -
Torngren   UFHplacebo -
Lahnborg, 1975   UFHplacebo -
Lahnborg, 1976     UFHplacebo -
Covey, 1975   UFHplacebo -
Belch, 1980   UFHplacebo -
Taberner, 1978   UFHplacebo -
Strand, 1975   UFHplacebo -
Roberts, 1975   UFHplacebo -
Ribaudo, 1975   UFHplacebo -
Wu, 1977   UFHplacebo -
Lawrence, 1977   UFHplacebo -
Muiticentre, 1984   UFHplacebo -
Jourdan, 1984   UFHplacebo -
Torngren, 1978   UFHplacebo -
Kruse-Blinkenberg, 1980   UFHplacebo -
Kraytman, 1977   UFHplacebo -
Marchetti, 1982   UFHplacebo -
Bejjani, 1983   UFHplacebo -
Hedlund, 1979   UFHplacebo -
Kutnowski, 1977   UFHplacebo -
Vandendris, 1980   UFHplacebo -
Pitt, 1980   UFHplaceboRisk of bias negative-53%
Siragusa (H), 1994   IPC + UFHUFHnegative-40%
Ramos, 1996     IPC + UFHUFHsuggesting
Loew, 1977   UFHaspirin -
Vinazzer, 1980   UFHaspirin -
Muiticentre 53,S4, 1984   UFHDHE -
Muiticentre, 1984   UFHDHE -
van Geloven, 1977   UFHoral anticoagulant -
Manganelli, 1998     out of hospital UFHstandard prophylaxisnegative
Wille-Jorgensen, 1991   GCS + UFHUFHsuggesting-83%
Wille-Jorgensen, 1985   GCS + UFHUFHsuggesting-81%
*Rasmussen (adj), 1988   GCS + UFHUFHnegative-12%
Torngren, 1980   GCS + UFHUFHsuggesting-67%