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Ticlopidine
antiplatelets drug
systematic review
meta-analysis
network meta-analysis
Ticlid - 5332C - 53 32C - 53-32C - Ticlodone - Ticlodix - Ticlopidine Hydrochloride - Ticlopidine
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acute coronary syndrome
acute myocardial infarction
CABG surgery
cardiovascular prevention
coronary artery disease
diabetes type 2
percutaneous coronary intervention
peripheral vascular diseases
stable angina
stent
thrombosis prevention
anti-agrégant
antiplatelet drugs
platelet aggregation inhibitors
thienopyridine
ticlopidine
vs placebo or control
vs placebo or no treatment
vs anticoagulant + antiplatelet
vs antiplatelet drugs
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Description
Synopsis
Comparison
Treatments
Patients
Characteristics
Method
Risk of bias
References
None
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Indexation
Results
Global trial result
Main results
All results
All result tag
NCT results
All cause death (53)
Non fatal MI (39)
Fatal MI (38)
myocardial infarction (fatal and non fatal) (36)
Non fatal stroke (34)
Fatal stroke (27)
Amputation (26)
Vascular death (26)
Vascular events (24)
Adverse events (22)
Fatal bleeding (22)
Major bleeding (22)
Cardiovascular death (20)
cardiovascular events (19)
stroke (fatal and non fatal) (14)
Amputations (13)
Bleeding (11)
Non cerebral major bleeding (11)
Extracranial hemorrhage (11)
augmentation de la distance de claudication initiale (11)
augmentation de la distance de claudication (11)
Non vascular death (11)
Revascularization (7)
GUSTO severe/moderate bleeding (7)
MACE (7)
stent thrombosis (7)
Cardiovascular death/MI/stent thrombosis (7)
any bleedings (7)
Deep vein thrombosis (6)
fatal pulmonary embolism (6)
non-fatal pulmonary embolism (6)
Coronary death (5)
Coronary event (5)
unstable angina (5)
stable angina (5)
Peripheral vascular events (5)
Treatment related complication (4)
Infection (4)
non pulmonary embolism death (3)
proximal DVT (3)
wound haematoma / infection (3)
all cause death, MI, stroke (2)
ischemic stroke (2)
Occlusion (2)
GI adverse events (2)
refractory ischemia (2)
fatal bleeding (2)
non cardiovascular death (1)
Options
Numeric
bar chart
forest plot
medians
Trial
Studied trt
Control trt
patients
tags
ROB
Trial result
All cause death
Non fatal MI
acute coronary syndrome
Knudsen-A, 1985
ticlopidine
control
negative
STAI, 1990
ticlopidine
control
suggesting
-46%
Florida UA
ticlopidine
placebo
negative
0%
acute myocardial infarction
Knudsen-A, 1985
ticlopidine
control
negative
CABG surgery
Knudsen-B, 1983
ticlopidine
control
-
Zurich, 1982
ticlopidine
control
-
Kohn, 1990
ticlopidine
control
-
Romeo, 1983
ticlopidine
control
-
Liège-I, 1984
ticlopidine
placebo
Low risk of bias
negative
Liège-II, 1987
ticlopidine
placebo
Low risk of bias
negative
-67%
cardiovascular prevention
EMATAP, 1993
ticlopidine
placebo
Low risk of bias
-
Hurlow, 1980
ticlopidine
placebo
Low risk of bias
-
Katsumara, 1982
ticlopidine
placebo
Low risk of bias
-
Birmingham-A, 1979
ticlopidine
placebo
negative
-100%
Aukland, 1982
ticlopidine
placebo
Low risk of bias
-
Krause, 1980
ticlopidine
placebo
Low risk of bias
-
Stiegler, 1984
ticlopidine
placebo
Low risk of bias
-
TIMAD, 1984
ticlopidine
placebo
negative
-27%
-67%
BTRS, 1992
ticlopidine
placebo
Low risk of bias
negative
-100%
Cloarec, 1986
ticlopidine
placebo
Low risk of bias
-
Nyberg, 1984
ticlopidine
placebo
Low risk of bias
negative
∞%
Arcan, 1988
ticlopidine
placebo
Low risk of bias
-
Berglund, 1985
ticlopidine
placebo
Low risk of bias
negative
Balsano, 1989
ticlopidine
placebo
Low risk of bias
-
Ellis, 1986
ticlopidine
placebo
Low risk of bias
-
STIMS, 1990
ticlopidine
placebo
Low risk of bias
-
London diabetes, 1983
ticlopidine
placebo
negative
5%
coronary artery disease
Berglund, 1985
ticlopidine
placebo
Low risk of bias
negative
diabetes type 2
Birmingham-A, 1979
ticlopidine
placebo
negative
-100%
London diabetes, 1983
ticlopidine
placebo
negative
5%
TIMAD, 1984
ticlopidine
placebo
negative
-27%
-67%
BTRS, 1992
ticlopidine
placebo
Low risk of bias
negative
-100%
Nyberg, 1984
ticlopidine
placebo
Low risk of bias
negative
∞%
percutaneous coronary intervention
White (ticlopidine), 1991
ticlopidine
placebo
-
TACT, 1990
ticlopidine
placebo
negative
-51%
Hall, 1996
ticlopidine + aspirin
aspirin
negative
STARS (vs aspirin), 1998
ticlopidine + aspirin
aspirin
suggesting
Foussas, 2000
ticlopidine + aspirin
coumadin + aspirin
suggesting
MATTIS, 1998
ticlopidine + aspirin
coumadin + aspirin
negative
FANTASTIC, 1998
ticlopidine + aspirin
coumadin + aspirin
negative
ISAR, 1996
ticlopidine + aspirin
coumadin + aspirin
suggesting
STARS (vs coumadin+asp), 1998
ticlopidine + aspirin
coumadin + aspirin
suggesting
peripheral vascular diseases
Becquemin, 1997
ticlopidine
contrôle
-
Balsano, 1989
ticlopidine
placebo
Low risk of bias
-
STIMS, 1990
ticlopidine
placebo
Low risk of bias
-
Hurlow, 1980
ticlopidine
placebo
Low risk of bias
-
Krause, 1980
ticlopidine
placebo
Low risk of bias
-
EMATAP, 1993
ticlopidine
placebo
Low risk of bias
-
Katsumara, 1982
ticlopidine
placebo
Low risk of bias
-
Aukland, 1982
ticlopidine
placebo
Low risk of bias
-
Stiegler, 1984
ticlopidine
placebo
Low risk of bias
-
Ellis, 1986
ticlopidine
placebo
Low risk of bias
-
Cloarec, 1986
ticlopidine
placebo
Low risk of bias
-
Arcan, 1988
ticlopidine
placebo
Low risk of bias
-
stable angina
Berglund, 1985
ticlopidine
placebo
Low risk of bias
negative
stent
Hall, 1996
ticlopidine + aspirin
aspirin
negative
STARS (vs aspirin), 1998
ticlopidine + aspirin
aspirin
suggesting
MATTIS, 1998
ticlopidine + aspirin
coumadin + aspirin
negative
Foussas, 2000
ticlopidine + aspirin
coumadin + aspirin
suggesting
STARS (vs coumadin+asp), 1998
ticlopidine + aspirin
coumadin + aspirin
suggesting
ISAR, 1996
ticlopidine + aspirin
coumadin + aspirin
suggesting
FANTASTIC, 1998
ticlopidine + aspirin
coumadin + aspirin
negative
thrombosis prevention
Gardecki
Ticlopidine
placebo
Exploratory
negative
Lyon-II
Ticlopidine
placebo
Exploratory
negative
Lasierra, 1982
ticlopidine
placebo
Low risk of bias
-
Walker, 1974
ticlopidine
placebo
Low risk of bias
-
McKenna-II, 1983
Ticlopidine
placebo
Exploratory
negative
McKenna-II , 1983
ticlopidine
placebo
Low risk of bias
negative
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