chemotherapy

Pemetrexed      

Select            
Trial Studied trt Control trt patientstagsROB Trial resultobjective response (ORR)death (overall survival)

lung cancer (metastatic)  

pemetrexed  
Chen, 2008   pemetrexeddocetaxel -
Hanna, 2004     pemetrexeddocetaxel -
Li, 2012     pemetrexeddocetaxel -
Sun, 2013      NCTpemetrexeddocetaxel -
Jose, 2011     pemetrexed plus carboplatindocetaxel plus carboplatin -
Socinski, 2010      NCTpemetrexed plus carboplatindocetaxel plus carboplatin -
Smit, 2009   pemetrexed plus carboplatinpemetrexedsuggesting 191%-15%
vandetanib  
De Boer, 2011     vandetanib plus pemetrexedpemetrexednegative 142%-11%