Vemurafenib B-Raf enzyme inhibitors  

PLX 4032 - PLX4032 - RG-7204 - RG7204 - R05185426 - Zelboraf - vemurafenib      

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Trial Studied trt Control trt patientstagsROB Trial resultdeath (overall survival) progression or death (progression free survival PFS)

melanoma  

BRIM 8, 2018      NCTvemurafenibplaceboadjuvantsuggesting-28%-35%
BRIM 8 (cohort IIIC)   vemurafenibplacebonegative-20%