Various diuretics diuretics  

     

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Trial Studied trt Control trt patientstagsROB Trial resultAll cause deathCardiovascular death

hypertension  

HDFP, 1979    NCTHigh-dose diureticscontrolsuggesting
VA-I, 1967   High-dose diureticsplacebosuggesting
VA II, 1970   High-dose diureticsplacebosuggesting -50%-56%
Barraclough, 1973   High-dose diureticsplacebonegative
MRC (diu vs BB), 1985   High-dose diureticsbeta-blockers -