Trastuzumab HER2 inhibitors
systematic review meta-analysis network meta-analysis
 

Herceptin      

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Trial Studied trt Control trt patientstagsROB Trial result

advanced breast cancer (metastatic)  

TAnDEM (Kaufman), 2009   trastuzumab + anastrozoleanastrozole alone HER-2 positive HR positive -
von Minckwitz, 2009   trastuzumab + capecitabinecapecitabine alone HER-2 positive previously treated by HER-2 antibody trastuzumab failure -
Marty, 2005   trastuzumab + docetaxeldocetaxel alone 1st line HER-2 positive -
Blackwell, 2010   trastuzumab + lapatiniblapatinib alone ErbB2 positive previously treated by HER-2 antibody trastuzumab failure -
Huober, 2012   trastuzumab + letrozoleletrozole alone HER-2 positive HR positive -
Gasparini, 2006   trastuzumab + paclitaxelpaclitaxel alone HER-2 positive -
Slamon, 2001   trastuzumab + standard chemotherapystandard chemotherapy alone HER-2 positive -

early breast cancer  

NSABP B31, 2005   trastuzumabcontrolsuggesting
BCIRG006, 2013   trastuzumabcontrolsuggesting
Buzdar, 2005   trastuzumabcontrolsuggesting
FinHer, 2006   trastuzumabcontrolnegative
HERA, 2005   trastuzumabcontrolsuggesting
N9831, 2005   trastuzumabcontrolsuggesting
NOAH, 2010   trastuzumabcontrolnegative
PACS-04, 2009   trastuzumabcontrolsuggesting
N9831 (1)   trastuzumabcontrolsuggesting
N9831 (2)   trastuzumabcontrolsuggesting
FinHer (1)   trastuzumabcontrolnegative



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