Clinical trials of everolimus - TrialResults-center.org

Certican - Afinitor - RAD001 - RAD 001 - 40-O-(2-hydroxyethyl)-rapamycin - SDZ-RAD - SDZ RAD

Trial	Studied trt	Control trt	tags	ROB	Trial result	progression or death (progression free survival PFS)
Group by... in first in second in third	Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation				Global trial result Main results All results All result tag NCT results	Numeric bar chart forest plot medians
advanced breast cancer (metastatic)
BOLERO-2, 2011 NCT	everolimus + exemestane	exemestane alone	HER-2 negative HR positive nsNAI failure previously treated with endocrine therapy	Low risk of bias	conclusive
TAMRAD , 2012 NCT	everolimus + tamoxifen	tamoxifen alone	1st line HER-2 negative HR positive postmenopausal previously treated with endocrine therapy	Risk of bias	suggesting
BOLERO-3, 2014 NCT	everolimus + trastuzumab + vinorelbine	trastuzumab + vinorelbine alone	HER-2 positive previously treated by taxanes trastuzumab failure	Low risk of bias	conclusive
renal-cell carcinoma (advanced)
RECORD-1, 2008 NCT	everolimus	placebo			suggesting
RECORD 3, 2014 NCT	everolimus	sunitinib			-

Everolimus mTOR inhibitor systematic review meta-analysis network meta-analysis