Amlodipine calcium channel blockers
systematic review meta-analysis network meta-analysis
 

     

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Trial Studied trt Control trt patientstagsROB Trial resultAll cause deathcardiovascular events

diabetes type 2  

IDNT (amlodipine vs PBO), 2001       amlodipineplaceboLow risk of bias negative-12%-12%
ALLHAT (amlodipine vs chlor, diabetic subgroup), 2002       amlodipinechlorthalidoneLow risk of bias negative-4%6%
FACET, 1997     amlodipinefosinoprilRisk of bias suggesting-19%-51%

diabetic kidney disease  

IDNT (amlodipine vs PBO), 2001       amlodipineplaceboLow risk of bias negative-12%-12%

heart failure  

Packer, 1991   amlodipinecontrolLow risk of bias -
Smith, 1994     amlodipinecontrolLow risk of bias -
Udelson, 1996   amlodipinecontrolLow risk of bias -
Binkley, 1996   amlodipinecontrolLow risk of bias -
Ghali, 1997   amlodipinecontrolLow risk of bias -
PRAISE, 1996     amlodipineplaceboLow risk of bias negative-13%-8%
PRAISE II , 2000     AmlodipineplaceboLow risk of bias negative6%

hypertension  

IDNT (amlodipine vs PBO), 2001       amlodipineplaceboLow risk of bias negative-12%-12%
IDNT (amlodipine vs pbo), 2001     amlodipineplaceboLow risk of bias negative-10%
Tepel et al, 2008      NCTamlodipineplaceboLow risk of bias negative-22%-38%
ASCOT-BPLA, 2005     amlodipineatenololRisk of bias suggesting-10%-15%
ALLHAT (CCB vs diu), 2002     amlodipinechlorthalidonenegative -4%4%
ALLHAT (amlodipine vs chlor, diabetic subgroup), 2002       amlodipinechlorthalidoneLow risk of bias negative-4%6%
FACET, 1997     amlodipinefosinoprilRisk of bias suggesting-19%-51%
ACCOMPLISH, 2008        NCTamlodipine plus benazeprilhydrochlorothiazide plus benazeprilLow risk of bias suggesting-10%-18%
ALLHAT (CCB vs ACEI), 2002     amlodipinelisinoprilsuggesting-4%-3%
AASK (amlodipine vs metoprolol), 2002     amlodipinemetoprololnegative-30%

percutaneous coronary intervention  

Jorgensen (NICOLE), 2001     amlodipineplaceboLow risk of bias suggesting



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