Sitagliptin antidiabetic drugs
systematic review meta-analysis network meta-analysis
 

MK-0431 - MK0431 - MK 0431 - Januvia - sitagliptin phosphate - sitagliptin      

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Trial Studied trt Control trt patientstagsROB Trial resultcardiovascular eventsCardiovascular death

diabetes type 2  

Stafford , 2011      NCTsitagliptin -
Reasner, 2011      NCTsitagliptincontrol (add on MET) -
Arechavaleta, 2011      NCTsitagliptinglimepiride (add on MET)Low risk of bias -
Aschner, 2010      NCTsitagliptin monotherapymetforminLow risk of bias -
Derosa , 2010     sitagliptin+piometformin+pio -
Goldstein, 2007      NCTsitagliptinplacebonegative
Hanefeld, 2007     sitagliptinplacebonegative
TECOS, 2015          NCTsitagliptinplaceboLow risk of bias negative-1%3%
Scott* (sit vs pbo), 2007     sitagliptin 50mg bid monotherapyplacebonegative
Aschner, 2006      NCTsitagliptin monotherapyplacebonegative
Nonaka, 2008      NCTsitagliptin monotherapyplaceboLow risk of bias negative
Raz, 2006     sitagliptin monotherapyplacebonegative
Barzilai, 2011      NCTsitagliptin monotherapyplaceboLow risk of bias -
Mohan , 2009     sitagliptin monotherapyplaceboLow risk of bias -
Chan, 2008     sitagliptin monotherapyplaceboLow risk of bias -
Vilsbøll, 2010      NCTsitagliptinplacebo (add on insulin+/-MET)Low risk of bias -
Charbonnel, 2006      NCTsitagliptinplacebo (add on MET)negative
Nauck, 2007          NCTsitagliptinplacebo (add on MET)negative
Scott** (sit vs pbo on top met), 2007     sitagliptinplacebo (add on MET)negative
raz, 2008      NCTsitagliptinplacebo (add on MET) -
Rosenstock , 2006      NCTsitagliptinplacebo (add on PIO)Low risk of bias -
Rosenstock (sit on top pio vs pbo), 2006      NCTsitagliptinplacebo (on top PIO)suggesting
Hermansen, 2007     sitagliptinplacebo (on-top glimepiride+/- metformine)negative
Rigby , 2010     sitagliptinrosiglitazone (add on MET) -
Al Sifri, 2011     sitagliptinSulphonylurea (on top MET) -
Iwamoto , 2010     sitagliptin monotherapyvogliboseLow risk of bias -
Scott* (sit vs glipi), 2007     sitagliptin 50mg bid monotherapyglipizideLow risk of bias -
Goldstein (sit vs met), 2007     sitagliptinmetformin -
Goldstein (sit+met vs met), 2007     sitagliptinmetformin -
Pérez-Monteverde, 2011      NCTsitagliptinpioglitazoneLow risk of bias -



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