Rosiglitazone antidiabetic drugs
systematic review meta-analysis network meta-analysis
 

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Trial Studied trt Control trt patientstagsROB Trial resultAll cause deathmyocardial infarction (fatal and non fatal)

diabetes type 2  

BRL 49653C/185   rosiglitazoneExploratory -
SB-712753/009   rosiglitazoneExploratory -
SB-712753/007   rosiglitazoneExploratory -
AVM100264    NCTrosiglitazoneExploratory -
Wang, 2005     rosiglitazonecontrolExploratory -
49653/097   rosiglitazoneglyburideExploratory -
49653/020   rosiglitazoneglyburideExploratory -
49653/143    NCTrosiglitazoneglyburideExploratory -
49653/079   rosiglitazoneglyburideExploratory -
49653/080   rosiglitazoneglyburideExploratory -
49653/137    NCTrosiglitazoneglyburide (add on MET)Exploratory -
49653/093   rosiglitazonemetforminExploratory -
49653/094   rosiglitazonemetforminExploratory -
DREAM rosiglitazone, 2006      NCTrosiglitazoneplaceboLow risk of bias suggesting 1%
49653/136   rosiglitazoneplaceboExploratory -
49653/011   rosiglitazoneplaceboExploratory -
49653/128   rosiglitazoneplaceboExploratory -
49653/134   rosiglitazoneplaceboExploratory -
49653/330   rosiglitazoneplaceboExploratory -
49653/331   rosiglitazoneplaceboExploratory -
BRL 49653/334    NCTrosiglitazoneplaceboExploratory -
AVA100193   rosiglitazoneplaceboExploratory -
49653/145   rosiglitazoneplacebo (add on glicazide)Exploratory -
49653/234   rosiglitazoneplacebo (add on glimepiride)Exploratory -
49653/135   rosiglitazoneplacebo (add on glipizide)Exploratory -
100684    NCTrosiglitazoneplacebo (add on glyburide)Exploratory -
49653/162   rosiglitazoneplacebo (add on glyburide)Exploratory -
49653/127   rosiglitazoneplacebo (add on glyburide)Exploratory -
BRL 49653/347    NCTrosiglitazoneplacebo (add on insulin)Exploratory -
49653/095   rosiglitazoneplacebo (add on insulin)Exploratory -
49653/085   rosiglitazoneplacebo (add on insulin)Exploratory -
49653/284    NCTrosiglitazoneplacebo (add on MET)Exploratory -
712753/008    NCTrosiglitazoneplacebo (add on MET)Exploratory -
SB-712753/002   rosiglitazoneplacebo (add on MET)Exploratory -
SB-712753/003   rosiglitazoneplacebo (add on MET)Exploratory -
49653/147   rosiglitazoneplacebo (add on SU)Exploratory -
49653/015   rosiglitazoneplacebo (add on SU)Exploratory -
49653/132   rosiglitazoneplacebo (add on SU)Exploratory -
49653/125    NCTrosiglitazoneplacebo (add on SU)Exploratory -
49653/211   rosiglitazoneusual careExploratory -
APPROACH, 2008        NCTrosiglitazoneglipizideLow risk of bias -
ADOPT, 2006        NCTrosiglitazonestandard glucose-lowering drugsLow risk of bias negative40%
RECORD, 2009          NCTrosiglitazonestandard glucose-lowering drugsRisk of bias negative -13%15%

impaired fasting glucose  

DREAM rosiglitazone, 2006      NCTrosiglitazoneplaceboLow risk of bias suggesting 1%



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