Taxanes

systematic review meta-analysis network meta-analysis

Select advanced breast cancer (metastatic)lung cancer (metastatic) All type of patient       3-weekly docetaxelA CLASSERdocetaxel-based doubletnab-paclitaxeltaxanes alonetaxanes in combinationweekly docetaxelweekly taxanes docetaxelnab-paclitaxelpaclitaxel vs A CLASSERvs combination chemotherapyvs Every three weeks regimenvs single-agent chemotherapy       1st line2nd line2nd+ lineHER-2 positivenot previously treated by anthracyclineprevious anthracycline

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Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result
advanced breast cancer (metastatic)
docetaxel
JCOG, 2005	docetaxel	doxorubicin + cyclophosphamide		1st line	Exploratory	negative
Blohmer, 2010	docetaxel + epirubicin	epirubicin, cyclophosphamide		1st line	Risk of bias	negative
Rivera , 2008	Weekly Docetaxel	Every three weeks Docetaxel				-
Tabernero , 2004	Weekly Docetaxel	Every three weeks Docetaxel				-
Sedky , 2002	Weekly Docetaxel	Every three weeks Docetaxel				-
Willemse , 2007	Weekly Docetaxel	Every three weeks Docetaxel				-
Bontenbal, 2005	docetaxel + doxorubicin	fluorouracil, doxorubicin, cyclophosphamide		1st line	Risk of bias	suggesting
Bonneterre, 2004	docetaxel + epirubicin	fluorouracil, epirubicin, cyclophosphamide			Risk of bias	suggesting
TXT Group, 2002	docetaxel	fluorouracil, vinorelbine		2nd line previous anthracycline	Exploratory	suggesting
304 Study Group, 1999	docetaxel	mitomycin, vinblastine		2nd+ line previous anthracycline	Risk of bias	suggesting
Sjostrom, 1999	docetaxel	sequential methotrexate and 5-fluorouracil		2nd+ line previous anthracycline	Exploratory	suggesting
HERNATA, 2011	docetaxel + trastuzumab	vinorelbine, trastuzumab		1st line HER-2 positive	Exploratory	suggesting
nab-paclitaxel
Gradishar, 2009              NCT	nab-paclitaxel	docetaxel		1st line	Exploratory	-
Roy, 2008        NCT	nab-paclitaxel +gencotabine	gencitabine		1st line		-
paclitaxel
Talbot, 2002	pacclitaxel	capecitabine			Exploratory	negative
TOG, 2005	paclitaxel	cisplatin, etoposide			Exploratory	negative
ANZ TITG, 1999	paclitaxel	CMFP		1st line	Risk of bias	suggesting
EORTC 10923, 2000	paclitaxel	doxorubicin		1st line	Exploratory	negative
ECOG E1193 (B), 2003	paclitaxel	doxorubicin			Exploratory	negative
UKCCCR AB01, 1997	paclitaxel + epirubicin	epirubicin, cyclophosphamide		1st line	Exploratory	suggesting
Gradishar , 2009	Weekly Paclitaxel	Every three weeks Docetaxel			Exploratory	negative
Fountzilas , 2008	Weekly Paclitaxel	Every three weeks Docetaxel				negative
Khoo , 2006	split dose	Every three weeks Paclitaxel		not previously treated by anthracycline		negative
CLGB 9840 (Seidman), 2008	Weekly Paclitaxel	Every three weeks Paclitaxel				suggesting
Frasci , 2006	Weekly Paclitaxel	Every three weeks Paclitaxel				negative
Frasci , 2005	Weekly Paclitaxel	Every three weeks Paclitaxel				negative
Sikov , 2002	Weekly Paclitaxel	Every three weeks Paclitaxel				negative
Jassem, 2001	paclitaxel + doxorubicin	fluorouracil, doxorubicin, cyclophosphamide		1st line	Exploratory	suggesting
CECOG BM1, 2005	gemcitabine, epirubicin, paclitaxel	fluorouracil, epirubicin, cyclophosphamide		1st line	Exploratory	suggesting
Dieras, 1995	paclitaxel	mitomycin			Exploratory	negative
lung cancer (metastatic)
docetaxel
TAX 317 (Shepherd) 100mg/m2, 2000	docetaxel					-
TAX 320 100mg/m2, 2000	docetaxel					-
DISTAl 01 (Gridelli) , 2004	weekly docetaxel	3-weekly docetaxel				-
Camps	weekly docetaxel	3-weekly docetaxel				-
Schuette	weekly docetaxel	3-weekly docetaxel				-
Gervais	weekly docetaxel	3-weekly docetaxel				-
Lai	weekly docetaxel	3-weekly docetaxel				-
Chen	weekly docetaxel	3-weekly docetaxel				-
Esteban, 2003	paclitaxel 80mg/m2	m2docetaxel 36 mg/				-