vasodilators therapy

systematic review meta-analysis network meta-analysis

Select acute heart failureheart failureperipheral vascular diseases acute decompensated heart failureAll type of patient       epoprostenolhuman B-type natriuretic peptidehydralazinehydralazine-ISDNisosorbide dinitrateprazosinsympathectomie avec chirurgieVasodilator Agents buflomedilcilostazolepoprostenolginko bilobahydralazinehydralazine-ISDNisosorbide dinitratenaftidrofurylnesiritidepentoxifylline vs placebo or controlvs placebo or no treatmentvs active treatmentvs angiotensin-converting enzyme inhibitorsvs prostaglandine      

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Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results	All cause death (32)Treatment related complication (15)myocardial infarction (fatal and non fatal) (13)stroke (fatal and non fatal) (6)Amputation (3)Revascularization (1)Cardiovascular death (1)cardiovascular events (1)Infection (1)cardiac death (1)Death from any cause or hospitalization for heart failure (1)amelioration of Dyspnea at 24 h (1)30-day death (1)hospitalisation for heart failure (1) Options Numeric bar chart forest plot medians
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	All cause death	Treatment related complication
heart failure
epoprostenol
FIRST, 1997	epoprostenol	standard care			Exploratory	-
hydralazine
Chatterjee, 1980	hydralazine	control			Exploratory	-
Magorien , 1984	hydralazine	placebo			Low risk of bias	-
Conradson , 1984	hydralazine	placebo			Exploratory	-
Franciosa, 1982	hydralazine	placebo			Low risk of bias	-
hydralazine-ISDN
VHeFT I (hydralazine ISDN), 1986	hydralazine-ISDN	placebo			Low risk of bias	negative
isosorbide dinitrate
NICE (Lewis), 1999	isosorbide dinitrate	placebo				-
Franciosa , 1978	isosorbide dinitrate	placebo			Low risk of bias	-
nesiritide
NSGET (comparative trial), 2000	nesiritide	control			Low risk of bias	remark
ASCEND-HF, 2011        NCT	nesiritide	placebo			Low risk of bias	negative
FUSION 2, 2008        NCT	nesiritide	placebo			Low risk of bias	remark
PROACTION, 2003	nesiritide	placebo			Low risk of bias	negative
BNP-CARDS, 2007          NCT	nesiritide	placebo			Low risk of bias	remark
NSGET (efficacy trial), 2000	nesiritide	placebo			Low risk of bias	negative
VMAC (intravenous neseritide), 2002      NCT	nesiritide	placebo			Low risk of bias	remark
PRECEDENT, 2002      NCT	nesiritide	dobutamine			Exploratory	remark
VMAC (24h), 2002      NCT	nesiritide	nitroglycerin			Risk of bias	negative
FUSION 1, 2004    NCT	nesiritide	standard care			Low risk of bias	remark
peripheral vascular diseases
buflomedil
Diamantopoulos, 2001	buflomédil	placebo				-
LIMB, 2008	buflomedil	placebo			Low risk of bias	suggesting
cilostazol
Strandness, 2002	cilostazol	placebo				-
Dawson (cilostazol), 2000	cilostazol	placebo				-
Elam, 1998	cilostazol	placebo			Low risk of bias	-
Otsuka 21-95-201	cilostazol	placebo			Low risk of bias	-
Beebe, 1999	cilostazol	placebo				-
Dawson, 1998	cilostazol	placebo				-
Money, 1998	cilostazol	placebo				-
ginko biloba
Peters, 1998	ginko biloba	placebo				-
Bauer, 1984	ginko biloba	placebo				-
naftidrofuryl
Meehan, 1982	naftidrofuryl IV	control				-
NCIS, 2001	naftidrofuryl	placebo				-
NIQOL belgium, 2001	naftidrofuryl	placebo				-
NIQOL germany, 1999	Naftidrofuryl	placebo				-
Clyne, 1980	naftidrofuryl	placebo				-
Testart, 1994	naftidrofuryl IV	placebo				-
D'Hooge D, 2001	naftidrofuryl IV	placebo				-
Negus, 1987	naftidrofuryl IV	prostacyclin				-
pentoxifylline
Belcaro, 2002	pentoxifylline	placebo				-
Dawson (pentoxifylline), 2000	pentoxifylline	placebo				-
Porter, 1982	pentoxifylline	placebo				-
Donaldson, 1984	pentoxifylline	placebo				-
APIC, 1989	pentoxifylline	placebo				-