stent

systematic review meta-analysis network meta-analysis

Select antiplatelets drugantithromboticsdual antiplatelet therapy All type of patient       6 months DAPTantiplatelet drugsdual antiplatelet therapyprolonged dual antiplatelet therapytriple antiplatelet cilostazolclopidogrelticlopidine vs anticoagulant + antiplateletvs antiplatelet drugsvs short antiplatelet drugvs standard clopidogrel      

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Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results	MACE (23)All cause death (14)stent thrombosis (14)myocardial infarction (fatal and non fatal) (13)stroke (fatal and non fatal) (12)Major bleeding (11)Cardiovascular death/MI/stent thrombosis (2)GUSTO severe/moderate bleeding (2)any bleedings (2)Cardiovascular death (2) Options Numeric bar chart forest plot medians
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	MACE	All cause death
antithrombotics
not classified
DECLARE-LONG II , 2011						-
EXCELLENT, 2011      NCT	6-month dual antiplatelet therapy	12 months dual antiplatelet				negative
PRODIGY, 2011      NCT	24 months of dual antiplatelet treatment	6 months dual antiplatelet				negative
WOEST    NCT	triple therapy	dual antiplatelet therapy				-
RESET    NCT	Endeavor stent and three months of DAPT	standard 12-month DAPT and other DES				negative
DES-LATE, 2010    NCT	prolonged dual antiplatelet therapy	12 months dual antiplatelet			Risk of bias	negative
ISAR-SAFE, 2009      NCT	12 months dual antiplatelet	6 months dual antiplatelet			Low risk of bias	-
CILON-T, 2010	triple antiplatelet	dual antiplatelet therapy			Exploratory	negative
cilostazol
Kunishima, 1997	cilostazol	aspirin				negative
Sekiya, 1998	cilostazol + aspirin	aspirin				negative
Yoon, 1999	cilostazol + aspirin	ticlopidine + aspirin				negative
Kamishirado, 2002	cilostazol + aspirin	ticlopidine + aspirin				negative
Kozuma, 2001	cilostazol + aspirin	ticlopidine + aspirin				negative
Ochiai, 1999	cilostazol + aspirin	ticlopidine + aspirin				negative
Park, 1999	cilostazol + aspirin	ticlopidine + aspirin				negative
clopidogrel
REAL-LATE, ZEST-LATE, 2010      NCT	clopidogrel+aspirin	aspirin				negative
GRAVITAS, 2011      NCT	high-dose clopidogrel	normal-dose clopidogrel			Risk of bias	negative
Müller, 2000	clopidogrel + aspirin	ticlopidine + aspirin				negative
CLASSICS, 2000	clopidogrel + aspirin	ticlopidine + aspirin				negative
TOPPS, 2001	clopidogrel + aspirin	ticlopidine + aspirin				negative
Piamsomboon, 2001	clopidogrel + aspirin	ticlopidine + aspirin				negative
ticlopidine
STARS (vs aspirin), 1998	ticlopidine + aspirin	aspirin				suggesting
Hall, 1996	ticlopidine + aspirin	aspirin				negative
FANTASTIC, 1998	ticlopidine + aspirin	coumadin + aspirin				negative
ISAR, 1996	ticlopidine + aspirin	coumadin + aspirin				suggesting
Foussas, 2000	ticlopidine + aspirin	coumadin + aspirin				suggesting
MATTIS, 1998	ticlopidine + aspirin	coumadin + aspirin				negative
STARS (vs coumadin+asp), 1998	ticlopidine + aspirin	coumadin + aspirin				suggesting
dual antiplatelet therapy
not classified
OPTIMIZE, 2013      NCT	3 months DAPT	12 months DAPT			Risk of bias	-
EXCELLENT, 2011      NCT	6-month dual antiplatelet therapy	12 months dual antiplatelet				negative
PRODIGY, 2011      NCT	24 months of dual antiplatelet treatment	6 months dual antiplatelet				negative
RESET    NCT	Endeavor stent and three months of DAPT	standard 12-month DAPT and other DES				negative
DES-LATE, 2010    NCT	prolonged dual antiplatelet therapy	12 months dual antiplatelet			Risk of bias	negative
ISAR-SAFE, 2009      NCT	12 months dual antiplatelet	6 months dual antiplatelet			Low risk of bias	-
clopidogrel
REAL-LATE, ZEST-LATE, 2010      NCT	clopidogrel+aspirin	aspirin				negative
GRAVITAS, 2011      NCT	high-dose clopidogrel	normal-dose clopidogrel			Risk of bias	negative