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Trial | Studied trt | Control trt | patients | tags | ROB | Trial result | All cause death | reinfarction |
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ISIS-4, 1995 | captopril | placebo | | | Low risk of bias | - | | |
CCS-1, 1995 | captopril | placebo | | | Low risk of bias | - | | |
French, 1999 | captopril | placebo | | | Low risk of bias | - | | |
CATS, 1996 | captopril | placebo | | | Low risk of bias | - | | |
ECCE, 1997 | captopril | placebo | | | Low risk of bias | - | | |
Sharpe, 1991 | captopril | placebo | | | Low risk of bias | - | | |
Ray, 1993 | captopril | placebo | | | Low risk of bias | - | | |
Nabel, 1991 | captopril | placebo | | | Low risk of bias | - | | |
Bussmann, 1992 | captopril | placebo | | | Low risk of bias | - | | |
Di Pasquale, 1994 | captopril | placebo | | | Low risk of bias | - | | |
Di Pasquale, 1997 | captopril | placebo | | | Low risk of bias | - | | |
Galcera, 1993 | captopril | placebo | | | Low risk of bias | - | | |
Hargreaves, 1992 | captopril | placebo | | | Low risk of bias | - | | |
SAVE, 1992 | captopril | placebo | | | Low risk of bias | - | | |
Pfeffer, 1988 | captopril | placebo | | | Low risk of bias | - | | |
Sogaard, 1994 | captopril | placebo | | | Low risk of bias | - | | |
Sharpe, 1988 | captopril | placebo | | | Low risk of bias | - | | |
Mortarino, 1990 | captopril | placebo | | | Low risk of bias | - | | |
PRACTICAL (captopril), 1994 | captopril or enalapril | placebo | | | Low risk of bias | - | | |
|
CONSENSUS 2, 1992 | enalapril | placebo | | | Low risk of bias | - | | |
Schulman, 1995 | enalapril | placebo | | | Low risk of bias | - | | |
|
FAMIS, 1998 | fosinopril | placebo | | | Low risk of bias | - | | |
|
GISSI 3, 1994 | lisinopril | placebo | | | Risk of bias | - | | |
|
Wagner, 2002 | ramipril | placebo | | | Low risk of bias | - | | |
AIRE, 1993 | ramipril | placebo | | | Low risk of bias | - | | |
|
TRACE, 1995 | trandolapril | placebo | | | Low risk of bias | - | | |
|
SMILE, 1995 | zofenopril | placebo | | | Low risk of bias | suggesting | | |
|
|
OPTIMAAL, 2002 | Losartan | Captopril | | | Low risk of bias | suggesting | | |
|
VALIANT (valsartan+capropril), 2003 | Valsartan+ACE inhibitor | ACE inhibitor only | | | Low risk of bias | negative | | |
VALIANT (valsartan alone), 2003 | Valsartan | Captopril | | | Low risk of bias | negative | | |
|
|
Koster and Dunning, 1985 | IM lidocaine (without infusion) | control | | | Risk of bias | negative | | |
Bennett, 1970 | IV lidocaine infusion | control | | | Risk of bias | negative | | |
Pitt, 1971 | IV lidocaine infusion | control | | | Risk of bias | negative | | |
Darby, 1972 | IV lidocaine infusion | control | | | Risk of bias | negative | | |
Sandlar | IM lidocaine (without infusion) | placebo | | | Low risk of bias | negative | | |
Singh and Kocot, 1976 | IM lidocaine (without infusion) | placebo | | | Low risk of bias | negative | | |
Lie (IM), 1978 | IM lidocaine (without infusion) | placebo | | | Low risk of bias | negative | | |
Dunn, 1985 | IM lidocaine (without infusion) | placebo | | | Low risk of bias | negative | | |
Kostuk and Beanlands | IV lidocaine infusion | placebo | | | Low risk of bias | negative | | |
Baker, 1971 | IV lidocaine infusion | placebo | | | Low risk of bias | negative | | |
Chopra, 1971 | IV lidocaine infusion | placebo | | | Low risk of bias | negative | | |
O | IV lidocaine infusion | placebo | | | Low risk of bias | negative | | |
Lie (IV), 1974 | IV lidocaine infusion | placebo | | | Low risk of bias | negative | | |
Wyse, 1988 | IV lidocaine infusion | placebo | | | Low risk of bias | negative | | |
|
DIAMOND MI, 1997 | dofetilide | placebo | | | Low risk of bias | - | | |
|
ISIS-4, 1995 | magnesium | control | | | | suggesting | | |
Wu, 1992 | magnesium | control | | | Low risk of bias | suggesting | | |
Zhu, 2002 | magnesium | control | | | | suggesting | | |
Abraham, 1987 | magnesium | placebo | | | Low risk of bias | negative | | |
MAGIC, 2000 NCT | magnesium | placebo | | | Low risk of bias | negative | | |
Bhargava, 1995 | magnesium | placebo | | | Low risk of bias | suggesting | | |
Ceremuzynski, 1989 | magnesium | placebo | | | | suggesting | | |
Chen, 1991 | magnesium | placebo | | | | suggesting | | |
Feldstedt, 1991 | magnesium | placebo | | | Low risk of bias | negative | | |
Gyamlani, 2000 | magnesium | placebo | | | Low risk of bias | suggesting | | |
Ising, 1990 | magnesium | placebo | | | | - | | |
Morton, 1984 | magnesium | placebo | | | Low risk of bias | negative | | |
Nakashima, 2004 | magnesium | placebo | | | Low risk of bias | negative | | |
Parikka, 1990 | magnesium | placebo | | | Low risk of bias | negative | | |
Raghu, 1999 | magnesium | placebo | | | Low risk of bias | suggesting | | |
Rasmussen, 1986 | magnesium | placebo | | | Low risk of bias | negative | | |
Santoro, 2000 | magnesium | placebo | | | Low risk of bias | negative | | |
Shechter, 1990 | magnesium | placebo | | | Low risk of bias | suggesting | | |
Shechter, 1991 | magnesium | placebo | | | Low risk of bias | negative | | |
Shechter, 1995 | magnesium | placebo | | | Low risk of bias | suggesting | | |
Singh, 1990 | magnesium | placebo | | | Low risk of bias | suggesting | | |
Smith, 1986 | magnesium | placebo | | | Low risk of bias | negative | | |
Thogersen, 1995 | magnesium | placebo | | | Low risk of bias | negative | | |
Urek, 1996 | magnesium | placebo | | | Low risk of bias | negative | | |
Woods, 1992 | magnesium | placebo | | | Low risk of bias | suggesting | | |
|
CAST II (early treatment), 1992 | moricizine | placebo | | | Low risk of bias | - | | |
|
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Sixty Plus reinfarction Study, 1980 | any anticoagulant | placebo | | | Low risk of bias | - | | |
German-Austrian Study Group (oac vs pbo), 1980 | phenprocoumon | placebo | | | Low risk of bias | negative | | |
EPSIM, 1982 | any anticoagulant | aspirin | | | | negative | | |
German-Austrian Study Group (oac vs asp), 1980 | phenprocoumon | aspirin | | | Low risk of bias | negative | | |
|
ASPECT-2 (coumadin+ASA vs ASA), 2002 | coumadin | control (on top of aspirin) | | | | negative | | |
ASPECT, 1994 | coumadin | placebo | | | Low risk of bias | suggesting | | |
ASPECT-2 (coumadin alone), 2002 | coumadin | aspirin | | | | suggesting | | |
|
APRICOT-2, 2002 | warfarin | control (on top of aspirin) | | | | suggesting | | |
Zibaeenezhad, 2004 | warfarin | control (on top of aspirin) | | | | negative | | |
WARIS, 1999 | warfarin | control (on top of aspirin) | | | Low risk of bias | - | | |
CHAMP, 2002 | warfarin | control (on top of aspirin) | | | | negative | | |
CARS (warafrin 3mg), 1997 | warfarin | control (on top of aspirin) | | | Low risk of bias | suggesting | | |
LoWASA, 2004 | warfarin | control (on top of aspirin) | | | Risk of bias | suggesting | | |
CARS (warfarin 1mg), 1997 | warfarin | control (on top of aspirin) | | | Low risk of bias | negative | | |
WARIS II (warfarin+ASA), 2002 | warfarin | control (on top of aspirin) | | | | suggesting | | |
Williams, 1997 | warfarin | placebo (on top of aspirin) | | | Low risk of bias | suggesting | | |
WARIS II (warfarin alone), 2002 | warfarin | aspirin | | | | suggesting | | |
|
|
Jones, 1987 | dazoxiben | control | | | | negative | | |
GRAND, 1987 | GR3219B | control | | | | negative | | |
Gent-AMI, 1968 | misc. | control | | | | negative | | |
Johannessen, 1989 | misc. | control | | | | negative | | |
French, 1993 | flurbiprofen | placebo | | | Low risk of bias | suggesting | | |
|
Huddinge, 1988 | aspirin | control | | | | negative | | |
Frankfurt, 1976 | aspirin | control | | | | negative | | |
Dutch-aspirin, 1990 | aspirin | placebo | | | Low risk of bias | negative | | |
ISIS-pilot, 1987 | aspirin | placebo | | | Low risk of bias | negative | | |
ISIS-2, 1988 | aspirin | placebo | | | Low risk of bias | suggesting | | |
APRICOT, 1993 | aspirin | placebo | | | Low risk of bias | suggesting | | |
|
COMMIT, 2005 NCT | clopidogrel | placebo | | | Low risk of bias | suggesting | | |
CLARITY-TIMI 28, 2005 | clopidogrel | placebo | | | Low risk of bias | - | | |
|
ERASE-MI, 2009 | elinogrel | placebo | | | Low risk of bias | negative | | |
|
Dutch sulphinpyrazone, 1986 | sulfinpyrazone | control | | | | negative | | |
Wilcox, 1980 | sulfinpyrazone | placebo | | | | negative | | |
Louvain sulphinpyrazone, 1983 | sulfinpyrazone | placebo | | | Low risk of bias | negative | | |
|
Knudsen-A, 1985 | ticlopidine | control | | | | negative | | |
|
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Sixty Plus reinfarction Study, 1980 | any anticoagulant | placebo | | | Low risk of bias | - | | |
German-Austrian Study Group (oac vs pbo), 1980 | phenprocoumon | placebo | | | Low risk of bias | negative | | |
EPSIM, 1982 | any anticoagulant | aspirin | | | | negative | | |
German-Austrian Study Group (oac vs asp), 1980 | phenprocoumon | aspirin | | | Low risk of bias | negative | | |
|
ARGAMI-2, 1998 | Argatroban | heparin | | | | - | | |
|
HERO, 1997 | bivalirudin | heparin | | | Low risk of bias | suggesting | | |
|
ASPECT-2 (coumadin+ASA vs ASA), 2002 | coumadin | control (on top of aspirin) | | | | negative | | |
ASPECT, 1994 | coumadin | placebo | | | Low risk of bias | suggesting | | |
ASPECT-2 (coumadin alone), 2002 | coumadin | aspirin | | | | suggesting | | |
|
FRAMI, 1997 | Dalteparin | placebo | | | | - | | |
BIOMACS II, 1999 | Dalteparin | placebo | | | Low risk of bias | - | | |
ASSENT Plus, 2003 | Dalteparin | UFH | | | | negative | | |
|
AMI-SK, 2002 | Enoxaparin | placebo | | | Low risk of bias | - | | |
ASSENT 3, 2001 | Enoxaparin | UFH | | | | suggesting | | |
HART II, 2001 | Enoxaparin | UFH | | | | negative | | |
Baird, 2002 | Enoxaparin | UFH | | | | negative | | |
ENTIRE-TIMI 2, 2002 | Enoxaparin | UFH | | | | suggesting | | |
ASSENT 3 Plus, 2003 | Enoxaparin | UFH | | | | negative | | |
|
MICHELANGELO OASIS-6, 2006 NCT | fondaparinux | placebo | | | Low risk of bias | suggesting | | |
|
HIT-4, 1999 | Hirudin | heparin | | | Low risk of bias | - | | |
TIMI 9B, 1996 | Hirudin | heparin | | | Risk of bias | - | | |
|
CREATE, 2005 | Reviparin | placebo | | | Low risk of bias | - | | |
|
ISIS-2 Pilot, 1987 | UFH | no heparin | | | | negative | | |
DUCCS, 1994 | UFH | no heparin | | | | negative | | |
ECSG, 1992 | UFH | placebo | | | Low risk of bias | negative | | |
OSIRIS, 1992 | UFH | placebo | | | Low risk of bias | negative | | |
|
APRICOT-2, 2002 | warfarin | control (on top of aspirin) | | | | suggesting | | |
Zibaeenezhad, 2004 | warfarin | control (on top of aspirin) | | | | negative | | |
WARIS, 1999 | warfarin | control (on top of aspirin) | | | Low risk of bias | - | | |
CHAMP, 2002 | warfarin | control (on top of aspirin) | | | | negative | | |
CARS (warafrin 3mg), 1997 | warfarin | control (on top of aspirin) | | | Low risk of bias | suggesting | | |
LoWASA, 2004 | warfarin | control (on top of aspirin) | | | Risk of bias | suggesting | | |
CARS (warfarin 1mg), 1997 | warfarin | control (on top of aspirin) | | | Low risk of bias | negative | | |
WARIS II (warfarin+ASA), 2002 | warfarin | control (on top of aspirin) | | | | suggesting | | |
Williams, 1997 | warfarin | placebo (on top of aspirin) | | | Low risk of bias | suggesting | | |
WARIS II (warfarin alone), 2002 | warfarin | aspirin | | | | suggesting | | |
|
|
Julian , 1982 | Sotalol | placebo | | | Low risk of bias | negative | | |
|
Azancot, 1982 | Acebutolol | placebo | | | | negative | | |
APSI, 1990 | Acebutolol | placebo | | | Low risk of bias | suggesting | | |
|
Andersen , 1979 | Alprenolol | placebo | | | Low risk of bias | negative | | |
Wilhelmsson , 1974 | Alprenolol | placebo | | | Low risk of bias | negative | | |
|
ISIS1 Collaborative Group , 1986 | Atenolol | placebo | | | | negative | | |
Van de Werf , 1993 | Atenolol | placebo | | | | negative | | |
Yusuf , 1980 | Atenolol | placebo | | | | negative | | |
|
Yang , 1987 | Betaxolol | placebo | | | | negative | | |
|
Basu , 1997 | Carvedilol | placebo | | | Low risk of bias | suggesting | | |
|
Heber , 1987 | Labetalol | placebo | | | | negative | | |
|
MIAMI Trial Research Group , 1985 | | placebo | | | | negative | | |
Von Essen , 1982 | | placebo | | | | negative | | |
TIMI IIB, 1989 | | placebo | | | | negative | | |
Hjalmarson , 1981 | Metoprolol | placebo | | | Low risk of bias | suggesting | | |
LIT Research Group , 1987 | Metoprolol | placebo | | | Low risk of bias | negative | | |
Manger Cats , 1983 | Metoprolol | placebo | | | Low risk of bias | negative | | |
Rehnqvist , 1983 | Metoprolol | placebo | | | Low risk of bias | suggesting | | |
Salathia , 1985 | Metoprolol | placebo | | | Low risk of bias | suggesting | | |
Waagstein , 1975 | Practololormetoprolol | placebo | | | | negative | | |
|
CPRG , 1981 | Oxprenolol | placebo | | | | negative | | |
Fuccella , 1968 | Oxprenolol | placebo | | | | negative | | |
Lombardo , 1979 | Oxprenolol | placebo | | | | negative | | |
Wilcox , 1980 | Oxprenolol | placebo | | | | negative | | |
EIS , 1984 | Oxprenolol | placebo | | | Low risk of bias | negative | | |
Schwartz (high risk and low risk) , 1992 | Oxprenolol | placebo | | | Low risk of bias | suggesting | | |
Taylor , 1982 | Oxprenolol | placebo | | | Low risk of bias | negative | | |
|
Owensby , 1984 | Pindolol | placebo | | | | negative | | |
Australian and Swedish study, 1983 | Pindolol | placebo | | | Low risk of bias | negative | | |
|
Evemy , 1978 | Practolol | placebo | | | | negative | | |
Johansson , 1980 | Practolol | placebo | | | | negative | | |
Macleod , 1980 | Practolol | placebo | | | | negative | | |
Snow , 1980 | Practolol | placebo | | | | negative | | |
Thompson , 1979 | Practolol | placebo | | | | negative | | |
Multicentre international , 1975 | Practolol | placebo | | | Low risk of bias | suggesting | | |
|
Aronow , 1997 | Propranolol | control | | | | suggesting | | |
Balcon , 1966 | Propranolol | placebo | | | | negative | | |
Barber , 1976 | Propranolol | placebo | | | | negative | | |
Clausen , 1966 | Propranolol | placebo | | | | negative | | |
Curtis , 1991 | Propranolol | placebo | | | | negative | | |
Dotremont , 1968 | Propranolol | placebo | | | | negative | | |
Gupta , 1982 | Propranolol | placebo | | | | negative | | |
Gupta , 1984 | Propranolol | placebo | | | | negative | | |
Hutton , 1979 | Propranolol | placebo | | | | negative | | |
Kahler , 1968 | Propranolol | placebo | | | | negative | | |
Ledwich , 1968 | Propranolol | placebo | | | | negative | | |
Mueller , 1980 | Propranolol | placebo | | | | negative | | |
Multicentre , 1966 | Propranolol | placebo | | | | negative | | |
Nigam , 1983 | Propranolol | placebo | | | | negative | | |
Norris , 1968 | Propranolol | placebo | | | | negative | | |
Norris , 1978 | Propranolol | placebo | | | | negative | | |
Norris , 1984 | Propranolol | placebo | | | | negative | | |
Peter , 1978 | Propranolol | placebo | | | | negative | | |
Pitt , 1976 | Propranolol | placebo | | | | negative | | |
Roberts , 1984 | Propranolol | placebo | | | | negative | | |
Singh , 1985 | Propranolol | placebo | | | | negative | | |
Sloman , 1967 | Propranolol | placebo | | | | negative | | |
Baber , 1980 | Propranolol | placebo | | | Low risk of bias | negative | | |
BHAT , 1982 NCT | Propranolol | placebo | | | Low risk of bias | suggesting | | |
Hansteen , 1982 | Propranolol | placebo | | | Low risk of bias | suggesting | | |
Wilcox , 1980 | Propranolol or atenolol | placebo | | | Low risk of bias | suggesting | | |
|
Lloyd , 1988 | Sotalol | placebo | | | | negative | | |
|
Campbell , 1984 | Timolol | placebo | | | | negative | | |
Federman , 1984 | Timolol | placebo | | | | negative | | |
ICSG , 1984 | Timolol | placebo | | | | negative | | |
Ranganathan , 1988 | Timolol | placebo | | | | negative | | |
Tonkin , 1981 | Timolol | placebo | | | | negative | | |
UKCSG , 1983 | Timolol | placebo | | | | negative | | |
Norwegian Multicentre Study Group , 1981 | Timolol | placebo | | | Low risk of bias | suggesting | | |
|
McMurray , 1991 | Xamoterol | placebo | | | | negative | | |
|
|
Eichler, 1985 | Tiapamil | control | | | Low risk of bias | negative | | |
|
Machecourt, 1986 | diltiazem | | | | | negative | | |
Gibson, 1986 | diltiazem | placebo | | | Low risk of bias | negative | | |
MDPIT, 1988 | diltiazem | placebo | | | Low risk of bias | negative | | |
Zannad, 1988 | diltiazem | placebo | | | Low risk of bias | negative | | |
|
Muller, 1984 | nifedipine | | | | Low risk of bias | negative | | |
Gordon, 1984 | nifedipine | | | | | negative | | |
MI study group, 1979 | nifedipine | | | | | - | | |
Eisenberg, 1985 | nifedipine | placebo | | | Low risk of bias | negative | | |
Bradagan, 1986 | nifedipine | placebo | | | Low risk of bias | negative | | |
Jaffe, 1987 | nifedipine | placebo | | | | negative | | |
Gottlieb, 1988 | nifedipine | placebo | | | Low risk of bias | negative | | |
Erbel, 1988 | nifedipine | placebo | | | Low risk of bias | negative | | |
SPRINT I, 1988 | nifedipine | placebo | | | Low risk of bias | negative | | |
SPRINT II, 1993 | nifedipine | placebo | | | Low risk of bias | negative | | |
Loogna, 1985 | nifedipine | placebo | | | Low risk of bias | negative | | |
TRENT (Wilcox), 1986 | nifedipine | placebo | | | Low risk of bias | negative | | |
Walker, 1988 | nifedipine | placebo | | | Low risk of bias | negative | | |
Sirnes, 1984 | nifedipine | placebo | | | Low risk of bias | negative | | |
|
Bussman, 1984 | verapamil | control | | | | negative | | |
DAVIT I, 1984 | verapamil | placebo | | | Low risk of bias | - | | |
Crea, 1985 | verapamil | placebo | | | | negative | | |
DAVIT II, 1990 | verapamil | placebo | | | Low risk of bias | negative | | |
CRIS, 1996 | verapamil | placebo | | | Low risk of bias | negative | | |
Danish study, 1984 | verapamil | placebo | | | Low risk of bias | negative | | |
|
|
MAGIC (cell infusion ), 2004 | autologous bone marrow stem cells | control | | | | - | | |
Suarez de Lezo (cell), 2007 | autologous bone marrow stem cells | control | | | | - | | |
TCT-STAMI (Ge), 2006 | autologous bone marrow stem cells | control | | | | negative | | |
Huang, 2006 | autologous bone marrow stem cells | control | | | | - | | |
MAGIC Cell-3-DES (Kang), 2006 | autologous bone marrow stem cells | control | | | | negative | | |
Karpov, 2005 | autologous bone marrow stem cells | control | | | | - | | |
Li, 2007 | autologous bone marrow stem cells | control | | | | - | | |
ASTAMi (Lunde), 2006 | autologous bone marrow stem cells | control | | | | negative | | |
Meluzin LD, 2006 | autologous bone marrow stem cells | control | | | | negative | | |
Meluzin HD, 2006 | autologous bone marrow stem cells | control | | | | negative | | |
BOOSt (Meyer), 2004 | autologous bone marrow stem cells | control | | | | negative | | |
Penicka, 2007 | autologous bone marrow stem cells | control | | | | negative | | |
Ruan, 2005 | autologous bone marrow stem cells | control | | | | - | | |
Chen, 2004 | autologous bone marrow stem cells | control | | | | - | | |
Suzuki, 2006 | G-CSF | control | | | | - | | |
Deng, 2006 | G-CSF | control | | | | negative | | |
FIRSTLINE-AMI (Ince), 2005 | G-CSF | control | | | | negative | | |
MAGIC Cell-3-DES (Kang), 2006 | G-CSF | control | | | | negative | | |
MAGIC (G-CSF) (Kang), 2004 | G-CSF | control | | | | negative | | |
MAGIC 1 (Kang), 2007 | G-CSF | control | | | | negative | | |
Takano, 2007 | G-CSF | control | | | | negative | | |
RIGENERA (Leone), 2007 | G-CSF | control | | | | negative | | |
Suarez de Lezo (G-CSF), 2007 | G-CSF | control | | | | negative | | |
Janssens, 2006 | autologous bone marrow stem cells | placebo | | | Low risk of bias | negative | | |
REPAIR-AMI (Schachinger), 2006 NCT | autologous bone marrow stem cells | placebo | | | Low risk of bias | negative | | |
REVIVAL-2 (Zohlnhöfer ), 2006 NCT | G-CSF | placebo | | | Low risk of bias | negative | | |
STEMMI (Ripa), 2006 | G-CSF | placebo | | | Low risk of bias | negative | | |
G-CSF-STEMI (Engelmann), 2006 | G-CSF | placebo | | | Low risk of bias | negative | | |
Valgimigli, 2005 | G-CSF | placebo | | | Low risk of bias | negative | | |
Ellis, 2006 NCT | G-CSF | placebo | | | Low risk of bias | negative | | |
|
|
PROVE-IT, 2004 | atorvastatin high dose | pravastatin | diabetic | early initiation | Low risk of bias | suggesting | | |
|
|
APEX-AMI, 2007 NCT | pexelizumab | placebo | | | Low risk of bias | negative | | |
COMMA, 2003 | pexelizumab | placebo | | | Low risk of bias | negative | | |
COMPLY, 2003 | pexelizumab | placebo | | | Low risk of bias | negative | | |
|
|
STAR, 1995 | recombinant staphylokinase | t-PA | | | | negative | | |
TAMI 5 (t-PA+uroK vs tPA), 1991 | t-PA + urokinase | t-PA | | | | - | | |
|
TEAM 2, 1991 | anistreplase | streptokinase | | | Low risk of bias | - | | |
|
APSIM, 1989 | APSAC | control | | | | negative | | |
AIMS, 1988 | APSAC | placebo | | | Low risk of bias | suggesting | | |
German Multicenter Trial, 1988 | APSAC | placebo | | | | suggesting | | |
ISIS III (SK/APSAC), 1992 | APSAC | streptokinase | | | Low risk of bias | negative | | |
TEAM 3, 1992 | APSAC | t-PA | | | Low risk of bias | - | | |
|
InTIME-II, 2000 | lanoteplase | accelerated t-PA | | | Low risk of bias | negative | | |
|
GUSTO III, 1997 | reteplase | accelerated t-PA | | | | negative | | |
RAPID-2, 1996 | reteplase | accelerated t-PA | | | Exploratory | suggesting | | |
INJECT, 1995 | reteplase | streptokinase | | | Low risk of bias | negative | | |
|
COMPASS, 1998 | saruplase | streptokinase | | | Low risk of bias | negative | | |
PRIMI (vs SK), 1989 | saruplase | streptokinase | | | Low risk of bias | - | | |
SESAM, 1997 | saruplase | t-PA | | | Exploratory | negative | | |
PRIMI (vs UK), 1989 | saruplase | urokinase | | | Low risk of bias | - | | |
|
ISAM, 1986 | streptokinase | placebo | | | Low risk of bias | negative | | |
ISIS-2 (SK), 1988 | streptokinase | placebo | | | Low risk of bias | suggesting | | |
Western Washington Intravenous Trial, 1988 NCT | streptokinase | placebo | | | | negative | | |
GISSI I, 1986 | streptokinase | placebo | | | | suggesting | | |
EMERAS (all delay), 1993 | streptokinase | placebo | | | Low risk of bias | negative | | |
ISIS 2 pilot, 1987 | streptokinase | placebo | | | Low risk of bias | - | | |
EMERAS (7-12h), 1993 | streptokinase | placebo | | | Low risk of bias | - | | |
GUSTO tPA-SK Hiv, 1993 | t-PA + streptokinase | streptokinase | | | | negative | | |
|
ASSET, 1988 | t-PA | placebo | | | Low risk of bias | suggesting | | |
LATE, 1993 | t-PA | placebo | | | Low risk of bias | negative | | |
TAMI 6, 1992 | t-PA | placebo | | | Low risk of bias | negative | | |
COBALT, 1997 | bolus t-PA | accelerated t-PA | | | Low risk of bias | negative | | |
TAPS, 1992 | accelerated t-PA | APSAC | | | | negative | | |
TIMI 4, 1994 | accelerated t-PA | APSAC | | | Low risk of bias | - | | |
GUSTO tPA Hiv, 1993 | accelerated t-PA | streptokinase | | | | suggesting | | |
GISSI II, 1990 | t-PA | streptokinase | | | | suggesting | | |
International Study Group, 1990 | t-PA | streptokinase | | | Low risk of bias | suggesting | | |
ISIS III (SK/tPA), 1992 | t-PA | streptokinase | | | Low risk of bias | suggesting | | |
Centre Illinois, 1993 | t-PA | streptokinase | | | | - | | |
Cherng, 1992 | t-PA | streptokinase | | | | negative | | |
ECSG, 1985 | t-PA | streptokinase | | | | negative | | |
PAIMS, 1989 | t-PA | streptokinase | | | | - | | |
TIMI-1, 1987 NCT | t-PA | streptokinase | | | Low risk of bias | - | | |
White, 1989 | t-PA | streptokinase | | | Low risk of bias | - | | |
RAAMI, 1992 | accelerated t-PA | t-PA | | | | - | | |
KAMIT, 1991 | t-PA half dose | t-PA | | | Exploratory | negative | | |
TAMI 5 (t-PA vs uroK), 1991 | t-PA | urokinase | | | | - | | |
|
ASSENT-2, 1999 | tenecteplase | accelerated t-PA | | | Low risk of bias | suggesting | | |
|
USIM, 1991 | urokinase | control | | | | - | | |
|
|
OASIS 6, 2007 NCT | GIK infusion | control | | | | - | | |
CREATE-ECLA , 2006 | GIK infusion | control | | | | - | | |
Glucose-insulin-potassium study II, 2007 | GIK infusion | control | | | | - | | |
Krljanac, 2005 | GIK infusion | control | | | | - | | |
Bucciarelli-Ducci , 2006 | GIK infusion | placebo | | | | - | | |
|
|
HART II, 2001 | Enoxaparin | UFH | | | | negative | | |
Baird, 2002 | Enoxaparin | UFH | | | | negative | | |
|
DUCCS, 1994 | UFH | no heparin | | | | negative | | |
ECSG, 1992 | UFH | placebo | | | Low risk of bias | negative | | |
|
|
IRIS, 2009 NCT | early implantation of ICD after MI | control | | | Risk of bias | suggesting | | |
MADIT-II, 2002 | ICD | no ICD | | | | suggesting | | |
DINAMIT, 2004 | ICD | no ICD | | | | negative | | |
|
|
REVEAL NCT | erythropoietin | placebo | | | Low risk of bias | - | | |
REVIVAL-3 NCT | recombinant human erythropoietin beta | placebo | | | Low risk of bias | - | | |
|
HEBE III, 2010 | epoetin alfa | placebo | | | Exploratory | negative | | |
|
|
TOMIIS, 1994 | late PTCA | no PTCA | | | | negative | | |
Horie et al, 1998 | late PTCA | no PTCA | | | | suggesting | | |
TOAT, 2002 | late PTCA | no PTCA | | | | negative | | |
DECOPI, 2004 | late PTCA | no PTCA | | | | negative | | |
Silva et al, 2005 | late PTCA | no PTCA | | | | negative | | |
OAT, 2006 | late PTCA | no PTCA | | | | negative | | |
TOSCA-2, 2006 NCT | late PTCA | no PTCA | | | | - | | |
|
EMERAS (7-12h), 1993 | streptokinase | placebo | | | Low risk of bias | - | | |
|
LATE, 1993 | t-PA | placebo | | | Low risk of bias | negative | | |
TAMI 6, 1992 | t-PA | placebo | | | Low risk of bias | negative | | |
|
|
DANAMI, 1997 | invasive strategy | concervative strategy | | | | - | | |
CARESS, 2008 | thrombolysis + angioplasty | immediate thrombolysis | | | | - | | |
CAPITAL AMI, 2005 | thrombolysis + angioplasty | immediate thrombolysis | | | | suggesting | | |
PRAGUE-1 (thrombolysis+PTCA), 2000 | thrombolysis + angioplasty | immediate thrombolysis | | | | - | | |
NORDISTEMI, 2009 NCT | thrombolysis + angioplasty | immediate thrombolysis | | | | suggesting | | |
REACT (repeat fibrinolysis), 2005 | repeat fibrinolysis | no repeat fibrinolysis | | | | negative | | |
Sarullo, 2000 | repeat fibrinolysis | no repeat fibrinolysis | | | Low risk of bias | negative | | |
Mounsey, 1995 | repeat fibrinolysis | no repeat fibrinolysis | | | | - | | |
STOPAMI 1, 2000 | facilitated stenting | alteplase | | | | - | | |
TEAHAT, 1990 | Prehospital thrombolysis | at hospital thrombolysis | | | | - | | |
MITI, 1993 NCT | Prehospital thrombolysis | at hospital thrombolysis | | | | negative | | |
GREAT, 1994 | Prehospital thrombolysis | at hospital thrombolysis | | | | negative | | |
EMIP, 1993 | Prehospital thrombolysis | at hospital thrombolysis | | | | negative | | |
Castaigne , 1989 | Prehospital thrombolysis | at hospital thrombolysis | | | | negative | | |
Roth, 1990 | Prehospital thrombolysis | at hospital thrombolysis | | | | negative | | |
Schofer, 1990 | Prehospital thrombolysis | at hospital thrombolysis | | | | negative | | |
Barbash, 1990 | Prehospital thrombolysis | at hospital thrombolysis | | | | - | | |
Castaigne, 1987 | Prehospital thrombolysis | at hospital thrombolysis | | | | - | | |
Mcneill, 1989 | Prehospital thrombolysis | at hospital thrombolysis | | | | - | | |
STOPAMI 4, 2004 | | balloon angioplasty | | | | negative | | |
AIR-PAMI , 2002 | transfer for primary angioplasty | immediate thrombolysis | | | | negative | | |
DANAMI-2 , 2003 | transfer for primary angioplasty | immediate thrombolysis | | | | negative | | |
PRAGUE-2 , 2003 | transfer for primary angioplasty | immediate thrombolysis | | | | - | | |
STAR, 1995 | recombinant staphylokinase | t-PA | | | | negative | | |
TAMI 5 (t-PA+uroK vs tPA), 1991 | t-PA + urokinase | t-PA | | | | - | | |
|
BRAVE (Kastrati), 2004 | Abciximab + reteplase | primary intervention | | | | - | | |
ERAMI (Mesquita Gabriel), 2003 | Abciximab | primary intervention | | | | negative | | |
REOMOBILE (Arntz), 2003 | Abciximab | primary intervention | | | | negative | | |
Zorman, 2002 | Abciximab | primary intervention | | | | negative | | |
ReoPro-BRIDGING (Gyongyosi), 2004 | Abciximab | primary intervention | | | | negative | | |
Bellandi, 2006 | Abciximab | primary intervention | | | | negative | | |
FINESSE (abciximab-facilitated PCI), 2008 NCT | Abciximab | primary intervention | | | | negative | | |
FINESSE (combination-facilitated PCI), 2008 NCT | Abciximab + reteplase | primary intervention | | | | negative | | |
|
LIMI (Vermeer), 1999 | alteplase | primary intervention | | | | negative | | |
PACT (Ross,), 1999 | alteplase | primary intervention | | | | negative | | |
|
TEAM 2, 1991 | anistreplase | streptokinase | | | Low risk of bias | - | | |
|
APSIM, 1989 | APSAC | control | | | | negative | | |
AIMS, 1988 | APSAC | placebo | | | Low risk of bias | suggesting | | |
German Multicenter Trial, 1988 | APSAC | placebo | | | | suggesting | | |
ISIS III (SK/APSAC), 1992 | APSAC | streptokinase | | | Low risk of bias | negative | | |
TEAM 3, 1992 | APSAC | t-PA | | | Low risk of bias | - | | |
|
DEDICATION, 2008 NCT | drug-eluting stents | bare-metal stent | | | Risk of bias | suggesting | | |
PASEO, 2009 | drug-eluting stents | bare-metal stent | | | | - | | |
|
INTAMI (Zeymer), 2005 | Eptifibatide | primary intervention | | | | negative | | |
|
InTIME-II, 2000 | lanoteplase | accelerated t-PA | | | Low risk of bias | negative | | |
|
PASSION, 2006 | paclitaxel eluting stent | bare-metal stent | | | Risk of bias | negative | | |
HAAMU-STENT, 2006 | paclitaxel eluting stent | bare-metal stent | | | Exploratory | negative | | |
HORIZONS-AMI Stent, 2008 | paclitaxel eluting stent | bare-metal stent | | | | suggesting | | |
|
WEST, 2006 | systematic PCI (+stent) | no systematic PCI | | | | negative | | |
CAPITAL AMI, 2005 | systematic PCI (+stent) | no systematic PCI | | | | negative | | |
GRACIA-1, 2004 | systematic PCI (+stent) | no systematic PCI | | | Risk of bias | negative | | |
SIAM III, 2002 | systematic PCI (+stent) | no systematic PCI | | | | negative | | |
PRAGUE, 2000 | systematic PCI (+stent) | no systematic PCI | | | | negative | | |
C-PORT, 2002 | primary PCI | accelerated t-PA | | | | - | | |
STAT, 2001 | primary stenting | accelerated t-PA | | | | - | | |
Jaksch, 1998 | primary stenting | balloon angioplasty | | | | suggesting | | |
GRAMI (Rodriguez), 1998 | primary stenting | balloon angioplasty | | | | negative | | |
Zwolle 5 (Suryapranata), 1998 | primary stenting | balloon angioplasty | | | | suggesting | | |
stent-PAMI (Grines), 1999 | primary stenting | balloon angioplasty | | | | suggesting | | |
PASTA (Saito), 1999 | primary stenting | balloon angioplasty | | | | suggesting | | |
PRISAM (Kawashima), 1999 | primary stenting | balloon angioplasty | | | | negative | | |
STENTIM-2 (Maillard), 2000 | primary stenting | balloon angioplasty | | | | negative | | |
PSSAAMI (Scheller), 2001 | primary stenting | balloon angioplasty | | | | suggesting | | |
FRESCO, 1998 | primary stenting | balloon angioplasty | | | | - | | |
CADILLAC abciximab., 2002 | primary stenting | balloon angioplasty | | | | - | | |
CADILLAC (no abciximab), 2002 | primary stenting | balloon angioplasty | | | | - | | |
ZWOLLE 6, 2005 | primary stenting | balloon angioplasty | | | | - | | |
STOPAMI 3, 2004 | primary stenting | balloon angioplasty | | | | - | | |
STOPAMI 2, 2002 | primary stenting | immediate thrombolysis | | | | - | | |
senior PAMI, 2005 NCT | primary PCI | Thrombolysis | | | Risk of bias | suggesting | | |
|
Ribichini, 1996 | primary ballon angioplasty | accelerated t-PA | | | | - | | |
Garcia, 1997 | primary ballon angioplasty | accelerated t-PA | | | | - | | |
GUSTO 2B, 1997 | primary ballon angioplasty | accelerated t-PA | | | | - | | |
DANAMI-2, 1997 | primary ballon angioplasty | accelerated t-PA | | | | - | | |
DeWood, 1989 | primary ballon angioplasty | duteplase | | | | - | | |
Gibbons, 1993 | primary ballon angioplasty | duteplase | | | | - | | |
O'Neill, 1986 | primary ballon angioplasty | intracoronary streptokinase | | | | - | | |
Zwolle, 1994 | primary ballon angioplasty | streptokinase | | | | negative | | |
Ribeiro, 1993 | primary ballon angioplasty | streptokinase | | | | - | | |
Grinfeld, 1996 | primary ballon angioplasty | streptokinase | | | | - | | |
Zijlstra, 1997 | primary ballon angioplasty | streptokinase | | | | - | | |
Zijlstra , 1993 | primary ballon angioplasty | streptokinase | | | | - | | |
Akhras, 1997 | primary ballon angioplasty | streptokinase | | | | - | | |
PAMI, 1993 | primary ballon angioplasty | t-PA | | | | - | | |
TRIANA, 2009 NCT | primary ballon angioplasty | tenecteplase | | | Risk of bias | negative | | |
|
MAASTRICHT (Vermeer), 1999 | primary angioplasty | immediate thrombolysis | | | | negative | | |
PRAGUE-1, 2000 | primary angioplasty | immediate thrombolysis | | | | suggesting | | |
AIR-PAMI, 2002 | primary angioplasty | immediate thrombolysis | | | | negative | | |
CAPTIM, 2002 | primary angioplasty | immediate thrombolysis | | | | negative | | |
DANAMI-2, 2003 | primary angioplasty | immediate thrombolysis | | | | suggesting | | |
PRAGUE-2, 2003 | primary angioplasty | immediate thrombolysis | | | | suggesting | | |
TAMI 1 pilot, 1987 | immediate systematic ballon angioplastyte | no immediate angioplasty | | | Exploratory | suggesting | | |
ECSG, 1988 | immediate systematic ballon angioplastyte | no immediate angioplasty | | | Exploratory | negative | | |
TAMI-5 (Califf), 1991 | immediate systematic ballon angioplastyte | no immediate angioplasty | | | | - | | |
SHOCK (Hochman), 1999 NCT | immediate systematic ballon angioplastyte | no immediate angioplasty | | | Risk of bias | suggesting | | |
Ellis, 1994 | immediate systematic ballon angioplastyte | no immediate angioplasty | | | | - | | |
Erbel, 1989 | immediate systematic ballon angioplastyte | no immediate angioplasty | | | | - | | |
MERLIN (Sutton), 2004 | immediate systematic ballon angioplastyte | no immediate angioplasty | | | | - | | |
SWISS-SMASH, 1999 | immediate systematic ballon angioplastyte | no immediate angioplasty | | | Exploratory | negative | | |
TIMI 2A, 1988 | immediate systematic ballon angioplastyte | no immediate angioplasty | | | Exploratory | - | | |
Belenkie, 1991 | immediate systematic ballon angioplastyte | no immediate angioplasty | | | Exploratory | - | | |
Topol, 1987 | immediate systematic ballon angioplastyte | no immediate angioplasty | | | Exploratory | - | | |
TOMIIS, 1994 | late PTCA | no PTCA | | | | negative | | |
Horie et al, 1998 | late PTCA | no PTCA | | | | suggesting | | |
TOAT, 2002 | late PTCA | no PTCA | | | | negative | | |
DECOPI, 2004 | late PTCA | no PTCA | | | | negative | | |
Silva et al, 2005 | late PTCA | no PTCA | | | | negative | | |
OAT, 2006 | late PTCA | no PTCA | | | | negative | | |
TOSCA-2, 2006 NCT | late PTCA | no PTCA | | | | - | | |
REACT (rescue PCI), 2005 | rescue PTCA | no rescue PTCA | | | | suggesting | | |
MERLIN, 2004 | rescue PTCA | no rescue PTCA | | | | negative | | |
RESCUE II, 2000 | rescue PTCA | no rescue PTCA | | | | negative | | |
RESCUE, 1994 | rescue PTCA | no rescue PTCA | | | | negative | | |
Belenkie, 1992 | rescue PTCA | no rescue PTCA | | | Risk of bias | negative | | |
SWIFT, 1991 | systematic ballon angioplasty | no systematic angioplasty | | | Risk of bias | negative | | |
SIAM, 1992 | systematic ballon angioplasty | no systematic angioplasty | | | Exploratory | negative | | |
TIMI 2, 1989 | systematic ballon angioplasty | no systematic angioplasty | | | Risk of bias | negative | | |
Guerci, 1987 | systematic ballon angioplasty | no systematic angioplasty | | | Exploratory | negative | | |
Van den Brand, 1991 | systematic ballon angioplasty | no systematic angioplasty | | | Exploratory | negative | | |
TOPS, 1992 | systematic ballon angioplasty | no systematic angioplasty | | | Exploratory | negative | | |
TIMI II-A (defered) | systematic ballon angioplasty | no systematic angioplasty | | | | - | | |
Vermeer, 1999 | systematic ballon angioplasty | no systematic angioplasty | | | | - | | |
TAMI 6, 1992 | systematic ballon angioplasty | no systematic angioplasty | | | | - | | |
Barbash, 1990 | systematic ballon angioplasty | no systematic angioplasty | | | | - | | |
|
GUSTO III, 1997 | reteplase | accelerated t-PA | | | | negative | | |
RAPID-2, 1996 | reteplase | accelerated t-PA | | | Exploratory | suggesting | | |
INJECT, 1995 | reteplase | streptokinase | | | Low risk of bias | negative | | |
|
COMPASS, 1998 | saruplase | streptokinase | | | Low risk of bias | negative | | |
PRIMI (vs SK), 1989 | saruplase | streptokinase | | | Low risk of bias | - | | |
SESAM, 1997 | saruplase | t-PA | | | Exploratory | negative | | |
PRIMI (vs UK), 1989 | saruplase | urokinase | | | Low risk of bias | - | | |
|
TYPHOON, 2006 NCT | sirolimus eluting stent | bare-metal stent | | | | suggesting | | |
SESAMI, 2007 NCT | sirolimus eluting stent | bare-metal stent | | | Risk of bias | suggesting | | |
MISSION, 2008 | sirolimus eluting stent | bare-metal stent | | | Risk of bias | suggesting | | |
Díaz de la Llera, 2007 | sirolimus eluting stent | bare-metal stent | | | | - | | |
PROSIT, 2006 | sirolimus eluting stent | paclitaxel eluting stent | | | | negative | | |
Di Lorenzo et al., 2005 | sirolimus eluting stent | paclitaxel eluting stent | | | | negative | | |
Juwana, 2009 | sirolimus eluting stent | paclitaxel eluting stent | | | | negative | | |
|
ISAM, 1986 | streptokinase | placebo | | | Low risk of bias | negative | | |
ISIS-2 (SK), 1988 | streptokinase | placebo | | | Low risk of bias | suggesting | | |
Western Washington Intravenous Trial, 1988 NCT | streptokinase | placebo | | | | negative | | |
GISSI I, 1986 | streptokinase | placebo | | | | suggesting | | |
EMERAS (all delay), 1993 | streptokinase | placebo | | | Low risk of bias | negative | | |
ISIS 2 pilot, 1987 | streptokinase | placebo | | | Low risk of bias | - | | |
EMERAS (7-12h), 1993 | streptokinase | placebo | | | Low risk of bias | - | | |
SAMI (O’Neill), 1992 | streptokinase | primary intervention | | | | negative | | |
PRAGUE (Widimisky), 2000 | streptokinase | primary intervention | | | | negative | | |
GUSTO tPA-SK Hiv, 1993 | t-PA + streptokinase | streptokinase | | | | negative | | |
|
ASSET, 1988 | t-PA | placebo | | | Low risk of bias | suggesting | | |
LATE, 1993 | t-PA | placebo | | | Low risk of bias | negative | | |
TAMI 6, 1992 | t-PA | placebo | | | Low risk of bias | negative | | |
COBALT, 1997 | bolus t-PA | accelerated t-PA | | | Low risk of bias | negative | | |
TAPS, 1992 | accelerated t-PA | APSAC | | | | negative | | |
TIMI 4, 1994 | accelerated t-PA | APSAC | | | Low risk of bias | - | | |
GUSTO tPA Hiv, 1993 | accelerated t-PA | streptokinase | | | | suggesting | | |
GISSI II, 1990 | t-PA | streptokinase | | | | suggesting | | |
International Study Group, 1990 | t-PA | streptokinase | | | Low risk of bias | suggesting | | |
ISIS III (SK/tPA), 1992 | t-PA | streptokinase | | | Low risk of bias | suggesting | | |
Centre Illinois, 1993 | t-PA | streptokinase | | | | - | | |
Cherng, 1992 | t-PA | streptokinase | | | | negative | | |
ECSG, 1985 | t-PA | streptokinase | | | | negative | | |
PAIMS, 1989 | t-PA | streptokinase | | | | - | | |
TIMI-1, 1987 NCT | t-PA | streptokinase | | | Low risk of bias | - | | |
White, 1989 | t-PA | streptokinase | | | Low risk of bias | - | | |
RAAMI, 1992 | accelerated t-PA | t-PA | | | | - | | |
KAMIT, 1991 | t-PA half dose | t-PA | | | Exploratory | negative | | |
TAMI 5 (t-PA vs uroK), 1991 | t-PA | urokinase | | | | - | | |
|
ADVANCE-MI, 2005 | Eptifibatide + tenecteplase | primary intervention | | | | - | | |
ASSENT-2, 1999 | tenecteplase | accelerated t-PA | | | Low risk of bias | suggesting | | |
ASSENT-4 PCI (Van de Werf), 2006 NCT | | primary intervention | | | | negative | | |
GRACIA (Fernandez-Aviles,), 2004 | tenecteplase | primary intervention | | | | negative | | |
|
On-Time (van’t Hof), 2004 | Tirofiban | primary intervention | | | | negative | | |
TIGER-PA (Lee), 2003 | Tirofiban | primary intervention | | | | negative | | |
Cutlip, 2003 | Tirofiban | primary intervention | | | | negative | | |
|
USIM, 1991 | urokinase | control | | | | - | | |
|
ZEST AMI (vs PES), 2009 NCT | zotarolimus eluting stent | paclitaxel eluting stent | | | Risk of bias | negative | | |
ZEST AMI (vs SES), 2009 NCT | zotarolimus eluting stent | sirolimus eluting stent | | | | negative | | |
|
|
Hockings, 1981 | nitroprusside | control | | | Exploratory | negative | | |
Zharov, 1991 | error | error | | | Exploratory | - | | |
Durrer, 1982 | nitroprusside | placebo | | | Risk of bias | suggesting | | |
Cohn, 1982 | nitroprusside | placebo | | | Low risk of bias | negative | | |
|
Hildebrandt, 1992 | isosorbide dinitrate | placebo | | | Low risk of bias | negative | | |
ISIS-4, 1995 | isosorbide mononitrate | placebo | | | Low risk of bias | suggesting | | |
Hargreaves, 1992 | isosorbide mononitrate | placebo | | | Low risk of bias | negative | | |
Fitzgerald, 1990 | isosorbide mononitrate | placebo | | | Low risk of bias | negative | | |
|
ESPRIM, 1994 | molsidomine | placebo | | | Low risk of bias | negative | | |
Beaufils, 1988 | molsidomine | placebo | | | Low risk of bias | negative | | |
|
Chiche, 1979 | nitroglycerin | control | | | Risk of bias | negative | | |
Bussman, 1981 | nitroglycerin | control | | | Exploratory | suggesting | | |
Nelson, 1983 | nitroglycerin | control | | | Risk of bias | negative | | |
Jugdutt, 1983 | nitroglycerin | control | | | Exploratory | suggesting | | |
GISSI-3, 1994 | nitroglycerin | control | | | Risk of bias | suggesting | | |
Jugdutt, 1988 | nitroglycerin | control | | | Exploratory | suggesting | | |
Flaherty, 1983 | nitroglycerin | placebo | | | Risk of bias | negative | | |
Jaffe, 1983 | nitroglycerin | placebo | | | Low risk of bias | negative | | |
Lis, 1984 | nitroglycerin | placebo | | | Low risk of bias | negative | | |
Charvat, 1990 | nitroglycerin | placebo | | | Low risk of bias | negative | | |
|
|
Dekleva, 2004 | error | control | | | | negative | | |
Sharifi, 2004 | hyperbaric oxygen | control | | | | suggesting | | |
Swift, 1992 | hyperbaric oxygen | control | | | | - | | |
Thurston, 1973 | hyperbaric oxygen | control | | | | suggesting | | |
Hot MI, 1997 | hyperbaric oxygen | control | | | | negative | | |
HOT MI pilot, 1997 | Hyperbaric oxygen | control | | | | - | | |
Rawles, 1976 | oxygen therapy | control | | | | negative | | |
Wilson, 1997 | oxygen therapy | control | | | | negative | | |
Ukholkina, 2005 | oxygen therapy | control | | | | negative | | |
AMIHOT, 2007 | supersaturated oxygen | control | | | | - | | |
AMIHOT II , 2000 NCT | supersaturated oxygen | control | | | | - | | |
Kerr, 1975 | Entonox | placebo | | | Low risk of bias | - | | |
|
|
DANAMI, 1997 | invasive strategy | concervative strategy | | | | - | | |
CARESS, 2008 | thrombolysis + angioplasty | immediate thrombolysis | | | | - | | |
CAPITAL AMI, 2005 | thrombolysis + angioplasty | immediate thrombolysis | | | | suggesting | | |
PRAGUE-1 (thrombolysis+PTCA), 2000 | thrombolysis + angioplasty | immediate thrombolysis | | | | - | | |
NORDISTEMI, 2009 NCT | thrombolysis + angioplasty | immediate thrombolysis | | | | suggesting | | |
REACT (repeat fibrinolysis), 2005 | repeat fibrinolysis | no repeat fibrinolysis | | | | negative | | |
Sarullo, 2000 | repeat fibrinolysis | no repeat fibrinolysis | | | Low risk of bias | negative | | |
Mounsey, 1995 | repeat fibrinolysis | no repeat fibrinolysis | | | | - | | |
STOPAMI 1, 2000 | facilitated stenting | alteplase | | | | - | | |
STOPAMI 4, 2004 | | balloon angioplasty | | | | negative | | |
AIR-PAMI , 2002 | transfer for primary angioplasty | immediate thrombolysis | | | | negative | | |
DANAMI-2 , 2003 | transfer for primary angioplasty | immediate thrombolysis | | | | negative | | |
PRAGUE-2 , 2003 | transfer for primary angioplasty | immediate thrombolysis | | | | - | | |
|
DEDICATION, 2008 NCT | drug-eluting stents | bare-metal stent | | | Risk of bias | suggesting | | |
PASEO, 2009 | drug-eluting stents | bare-metal stent | | | | - | | |
|
PASSION, 2006 | paclitaxel eluting stent | bare-metal stent | | | Risk of bias | negative | | |
HAAMU-STENT, 2006 | paclitaxel eluting stent | bare-metal stent | | | Exploratory | negative | | |
HORIZONS-AMI Stent, 2008 | paclitaxel eluting stent | bare-metal stent | | | | suggesting | | |
|
WEST, 2006 | systematic PCI (+stent) | no systematic PCI | | | | negative | | |
CAPITAL AMI, 2005 | systematic PCI (+stent) | no systematic PCI | | | | negative | | |
GRACIA-1, 2004 | systematic PCI (+stent) | no systematic PCI | | | Risk of bias | negative | | |
SIAM III, 2002 | systematic PCI (+stent) | no systematic PCI | | | | negative | | |
PRAGUE, 2000 | systematic PCI (+stent) | no systematic PCI | | | | negative | | |
C-PORT, 2002 | primary PCI | accelerated t-PA | | | | - | | |
STAT, 2001 | primary stenting | accelerated t-PA | | | | - | | |
Jaksch, 1998 | primary stenting | balloon angioplasty | | | | suggesting | | |
GRAMI (Rodriguez), 1998 | primary stenting | balloon angioplasty | | | | negative | | |
Zwolle 5 (Suryapranata), 1998 | primary stenting | balloon angioplasty | | | | suggesting | | |
stent-PAMI (Grines), 1999 | primary stenting | balloon angioplasty | | | | suggesting | | |
PASTA (Saito), 1999 | primary stenting | balloon angioplasty | | | | suggesting | | |
PRISAM (Kawashima), 1999 | primary stenting | balloon angioplasty | | | | negative | | |
STENTIM-2 (Maillard), 2000 | primary stenting | balloon angioplasty | | | | negative | | |
PSSAAMI (Scheller), 2001 | primary stenting | balloon angioplasty | | | | suggesting | | |
FRESCO, 1998 | primary stenting | balloon angioplasty | | | | - | | |
CADILLAC abciximab., 2002 | primary stenting | balloon angioplasty | | | | - | | |
CADILLAC (no abciximab), 2002 | primary stenting | balloon angioplasty | | | | - | | |
ZWOLLE 6, 2005 | primary stenting | balloon angioplasty | | | | - | | |
STOPAMI 3, 2004 | primary stenting | balloon angioplasty | | | | - | | |
STOPAMI 2, 2002 | primary stenting | immediate thrombolysis | | | | - | | |
senior PAMI, 2005 NCT | primary PCI | Thrombolysis | | | Risk of bias | suggesting | | |
|
Ribichini, 1996 | primary ballon angioplasty | accelerated t-PA | | | | - | | |
Garcia, 1997 | primary ballon angioplasty | accelerated t-PA | | | | - | | |
GUSTO 2B, 1997 | primary ballon angioplasty | accelerated t-PA | | | | - | | |
DANAMI-2, 1997 | primary ballon angioplasty | accelerated t-PA | | | | - | | |
DeWood, 1989 | primary ballon angioplasty | duteplase | | | | - | | |
Gibbons, 1993 | primary ballon angioplasty | duteplase | | | | - | | |
O'Neill, 1986 | primary ballon angioplasty | intracoronary streptokinase | | | | - | | |
Zwolle, 1994 | primary ballon angioplasty | streptokinase | | | | negative | | |
Ribeiro, 1993 | primary ballon angioplasty | streptokinase | | | | - | | |
Grinfeld, 1996 | primary ballon angioplasty | streptokinase | | | | - | | |
Zijlstra, 1997 | primary ballon angioplasty | streptokinase | | | | - | | |
Zijlstra , 1993 | primary ballon angioplasty | streptokinase | | | | - | | |
Akhras, 1997 | primary ballon angioplasty | streptokinase | | | | - | | |
PAMI, 1993 | primary ballon angioplasty | t-PA | | | | - | | |
TRIANA, 2009 NCT | primary ballon angioplasty | tenecteplase | | | Risk of bias | negative | | |
|
MAASTRICHT (Vermeer), 1999 | primary angioplasty | immediate thrombolysis | | | | negative | | |
PRAGUE-1, 2000 | primary angioplasty | immediate thrombolysis | | | | suggesting | | |
AIR-PAMI, 2002 | primary angioplasty | immediate thrombolysis | | | | negative | | |
CAPTIM, 2002 | primary angioplasty | immediate thrombolysis | | | | negative | | |
DANAMI-2, 2003 | primary angioplasty | immediate thrombolysis | | | | suggesting | | |
PRAGUE-2, 2003 | primary angioplasty | immediate thrombolysis | | | | suggesting | | |
TAMI 1 pilot, 1987 | immediate systematic ballon angioplastyte | no immediate angioplasty | | | Exploratory | suggesting | | |
ECSG, 1988 | immediate systematic ballon angioplastyte | no immediate angioplasty | | | Exploratory | negative | | |
TAMI-5 (Califf), 1991 | immediate systematic ballon angioplastyte | no immediate angioplasty | | | | - | | |
Ellis, 1994 | immediate systematic ballon angioplastyte | no immediate angioplasty | | | | - | | |
Erbel, 1989 | immediate systematic ballon angioplastyte | no immediate angioplasty | | | | - | | |
MERLIN (Sutton), 2004 | immediate systematic ballon angioplastyte | no immediate angioplasty | | | | - | | |
SWISS-SMASH, 1999 | immediate systematic ballon angioplastyte | no immediate angioplasty | | | Exploratory | negative | | |
TIMI 2A, 1988 | immediate systematic ballon angioplastyte | no immediate angioplasty | | | Exploratory | - | | |
Belenkie, 1991 | immediate systematic ballon angioplastyte | no immediate angioplasty | | | Exploratory | - | | |
Topol, 1987 | immediate systematic ballon angioplastyte | no immediate angioplasty | | | Exploratory | - | | |
REACT (rescue PCI), 2005 | rescue PTCA | no rescue PTCA | | | | suggesting | | |
MERLIN, 2004 | rescue PTCA | no rescue PTCA | | | | negative | | |
RESCUE II, 2000 | rescue PTCA | no rescue PTCA | | | | negative | | |
RESCUE, 1994 | rescue PTCA | no rescue PTCA | | | | negative | | |
Belenkie, 1992 | rescue PTCA | no rescue PTCA | | | Risk of bias | negative | | |
SWIFT, 1991 | systematic ballon angioplasty | no systematic angioplasty | | | Risk of bias | negative | | |
SIAM, 1992 | systematic ballon angioplasty | no systematic angioplasty | | | Exploratory | negative | | |
TIMI 2, 1989 | systematic ballon angioplasty | no systematic angioplasty | | | Risk of bias | negative | | |
Guerci, 1987 | systematic ballon angioplasty | no systematic angioplasty | | | Exploratory | negative | | |
Van den Brand, 1991 | systematic ballon angioplasty | no systematic angioplasty | | | Exploratory | negative | | |
TOPS, 1992 | systematic ballon angioplasty | no systematic angioplasty | | | Exploratory | negative | | |
TIMI II-A (defered) | systematic ballon angioplasty | no systematic angioplasty | | | | - | | |
Vermeer, 1999 | systematic ballon angioplasty | no systematic angioplasty | | | | - | | |
TAMI 6, 1992 | systematic ballon angioplasty | no systematic angioplasty | | | | - | | |
Barbash, 1990 | systematic ballon angioplasty | no systematic angioplasty | | | | - | | |
|
TYPHOON, 2006 NCT | sirolimus eluting stent | bare-metal stent | | | | suggesting | | |
SESAMI, 2007 NCT | sirolimus eluting stent | bare-metal stent | | | Risk of bias | suggesting | | |
MISSION, 2008 | sirolimus eluting stent | bare-metal stent | | | Risk of bias | suggesting | | |
Díaz de la Llera, 2007 | sirolimus eluting stent | bare-metal stent | | | | - | | |
DEBATER (SES vs BMS), 2009 | sirolimus eluting stent | bare-metal stent | | | | suggesting | | |
PROSIT, 2006 | sirolimus eluting stent | paclitaxel eluting stent | | | | negative | | |
Di Lorenzo et al., 2005 | sirolimus eluting stent | paclitaxel eluting stent | | | | negative | | |
Juwana, 2009 | sirolimus eluting stent | paclitaxel eluting stent | | | | negative | | |
|
ZEST AMI (vs PES), 2009 NCT | zotarolimus eluting stent | paclitaxel eluting stent | | | Risk of bias | negative | | |
ZEST AMI (vs SES), 2009 NCT | zotarolimus eluting stent | sirolimus eluting stent | | | | negative | | |
|
|
Arias, 2005 | IABP | non-IABP | | | Exploratory | negative | | |
IABP SHOCK II, 2012 NCT | IABP | non-IABP | | | Risk of bias | negative | | |
TACTICS, 2005 | IABP | non-IABP | | | Risk of bias | negative | | |
IABP SHOCK (Prondzinsky), 2010 NCT | IABP | non-IABP | | | Risk of bias | negative | | |
Burkhoff, 2006 | IABP | other LVAD | | | Exploratory | negative | | |
Seyfarth, 2008 | IABP | other LVAD | | | Exploratory | negative | | |
Thiele, 2005 | IABP | other LVAD | | | Exploratory | negative | | |
|
|
Seyfarth, 2008 | Impella LP2.5 | intra-aortic balloon pump | | | | negative | | |
Burkhoff, 2006 | TandemHeart | intra-aortic balloon pump | | | | negative | | |
Thiele, 2005 | TandemHeart | intra-aortic balloon pump | | | | negative | | |
|
|
Wang, 2003 | Angioguard | conventional PCI | | | | - | | |
DIPLOMATE, 2004 | Angioguard | conventional PCI | | | | negative | | |
AiMI, 2006 | AngioJet | conventional PCI | | | | negative | | |
Florence, 2004 | AngioJet | conventional PCI | | | | negative | | |
JETSTENT, 2010 | AnjioJet | conventional PCI | | | Exploratory | negative | | |
Export (Chevalier), 2008 | Export | conventional PCI | | | | suggesting | | |
EXPIRA, 2005 | Export | conventional PCI | | | | negative | | |
Noel, 2005 | Export | conventional PCI | | | | negative | | |
TAPAS, 2008 | Export | conventional PCI | | | | suggesting | | |
Lipiecki, 2009 | Export | conventional PCI | | | | - | | |
PROMISE, 2005 | FilterWire | conventional PCI | | | | - | | |
UpFlow MI, 2007 | FilterWire | conventional PCI | | | | negative | | |
DEDICATION, 2008 | FilterWireg | conventional PCI | | | | negative | | |
ASPARAGUS, 2008 | Guardwire | conventional PCI | | | | negative | | |
Nanasato, 2004 | Guardwire | conventional PCI | | | | - | | |
EMERALD, 2005 | GuardWire | conventional PCI | | | | negative | | |
Ochala, 2007 | GuardWire | conventional PCI | | | | negative | | |
MICADO, 2007 | GuardWire | conventional PCI | | | | negative | | |
Tahk, 2008 | GuardWire | conventional PCI | | | | suggesting | | |
DEAR-MI, 2006 NCT | Pronto | conventional PCI | | | | suggesting | | |
NONSTOP, 2004 | Rescue | conventional PCI | | | | - | | |
Dudek, 2004 | Rescue | conventional PCI | | | | suggesting | | |
Kaltoft, 2006 | Rescue | conventional PCI | | | | negative | | |
PREMIAR, 2007 | SpideRX | conventional PCI | | | | negative | | |
Ciszewski, 2011 | thrombectomy | conventional PCI | | | | - | | |
TROPHI | thrombectomy | conventional PCI | | | | - | | |
Chao, 2008 | thrombectomy | conventional PCI | | | | - | | |
INFUSE AMI, 2013 | thrombectomy | conventional PCI | | | | - | | |
Liistro, 2009 | thrombectomy | conventional PCI | | | | - | | |
VAMPIRE, 2004 | TVAC | conventional PCI | | | | suggesting | | |
Napodano, 2003 | X-sizer | conventional PCI | | | | suggesting | | |
X AMINE ST, 2005 | X-sizer | conventional PCI | | | | suggesting | | |
Beran, 2002 | X-sizer | conventional PCI | | | | suggesting | | |
TASTE (Fröbert), 2013 NCT | thrombectomy | PCI only | | | | - | | |
TOTAL, 2015 NCT | thrombectomy | PCI only | aaa | | | negative | | |
|
PIHRATE, 2004 | Diver | conventional PCI | | | | negative | | |
REMEDIA, 2005 | Diver | conventional PCI | | | | suggesting | | |
De Luca, 2006 | Diver | conventional PCI | | | | suggesting | | |
Sardella, 2005 | Diver | conventional PCI | | | | - | | |