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pentasaccharide
systematic review
meta-analysis
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thrombosis prevention
abdominal surgery
All type of patient
medical patients
orthopedic surgery
synthetic oligosaccharide
fondaparinux
vs placebo or control
vs fondaparinux
vs Low molecular weight heparin
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Description
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Characteristics
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NCT results
Major bleeding (17)
Venous thromboembolism (14)
Deep vein thrombosis (14)
Symptomatic pulmonary embolism (13)
All cause death (13)
proximal DVT (12)
Symptomatic venous thromboembolism (DVT, PE) (12)
Symptomatic deep-vein thrombosis (11)
non-fatal pulmonary embolism (10)
fatal pulmonary embolism (10)
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medians
Trial
Studied trt
Control trt
patients
tags
ROB
Trial result
Major bleeding
Venous thromboembolism
thrombosis prevention
fondaparinux
DRI4757
fondaparinux
placebo
knee surgery
Low risk of bias
-
ARTEMIS (Cohen), 2006
fondaparinux
placebo
medical patients
Low risk of bias
negative
-3%
APOLLO (Turpie), 2007
fondaparinux
placebo (on top intermittent pneumatic comp.)
abdominal surgery
Low risk of bias
suggesting
924%
-69%
PENTAMAKS (Bauer), 2001
fondaparinux
enoxaparin
knee surgery
Low risk of bias
suggesting
1000%
-55%
PENTHIFRA (Eriksson), 2001
fondaparinux
enoxaparin
hip surgery
Low risk of bias
suggesting
-4%
-56%
PENTATHLON (Turpie), 2002
fondaparinux
enoxaparin
hip surgery
Low risk of bias
suggesting
82%
-26%
EPHESUS (Lassen), 2002
fondaparinux
enoxaparin
hip surgery
Low risk of bias
suggesting
51%
-56%
Turpie, 2001
fondaparinux
enoxaparin
hip surgery
Low risk of bias
-
L8541
fondaparinux
enoxaparin
orthopaedic surgery
Low risk of bias
negative
-8%
L8635
fondaparinux
enoxaparin
knee surgery
Exploratory
negative
-22%
PEGASUS, 2005
fondaparinux
enoxaparin
abdominal surgery
Low risk of bias
negative
39%
-25%
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