New P2Y12 Inhibitors

systematic review meta-analysis network meta-analysis

Select acute coronary syndrome uncoded clinical condition ***       P2Y12 receptor antagonistreversible ADP receptor antagonistthienopyridine cangrelorelinogrelprasugrelticagrelor vs placebo or controlvs clopidogrel      

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Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results	All cause death (5)Major bleeding (5)cardiovascular events (5)myocardial infarction (fatal and non fatal) (4)stroke (fatal and non fatal) (4)Vascular death (3)Bleeding (3)Non fatal MI (2)Non fatal stroke (2)fatal bleeding (2)all cause death, MI, stroke (2)Revascularization (1)death, MI, unplanned revascularization (1)major bleeding TIMI (1)Cardiovascular death (1)Urgent target-vessel revascularization (1)Stent thrombosis (any, end of follow up) (1)Major or minor TIMI bleeding (1)Non vascular death (1)ischemic stroke (1)MACE (1) Options Numeric bar chart forest plot medians
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	All cause death	Major bleeding
acute coronary syndrome
cangrelor
CHAMPION-PCI, 2009      NCT	cangrelor up front	clopidogrel up front			Low risk of bias	negative
CHAMPION-PLATFORM, 2009    NCT	cangrelor up front	delayed clopidogrel			Low risk of bias	negative
elinogrel
ERASE-MI, 2009	elinogrel	placebo			Low risk of bias	negative
prasugrel
JUMBO-TIMI 26, 2005	prasugrel	clopidogrel			Low risk of bias	negative
TRITON-TIMI 38, 2007      NCT	prasugrel	clopidogrel			Low risk of bias	suggesting
ticagrelor
PLATO, 2009      NCT	ticagrelor	clopidogrel			Low risk of bias	suggesting
DISPERSE-2 (90mg), 2007	ticagrelor	clopidogrel			Low risk of bias	negative