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niacin
systematic review
meta-analysis
network meta-analysis
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cardiovascular prevention
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niacin
niacin (on top statin)
niacin in association
other cholesterol lowering drugs
niacin
vs placebo or control
vs ezetimibe
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NCT results
Coronary event (10)
cardiovascular events (9)
All cause death (6)
stroke (fatal and non fatal) (6)
Coronary death (3)
non cardiovascular death (3)
Cardiovascular death (3)
Death from cancer (2)
Non fatal MI (2)
cardiac death (1)
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Studied trt
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Trial result
Coronary event
cardiovascular events
cardiovascular prevention
niacin
VA drugs, 1968
niacin
control
Low risk of bias
negative
UCSF SCOR, 1990
niacin+colestipol
control
Exploratory
negative
-100%
-100%
Carlson (Stockholm), 1977
clofibtate+niacin
placebo
secondary prevention
Risk of bias
suggesting
-29%
CLAS, 1987
colestipol-niacin
placebo
secondary prevention
Exploratory
negative
CDP niacin, 1975
niacin
placebo
Low risk of bias
suggesting
-15%
FATS, 1990
niacin+colestipol
placebo
Low risk of bias
suggesting
-78%
AIM-HIGH, 2011
NCT
niacin
placebo (on top statin)
Low risk of bias
negative
4%
2%
HPS 2-Thrive
NCT
niacin
placebo (on top statin)
Low risk of bias
negative
-4%
-4%
Oxford Niaspan Study, 2009
NCT
niacin
placebo (on top statin)
Exploratory
-
ARBITER 2, 2009
niacin
placebo (on top statin)
Exploratory
negative
-8%
-61%
HATS, 2001
niacin
placebo (on top statin)
Low risk of bias
negative
-80%
-60%
ARBITER 6-HALTS (niacin vs ezetimibe), 2009
NCT
niacin
ezetimibe
Exploratory
suggesting
-79%
2849%
Guyton, 2008
niacin+ezetimibe
simvastatin+ezetimibe
Low risk of bias
negative
-60%
2153%
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